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1. Full Text Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry
by Eisen, Alon and Bhatt, Deepak L and Steg, P. Gabriel and Eagle, Kim A and Goto, Shinya and Guo, Jianping and Smith, Sidney C and Ohman, E. Magnus and Scirica, Benjamin M and REACH Registry Investigators and the REACH Registry Investigators
Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods... 
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
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2. Full Text Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study
by Vidailhet, Marie, MD and Yelnik, Jerome, MD and Lagrange, Christelle, PhD and Fraix, Valerie, MD and Grabli, David, MD and Thobois, Stephane, MD and Burbaud, Pierre, MD and Welter, Marie-Laure, MD and Xie-Brustolin, Jin, MD and Braga, Maria-Clara Coelho, MD and Ardouin, Claire, PhD and Czernecki, Virginie, PhD and Klinger, Hélène, MD and Chabardes, Stephan, MD and Seigneuret, Eric, MD and Mertens, Patrick, MD and Cuny, Emmanuel, MD and Navarro, Soledad, MD and Cornu, Philippe, MD and Benabid, Alim-Louis, MD and LeBas, Jean-Francois, MD and Dormont, Didier, MD and Hermier, Marc, MD and Dujardin, Kathy, PhD and Blond, Serge, MD and Krystkowiak, Pierre, MD and Destée, Alain, MD and Bardinet, Eric, PhD and Agid, Yves, MD and Krack, Paul, PhD and Broussolle, Emmanuel, MD and Pollak, Pierre, MD and French SPIDY-2Study Grp and French SPIDY-2 Study Group
Lancet Neurology, The, ISSN 1474-4422, 2009, Volume 8, Issue 8, pp. 709 - 717
Summary Background Cerebral palsy (CP) with dystonia-choreoathetosis is a common cause of disability in children and in adults, and responds poorly to medical... 
Neurology | ATLAS | PRIMARY GENERALIZED DYSTONIA | INTERNUS | DISEASE | GLOBUS-PALLIDUS | FOLLOW-UP | SCALE | CLINICAL NEUROLOGY | Disability Evaluation | Dystonia - therapy | Severity of Illness Index | Prospective Studies | Dystonia - complications | Chorea - therapy | Humans | Globus Pallidus - physiology | Magnetic Resonance Imaging - methods | Male | Athetosis - therapy | Basal Ganglia - pathology | Functional Laterality | Deep Brain Stimulation - methods | Young Adult | Pilot Projects | Cerebral Palsy - complications | Chorea - complications | Athetosis - complications | Cerebral Palsy - therapy | Statistics, Nonparametric | Adult | Female | Cerebral palsy | Brain | Medical research | Care and treatment | Neurosciences | Medicine, Experimental | Adults | Bioengineering | Nuclear medicine | Medical Physics | Acoustics | Medical Imaging | Physics | Life Sciences | Signal and Image Processing | Image Processing | Imaging | Computer Science | Mechanics | Engineering Sciences
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3. Full Text Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study
by Vidailhet, Marie, MD and Vercueil, Laurent, MD and Houeto, Jean-Luc, MD and Krystkowiak, Pierre, MD and Lagrange, Christelle, PhD and Yelnik, Jerôme, MD and Bardinet, Eric, PhD and Benabid, Alim-Louis, MD and Navarro, Soledad, MD and Dormont, Didier, MD and Grand, Sylvie, MD and Blond, Serge, MD and Ardouin, Claire, PhD and Pillon, Bernard, PhD and Dujardin, Katy, PhD and Hahn-Barma, Valérie, PhD and Agid, Yves, MD and Destée, Alain, MD and Pollak, Pierre, MD and French SPIDY Study Grp and French SPIDY Study Group
Lancet Neurology, The, ISSN 1474-4422, 2007, Volume 6, Issue 3, pp. 223 - 229
Summary Background We have previously reported the efficacy and safety of bilateral pallidal stimulation for primary generalised dystonia in a prospective,... 
Neurology | GLOBUS-PALLIDUS | QUALITY-OF-LIFE | CERVICAL DYSTONIA | HARDWARE-RELATED COMPLICATIONS | INTERNUS | CLINICAL NEUROLOGY | Disability Evaluation | Dystonia - psychology | Dystonia - therapy | Prospective Studies | Follow-Up Studies | Humans | Globus Pallidus - physiology | Molecular Chaperones - genetics | Dystonia - physiopathology | Male | Treatment Outcome | Affect | Neuropsychological Tests | Magnetic Resonance Imaging | Psychiatric Status Rating Scales | Movement - physiology | Adolescent | Age of Onset | Deep Brain Stimulation | Cognition - physiology | Quality of Life | Adult | Female | Surveys and Questionnaires | Neurosciences | Molecular Chaperones | Globus Pallidus | Movement | Cognition | Questionnaires | Dystonia
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4. Full Text mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
by Morita, Masahiro and Gravel, Simon-Pierre and Chénard, Valérie and Sikström, Kristina and Zheng, Liang and Alain, Tommy and Gandin, Valentina and Avizonis, Daina and Arguello, Meztli and Zakaria, Chadi and McLaughlan, Shannon and Nouet, Yann and Pause, Arnim and Pollak, Michael and Gottlieb, Eyal and Larsson, Ola and St-Pierre, Julie and Topisirovic, Ivan and Sonenberg, Nahum
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 698 - 711
mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases... 
MAMMALIAN TARGET | RAPAMYCIN | BINDING PARTNER | SKELETAL-MUSCLE | DIFFERENTIAL TRANSLATION | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | GENOME-WIDE | MOTIF PHOSPHORYLATION | CELL-GROWTH | COMPLEX 2 | CELL BIOLOGY | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondrial Turnover | Adenosine Triphosphate - biosynthesis | Mechanistic Target of Rapamycin Complex 2 | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Cell Nucleus - metabolism | Cell Respiration | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Autophagy - genetics | DNA, Mitochondrial - biosynthesis | Eukaryotic Initiation Factors - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Mitochondria - metabolism | Genome, Human - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Mice | Adaptor Proteins, Signal Transducing - metabolism | RNA | Physiological aspects | Biosynthesis | Mitochondrial DNA | Diabetes | Binding proteins | Heart diseases | Genetic translation | Protein binding
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5. Full Text MTOR coordinates protein synthesis, mitochondrial activity
by Morita, Masahiro and Gravel, Simon-Pierre and Hulea, Laura and Larsson, Ola and Pollak, Michael and St-Pierre, Julie and Topisirovic, Ivan
Cell Cycle, ISSN 1538-4101, 02/2015, Volume 14, Issue 4, pp. 473 - 480
Mitochondria | Tca cycle | Oxidative phosphorylation | MRNA translation | 4E-BP1 | Metabolism | EIF4E | MTOR
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6. Full Text Anterior pallidal deep brain stimulation for Tourette's syndrome: a randomised, double-blind, controlled trial
by Welter, Marie-Laure, MD and Houeto, Jean-Luc, Prof and Thobois, Stéphane, Prof and Bataille, Benoit, Prof and Guenot, Marc, Prof and Worbe, Yulia, MD and Hartmann, Andreas, MD and Czernecki, Virginie, PhD and Bardinet, Eric, PhD and Yelnik, Jerome, MD and du Montcel, Sophie Tezenas, MD and Agid, Yves, Prof and Vidailhet, Marie, Prof and Cornu, Philippe, Prof and Tanguy, Audrey and Ansquer, Solène, MD and Jaafari, Nematollah, MD and Poulet, Emmanuel, MD and Serra, Giulia, MD and Burbaud, Pierre, Prof and Cuny, Emmanuel, Prof and Aouizerate, Bruno, Prof and Pollak, Pierre, Prof and Chabardes, Stephan, Prof and Polosan, Mircea, MD and Borg, Michel, Prof and Fontaine, Denys, Prof and Giordana, Bruno, MD and Raoul, Sylvie, Prof and Rouaud, Tiphaine, MD and Sauvaget, Anne, MD and Jalenques, Isabelle, Prof and Karachi, Carine, MD and Mallet, Luc, Prof and STIC Study Grp and STIC study group
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 8, pp. 610 - 619
Summary Background Deep brain stimulation (DBS) has been proposed to treat patients with severe Tourette's syndrome, and open-label trials and two small... 
Neurology | EUROPEAN CLINICAL GUIDELINES | DSM-IV | PRIMARY GENERALIZED DYSTONIA | THALAMIC-STIMULATION | TIC SEVERITY | GLOBUS-PALLIDUS | DISORDERS | DYSFUNCTION | SCALE | CLINICAL NEUROLOGY | Severity of Illness Index | Tourette Syndrome - therapy | Globus Pallidus | Double-Blind Method | Outcome Assessment (Health Care) | Humans | Middle Aged | Male | Deep Brain Stimulation - adverse effects | Deep Brain Stimulation - methods | Young Adult | Treatment Failure | Adult | Female | Clinical trials | Attention deficit disorder | Obsessive compulsive disorder | Mental disorders | Deep brain stimulation | Globus pallidus | Electrodes | Studies | Side effects | Neuroses | Surgery | Gilles de la Tourette syndrome | Physiology | Anxiety | Tourette syndrome | Psychiatry | Movement disorders | Life Sciences
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7. Full Text Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
by Benabid, Alim Louis, MD and Chabardes, Stephan, MD and Mitrofanis, John, PhD and Pollak, Pierre, MD
Lancet Neurology, The, ISSN 1474-4422, 2009, Volume 8, Issue 1, pp. 67 - 81
Summary High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN-HFS) is the preferred surgical treatment for advanced Parkinson's disease.... 
Neurology | HARDWARE-RELATED COMPLICATIONS | MPTP-TREATED MONKEYS | LEVODOPA-INDUCED DYSKINESIAS | MOTOR CORTEX STIMULATION | HUMAN PEDUNCULOPONTINE NUCLEUS | CHRONIC BILATERAL STIMULATION | DBS REPLACES LEVODOPA | HIGH-FREQUENCY STIMULATION | QUALITY-OF-LIFE | 2-YEAR FOLLOW-UP | CLINICAL NEUROLOGY | Parkinson Disease - therapy | Neurosurgical Procedures - adverse effects | Parkinson Disease - complications | Prognosis | Speech Disorders - therapy | Humans | Electrodes - adverse effects | Muscle Rigidity - therapy | Treatment Outcome | Deep Brain Stimulation - adverse effects | Parkinson Disease - psychology | Contraindications | Randomized Controlled Trials as Topic | Subthalamic Nucleus - physiology | Speech Disorders - etiology | Muscle Rigidity - etiology | Quality of Life | Tremor - therapy | Tremor - etiology | Cohort Studies | Drug therapy | Parkinson's disease | Subthalamic Nucleus | Tremor | Muscle Rigidity | Neurons and Cognition | Speech Disorders | Electrodes | Parkinson Disease | Life Sciences | Neurosurgical Procedures | Deep Brain Stimulation
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8. Full Text mTOR coordinates protein synthesis, mitochondrial activity and proliferation
by Morita, Masahiro and Gravel, Simon-Pierre and Hulea, Laura and Larsson, Ola and Pollak, Michael and St-Pierre, Julie and Topisirovic, Ivan
Cell Cycle, ISSN 1538-4101, 02/2015, Volume 14, Issue 4, pp. 473 - 480
Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase... 
eIF4E | mRNA translation | mitochondria | TCA cycle | mTOR | 4E-BP1 | metabolism | oxidative phosphorylation | BINDING PARTNER | FACTOR EIF-4E | LIFE-SPAN | MESSENGER-RNA TRANSLATION | RAG GTPASES | INITIATION | PHOSPHORYLATION | SIGNAL INTEGRATION | CELL-GROWTH | CELL BIOLOGY | S6 KINASE | Animals | Models, Biological | Humans | Cell Proliferation - physiology | Protein Biosynthesis - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Mitochondria - physiology
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9. Full Text Subthalamic Nucleus Stimulation in Severe Obsessive–Compulsive Disorder
by Mallet, Luc and Polosan, Mircea and Jaafari, Nematollah and Baup, Nicolas and Welter, Marie-Laure and Fontaine, Denys and Montcel, Sophie Tezenas du and Yelnik, Jérôme and Chéreau, Isabelle and Arbus, Christophe and Raoul, Sylvie and Aouizerate, Bruno and Damier, Philippe and Chabardès, Stephan and Czernecki, Virginie and Ardouin, Claire and Krebs, Marie-Odile and Bardinet, Eric and Chaynes, Patrick and Burbaud, Pierre and Cornu, Philippe and Derost, Philippe and Bougerol, Thierry and Bataille, Benoit and Mattei, Vianney and Dormont, Didier and Devaux, Bertrand and Vérin, Marc and Houeto, Jean-Luc and Pollak, Pierre and Benabid, Alim-Louis and Agid, Yves and Krack, Paul and Millet, Bruno and Pelissolo, Antoine and STOC Study Grp and STOC Study Group
The New England Journal of Medicine, ISSN 0028-4793, 11/2008, Volume 359, Issue 20, pp. 2121 - 2134
In this 10-month, crossover, double-blind study of 16 patients with severe, refractory obsessive–compulsive disorder (OCD), stimulation of the subthalamic... 
MEDICINE, GENERAL & INTERNAL | DSM-IV | CAPSULAR STIMULATION | ELECTRICAL-STIMULATION | INTERVIEW | FOLLOW-UP | RELIABILITY | SCALE | DEEP BRAIN-STIMULATION | INTERRATER | PARKINSONS-DISEASE | Cross-Over Studies | Subthalamic Nucleus | Double-Blind Method | Electric Stimulation Therapy - adverse effects | Humans | Middle Aged | Obsessive-Compulsive Disorder - therapy | Adult | Female | Male | Infection - etiology | Cerebral Hemorrhage - etiology | Care and treatment | Obsessive-compulsive disorder | Diagnosis | Risk factors | Nuclear magnetic resonance--NMR | Behavior modification | Neuroses | Parkinsons disease | Computer Science | Medical Imaging
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10. Full Text NanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
by Gandin, Valentina and Masvidal, Laia and Hulea, Laura and Gravel, Simon-Pierre and Cargnello, Marie and McLaughlan, Shannon and Cai, Yutian and Balanathan, Preetika and Morita, Masahiro and Rajakumar, Arjuna and Furic, Luc and Pollak, Michael and Porco, John A and St-Pierre, Julie and Pelletier, Jerry and Larsson, Ola and Topisirovic, Ivan
Genome Research, ISSN 1088-9051, 05/2016, Volume 26, Issue 5, pp. 636 - 648
The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation... 
MAMMALIAN TRANSLATION | EIF4A | MITOCHONDRIAL ACTIVITY | NONCODING REGION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS | 4E-BP1 PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MCF-7 Cells | TOR Serine-Threonine Kinases - metabolism | Humans | Protein Biosynthesis - physiology | Eukaryotic Initiation Factor-4E - metabolism | Female | Apoptosis - physiology | 5' Untranslated Regions - physiology | Toll-like receptors | Messenger RNA | Research | Genetic translation
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11. Full Text Serine deprivation enhances antineoplastic activity of biguanides
by Gravel, Simon-Pierre and Hulea, Laura and Toban, Nader and Birman, Elena and Blouin, Marie-José and Zakikhani, Mahvash and Zhao, Yunhua and Topisirovic, Ivan and St-Pierre, Julie and Pollak, Michael
Cancer Research, ISSN 0008-5472, 12/2014, Volume 74, Issue 24, pp. 7521 - 7533
Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported... 
BREAST-CANCER | METFORMIN | MTORC1 | REDUCTIVE GLUTAMINE-METABOLISM | AMP | ONCOLOGY | PROSTATE-CANCER CELLS | PYRUVATE-KINASE M2 | ALPHA-KETOGLUTARATE | GROWTH IN-VIVO | COLON-CARCINOMA | Neoplasms - metabolism | Phenformin - administration & dosage | Biguanides - administration & dosage | Humans | Serine - biosynthesis | Glycolysis - drug effects | Serine - metabolism | Neoplasms - drug therapy | Oxidative Phosphorylation - drug effects | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice | Metformin | Neoplasms - pathology
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