Nature Methods, ISSN 1548-7091, 2009, Volume 6, Issue 9, pp. 677 - 681
Detection and characterization of genomic structural variation are important for understanding the landscape of genetic variation in human populations and in...
COPY-NUMBER ALTERATIONS | SEQUENCE | BIOCHEMICAL RESEARCH METHODS | DNA - genetics | Genetic Variation | Algorithms | Base Sequence | Computer Simulation | Humans | Genome, Human | Genomics - methods | Sequence Analysis, DNA - methods | Leukemia, Myeloid, Acute - genetics | Usage | Research | Single nucleotide polymorphisms | Nucleotide sequence | Genetic algorithms | Data analysis | Biomedical research | Genomics | Research methodology
COPY-NUMBER ALTERATIONS | SEQUENCE | BIOCHEMICAL RESEARCH METHODS | DNA - genetics | Genetic Variation | Algorithms | Base Sequence | Computer Simulation | Humans | Genome, Human | Genomics - methods | Sequence Analysis, DNA - methods | Leukemia, Myeloid, Acute - genetics | Usage | Research | Single nucleotide polymorphisms | Nucleotide sequence | Genetic algorithms | Data analysis | Biomedical research | Genomics | Research methodology
Journal Article
Nature, ISSN 0028-0836, 2004, Volume 432, Issue 7018, pp. 695 - 716
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first...
phylogenetic analysis | mammalian evolution | tissue-specific genes | brown-norway rat | non-ltr retrotransposons | major histocompatibility complex | olfactory receptor | mouse genome | recent segmental duplications | alcohol-dehydrogenase | MOUSE GENOME | NON-LTR RETROTRANSPOSONS | ALCOHOL-DEHYDROGENASE | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | BROWN-NORWAY RAT | RECENT SEGMENTAL DUPLICATIONS | MAJOR HISTOCOMPATIBILITY COMPLEX | TISSUE-SPECIFIC GENES | OLFACTORY RECEPTOR | MAMMALIAN EVOLUTION | Gene Duplication | Multigene Family - genetics | Conserved Sequence - genetics | Vertebrates - genetics | Physical Chromosome Mapping | Genomics | Humans | Long Interspersed Nucleotide Elements - genetics | Mutagenesis - genetics | Synteny | Genes - genetics | Short Interspersed Nucleotide Elements - genetics | RNA, Untranslated - genetics | Sequence Analysis, DNA | Pseudogenes - genetics | Animals | Retroviridae - genetics | DNA Transposable Elements - genetics | Chickens - genetics | Genome | Avian Proteins - genetics | Evolution, Molecular | Birds | Evolution | Genetic diversity | Gene expression | Mammals | Chromosomes | Research Support; U.S. Gov't; P.H.S | Research Support; U.S. Gov't; Non-P.H.S | Comparative Study | Long Interspersed Nucleotide Elements/genetics | Biology | Avian Proteins/genetics | Vertebrates/genetics | Short Interspersed Nucleotide Elements/genetics | Pseudogenes/genetics | Genetics | Research Support; Non-U.S. Gov't | Biologi | Natural Sciences | Biological Sciences | RNA; Untranslated/genetics | Mutagenesis/genetics | DNA Transposable Elements/genetics | Multigene Family/genetics | Retroviridae/genetics | Sequence Analysis; DNA | Genetik | Genes/genetics | Naturvetenskap | Conserved Sequence/genetics | Evolution; Molecular | Biologiska vetenskaper | Cell and molecular biology | Chickens/genetics | Cell- och molekylärbiologi
phylogenetic analysis | mammalian evolution | tissue-specific genes | brown-norway rat | non-ltr retrotransposons | major histocompatibility complex | olfactory receptor | mouse genome | recent segmental duplications | alcohol-dehydrogenase | MOUSE GENOME | NON-LTR RETROTRANSPOSONS | ALCOHOL-DEHYDROGENASE | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | BROWN-NORWAY RAT | RECENT SEGMENTAL DUPLICATIONS | MAJOR HISTOCOMPATIBILITY COMPLEX | TISSUE-SPECIFIC GENES | OLFACTORY RECEPTOR | MAMMALIAN EVOLUTION | Gene Duplication | Multigene Family - genetics | Conserved Sequence - genetics | Vertebrates - genetics | Physical Chromosome Mapping | Genomics | Humans | Long Interspersed Nucleotide Elements - genetics | Mutagenesis - genetics | Synteny | Genes - genetics | Short Interspersed Nucleotide Elements - genetics | RNA, Untranslated - genetics | Sequence Analysis, DNA | Pseudogenes - genetics | Animals | Retroviridae - genetics | DNA Transposable Elements - genetics | Chickens - genetics | Genome | Avian Proteins - genetics | Evolution, Molecular | Birds | Evolution | Genetic diversity | Gene expression | Mammals | Chromosomes | Research Support; U.S. Gov't; P.H.S | Research Support; U.S. Gov't; Non-P.H.S | Comparative Study | Long Interspersed Nucleotide Elements/genetics | Biology | Avian Proteins/genetics | Vertebrates/genetics | Short Interspersed Nucleotide Elements/genetics | Pseudogenes/genetics | Genetics | Research Support; Non-U.S. Gov't | Biologi | Natural Sciences | Biological Sciences | RNA; Untranslated/genetics | Mutagenesis/genetics | DNA Transposable Elements/genetics | Multigene Family/genetics | Retroviridae/genetics | Sequence Analysis; DNA | Genetik | Genes/genetics | Naturvetenskap | Conserved Sequence/genetics | Evolution; Molecular | Biologiska vetenskaper | Cell and molecular biology | Chickens/genetics | Cell- och molekylärbiologi
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2009, Volume 361, Issue 11, pp. 1058 - 1066
A comparison of the genomic sequence of a tumor sample from a patient with acute myeloid leukemia (AML) and that of a normal skin sample from the same patient...
AML | MEDICINE, GENERAL & INTERNAL | COPY NUMBER ALTERATIONS | GENE | ABNORMALITIES | IDH1 | CLASSIFICATION | PATTERNS | EXPRESSION | CANCER | Gene Frequency | Humans | Middle Aged | Isocitrate Dehydrogenase - genetics | Male | Point Mutation | DNA Mutational Analysis | Adult | Female | Mutation | Genome, Human | Sequence Analysis, DNA - methods | Leukemia, Myeloid, Acute - genetics | Gene mutations | Research | Nucleotide sequencing | Leukemia | Genes | Bone marrow | Breast cancer | Genomes | Patients
AML | MEDICINE, GENERAL & INTERNAL | COPY NUMBER ALTERATIONS | GENE | ABNORMALITIES | IDH1 | CLASSIFICATION | PATTERNS | EXPRESSION | CANCER | Gene Frequency | Humans | Middle Aged | Isocitrate Dehydrogenase - genetics | Male | Point Mutation | DNA Mutational Analysis | Adult | Female | Mutation | Genome, Human | Sequence Analysis, DNA - methods | Leukemia, Myeloid, Acute - genetics | Gene mutations | Research | Nucleotide sequencing | Leukemia | Genes | Bone marrow | Breast cancer | Genomes | Patients
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7291, pp. 999 - 1005
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour...
MYELOID-LEUKEMIA GENOME | LUNG-CANCER | COLORECTAL CANCERS | SUBTYPES | MULTIDISCIPLINARY SCIENCES | RESOLUTION | TUMOR-SUPPRESSOR | DIFFERENTIATION | TAZ | SOMATIC MUTATIONS | Neoplasm Transplantation | Gene Frequency - genetics | Genomics | Humans | Brain Neoplasms - genetics | Transplantation, Heterologous | DNA Copy Number Variations - genetics | Mutation - genetics | Disease Progression | Genome, Human - genetics | Brain Neoplasms - secondary | Breast Neoplasms - genetics | Breast Neoplasms - pathology | DNA Mutational Analysis | Adult | Female | alpha Catenin - genetics | Translocation, Genetic - genetics | Usage | Gene mutations | Development and progression | Genetic aspects | Breast cancer | Metastasis | Research | Nucleotide sequencing | Health aspects | Risk factors | Methods | Gene amplification | Chemotherapy | Genetics | Mutation | Genetic testing | Comparative analysis | Cancer therapies | DNA repair | Cancer | Enrichment | Mutations | Tumours | Deoxyribonucleic acid | Deletion | Breast | Genomes
MYELOID-LEUKEMIA GENOME | LUNG-CANCER | COLORECTAL CANCERS | SUBTYPES | MULTIDISCIPLINARY SCIENCES | RESOLUTION | TUMOR-SUPPRESSOR | DIFFERENTIATION | TAZ | SOMATIC MUTATIONS | Neoplasm Transplantation | Gene Frequency - genetics | Genomics | Humans | Brain Neoplasms - genetics | Transplantation, Heterologous | DNA Copy Number Variations - genetics | Mutation - genetics | Disease Progression | Genome, Human - genetics | Brain Neoplasms - secondary | Breast Neoplasms - genetics | Breast Neoplasms - pathology | DNA Mutational Analysis | Adult | Female | alpha Catenin - genetics | Translocation, Genetic - genetics | Usage | Gene mutations | Development and progression | Genetic aspects | Breast cancer | Metastasis | Research | Nucleotide sequencing | Health aspects | Risk factors | Methods | Gene amplification | Chemotherapy | Genetics | Mutation | Genetic testing | Comparative analysis | Cancer therapies | DNA repair | Cancer | Enrichment | Mutations | Tumours | Deoxyribonucleic acid | Deletion | Breast | Genomes
Journal Article
Science, ISSN 0036-8075, 4/2007, Volume 316, Issue 5822, pp. 222 - 234
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they...
Chimpanzees | Humans | Genes | Genomics | Positive selection | Primates | Evolution | Genomes | Genetic mutation | Chromosomes | Research Article | GENE | DATABASE | MODELS | PRIMATE SEGMENTAL DUPLICATIONS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | DISEASE | SITES | MALE MUTATION BIAS | SUBSTITUTION RATES | CHIMPANZEE | Gene Duplication | Multigene Family | Species Specificity | Pan troglodytes - genetics | Genetic Diseases, Inborn | Male | Sequence Analysis, DNA | Genetic Variation | Animals | Gene Rearrangement | Macaca mulatta - genetics | Biomedical Research | Female | Mutation | Genome | Evolution, Molecular | Rhesus monkey | Medical research | Medicine, Experimental | Genetic aspects | Research | Natural history
Chimpanzees | Humans | Genes | Genomics | Positive selection | Primates | Evolution | Genomes | Genetic mutation | Chromosomes | Research Article | GENE | DATABASE | MODELS | PRIMATE SEGMENTAL DUPLICATIONS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | DISEASE | SITES | MALE MUTATION BIAS | SUBSTITUTION RATES | CHIMPANZEE | Gene Duplication | Multigene Family | Species Specificity | Pan troglodytes - genetics | Genetic Diseases, Inborn | Male | Sequence Analysis, DNA | Genetic Variation | Animals | Gene Rearrangement | Macaca mulatta - genetics | Biomedical Research | Female | Mutation | Genome | Evolution, Molecular | Rhesus monkey | Medical research | Medicine, Experimental | Genetic aspects | Research | Natural history
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7192, pp. 175 - 183
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian...
MONOTREME | CATHELICIDINS | ELECTRORECEPTION | ARRANGEMENT | MONODELPHIS-DOMESTICA | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | CHROMOSOMES | EXPRESSION | INSIGHTS | FAMILY | Mammals - genetics | Platypus - immunology | Repetitive Sequences, Nucleic Acid - genetics | Humans | Genome - genetics | Male | Milk Proteins - genetics | Reptiles - genetics | Phylogeny | Platypus - genetics | Platypus - physiology | Spermatozoa - metabolism | Venoms - genetics | Sequence Analysis, DNA | Genomic Imprinting - genetics | Animals | Base Composition | Dentition | Receptors, Odorant - genetics | Zona Pellucida - metabolism | Female | MicroRNAs - genetics | Immunity - genetics | Evolution, Molecular | Temperature | Digestive system | Genomics | Evolution | Reproductive system | Artificial chromosomes | Marine mammals | Index Medicus
MONOTREME | CATHELICIDINS | ELECTRORECEPTION | ARRANGEMENT | MONODELPHIS-DOMESTICA | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | CHROMOSOMES | EXPRESSION | INSIGHTS | FAMILY | Mammals - genetics | Platypus - immunology | Repetitive Sequences, Nucleic Acid - genetics | Humans | Genome - genetics | Male | Milk Proteins - genetics | Reptiles - genetics | Phylogeny | Platypus - genetics | Platypus - physiology | Spermatozoa - metabolism | Venoms - genetics | Sequence Analysis, DNA | Genomic Imprinting - genetics | Animals | Base Composition | Dentition | Receptors, Odorant - genetics | Zona Pellucida - metabolism | Female | MicroRNAs - genetics | Immunity - genetics | Evolution, Molecular | Temperature | Digestive system | Genomics | Evolution | Reproductive system | Artificial chromosomes | Marine mammals | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2005, Volume 437, Issue 7055, pp. 69 - 87
Here we present a draft genome sequence of the common chimpanzee ( Pan troglodytes). Through comparison with the human genome, we have generated a largely...
GREAT APE | BACKGROUND SELECTION | CHROMOSOME FUSION SITE | DNA-SEQUENCES | POSITIVE SELECTION | ACCELERATED EVOLUTION | MULTIDISCIPLINARY SCIENCES | MOLECULAR EVOLUTION | RECOMBINATION RATES | SUBSTITUTION RATES | DELETERIOUS MUTATIONS | Disease | Genomics | Humans | Computational Biology | Mutagenesis - genetics | Pan troglodytes - genetics | Phylogeny | Sequence Analysis, DNA | Animals | Time Factors | Base Composition | Alleles | DNA Transposable Elements - genetics | Recombination, Genetic - genetics | Polymorphism, Genetic - genetics | Genome, Human | Alu Elements - genetics | Evolution, Molecular | Telomere - genetics | Genes | Comparative studies | Evolution | Genetic diversity | Mutation | Monkeys & apes | Hominids | Genetik | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Cell and molecular biology | Genetics | Biology | Biologi | Natural Sciences | Cell- och molekylärbiologi
GREAT APE | BACKGROUND SELECTION | CHROMOSOME FUSION SITE | DNA-SEQUENCES | POSITIVE SELECTION | ACCELERATED EVOLUTION | MULTIDISCIPLINARY SCIENCES | MOLECULAR EVOLUTION | RECOMBINATION RATES | SUBSTITUTION RATES | DELETERIOUS MUTATIONS | Disease | Genomics | Humans | Computational Biology | Mutagenesis - genetics | Pan troglodytes - genetics | Phylogeny | Sequence Analysis, DNA | Animals | Time Factors | Base Composition | Alleles | DNA Transposable Elements - genetics | Recombination, Genetic - genetics | Polymorphism, Genetic - genetics | Genome, Human | Alu Elements - genetics | Evolution, Molecular | Telomere - genetics | Genes | Comparative studies | Evolution | Genetic diversity | Mutation | Monkeys & apes | Hominids | Genetik | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Cell and molecular biology | Genetics | Biology | Biologi | Natural Sciences | Cell- och molekylärbiologi
Journal Article