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by Morrissy, A. Sorana and Garzia, Livia and Shih, David J. H and Zuyderduyn, Scott and Huang, Xi and Skowron, Patryk and Remke, Marc and Cavalli, Florence M. G and Ramaswamy, Vijay and Lindsay, Patricia E and Jelveh, Salomeh and Donovan, Laura K and Wang, Xin and Luu, Betty and Zayne, Kory and Li, Yisu and Mayoh, Chelsea and Thiessen, Nina and Mercier, Eloi and Mungall, Karen L and Ma, Yusanne and Tse, Kane and Zeng, Thomas and Shumansky, Karey and Roth, Andrew J. L and Shah, Sohrab and Farooq, Hamza and Kijima, Noriyuki and Holgado, Borja L and Lee, John J. Y and Matan-Lithwick, Stuart and Liu, Jessica and Mack, Stephen C and Manno, Alex and Michealraj, K.A and Nor, Carolina and Peacock, John and Qin, Lei and Reimand, Juri and Rolider, Adi and Thompson, Yuan Y and Wu, Xiaochong and Pugh, Trevor and Ally, Adrian and Bilenky, Mikhail and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Young and Chuah, Eric and Corbett, Richard D and Dhalla, Noreen and He, An and Lee, Darlene and Li, Haiyan I and Long, William and Mayo, Michael and Plettner, Patrick and Qian, Jenny Q and Schein, Jacqueline E and Tam, Angela and Wong, Tina and Birol, Inanc and Zhao, Yongjun and Faria, Claudia C and Pimentel, José and Nunes, Sofia and Shalaby, Tarek and Grotzer, Michael and Pollack, Ian F and Hamilton, Ronald L and Li, Xiao-Nan and Bendel, Anne E and Fults, Daniel W and Walter, Andrew W and Kumabe, Toshihiro and Tominaga, Teiji and Collins, V. Peter and Cho, Yoon-Jae and Hoffman, Caitlin and Lyden, David and Wisoff, Jeffrey H and Garvin, James H and Stearns, Duncan S and Massimi, Luca and Schüller, Ulrich and Sterba, Jaroslav and Zitterbart, Karel and Puget, Stephanie and Ayrault, Olivier and Dunn, Sandra E and Tirapelli, Daniela P. C and Carlotti, Carlos G and Wheeler, Helen and Hallahan, Andrew R and Ingram, Wendy and MacDonald, Tobey J and Olson, Jeffrey J and Van Meir, Erwin G and Lee, Ji-Yeoun and Wang, Kyu-Chang and ...
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 351 - 357
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related... 
HETEROGENEITY | CANCER EVOLUTION | CELLS | IMPACT | MULTIDISCIPLINARY SCIENCES | SUBGROUP MEDULLOBLASTOMA | DYNAMICS | MUTATIONS | SEQUENCING DATA | LYMPHOBLASTIC-LEUKEMIA | GENOME | Clone Cells - drug effects | Humans | Male | Medulloblastoma - therapy | Radiotherapy, Image-Guided | Selection, Genetic - drug effects | Drosophila melanogaster - genetics | Neoplasm Recurrence, Local - pathology | Medulloblastoma - radiotherapy | DNA Mutational Analysis | Medulloblastoma - pathology | Female | Medulloblastoma - surgery | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Molecular Targeted Therapy - methods | Disease Models, Animal | Signal Transduction | Neoplasm Recurrence, Local - therapy | Drosophila melanogaster - cytology | Cerebellar Neoplasms - genetics | Clone Cells - metabolism | Genome, Human - genetics | Xenograft Model Antitumor Assays | Animals | Clone Cells - pathology | Craniospinal Irradiation | Neoplasm Recurrence, Local - genetics | Mice | Cerebellar Neoplasms - therapy | Cerebellar Neoplasms - surgery | Cerebellar Neoplasms - radiotherapy | Clonal selection theory | Care and treatment | Medulloblastoma | Oncology, Experimental | Genetic aspects | Research | Cancer | Genes | Cloning | Clinical trials | Cytotoxicity | Genomes | Radiation therapy | Metastasis | Cancer therapies | Rodents | Medical prognosis | Mutation | Tumors | Index Medicus
Journal Article
by Morrissy, A. Sorana and Cavalli, Florence M. G and Remke, Marc and Ramaswamy, Vijay and Shih, David J. H and Holgado, Borja L and Farooq, Hamza and Donovan, Laura K and Garzia, Livia and Agnihotri, Sameer and Kiehna, Erin N and Mercier, Eloi and Mayoh, Chelsea and Papillon-Cavanagh, Simon and Nikbakht, Hamid and Gayden, Tenzin and Torchia, Jonathon and Picard, Daniel and Merino, Diana M and Vladoiu, Maria and Luu, Betty and Wu, Xiaochong and Daniels, Craig and Horswell, Stuart and Thompson, Yuan Yao and Hovestadt, Volker and Northcott, Paul A and Jones, David T. W and Peacock, John and Wang, Xin and Mack, Stephen C and Reimand, Jüri and Albrecht, Steffen and Fontebasso, Adam M and Thiessen, Nina and Li, Yisu and Schein, Jacqueline E and Lee, Darlene and Carlsen, Rebecca and Mayo, Michael and Tse, Kane and Tam, Angela and Dhalla, Noreen and Ally, Adrian and Chuah, Eric and Cheng, Young and Plettner, Patrick and Li, Haiyan I and Corbett, Richard D and Wong, Tina and Long, William and Loukides, James and Buczkowicz, Pawel and Hawkins, Cynthia E and Tabori, Uri and Rood, Brian R and Myseros, John S and Packer, Roger J and Korshunov, Andrey and Lichter, Peter and Kool, Marcel and Pfister, Stefan M and Schüller, Ulrich and Dirks, Peter and Huang, Annie and Bouffet, Eric and Rutka, James T and Bader, Gary D and Swanton, Charles and Ma, Yusanne and Moore, Richard A and Mungall, Andrew J and Majewski, Jacek and Jones, Steven J. M and Das, Sunit and Malkin, David and Jabado, Nada and Marra, Marco A and Taylor, Michael D
Nature Genetics, ISSN 1061-4036, 05/2017, Volume 49, Issue 5, pp. 780 - 788
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification... 
IN-VITRO | EVOLUTION | SOLID TUMORS | SUBTYPES | INTRATUMOR HETEROGENEITY | GROWTH | GENETICS & HEREDITY | EXPRESSION | RENAL-CELL CARCINOMA | T-CELLS | LYMPHOCYTES | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Child, Preschool | Male | INDEL Mutation | DNA Copy Number Variations | Medulloblastoma - pathology | Aged, 80 and over | Adult | Female | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Child | Principal Component Analysis | Genome-Wide Association Study | Gene Expression Profiling - methods | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genetic Heterogeneity | Aged | Polymorphism, Single Nucleotide | Mutation | Cluster Analysis | Brain | Gene mutations | Biopsy | Medulloblastoma | Genetic aspects | Diagnosis | Health aspects | Methods | Pediatrics | Laboratories | Neuropathology | Brain cancer | Colleges & universities | Oncology | Genomes | Biology | Neurosurgery | Consortia | Heterogeneity | Immunology | Renal cell carcinoma | Genetics | Bioindicators | Research centers | Medical research | Hematology | Gene expression | Children & youth | Genetic markers | Hospitals | Glioma | Biomarkers | Tumors | Index Medicus | Spatial heterogeneity | glioblastoma multiforme | renal cell carcinoma | gene expression profiling | medulloblastoma | whole exome sequencing
Journal Article
Nature Communications, ISSN 2041-1723, 02/2015, Volume 6, Issue 1, pp. 6351 - 6351
Journal Article
by Ley, Timothy J and Miller, Christopher and Ding, Li and Raphael, Benjamin J and Mungall, Andrew J and Robertson, Gordon and Hoadley, Katherine and Triche Jr, Timothy J and Laird, Peter W and Baty, Jack D and Fulton, Lucinda L and Fulton, Robert and Heath, Sharon E and Kalicki-Veizer, Joelle and Kandoth, Cyriac and Klco, Jeffery M and Koboldt, Daniel C and Kanchi, Krishna-Latha and Kulkarni, Shashikant and Lamprecht, Tamara L and Larson, David E and Lin, G and Lu, Charles and McLellan, Michael D and McMichael, Joshua F and Payton, Jacqueline and Schmidt, Heather and Spencer, David H and Tomasson, Michael H and Wallis, John W and Wartman, Lukas D and Watson, Mark A and Welch, John and Wendl, Michael C and Ally, Adrian and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron and Chiu, Readman and Chu, Andy and Chuah, Eric and Chun, Hye-Jung and Corbett, Richard and Dhalla, Noreen and Guin, Ranabir and He, An and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Jones, Steven and Karsan, Aly and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Karen and Parker, Jeremy and Pleasance, Erin and Plettner, Patrick and Schein, Jacquie and Stoll, Dominik and Swanson, Lucas and Tam, Angela and Thiessen, Nina and Varhol, Richard and Wye, Natasja and Zhao, Yongjun and Gabriel, Stacey and Getz, Gad and Sougnez, Carrie and Zou, Lihua and Leiserson, Mark D. M and Vandin, Fabio and Wu, Hsin-Ta and Applebaum, Frederick and Baylin, Stephen B and Akbani, Rehan and Broom, Bradley M and Chen, Ken and Motter, Thomas C and Nguyen, Khanh and Weinstein, John N and Zhang, Nianziang and Ferguson, Martin L and Adams, Christopher and Black, Aaron and Bowen, Jay and Gastier-Foster, Julie and Grossman, Thomas and Lichtenberg, Tara and Wise, Lisa and Davidsen, Tanja and Demchok, John A and Mills Shaw, Kenna R and Sheth, Margi and Sofia, Heidi J and Yang, Liming and Downing, James R and Eley, Greg and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England Journal of Medicine, ISSN 0028-4793, 05/2013, Volume 368, Issue 22, pp. 2059 - 2074
Journal Article
by Getz, Gad and Gabriel, Stacey B and Cibulskis, Kristian and Lander, Eric and Sivachenko, Andrey and Sougnez, Carrie and Lawrence, Mike and Kandoth, Cyriac and Dooling, David and Fulton, Robert and Fulton, Lucinda and Kalicki-Veizer, Joelle and McLellan, Michael D and O'Laughlin, Michelle and Schmidt, Heather and Wilson, Richard K and Ye, Kai and Li, Ding and Ally, Adrian and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Holt, Robert A and Jones, Steven J.M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Plettner, Patrick and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Varhol, Richard J and Gordon Robertson, A and Cherniack, Andrew D and Pashtan, Itai and Saksena, Gordon and Onofrio, Robert C and Schumacher, Steven E and Tabak, Barbara and Carter, Scott L and Hernandez, Bryan and Gentry, Jeff and Salvesen, Helga B and Ardlie, Kristin and Winckler, Wendy and Beroukhim, Rameen and Meyerson, Matthew and Hadjipanayis, Angela and Lee, Semin and Mahadeshwar, Harshad S and Park, Peter and Protopopov, Alexei and Ren, Xiaojia and Seth, Sahil and Song, Xingzhi and Tang, Jiabin and Xi, Ruibin and Yang, Lixing and Dong, Zeng and Kucherlapati, Raju and Chin, Lynda and Zhang, Jianhua and Todd Auman, J and Balu, Saianand and Bodenheimer, Tom and Buda, Elizabeth and Neil Hayes, D and Hoyle, Alan P and Jefferys, Stuart R and Jones, Corbin D and Meng, Shaowu and Mieczkowski, Piotr A and Mose, Lisle E and Parker, Joel S and Perou, Charles M and Roach, Jeff and Yan, Shi and Simons, Janae V and Soloway, Mathew G and Tan, Donghui and Topal, Michael D and Waring, Scot and Wu, Junyuan and Hoadley, Katherine A and Baylin, Stephen B and Bootwalla, Moiz S and Lai, Phillip H and Triche Jr, Timothy J and Van Den Berg, David J and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7447, pp. 67 - 73
Journal Article
by Creighton, Chad J and Morgan, Margaret and Gunaratne, Preethi H and Wheeler, David A and Gibbs, Richard A and Robertson, Gordon and Chu, Andy and Beroukhim, Rameen and Cibulskis, Kristian and Signoretti, Sabina and Vandin, Fabio and Wu, Hsin-Ta and Raphael, Benjamin J and Verhaak, Roel G.W and Tamboli, Pheroze and Torres-Garcia, Wandaliz and Akbani, Rehan and Weinstein, John N and Reuter, Victor and Hsieh, James J and Brannon, A. Rose and Hakimi, A. Ari and Jacobsen, Anders and Ciriello, Giovanni and Reva, Boris and Ricketts, Christopher J and Linehan, W. Marston and Stuart, Joshua M and Rathmell, W. Kimryn and Hui, Shen and Laird, Peter W and Muzny, Donna and Davis, Caleb and Liu, Xi and Chang, Kyle and Kakkar, Nipun and Treviño, Lisa R and Benton, Susan and Reid, Jeffrey G and Morton, Donna and Doddapaneni, Harsha and Yi, Han and Lewis, Lora and Huyen, Dinh and Kovar, Christie and Zhu, Yiming and Santibanez, Jireh and Min, Wang and Hale, Walker and Kalra, Divya and Getz, Gad and Lawrence, Michael S and Sougnez, Carrie and Carter, Scott L and Sivachenko, Andrey and Lee, Lichtenstein and Stewart, Chip and Voet, Doug and Fisher, Sheila and Gabriel, Stacey B and Lander, Eric and Schumacher, Steve E and Tabak, Barbara and Saksena, Gordon and Onofrio, Robert C and Cherniack, Andrew D and Gentry, Jeff and Ardlie, Kristin and Meyerson, Matthew and Chun, Hye-Jung E and Mungall, Andrew J and Sipahimalani, Payal and Stoll, Dominik and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S.N and Carlsen, Rebecca and Carter, Candace and Chuah, Eric and Coope, Robin J.N and Dhalla, Noreen and Gorski, Sharon and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lebovitz, Chandra and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Pleasance, Erin and Plettner, Patrick and Schein, Jacqueline E and Shafiei, Arash and Slobodan, Jared R and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and ... and Canc Genome Atlas Res Network and Anal Working Grp
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 43 - 49
Genetic changes underlying clear cell renal cell carcinoma(ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the... 
GENETIC-BASIS | METHYLATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | ARM | KIDNEY CANCER | Proteins | DNA methylation | Mutation | Kinases | Chromosomes | Genes
Journal Article