Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (17) 17
humans (12) 12
article (9) 9
genetics (8) 8
genomes (8) 8
neurosciences (8) 8
amyotrophic lateral sclerosis (6) 6
analysis (6) 6
genes (6) 6
research (6) 6
amyotrophic lateral sclerosis - genetics (5) 5
amyotrophic-lateral-sclerosis (5) 5
chromatin (5) 5
female (5) 5
gene expression (5) 5
genetic aspects (5) 5
genetic research (5) 5
genotype (5) 5
male (5) 5
mutation (5) 5
animals (4) 4
biochemistry & molecular biology (4) 4
genome-wide association study (4) 4
genomics (4) 4
geriatrics & gerontology (4) 4
gwas (4) 4
internal medicine (4) 4
multidisciplinary sciences (4) 4
neurology (4) 4
transcription factors (4) 4
accessibility (3) 3
aged (3) 3
als (3) 3
atac-seq (3) 3
c9orf72 protein (3) 3
cells (3) 3
clinical neurology (3) 3
combinatorial analysis (3) 3
expression (3) 3
genetic predisposition to disease - genetics (3) 3
genetics & heredity (3) 3
genome-wide association (3) 3
methods (3) 3
middle aged (3) 3
proteins - genetics (3) 3
read alignment (3) 3
risk factors (3) 3
single-cell analysis - methods (3) 3
age of onset (2) 2
algorithms (2) 2
alleles (2) 2
alzheimers-disease (2) 2
amyotrophic lateral sclerosis - pathology (2) 2
bioinformatics (2) 2
case-control studies (2) 2
cell biology (2) 2
cell fate (2) 2
chromatin - metabolism (2) 2
chromatin accessibility (2) 2
common variants (2) 2
developmental biology (2) 2
disease (2) 2
dna methylation (2) 2
dna repeat expansion (2) 2
dna-damage (2) 2
embryogenesis (2) 2
embryonic development (2) 2
embryonic growth stage (2) 2
epigenesis, genetic (2) 2
frontotemporal dementia (2) 2
frontotemporal dementia - genetics (2) 2
gcta (2) 2
gene expression regulation (2) 2
gene regulation (2) 2
gene-expression (2) 2
genetic association studies (2) 2
genetic predisposition to disease (2) 2
genetic transcription (2) 2
genome (2) 2
genome-wide association study - methods (2) 2
greece (2) 2
heart (2) 2
hek293 cells (2) 2
heritability (2) 2
hexanucleotide repeat (2) 2
human genome (2) 2
identification (2) 2
imputation (2) 2
kidneys (2) 2
landscapes (2) 2
meta-analysis (2) 2
mice (2) 2
mutations (2) 2
parkinson disease - genetics (2) 2
parkinson's disease (2) 2
parkinsons-disease (2) 2
proteins (2) 2
risk (2) 2
risk profiles (2) 2
sequencing data (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Reversed graph embedding resolves complex single-cell trajectories
by Qiu, Xiaojie and Mao, Qi and Tang, Ying and Wang, Li and Chawla, Raghav and Pliner, Hannah A and Trapnell, Cole
Nature Methods, ISSN 1548-7091, 10/2017, Volume 14, Issue 10, pp. 979 - 982
Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex trajectories with multiple... 
BIOCHEMICAL RESEARCH METHODS | Transcription Factors - metabolism | Algorithms | Animals | Models, Biological | Computer Simulation | Mutation | Transcription Factors - genetics | Transcriptome - physiology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Usage | Research | Genes | Transcription factors | Cell fate | Gene regulation | Computer applications | Decisions | Embedding | Trajectories | Gene expression | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing
by Cusanovich, Darren A and Daza, Riza and Adey, Andrew and Pliner, Hannah A and Christiansen, Lena and Gunderson, Kevin L and Steemers, Frank J and Trapnell, Cole and Shendure, Jay
Science, ISSN 0036-8075, 05/2015, Volume 348, Issue 6237, pp. 910 - 914
Technical advances have enabled the collection of genome and transcriptome data sets with single-cell resolution. However, single-cell characterization of the... 
IN-VITRO | HUMAN GENOME | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | CONTIGUITY | FATE | EXPRESSION | TRANSPOSITION | HL-60 Cells | Chromatin - metabolism | Single-Cell Analysis - methods | Epigenesis, Genetic | Humans | HEK293 Cells | Chromatin | Research | Analysis | Cells | Indexing | Cellular biology | Tissue | Index Medicus | Multiplexing | Cellular | Landscapes | Accessibility | Strategy | Culture | Combinatorial analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text The accessible chromatin landscape of the murine hippocampus at single-cell resolution
by Sinnamon, JR and Torkenczy, KA and Linhoff, MW and Vitak, SA and Mulqueen, RM and Pliner, HA and Trapnell, C and Steemers, FJ and Mandel, G and Adey, AC
GENOME RESEARCH, ISSN 1088-9051, 05/2019, Volume 29, Issue 5, pp. 857 - 869
Here we present a comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution. Substantial advances of this work... 
SYSTEM | MARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ELECTROPHYSIOLOGY | MEMORY | GENOMES | CORTEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | NEURONS | DIVERSITY | EXPRESSION
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text The cis-regulatory dynamics of embryonic development at single-cell resolution
by Cusanovich, Darren A and Reddington, James P and Garfield, David A and Daza, Riza M and Aghamirzaie, Delasa and Marco-Ferreres, Raquel and Pliner, Hannah A and Christiansen, Lena and Qiu, Xiaojie and Steemers, Frank J and Trapnell, Cole and Shendure, Jay and Furlong, Eileen E. M
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 538 - 542
Understanding how gene regulatory networks control the progressive restriction of cell fates is a long-standing challenge. Recent advances in measuring gene... 
DROSOPHILA MESODERM | READ ALIGNMENT | T-SNE | CHROMATIN | GENE | MESENDODERM | MULTIDISCIPLINARY SCIENCES | ENDODERM | GATA FACTOR SERPENT | EXPRESSION | TRANSPOSITION | Genetic research | Embryonic development | Unicellular organisms | Genetic aspects | Research | Genetic regulation | Ectoderm | Chromatin | Accessibility | Spatial discrimination | Transgenic | Mesoderm | Genomes | Regulatory sequences | Nuclei | Embryogenesis | Cell fate | Egg laying | Blastoderm | Bioinformatics | Endoderm | Mesendoderm | Discriminant analysis | Gastrulation | Drosophila | Gene expression | Transposase | Embryos | Embryonic growth stage | Enhancers | Dynamic tests | Landscapes | Insects | Spatial heterogeneity | Nuclei (cytology) | Combinatorial analysis | Index Medicus | regulatory landscape | single cell | single cell epigenetics | embryonic development | open chromatin | developmental enhancers | cell fate decisions | ATAC-seq
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
by Johnson, Janel O and Pioro, Erik P and Boehringer, Ashley and Chia, Ruth and Feit, Howard and Renton, Alan E and Pliner, Hannah A and Abramzon, Yevgeniya and Marangi, Giuseppe and Winborn, Brett J and Gibbs, J. Raphael and Nalls, Michael A and Morgan, Sarah and Shoai, Maryam and Hardy, John and Pittman, Alan and Orrell, Richard W and Malaspina, Andrea and Sidle, Katie C and Fratta, Pietro and Harms, Matthew B and Baloh, Robert H and Pestronk, Alan and Weihl, Conrad C and Rogaeva, Ekaterina and Zinman, Lorne and Drory, Vivian E and Borghero, Giuseppe and Mora, Gabriele and Calvo, Andrea and Rothstein, Jeffrey D and Drepper, Carsten and Sendtner, Michael and Singleton, Andrew B and Taylor, J Paul and Cookson, Mark R and Restagno, Gabriella and Sabatelli, Mario and Bowser, Robert and Chio`, Adriano and Traynor, Bryan J and Moglia, Cristina and Cammarosano, Stefania and Canosa, Antonio and Gallo, Sara and Brunetti, Maura and Ossola, Irene and Marinou, Kalliopi and Papetti, Laura and Pisano, Fabrizio and Pinter, Giuseppe Lauria and Conte, Amelia and Luigetti, Marco and Zollino, Marcella and Lattante, Serena and Marangi, Giuseppe and la Bella, Vincenzo and Spataro, Rossella and Colletti, Tiziana and Battistini, Stefania and Ricci, Claudia and Caponnetto, Claudia and Mancardi, Gianluigi and Mandich, Paola and Salvi, Fabrizio and Bartolomei, Ilaria and Mandrioli, Jessica and Sola, Patrizia and Lunetta, Christian and Penco, Silvana and Monsurrò, Maria Rosaria and Conforti, Francesca Luisa and Tedeschi, Gioacchino and Gambardella, Antonio and Quattrone, Aldo and Volanti, Paolo and Floris, Gianluca and Cannas, Antonino and Piras, Valeria and Marrosu, Francesco and Marrosu, Maria Giovanna and Murru, Maria Rita and Pugliatti, Maura and Parish, Leslie D and Sotgiu, Alessandra and Solinas, Giuliana and Ulgheri, Lucia and Ticca, Anna and Simone, Isabella and Logroscino, Giancarlo and Pirisi, Angelo and ITALSGEN
Nature Neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 5, pp. 664 - 666
MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal... 
DOMINANT DISTAL MYOPATHY | ALS | PROTEIN | NUCLEAR-MATRIX | NEUROSCIENCES | COMPLEXES | RNA-Binding Proteins - genetics | Genetic Predisposition to Disease - genetics | Spinal Cord - metabolism | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Computational Biology | Nuclear Matrix-Associated Proteins - metabolism | Family Health | Genotype | Male | Muscle, Skeletal - metabolism | Mutation - genetics | DNA-Binding Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Neurologic Examination | Nuclear Matrix-Associated Proteins - genetics | DNA Mutational Analysis | Spinal Cord - pathology | Aged, 80 and over | Female | Aged | Muscle, Skeletal - pathology | RNA-Binding Proteins - metabolism | Gene mutations | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Research | Neurological research | Neurophysiology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Joint profiling of chromatin accessibility and gene expression in thousands of single cells
by Cao, Junyue and Cusanovich, Darren A and Ramani, Vijay and Aghamirzaie, Delasa and Pliner, Hannah A and Hill, Andrew J and Daza, Riza M and McFaline-Figueroa, Jose L and Packer, Jonathan S and Christiansen, Lena and Steemers, Frank J and Adey, Andrew C and Trapnell, Cole and Shendure, Jay
Science, ISSN 0036-8075, 09/2018, Volume 361, Issue 6409, pp. 1380 - 1385
Although we can increasingly measure transcription, chromatin, methylation, and other aspects of molecular biology at single-cell resolution, most assays... 
HETEROGENEITY | DNA METHYLATION | BINDING | MULTIDISCIPLINARY SCIENCES | SEQ | GENOME | A549 Cells | Chromatin - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Kidney - drug effects | Humans | Regulatory Elements, Transcriptional - drug effects | Gene Expression Profiling - methods | Kidney - cytology | Gene Expression Regulation - drug effects | Animals | Dexamethasone - pharmacology | Single-Cell Analysis - methods | HEK293 Cells | Mice | Genomics - methods | Chromatin | Corticosteroids | RNA | Genes | Genetic transcription | Molecular biology | Methylation | RNA sequencing | Genetic research | Genetic aspects | Research | Gene expression | Cells | Methods | Adenocarcinoma | Dexamethasone | Kidneys | Accessibility | Lung | Genomes | Biology | Subgroups | Covariance | Ribonucleic acids | DNA methylation | Combinatorial analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility
by Cusanovich, Darren A and Hill, Andrew J and Aghamirzaie, Delasa and Daza, Riza M and Pliner, Hannah A and Berletch, Joel B and Filippova, Galina N and Huang, Xingfan and Christiansen, Lena and DeWitt, William S and Lee, Choli and Regalado, Samuel G and Read, David F and Steemers, Frank J and Disteche, Christine M and Trapnell, Cole and Shendure, Jay
Cell, ISSN 0092-8674, 08/2018, Volume 174, Issue 5, pp. 1309 - 1324.e18
We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide chromatin accessibility in ∼100,000 single cells from 13 adult mouse tissues.... 
single cell | GWAS | chromatin accessibility | regulatory | epigenomics | chromatin | epigenetics | ATAC-seq | REGULATORY DNA | ELEMENTS | READ ALIGNMENT | NEURONAL SUBTYPES | MOUSE GENOME | ANNOTATION | INFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | SEQUENCING DATA | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Genome-Wide Association Study | Epigenomics | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Male | Mammals | Animals | Single-Cell Analysis - methods | Mice | Transcription Factors | Genome, Human | Chromatin - chemistry | Cluster Analysis | Epigenetic inheritance | Chromatin | Genetic transcription | Analysis | Genomics | Cells | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
by Nicolas, Aude and Kenna, Kevin P and Kenna, Aoife and Kenna, Kevin and Kenna, Brendan J and Renton, Alan E and Ticozzi, Nicola and Faghri, Faraz and Chia, Ruth and Dominov, Janice A and Nalls, Mike A and Keagle, Pamela and Rivera, Alberto M and van Rheenen, Wouter and Murphy, Natalie A and van Vugt, Joke and van Vugt, Joke J.F.A and Geiger, Joshua T and Van der Spek, Rick A and Pliner, Hannah A and Shankaracharya and Smith, Bradley N and Marangi, Giuseppe and Topp, Simon D and Abramzon, Yevgeniya and Gkazi, Athina Soragia and Eicher, John D and Logullo, Francesco O and Simone, Isabella and Simone, Isabella L and Logroscino, Giancarlo and Salvi, Fabrizio and Bartolomei, Ilaria and Borghero, Giuseppe and Murru, Maria Rita and Costantino, Emanuela and Pani, Carla and Puddu, Roberta and Caredda, Carla and Piras, Valeria and Tranquilli, Stefania and Cuccu, Stefania and Corongiu, Daniela and Melis, Maurizio and Milia, Antonio and Marrosu, Francesco and Marrosu, Maria Giovanna and Floris, Gianluca and Cannas, Antonino and Capasso, Margherita and Caponnetto, Claudia and Mancardi, Gianluigi and Origone, Paola and Mandich, Paola and Conforti, Francesca L and Cavallaro, Sebastiano and Mora, Gabriele and Mora, Jesús S and Marinou, Kalliopi and Sideri, Riccardo and Penco, Silvana and Mosca, Lorena and Lunetta, Christian and Pinter, Giuseppe Lauria and Corbo, Massimo and Riva, Nilo and Carrera, Paola and Volanti, Paolo and Mandrioli, Jessica and Fini, Nicola and Fasano, Antonio and Tremolizzo, Lucio and Arosio, Alessandro and Ferrarese, Carlo and Trojsi, Francesca and Tedeschi, Gioacchino and Monsurrò, Maria Rosaria and Piccirillo, Giovanni and Femiano, Cinzia and Ticca, Anna and Ortu, Enzo and La Bella, Vincenzo and Spataro, Rossella and Colletti, Tiziana and Sabatelli, Mario and Zollino, Marcella and Conte, Amelia and Luigetti, Marco and Lattante, Serena and Santarelli, Marialuisa and Petrucci, Antonio and Pugliatti, Maura and Pirisi, Angelo and Parish, Leslie D and Occhineri, Patrizia and Giannini, Fabio and Battistini, Stefania and Ricci, Claudia and Benigni, Michele and Cau, Tea B and ... and Genomic Translation ALS Care GTAC and ALS Sequencing Consortium and Clinical Res ALS Related Disorders and NYGC ALS Consortium and ITALSGEN Consortium and SLAGEN Consortium and French ALS Consortium and Project MinE ALS Sequencing Consor and Answer ALS Fdn and Project MinE ALS Sequencing Consortium and Genomic Translation for ALS Care (GTAC) Consortium and Answer ALS Foundation and Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium and Medicinska fakulteten and Institutionen för farmakologi och klinisk neurovetenskap and Umeå universitet
Neuron, ISSN 0896-6273, 03/2018, Volume 97, Issue 6, pp. 1268 - 1283.e6
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases... 
WGS | GWAS | WES | KIF5A | ALS | axonal transport | cargo | MOTOR-NEURONS | TARGETED DISRUPTION | GENOTYPE IMPUTATION | DNA-DAMAGE | AXONAL-TRANSPORT | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | KINESIN HEAVY-CHAIN | HEXANUCLEOTIDE REPEAT | NEUROSCIENCES | FAMILIAL ALS | Genetic research | Genes | Analysis | Genomics | Phenotypes | Disease | Neurodegenerative diseases | Pathogenesis | Homeostasis | Amyotrophic lateral sclerosis | Genomes | Risk factors | Consortia | Hereditary spastic paraplegia | Proteins | Paraplegia | Charcot-Marie-Tooth disease | Cytoskeleton | Mutation | Spastic paraplegia | Index Medicus | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Genome-wide identification and expression of xenopus F-box family of proteins
by Saritas-Yildirim, Banu and Pliner, Hannah A and Ochoa, Angelica and Silva, Elena M and Klymkowsky, Michael
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0136929 - e0136929
Protein degradation via the multistep ubiquitin/26S proteasome pathway is a rapid way to alter the protein profile and drive cell processes and developmental... 
SEL-10 | DATABASE | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | SCF | NOTCH | DEGRADATION | CELL-CYCLE | HYBRIDIZATION | DIFFERENTIATION | UBIQUITIN LIGASES | Animals | Proteolysis | SKP Cullin F-Box Protein Ligases - genetics | Xenopus - genetics | Gene Expression Regulation, Developmental - genetics | Phylogeny | Genome-Wide Association Study - methods | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Embryonic development | Genetic aspects | Research | Amphibians | Heart | Ubiquitin | Brain | Spinal cord | Regulators | Fourier transforms | Target recognition | Genes | Genomes | Somites | Tissues | Data bases | Recruitment | Degradation | Proteins | Embryogenesis | Developmental stages | Cell cycle | Phylogenetics | Bioinformatics | Adaptor proteins | Kidneys | Developmental biology | Zebrafish | Gene expression | Neural crest | Embryonic growth stage | Studies | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Searching for Grendel: origin and global spread of the C9ORF72 repeat expansion
by Pliner, Hannah A and Mann, David M and Traynor, Bryan J
Acta Neuropathologica, ISSN 0001-6322, 3/2014, Volume 127, Issue 3, pp. 391 - 396
Recent advances are uncovering more and more of the genetic architecture underlying amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative condition... 
Medicine & Public Health | Pathology | Neurosciences | GENETICS | GGGGCC HEXANUCLEOTIDE REPEAT | FAMILIES | FRONTOTEMPORAL DEMENTIA | MUTATION | DISEASE | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | HAPLOTYPE | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | Proteins - genetics | DNA Repeat Expansion | European Continental Ancestry Group - genetics | Time Factors | Internationality | Amyotrophic Lateral Sclerosis - genetics | Humans | C9orf72 Protein | Human Migration | Evolution, Molecular | Amyotrophic lateral sclerosis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights