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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Medical services | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2014, Volume 136, Issue 11, pp. 4245 - 4256
We investigated the correlation between the polymer backbone structural regularity and the charge transport properties of... 
POLYMER SOLAR-CELLS | FILM MORPHOLOGY | DONOR | PERFORMANCE | POLY(3-HEXYLTHIOPHENE) | CHARGE-TRANSPORT | DISORDER | CHEMISTRY, MULTIDISCIPLINARY | FIELD-EFFECT TRANSISTORS | AGGREGATION | AMBIPOLAR | Usage | Research | X-ray spectroscopy | Electron transport | Transmission electron microscopes
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, pp. 28032 - 28032
In acute myeloid leukemia (AML), the Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes. Recently, a new and recurrent juxtamembrane... 
ACTIVATION | MUTANTS | INHIBITION | TRKA | PROGNOSIS | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | Index Medicus
Journal Article
Experimental Hematology, ISSN 0301-472X, 2013, Volume 41, Issue 3, pp. 271 - 280.e4
In addition to overexpression and the occurrence of activating mutations, receptors can be aberrantly activated by impaired downregulation. In this study, we... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | MEDICINE, RESEARCH & EXPERIMENTAL | NEOPLASMS | UBIQUITIN LIGASE | C-CBL | ACUTE MYELOGENOUS LEUKEMIA | GROWTH | ACQUIRED UNIPARENTAL DISOMY | ACUTE MYELOID-LEUKEMIA | MUTATIONS | HEMATOLOGY | BINDING | CHRONIC MYELOMONOCYTIC LEUKEMIA | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Proto-Oncogene Proteins c-cbl - metabolism | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Apoptosis - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | fms-Like Tyrosine Kinase 3 - genetics | Flow Cytometry | Transfection | Cell Transformation, Neoplastic - genetics | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Cell Line | Benzothiazoles - pharmacology | Morpholines - pharmacology | Signal Transduction - genetics | Binding Sites - genetics | Blotting, Western | fms-Like Tyrosine Kinase 3 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Tyrosine - metabolism | Animals | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Protein Binding | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tyrosine - genetics | Ubiquitin | Tyrosine | Platelet-derived growth factor | Ligases | Leukemia | Phenols | Lymphomas | Phosphotransferases | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 10, pp. 1761 - 1769
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2012, Volume 11, Issue 11, pp. 2373 - 2383
Journal Article
by Trojano, Maria and Butzkueven, Helmut and Kappos, Ludwig and Wiendl, Heinz and Spelman, Tim and Pellegrini, Fabio and Chen, Yi and Dong, Qunming and Koendgen, Harold and Belachew, Shibeshih and Correale, Jorge and Caride, Alejandro and Deri, Norma H and Ballario, Carlos and Broadley, Simon and Kneebone, Chris and Barnett, Michael and Pollard, John and Hodgkinson, Suzanne and Kermode, Allan and Macdonell, Richard and King, John and Lechner-Scott, Jeannette and Saines, Noel and Slee, Mark and Plummer, Chris and Willekens, Barbara and Vanopdenbosch, Ludo and Phan-Ba, Rémy and Delvaux, Valérie and Bissay, Veronique and Debruyne, Jan and Decoo, Danny and Crols, Roeland and Symons, Anoek and Nagels, Guy and Van Pesch, Vincent and Sindic, Christian and Dubois, Benedicte and Medaer, Robert and Medaer, R and D'Hooghe, Marie and Guillaume, Daniel and De Smet, Eric and Seeldrayers, Pierrette and Lysandropoulos, Andreas and Vokaer, Mathieu and Geens, Karine and Willems, Christina and Denayer, Pierre and Bureau, Michel and Retif, Cecile and Dupuis, Michel and Bouquiaux, Olivier and Vanderdonckt, Patrick and van Landegem, William and Caekebeke, Jo and Van Ingelghem, Erwin and Peeters, Katelijne and Gerard, Pascale and de Noordhout, Alain Maertens and Desfontaines, Philippe and Urbain, Etienne and Declercq, Inge and Van Wijmeersch, Bart and Vanroose, Erwin and Wibail, Alain and Barthomolé, Emmanuel and Ursell, Melanie and Sweet, Margaret Elizabeth and Howse, David and Jichici, Draga and Shawush, Melad and Namaka, Mike and Traboulsee, Anthony and Hashimoto, Stan and Lo, Raymond and Marchetti, Paul and Lapierre, Yves and Jacques, Francois and MacLean, Gregg and Bhan, Virender and Duquette, Pierre and Stewart, Bradley and Paulseth, John and Kremenchutzky, Marcelo and Vorobeychik, Galina and O'Connor, Paul and Grand'Maison, François and Havrdova, Eva and Meluzinová, Eva and Valis, Martin and Talab, Radomír and Stourac, Pavel and Zapletalová, Olga and Dufek, Michal and Sládková, Vladimíra and Novotna, Alena and Vancurová, Romana and Lhotaková, Libuse and ... and Tysabri Observational Program TOP and Tysabri® Observational Program (TOP) Investigators
Multiple Sclerosis and Related Disorders, ISSN 2211-0348, 08/2018, Volume 24, pp. 11 - 19
Journal Article
Mammalian Biology, ISSN 1616-5047, 06/2013, Volume 78, Issue 4, pp. 283 - 289
For habitat specialists, fragmentation has major consequences as it means less suitable habitat for the species to live in. In a fragmented landscape, we would... 
Austria | Habitat management | Landscape fragmentation | Conservation | LOCATION | ZOOLOGY | HOME-RANGE | CHIROPTERA | Bats | Environmental protection
Journal Article
Folia Phoniatrica et Logopaedica, ISSN 1021-7762, 11/2006, Volume 58, Issue 6, pp. 469 - 470
Journal Article
Folia Phoniatrica et Logopaedica, ISSN 1021-7762, 11/2006, Volume 58, Issue 6, pp. 467 - 468
Journal Article
Folia Phoniatrica et Logopaedica, ISSN 1021-7762, 11/2006, Volume 58, Issue 6, pp. 456 - 464
Journal Article