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by De Angelis, Martin Hrabě and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and Adams, David J and Adams, Niels C and Adler, Thure and Aguilar-Pimentel, Antonio and Ali-Hadji, Dalila and Amann, Gregory and André, Philippe and Atkins, Sarah and Auburtin, Aurelie and Ayadi, Abdel and Becker, Julien and Becker, Lore and Bedu, Elodie and Bekeredjian, Raffi and Birling, Marie-Christine and Blake, Andrew and Bottomley, Joanna and Bowl, Michael R and Brault, Véronique and Busch, Dirk H and Bussell, James N and Calzada-Wack, Julia and Cater, Heather and Champy, Marie-France and Charles, Philippe and Chevalier, Claire and Chiani, Francesco and Codner, Gemma F and Combe, Roy and Cox, Roger and Dalloneau, Emilie and Dierich, André and Di Fenza, Armida and Doe, Brendan and Duchon, Arnaud and Eickelberg, Oliver and Esapa, Chris T and Fertak, Lahcen El and Feigel, Tanja and Emelyanova, Irina and Estabel, Jeanne and Favor, Jack and Flenniken, Ann and Gambadoro, Alessia and Garrett, Lilian and Gates, Hilary and Gerdin, Anna-Karin and Gkoutos, George and Greenaway, Simon and Glasl, Lisa and Goetz, Patrice and Da Cruz, Isabelle Goncalves and Götz, Alexander and Graw, Jochen and Guimond, Alain and Hans, Wolfgang and Hicks, Geoff and Hölter, Sabine M and Höfler, Heinz and Hancock, John M and Hoehndorf, Robert and Hough, Tertius and Houghton, Richard and Hurt, Anja and Ivandic, Boris and Jacobs, Hughes and Jacquot, Sylvie and Jones, Nora and Karp, Natasha A and Katus, Hugo A and Kitchen, Sharon and Klein-Rodewald, Tanja and Klingenspor, Martin and Klopstock, Thomas and Lalanne, Valerie and Leblanc, Sophie and Lengger, Christoph and Le Marchand, Elise and Ludwig, Tonia and Lux, Aline and McKerlie, Colin and Maier, Holger and Mandel, Jean-Louis and Marschall, Susan and Mark, Manuel and Melvin, David G and Meziane, Hamid and Micklich, Kateryna and Mittelhauser, Christophe and Monassier, Laurent and ... and EUMODIC Consortium
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 969 - 978
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the... 
EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | GENOME-WIDE | EMPRESS | KNOCKOUT MICE | ACCESS | RESOURCE | Homozygote | Phenotype | Animals | Genetic Association Studies | Humans | Mice, Inbred C57BL | Molecular Sequence Annotation | Female | Heterozygote | Male | Mutation | Mice, Knockout | Research | Gene mutations | Human genome | Identification and classification | Health aspects | Consortia | Genotype & phenotype | Physiology | Genomes | Metabolism | Power
Journal Article
Nature Reviews Nephrology, ISSN 1759-5061, 11/2018, Volume 14, Issue 11, pp. 678 - 687
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially lethal, monogenic diseases and is caused predominantly by mutations... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | ORTHOLOGOUS MOUSE MODEL | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | GLUCOSE-METABOLISM | MTOR PATHWAY | RENAL-FUNCTION | UROLOGY & NEPHROLOGY | CELL-PROLIFERATION | CYST GROWTH | RAT MODEL | Proteins | Mitochondria | Phosphorylation | Pathogenesis | Mitochondrial DNA | Mutation | Kidney diseases | Metabolism | Kinases
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54458
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of... 
OBESITY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FATTY LIVER | DOWN-REGULATION | PTEN | KAPPA-B | CANCER | PROGRESSION | IL-6 | Immunohistochemistry | Humans | Fatty Liver - complications | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Fatty Liver - chemically induced | Liver Neoplasms - etiology | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Tumor Microenvironment - genetics | Cell Nucleus - pathology | Carcinoma, Hepatocellular - genetics | Diet, High-Fat | Diethylnitrosamine | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - etiology | Biomarkers - metabolism | Fatty Liver - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Fatty Liver - metabolism | Liver Neoplasms - genetics | Gene Expression Regulation | Mice, Knockout | Animals | Histones - genetics | Cell Nucleus - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Mice | Histones - metabolism | Carcinoma, Hepatocellular - metabolism | Protein Isoforms - genetics | Prognosis | Phosphatases | Carcinoma | Liver | Research | Risk factors | Liver cancer | Colon cancer | Analysis | Physiological aspects | Genetic aspects | Diagnosis | Chromosomes | Cancer | Pathogenesis | Lung cancer | Immunoblotting | Phosphatase | Nuclei | Cell growth | Physiology | Lipid metabolism | Tensin | Obesity | Liver diseases | Melanoma | Anatomy & physiology | Metabolism | Fatty acids | Hospitals | Hepatocytes | Isoforms | Biomarkers | Nuclei (cytology) | Neurosciences | Animal models | Homology | Lipids | Hepatocellular carcinoma | Metabolic syndrome | High fat diet | Fatty liver | Metabolites | Rodents | Hepatology | Gastroenterology | Cell cycle | Colon | Tumor cells | Health risks | Risk reduction | Steatosis | Medicine | Biopsy | Diagnostic systems | PTEN protein | Tumors
Journal Article
Cell, ISSN 0092-8674, 07/2013, Volume 154, Issue 2, p. 452
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse... 
Journal Article
by White, Gemma and White, Jacqueline K and Gerdin, Anna-Karin and Karp, Natasha A and Ryder, Ed and Buljan, Marija and Bussell, James N and Salisbury, Jennifer and Clare, Simon and Ingham, Neil J and Podrini, Christine and Houghton, Richard and Estabel, Jeanne and Bottomley, Joanna R and Melvin, David G and Sunter, David and Adams, David J and Adams, Niels C and Baker, Lauren and Barnes, Caroline and Beveridge, Ryan and Cambridge, Emma and Carragher, Damian and Chana, Prabhjoat and Clarke, Kay and Hooks, Yvette and Igosheva, Natalia and Ismail, Ozama and Jackson, Hannah and Kane, Leanne and Lacey, Rosalind and Lafont, David Tino and Lucas, Mark and Maguire, Simon and McGill, Katherine and McIntyre, Rebecca E and Messager, Sophie and Mottram, Lynda and Mulderrig, Lee and Pearson, Laila and Pearson, Selina and Protheroe, Hayley J and Roberson, Laura-Anne and Salsbury, Grace and Sanderson, Mark and Sanger, Daniel and Shannon, Carl and Thompson, Paul C and Tuck, Elizabeth and Vancollie, Valerie E and Brackenbury, Lisa and Bushell, Wendy and Cook, Ross and Dalvi, Priya and Gleeson, Diane and Habib, Bishoy and Hardy, Matt and Liakath-Ali, Kifayathullah and Miklejewska, Evelina and Price, Stacey and Sethi, Debarati and Trenchard, Elizabeth and von Schiller, Dominique and Vyas, Sapna and West, Anthony P and Woodward, John and Wynn, Elizabeth and Evans, Arthur and Gannon, David and Griffiths, Mark and Holroyd, Simon and Iyer, Vivek and Kipp, Christian and Lewis, Morag and Li, Wei and Oakley, Darren and Richardson, David and Smedley, Damian and Agu, Chukwuma and Bryant, Jackie and Delaney, Liz and Gueorguieva, Nadia I and Tharagonnet, Helen and Townsend, Anne J and Biggs, Daniel and Brown, Terry and Brown, Ellen and Collinson, Adam and Dumeau, Charles-Etienne and Grau, Evelyn and Harrison, James and Harrison, Sarah and Ingle, Catherine E and Kundi, Helen and Madich, Alla and Mayhew, Danielle and Metcalf, Tom and Newman, Stuart and Pass, Johanna and Reynolds, Helen and ... and Sanger Inst Mouse Genetics Project and Sanger Institute Mouse Genetics Project
Cell, ISSN 0092-8674, 07/2013, Volume 154, Issue 2, pp. 452 - 464
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (2013) Correction:... 
Liver cancer | Hepatocellular carcinoma | Isoforms | Steatosis
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2012, Volume 189, Issue 1, pp. 102 - 111
Journal Article
FASEB Journal, ISSN 0892-6638, 05/2015, Volume 29, Issue 5, pp. 1676 - 1687
Journal Article