Journal of Hypertension, ISSN 0263-6352, 09/2016, Volume 34 Suppl 1 - ISH 2016 Abstract Book, pp. e382 - e383
Primary aldosteronism (PA) is severe form of hypertension characterized by a strongly increased aldosterone secretion mediated by adenomas or other forms of...
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 805 - 819
Abstract Background The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for HF....
Cardiovascular | Internal Medicine | angiotensin II | angiotensin-(1–7) | renin-angiotensin system | chymase | dilated cardiomyopathy | SYSTEM | DOMAIN | CARDIAC & CARDIOVASCULAR SYSTEMS | RENIN | HYPERTROPHY | CONVERTING ENZYME ACE | METABOLISM | INHIBITOR THERAPY | angiotensin-(1-7) | DYSFUNCTION | Heart Failure - complications | Acute Disease | Angiotensins - physiology | Humans | Middle Aged | Male | Heart Failure - blood | Case-Control Studies | Heart Failure - therapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aged, 80 and over | Female | Aged | Angiotensin Receptor Antagonists - therapeutic use | Chronic Disease | Heart failure | Enzymes | Biological products | Emergency medicine | Angiotensin | Enzyme inhibitors | Analysis | Cardiac patients | Physiological aspects | Liquid chromatography | Peptides | Colleges & universities | Emergency medical care | Scientific imaging | Mass spectrometry | Equilibrium
Cardiovascular | Internal Medicine | angiotensin II | angiotensin-(1–7) | renin-angiotensin system | chymase | dilated cardiomyopathy | SYSTEM | DOMAIN | CARDIAC & CARDIOVASCULAR SYSTEMS | RENIN | HYPERTROPHY | CONVERTING ENZYME ACE | METABOLISM | INHIBITOR THERAPY | angiotensin-(1-7) | DYSFUNCTION | Heart Failure - complications | Acute Disease | Angiotensins - physiology | Humans | Middle Aged | Male | Heart Failure - blood | Case-Control Studies | Heart Failure - therapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aged, 80 and over | Female | Aged | Angiotensin Receptor Antagonists - therapeutic use | Chronic Disease | Heart failure | Enzymes | Biological products | Emergency medicine | Angiotensin | Enzyme inhibitors | Analysis | Cardiac patients | Physiological aspects | Liquid chromatography | Peptides | Colleges & universities | Emergency medical care | Scientific imaging | Mass spectrometry | Equilibrium
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 11/2019
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 29, Issue 4, pp. 565 - 577
The innate inflammatory immune response must be tightly controlled to avoid damage to the host. Here, we showed that the tuberous sclerosis complex-mammalian...
MOLIMMUNO | LISTERIA-MONOCYTOGENES | MAMMALIAN TARGET | RAPAMYCIN | CELLS | ACTIVATION | STAT3 | IL-10 GENE | TUBEROUS SCLEROSIS | IMMUNOLOGY | NF-KAPPA-B | SIROLIMUS | Protein Kinases - metabolism | Humans | Tuberous Sclerosis | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | Listeria monocytogenes - immunology | Listeriosis - prevention & control | Th1 Cells - immunology | Lipopolysaccharides - immunology | Th1 Cells - metabolism | Inflammation - metabolism | Listeriosis - immunology | Female | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Tumor Suppressor Proteins - metabolism | Signal Transduction | Inflammation - immunology | Immunity, Innate | Sirolimus - pharmacology | Mice, Knockout | Monocytes - drug effects | Animals | Protein Kinases - immunology | Listeriosis - microbiology | Anti-Bacterial Agents - pharmacology | Mice | Mice, Inbred BALB C | TOR Serine-Threonine Kinases | Cytokines - biosynthesis | Proteins | Phosphorylation | Histology | Cytokines | Listeria | Kinases
MOLIMMUNO | LISTERIA-MONOCYTOGENES | MAMMALIAN TARGET | RAPAMYCIN | CELLS | ACTIVATION | STAT3 | IL-10 GENE | TUBEROUS SCLEROSIS | IMMUNOLOGY | NF-KAPPA-B | SIROLIMUS | Protein Kinases - metabolism | Humans | Tuberous Sclerosis | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | Listeria monocytogenes - immunology | Listeriosis - prevention & control | Th1 Cells - immunology | Lipopolysaccharides - immunology | Th1 Cells - metabolism | Inflammation - metabolism | Listeriosis - immunology | Female | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Tumor Suppressor Proteins - metabolism | Signal Transduction | Inflammation - immunology | Immunity, Innate | Sirolimus - pharmacology | Mice, Knockout | Monocytes - drug effects | Animals | Protein Kinases - immunology | Listeriosis - microbiology | Anti-Bacterial Agents - pharmacology | Mice | Mice, Inbred BALB C | TOR Serine-Threonine Kinases | Cytokines - biosynthesis | Proteins | Phosphorylation | Histology | Cytokines | Listeria | Kinases
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2017, Volume 69, Issue 24, p. 3011
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2017, Volume 69, Issue 24, pp. 3011 - 3013
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 25, pp. 2912 - 2914
N-terminal pro-B-type natriuretic peptide and active renin concentration were determined simultaneously. [...]plasmatic NEP activity was measured directly by...
Cardiovascular | Internal Medicine | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Humans | Angiotensin II - blood | Stroke Volume - physiology | Renin-Angiotensin System - physiology | Heart Failure - diagnosis | Biomarkers - blood | Heart Failure - blood | Angiotensin Receptor Antagonists - therapeutic use | Heart Failure - drug therapy | Heart failure | Angiotensin | Enzymes | Peptides | Metabolites | Scientific imaging | Fractions | Mass spectrometry
Cardiovascular | Internal Medicine | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Humans | Angiotensin II - blood | Stroke Volume - physiology | Renin-Angiotensin System - physiology | Heart Failure - diagnosis | Biomarkers - blood | Heart Failure - blood | Angiotensin Receptor Antagonists - therapeutic use | Heart Failure - drug therapy | Heart failure | Angiotensin | Enzymes | Peptides | Metabolites | Scientific imaging | Fractions | Mass spectrometry
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2017, Volume 69, Issue 24, pp. 3011 - 3013
Dr. Haugli and colleagues raised the issue that 2 recent papers published in the Journal on angiotensin (Ang) peptide levels in heart failure patients might...
CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | Heart | Heart failure | Converting | Peptidyl-dipeptidase A | Angiotensin | Angiotensin II | Beta blockers | ACE inhibitors | Heart diseases | Patients | Equilibrium
CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | Heart | Heart failure | Converting | Peptidyl-dipeptidase A | Angiotensin | Angiotensin II | Beta blockers | ACE inhibitors | Heart diseases | Patients | Equilibrium
Journal Article
Circulation Research, ISSN 0009-7330, 06/2017, Volume 121, Issue 1, pp. 43 - 55
Rationale:Neurogenic hypertension is characterized by an increase in sympathetic activity and often resistance to drug treatments. We previously reported that...
ACE2 | TNF-α convertase enzyme | hypertension | renin-angiotensin system | central nervous system | Hypertension | Enzymes | Reactive oxygen species | Astrocytes | Central nervous system | Extracellular signal-regulated kinase | Mass spectroscopy | Cerebrospinal fluid | Tumor necrosis factor-α | Renin | Peptidyl-dipeptidase A | Angiotensin | Metalloproteinase | Blood pressure | Angiotensin II | Acetic acid | ACE | Angiotensin Receptors | TNF-alpha convertase enzyme | Signal Transduction | Autonomic Nervous System | Cell Signaling | Renin Angiotensin System | Renin-angiotensin system
ACE2 | TNF-α convertase enzyme | hypertension | renin-angiotensin system | central nervous system | Hypertension | Enzymes | Reactive oxygen species | Astrocytes | Central nervous system | Extracellular signal-regulated kinase | Mass spectroscopy | Cerebrospinal fluid | Tumor necrosis factor-α | Renin | Peptidyl-dipeptidase A | Angiotensin | Metalloproteinase | Blood pressure | Angiotensin II | Acetic acid | ACE | Angiotensin Receptors | TNF-alpha convertase enzyme | Signal Transduction | Autonomic Nervous System | Cell Signaling | Renin Angiotensin System | Renin-angiotensin system
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 09/2013, Volume 52, Issue 9, pp. 783 - 792
Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II (Ang1-8) to angiotensin 1-7 (Ang1-7), a functional antagonist of Ang1-8, with vasodilatory,...
SYSTEM | FIBROSIS | ACE2 | REGULATOR | CARBOXYPEPTIDASE | PHYSIOLOGY | BIOLOGY | PHARMACOLOGY & PHARMACY | DEFICIENT MICE | EXPRESSION | BLOOD-PRESSURE | Peptidyl-Dipeptidase A - pharmacokinetics | Double-Blind Method | Humans | Angiotensin II - blood | Peptide Fragments - blood | Female | Male | Peptidyl-Dipeptidase A - administration & dosage | Recombinant Proteins - pharmacokinetics | Angiotensin I - blood | Recombinant Proteins - administration & dosage | Index Medicus
SYSTEM | FIBROSIS | ACE2 | REGULATOR | CARBOXYPEPTIDASE | PHYSIOLOGY | BIOLOGY | PHARMACOLOGY & PHARMACY | DEFICIENT MICE | EXPRESSION | BLOOD-PRESSURE | Peptidyl-Dipeptidase A - pharmacokinetics | Double-Blind Method | Humans | Angiotensin II - blood | Peptide Fragments - blood | Female | Male | Peptidyl-Dipeptidase A - administration & dosage | Recombinant Proteins - pharmacokinetics | Angiotensin I - blood | Recombinant Proteins - administration & dosage | Index Medicus
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 03/2019, Volume 316, Issue 3, pp. H506 - H515
Deletion of the prorenin receptor (PRR) in adipose tissue elevates systolic blood pressure (SBP) and the circulating soluble form of PRR (sPRR) in male mice...
adipose tissue | prorenin receptor | hypertension | vasopressin | soluble prorenin receptor | RENIN/PRORENIN RECEPTOR | URINE CONCENTRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | COLLECTING DUCT | SOLUBLE (PRO)RENIN RECEPTOR | NITRIC-OXIDE | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | PIVOTAL ROLE | Adipose tissues | Adipose tissue | Liver | Homeostasis | High fat diet | Infusion | Elevation | Mouse devices | Renin | Clonal deletion | Rodents | Gender aspects | Angiotensinogen | Deletion | Blood pressure | Angiotensin II | Recombinant | Urine | Organs | Sex differences | Vasopressin | Body fluids | Blood circulation | Diet | Angiotensin | Mice | Renal cortex
adipose tissue | prorenin receptor | hypertension | vasopressin | soluble prorenin receptor | RENIN/PRORENIN RECEPTOR | URINE CONCENTRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | COLLECTING DUCT | SOLUBLE (PRO)RENIN RECEPTOR | NITRIC-OXIDE | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | PIVOTAL ROLE | Adipose tissues | Adipose tissue | Liver | Homeostasis | High fat diet | Infusion | Elevation | Mouse devices | Renin | Clonal deletion | Rodents | Gender aspects | Angiotensinogen | Deletion | Blood pressure | Angiotensin II | Recombinant | Urine | Organs | Sex differences | Vasopressin | Body fluids | Blood circulation | Diet | Angiotensin | Mice | Renal cortex
Journal Article
Hypertension Research, ISSN 0916-9636, 07/2016, Volume 39, Issue 7, pp. 506 - 512
The renin-angiotensin system (RAS) is related to physiological adaptations induced by exercise. Angiotensin-converting enzyme (ACE) 2 is a major regulator of...
angiotensin-(1-7) | voluntary exercisem | angiotensin-converting enzyme 2 | gene expression | cardiac remodeling | ATROPHY | RECEPTOR | HEART | RENIN-ANGIOTENSIN SYSTEM | GROWTH | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | EXPRESSION | MAS | Adaptation, Physiological | Angiotensins - blood | Heart - physiology | Humans | Mice, Inbred C57BL | Male | Muscle, Skeletal - physiology | Exercise Test | Animals | Exercise | Myocardium | Mice | Peptidyl-Dipeptidase A - deficiency
angiotensin-(1-7) | voluntary exercisem | angiotensin-converting enzyme 2 | gene expression | cardiac remodeling | ATROPHY | RECEPTOR | HEART | RENIN-ANGIOTENSIN SYSTEM | GROWTH | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | EXPRESSION | MAS | Adaptation, Physiological | Angiotensins - blood | Heart - physiology | Humans | Mice, Inbred C57BL | Male | Muscle, Skeletal - physiology | Exercise Test | Animals | Exercise | Myocardium | Mice | Peptidyl-Dipeptidase A - deficiency
Journal Article
Hypertension, ISSN 0194-911X, 11/2019
Journal Article
Clinical Chemistry, ISSN 0009-9147, 03/2018, Volume 64, Issue 3, pp. 597 - 608
BACKGROUND: Blockade of the renin-angiotensin system (RAS) represents a main strategy in the therapy of heart failure with reduced ejection fraction (HFrEF),...
SYSTEM | ACTIVE RENIN | PLASMA | TASK-FORCE | GUIDELINES | DYSFUNCTION | MEDICAL LABORATORY TECHNOLOGY | SUPPRESSION | ANGIOTENSIN-CONVERTING ENZYME | PROGNOSTIC VALUE | INHIBITOR ALISKIREN | Heart failure | Enzymes | Medical research | Care and treatment | Phenotype | Enzyme inhibitors | Metabolites | Angiotensin | Medicine, Experimental | Genetic aspects | Mass spectrometry | Natriuretic peptides | Hypertension | Angiotensin-converting enzyme inhibitors | Heart | Brain natriuretic peptide | Therapy | Peptides | Therapeutic applications | Medical treatment | Medical services | Mass spectroscopy | Patients | Renin | Peptidyl-dipeptidase A | Scientific imaging | Angiotensin II | Heart diseases | Ejection
SYSTEM | ACTIVE RENIN | PLASMA | TASK-FORCE | GUIDELINES | DYSFUNCTION | MEDICAL LABORATORY TECHNOLOGY | SUPPRESSION | ANGIOTENSIN-CONVERTING ENZYME | PROGNOSTIC VALUE | INHIBITOR ALISKIREN | Heart failure | Enzymes | Medical research | Care and treatment | Phenotype | Enzyme inhibitors | Metabolites | Angiotensin | Medicine, Experimental | Genetic aspects | Mass spectrometry | Natriuretic peptides | Hypertension | Angiotensin-converting enzyme inhibitors | Heart | Brain natriuretic peptide | Therapy | Peptides | Therapeutic applications | Medical treatment | Medical services | Mass spectroscopy | Patients | Renin | Peptidyl-dipeptidase A | Scientific imaging | Angiotensin II | Heart diseases | Ejection
Journal Article
European journal of endocrinology, ISSN 0804-4643, 07/2019, Volume 181, Issue 1, pp. 39 - 44
Background: In patients suffering from primary adrenal insufficiency (AI) mortality is increased despite adequate glucocorticoid (GC) and mineralocorticoid...
CONVERTING ENZYME | DIAGNOSIS | MANAGEMENT | THERAPY | PROFILE | HEART-FAILURE | ENDOCRINOLOGY & METABOLISM | GLUCOCORTICOID REPLACEMENT | DYSFUNCTION | ADDISONS-DISEASE | HYDROCORTISONE | Blood Pressure | Body Mass Index | Cardiovascular Diseases - etiology | Angiotensins - blood | Cross-Sectional Studies | Humans | Middle Aged | Risk Factors | Aldosterone - blood | Aldosterone - physiology | Angiotensin II - blood | Addison Disease - physiopathology | Addison Disease - complications | Male | Renin-Angiotensin System - physiology | Renin - blood | Case-Control Studies | Adult | Female | Aged | Hydrocortisone - blood | Adrenocorticotropic Hormone - blood | Adrenal glands | Glucocorticoids | Clinical trials | Mass spectroscopy | Liquid chromatography | Hydrocortisone | Aldosterone | Risk factors | Renin | Metabolites | Angiotensin | Blood pressure | Hormone replacement therapy | Angiotensin II | Cardiovascular diseases | Health risk assessment
CONVERTING ENZYME | DIAGNOSIS | MANAGEMENT | THERAPY | PROFILE | HEART-FAILURE | ENDOCRINOLOGY & METABOLISM | GLUCOCORTICOID REPLACEMENT | DYSFUNCTION | ADDISONS-DISEASE | HYDROCORTISONE | Blood Pressure | Body Mass Index | Cardiovascular Diseases - etiology | Angiotensins - blood | Cross-Sectional Studies | Humans | Middle Aged | Risk Factors | Aldosterone - blood | Aldosterone - physiology | Angiotensin II - blood | Addison Disease - physiopathology | Addison Disease - complications | Male | Renin-Angiotensin System - physiology | Renin - blood | Case-Control Studies | Adult | Female | Aged | Hydrocortisone - blood | Adrenocorticotropic Hormone - blood | Adrenal glands | Glucocorticoids | Clinical trials | Mass spectroscopy | Liquid chromatography | Hydrocortisone | Aldosterone | Risk factors | Renin | Metabolites | Angiotensin | Blood pressure | Hormone replacement therapy | Angiotensin II | Cardiovascular diseases | Health risk assessment
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 2, p. 265
The renin-angiotensin-aldosterone system (RAAS) is a dominant player in several cardiovascular pathologies. This study investigated whether alterations induced...
L-NAME | Melatonin | Angiotensin 1–7 | Aldosterone | Angiotensin II | Fibrosis | Heart | Hypertension | Collagens | Rats | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Renin | Arginine | Metabolites | Nitric oxide | Rodents | Collagen | Angiotensin | Blood pressure | Ventricle | angiotensin 1–7 | fibrosis | l-NAME">">l-NAME | melatonin | angiotensin II | aldosterone
L-NAME | Melatonin | Angiotensin 1–7 | Aldosterone | Angiotensin II | Fibrosis | Heart | Hypertension | Collagens | Rats | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Renin | Arginine | Metabolites | Nitric oxide | Rodents | Collagen | Angiotensin | Blood pressure | Ventricle | angiotensin 1–7 | fibrosis | l-NAME">">l-NAME | melatonin | angiotensin II | aldosterone
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 2018, Volume 19, Issue 10, p. 3017
Ivabradine, the selective inhibitor of the If current in the sinoatrial node, exerts cardiovascular protection by its bradycardic effect and potentially...
L-NAME | ivabradine | heart function | aldosterone | angiotensin II | fibrosis | hypertension | RATE REDUCTION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | LEFT-VENTRICLE | ENDOTHELIAL FUNCTION | FAILURE | CHEMISTRY, MULTIDISCIPLINARY | DIASTOLIC DYSFUNCTION | CAPTOPRIL | NITRIC-OXIDE | E-DEFICIENT MICE | Angiotensins - blood | Echocardiography | Hydroxyproline - metabolism | Ventricular Function, Left - drug effects | Aldosterone - blood | Rats | Male | NG-Nitroarginine Methyl Ester - adverse effects | Renin - blood | Hypertension - physiopathology | Cardiovascular Agents - pharmacology | Hypertension - etiology | Hypertension - metabolism | Collagen - metabolism | Animals | Ivabradine - pharmacology | Hydroxyproline - blood | Biomarkers | Renin-Angiotensin System - drug effects | Blood Pressure - drug effects | Hypertension - diagnosis | Disease Models, Animal
L-NAME | ivabradine | heart function | aldosterone | angiotensin II | fibrosis | hypertension | RATE REDUCTION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | LEFT-VENTRICLE | ENDOTHELIAL FUNCTION | FAILURE | CHEMISTRY, MULTIDISCIPLINARY | DIASTOLIC DYSFUNCTION | CAPTOPRIL | NITRIC-OXIDE | E-DEFICIENT MICE | Angiotensins - blood | Echocardiography | Hydroxyproline - metabolism | Ventricular Function, Left - drug effects | Aldosterone - blood | Rats | Male | NG-Nitroarginine Methyl Ester - adverse effects | Renin - blood | Hypertension - physiopathology | Cardiovascular Agents - pharmacology | Hypertension - etiology | Hypertension - metabolism | Collagen - metabolism | Animals | Ivabradine - pharmacology | Hydroxyproline - blood | Biomarkers | Renin-Angiotensin System - drug effects | Blood Pressure - drug effects | Hypertension - diagnosis | Disease Models, Animal
Journal Article
Hypertension, ISSN 0194-911X, 09/2018, Volume 72, Issue Suppl_1
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 06/2019, Volume 62, Issue 6, pp. 1090 - 1093
Journal Article
Journal of Hypertension, ISSN 0263-6352, 10/2018, Volume 36 Suppl 3, pp. e193 - e193
OBJECTIVES:RAAS Triple-A testing is a novel mass spectrometry based approach providing a comprehensive biochemical evaluation of the circulating...
Hypertension | Usage | Hyperaldosteronism | Diagnosis | Research | Renin-angiotensin system | Mass spectrometry
Hypertension | Usage | Hyperaldosteronism | Diagnosis | Research | Renin-angiotensin system | Mass spectrometry
Journal Article
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