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index medicus (71) 71
rheumatology (68) 68
ankylosing spondylitis (59) 59
humans (57) 57
adult (31) 31
female (31) 31
male (31) 31
spondyloarthritis (30) 30
arthritis (28) 28
axial spondyloarthritis (27) 27
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spondylitis, ankylosing - drug therapy (20) 20
disease progression (19) 19
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inflammation (18) 18
antirheumatic agents - therapeutic use (17) 17
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tumor necrosis factor-tnf (17) 17
active ankylosing-spondylitis (16) 16
treatment (16) 16
abridged index medicus (14) 14
diagnosis (14) 14
spondylarthritis - diagnostic imaging (14) 14
spondylitis, ankylosing - diagnostic imaging (14) 14
inflammatory diseases (13) 13
rheumatic diseases (13) 13
severity of illness index (13) 13
spondylitis, ankylosing - pathology (13) 13
structural damage (13) 13
treatment outcome (13) 13
spondylarthritis (12) 12
placebo-controlled trial (11) 11
sacroiliitis (11) 11
spondylarthritis - drug therapy (11) 11
tnf inhibitors (11) 11
back pain (10) 10
bone-formation (10) 10
efficacy (10) 10
etanercept (10) 10
rheumatoid-arthritis (10) 10
sacroiliac joint - pathology (10) 10
spine - pathology (10) 10
tumor necrosis factor-alpha - antagonists & inhibitors (10) 10
anti-inflammatory agents, non-steroidal - therapeutic use (9) 9
nonsteroidal anti-inflammatory drugs (9) 9
open-label trial (9) 9
research (9) 9
rheumatoid arthritis (9) 9
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studies (9) 9
nuclear magnetic resonance--nmr (8) 8
spondyloarthropathies (8) 8
usage (8) 8
care and treatment (7) 7
classification (7) 7
cohort studies (7) 7
development and progression (7) 7
disease-activity (7) 7
medicine & public health (7) 7
nonsteroidal antiinflammatory drugs (7) 7
prognosis (7) 7
psoriasis (7) 7
sacroiliitis - diagnostic imaging (7) 7
safety (7) 7
secukinumab (7) 7
spondylarthritis - diagnosis (7) 7
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therapy (6) 6
tnf (6) 6
tumor necrosis factor (6) 6
whole-body mri (6) 6
asas (5) 5
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1. Antwort von Prof. Dr. Joachim Sieper und Dr. Denis Poddubnyy
by Sieper, Joachim and Poddubnyy, Denis
Zeitschrift fur Allgemeinmedizin, ISSN 0937-6801, 09/2011, Volume 87, Issue 9, pp. 378 - 379
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2. Full Text Axial spondyloarthritis
by Sieper, Joachim, Prof and Poddubnyy, Denis, Prof
Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10089, pp. 73 - 84
Summary The term axial spondyloarthritis covers both patients with non-radiographic and radiographic axial spondyloarthritis, which is also termed ankylosing... 
Internal Medicine | RADIOGRAPHIC SPINAL PROGRESSION | MEDICINE, GENERAL & INTERNAL | MODIFYING ANTIRHEUMATIC DRUGS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ANTI-TNF THERAPY | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | INTERNATIONAL SOCIETY CRITERIA | CHRONIC BACK-PAIN | ACTIVE ANKYLOSING-SPONDYLITIS | PROOF-OF-CONCEPT | Back Pain - etiology | Spondylitis, Ankylosing - diagnosis | Humans | Inflammation - classification | Spondylitis, Ankylosing - classification | Spondylitis, Ankylosing - epidemiology | Magnetic Resonance Imaging - methods | Inflammation - diagnosis | Spondylitis, Ankylosing - physiopathology | Early Diagnosis | Fluocinolone acetonide | Interleukins | Drugs | Pathogenesis | Interleukin | Clinical trials | Arthritis | Damage prevention | Inflammatory diseases | Bone growth | Classification | Tumor necrosis factor-TNF | Nonsteroidal anti-inflammatory drugs | Ankylosing spondylitis | Antiinflammatory agents | Cytokines | Rheumatic diseases | Inflammation | Patients | Interleukin 17 | Studies | Spondylitis | Magnetic resonance imaging | Tumor necrosis factor | Structural damage | Bone (long) | Histocompatibility antigen HLA | Bone | Osteogenesis | Tumors
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3. Full Text What is the best treatment target in axial spondyloarthritis: Tumour necrosis factor a, interleukin 17, or both?
by Poddubnyy, Denis and Sieper, Joachim
Rheumatology (United Kingdom), ISSN 1462-0324, 07/2018, Volume 57, Issue 7, pp. 1145 - 1150
Spondyloarthropathy | Treatment | Anti-TNF | Axial spondyloarthritis | Secukinumab | TNF blocker | Treat-to-target | Interleukin-17 | TNF | Ankylosing spondylitis
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4. Full Text Radiographic evaluation of sacroiliac joints in axial spondyloarthritis-still worth performing?
by Poddubnyy, Denis
Journal of Rheumatology, ISSN 0315-162X, 01/2017, Volume 44, Issue 1, pp. 1 - 3
RHEUMATOLOGY | CLINICAL-PRACTICE | SOCIETY CLASSIFICATION CRITERIA | PROGRESSION | Magnetic Resonance Imaging | Sacroiliitis - diagnostic imaging | Spondylarthritis - diagnostic imaging | Humans | Sacroiliac Joint - diagnostic imaging
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5. Full Text New evidence on the management of spondyloarthritis
by Sieper, Joachim and Poddubnyy, Denis
Nature Reviews Rheumatology, ISSN 1759-4790, 05/2016, Volume 12, Issue 5, pp. 282 - 295
Non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for patients with symptomatic axial spondyloarthritis (SpA), who seem to respond... 
MODIFYING ANTIRHEUMATIC DRUGS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SIGNIFICANTLY IMPROVES SIGNS | OPEN-LABEL TRIAL | PLACEBO-CONTROLLED TRIAL | NECROSIS-FACTOR BLOCKERS | RHEUMATOLOGY | NONRADIOGRAPHIC AXIAL SPONDYLOARTHRITIS | ACTIVE ANKYLOSING-SPONDYLITIS | SOCIETY CLASSIFICATION CRITERIA | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | Glucocorticoids - therapeutic use | Antibodies, Monoclonal, Humanized - therapeutic use | Spondylarthritis - diagnostic imaging | Spondylarthritis - immunology | Humans | Spondylitis, Ankylosing - drug therapy | Bone Density Conservation Agents - therapeutic use | Antibodies, Monoclonal - therapeutic use | Spondylarthritis - drug therapy | Ustekinumab - therapeutic use | Spondylitis, Ankylosing - diagnostic imaging | Radiography | Spondylitis, Ankylosing - immunology | Magnetic Resonance Imaging | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Abatacept - therapeutic use | Diphosphonates - therapeutic use | Disease Management | C-Reactive Protein - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Antirheumatic Agents - therapeutic use | Care and treatment | Antirheumatic agents | C-reactive protein | Tumor necrosis factor | Spondyloarthropathies | Development and progression | Arthritis | Dosage and administration | Research | Health aspects
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6. Full Text What is the best treatment target in axial spondyloarthritis: tumour necrosis factor α, interleukin 17, or both?
by Poddubnyy, Denis and Sieper, Joachim
Rheumatology, ISSN 1462-0324, 07/2018, Volume 57, Issue 7, pp. 1145 - 1150
Abstract After about 15 years of experience with the TNF blockers as the only effective drugs in axial spondyloarthritis patients who fail conventional... 
RHEUMATOID-ARTHRITIS | treatment | EFFICACY | SAFETY | treat-to-target | ankylosing spondylitis | secukinumab | PHASE-II | MONOCLONAL-ANTIBODY | ANKYLOSING-SPONDYLITIS | RHEUMATOLOGY | PSORIATIC-ARTHRITIS | axial spondyloarthritis | TNF | anti-TNF | interleukin-17 | spondyloarthropathy | DOUBLE-BLIND | TNF blocker | TNF-ALPHA | Tumor necrosis factor | Rheumatic diseases | Tumor necrosis factor-TNF | TNF inhibitors | Arthritis | Interleukin 17 | Inflammatory diseases | Tumors
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7. Full Text Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
by Poddubnyy, Denis and Hermann, Kay-Geert A and Callhoff, Johanna and Listing, Joachim and Sieper, Joachim
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2014, Volume 73, Issue 5, pp. 817 - 823
Objective To evaluate efficacy and safety of ustekinumab in patients with ankylosing spondylitis (AS). Methods In this prospective, open-label, single-arm,... 
ASAS RECOMMENDATIONS | CROHNS-DISEASE | EFFICACY | SHORT-TERM IMPROVEMENT | SAFETY | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | RHEUMATOLOGY | PSORIATIC-ARTHRITIS | AXIAL SPONDYLOARTHRITIS | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | Antibodies, Monoclonal, Humanized - therapeutic use | Prospective Studies | Time Factors | Humans | Immunosuppressive Agents - therapeutic use | Spondylitis, Ankylosing - drug therapy | Ustekinumab | Adult | Female | Male | Treatment Outcome | Spondylitis, Ankylosing - pathology | Treatment outcome | Drug therapy | Analysis | Ankylosing spondylitis | Psoriasis | Cytokines | Arthritis | Inflammation | Patients | Crohns disease | Quality of life | Studies | Proteins | Bone marrow | Tumor necrosis factor-TNF | Pharmaceutical industry | Drug dosages
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8. Full Text Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort
by Poddubnyy, Denis and Rudwaleit, Martin and Haibel, Hildrun and Listing, Joachim and Märker-Hermann, Elisabeth and Zeidler, Henning and Braun, Jürgen and Sieper, Joachim
Annals of the Rheumatic Diseases, ISSN 0003-4967, 10/2012, Volume 71, Issue 10, pp. 1616 - 1622
Objective To investigate the influence of non-steroidal anti-inflammatory drugs (NSAIDs) intake on radiographic spinal progression over 2 years in patients... 
PROPHYLAXIS | CYCLOOXYGENASE-2 | BONE-FORMATION | RECOMMENDATIONS | INDOMETHACIN | PREVENTION | TOTAL HIP-REPLACEMENT | ANKYLOSING-SPONDYLITIS | RHEUMATOLOGY | HETEROTOPIC OSSIFICATION | CELECOXIB | Radiography | Spine - diagnostic imaging | Spondylarthropathies - diagnostic imaging | Spondylarthropathies - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Humans | Disease Progression | Germany | Cohort Studies | Drugs | Dose-response relationship (Biochemistry) | Growth | Bones | Dosage and administration | Product/Service Evaluations | Nonsteroidal anti-inflammatory drugs | Research | Drug therapy | Ankylosing spondylitis | Studies | Ethics | TNF inhibitors | Drug dosages | Patients
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9. Full Text Axial spondyloarthritis: Is there a treatment of choice?
by Poddubnyy, Denis and Poddubnyy, Denis
Therapeutic Advances in Musculoskeletal Disease, ISSN 1759-720X, 2013, Volume 5, Issue 1, pp. 45 - 54
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly affecting the axial skeleton (sacroiliac joints and spine). Nonradiographic... 
Axial spondyloarthritis | Treatment | Nonsteroidal anti-inflammatory drugs | tumour necrosis factor α blocker | Tumour necrosis factor a Blocker | Ankylosing spondylitis | nonsteroidal anti-inflammatory drugs | treatment | Reviews | axial spondyloarthritis | ankylosing spondylitis
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10. Full Text Ist eine Hemmung der röntgenologischen Progression bei axialer Spondyloarthritis möglich?
by Poddubnyy, Denis and Sieper, Joachim
Aktuelle Rheumatologie, ISSN 0341-051X, 10/2019, Volume 44, Issue 5, pp. 352 - 359
Zusammenfassung Strukturschäden bei der axialen Spondyloarthritis (axSpA) entstehen in der Regel zunächst in den Sakroiliakalgelenken und später in der... 
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11. Full Text High disease activity according to the Ankylosing Spondylitis Disease Activity Score is associated with accelerated radiographic spinal progression in patients with early axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort
by Poddubnyy, Denis and Protopopov, Mikhail and Haibel, Hildrun and Braun, Jürgen and Rudwaleit, Martin and Sieper, Joachim
Annals of the Rheumatic Diseases, ISSN 0003-4967, 12/2016, Volume 75, Issue 12, pp. 2114 - 2118
ObjectiveThe aim of this work was to investigate the association between disease activity measured by the Ankylosing Spondylitis Disease Activity Score (ASDAS)... 
Ankylosing Spondylitis | Disease Activity | Outcomes research | Spondyloarthritis | SPONDYLARTHRITIS | STRUCTURAL DAMAGE | RHEUMATOLOGY | ASDAS | Severity of Illness Index | C-Reactive Protein | Humans | Middle Aged | Spondylitis, Ankylosing - blood | Logistic Models | Male | Disease Progression | Spondylitis, Ankylosing - diagnostic imaging | Radiography | Spine - diagnostic imaging | Time Factors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adult | Female | Spine - pathology | Spondylitis, Ankylosing - pathology | Germany | Cohort Studies | Spondyloarthropathies | Development and progression | Usage | Research
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12. Full Text Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis
by Poddubnyy, Denis and Rudwaleit, Martin and Haibel, Hildrun and Listing, Joachim and Märker-Hermann, Elisabeth and Zeidler, Henning and Braun, Jürgen and Sieper, Joachim
Annals of the Rheumatic Diseases, ISSN 0003-4967, 08/2011, Volume 70, Issue 8, pp. 1369 - 1374
Objective To assess the progression of radiographic sacroiliitis in a cohort of patients with early axial spondyloarthritis over a period of 2 years and to... 
SPONDYLARTHRITIS | UNDIFFERENTIATED SPONDYLOARTHRITIS | ADALIMUMAB | FOLLOW-UP | RHEUMATOLOGY | DIAGNOSTIC-CRITERIA | CLINICAL-RESPONSE | SOCIETY CLASSIFICATION CRITERIA | ACTIVE ANKYLOSING-SPONDYLITIS | Severity of Illness Index | Spondylarthritis - diagnostic imaging | Follow-Up Studies | Axis, Cervical Vertebra - diagnostic imaging | Humans | Middle Aged | Male | Disease Progression | Radiography | Sacroiliitis - diagnostic imaging | Sacroiliitis - etiology | Sex Factors | Adult | Female | Spondylarthritis - complications | Inflammatory bowel disease | Back pain | Psoriasis | Patients | Classification
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13. Full Text Inflammation, new bone formation and treatment options in axial spondyloarthritis
by Sieper, Joachim and Poddubnyy, Denis
Annals of the Rheumatic Diseases, ISSN 0003-4967, 08/2014, Volume 73, Issue 8, pp. 1439 - 1441
RADIOGRAPHIC PROGRESSION | SPONDYLARTHRITIS | RECOMMENDATIONS | SYNDESMOPHYTES | STRUCTURAL DAMAGE | RESONANCE-IMAGING PREDICT | MRI INFLAMMATION | RHEUMATOLOGY | ARTHRITIS | ACTIVE ANKYLOSING-SPONDYLITIS | DISEASE-ACTIVITY | Spondylarthritis - immunology | Humans | Spondylarthritis - physiopathology | Anti-Inflammatory Agents - therapeutic use | Spondylarthritis - drug therapy | Osteogenesis - immunology | Antirheumatic Agents - therapeutic use
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14. Full Text The IL-23–IL-17 pathway as a therapeutic target in axial spondyloarthritis
by Sieper, Joachim and Poddubnyy, Denis and Miossec, Pierre
Nature Reviews Rheumatology, ISSN 1759-4790, 09/2019
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15. Full Text Current Unmet Needs in Spondyloarthritis
by Poddubnyy, Denis and Sieper, Joachim
Current rheumatology reports, 07/2019, Volume 21, Issue 9, p. 43
There was a substantial progress in the field of spondyloarthritis (SpA) in terms of understanding disease mechanisms, early diagnosis, and improved treatment.... 
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16. Full Text Should we combine biologics with methotrexate in axial spondyloarthritis?
by Poddubnyy, Denis and Amital, Howard and Rubbert-Roth, Andrea
Autoimmunity Reviews, ISSN 1568-9972, 10/2019, p. 102402
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17. Full Text Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: results from a randomised multicentre trial (ENRADAS)
by Sieper, Joachim and Listing, Joachim and Poddubnyy, Denis and Song, In-Ho and Hermann, Kay-Geert and Callhoff, Johanna and Syrbe, Uta and Braun, Jürgen and Rudwaleit, Martin
Annals of the Rheumatic Diseases, ISSN 0003-4967, 08/2016, Volume 75, Issue 8, pp. 1438 - 1443
BackgroundTo date, only a single controlled trial provided evidence that non-steroidal anti-inflammatory drugs (NSAIDs) given continuously reduce radiographic... 
Ankylosing Spondylitis | Outcomes research | NSAIDs | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | RECOMMENDATIONS | SYNDESMOPHYTES | OSTEOBLASTS | PREVENTION | RHEUMATOLOGY | SELECTION | AXIAL SPONDYLOARTHRITIS | HETEROTOPIC OSSIFICATION | CELECOXIB | DAMAGE | Severity of Illness Index | Single-Blind Method | Drug Administration Schedule | Diclofenac - adverse effects | Humans | Middle Aged | Spondylitis, Ankylosing - drug therapy | Male | Treatment Outcome | Disease Progression | Spondylitis, Ankylosing - diagnostic imaging | Radiography | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Adult | Female | Diclofenac - administration & dosage | Treatment outcome | Dosage and administration | Drug therapy | Analysis | Ankylosing spondylitis | Diclofenac
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