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1. Full Text H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria
by Igor A. Pomytkin
Current Neuropharmacology, ISSN 1570-159X, 12/2012, Volume 10, Issue 4, pp. 311 - 320
This review is focused on the mechanistic aspects of the insulin-induced H2O2 signalling pathway in neurons and the molecules affecting it, which act as risk... 
CEREBELLAR GRANULE NEURONS | HUMAN NEUROBLASTOMA-CELLS | OXIDATIVE STRESS | ACTIVE-SITE CYSTEINE | mitochondria | ALZHEIMERS-DISEASE | hydrogen peroxide | brain | GROWTH-FACTOR-II | NEUROSCIENCES | TYROSINE-PHOSPHATASE 1B | OXIDOREDUCTASE COMPLEX-I | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | insulin receptor | Alzheimer's disease | HYDROGEN-PEROXIDE PRODUCTION | Brain | Mitochondria | Hydrogen peroxide | Insulin receptor | Alzheimer’s disease
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2. Full Text Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: A reciprocal risk factor for depression and insulin resistance?
by Pomytkin, Igor A and Cline, Brandon H and Anthony, Daniel C and Steinbusch, Harry W and Lesch, Klaus-Peter and Strekalova, Tatyana
Behavioural Brain Research, ISSN 0166-4328, 01/2015, Volume 276, pp. 111 - 117
Depression and diabetes are serious diseases with an increasing global prevalence. Intriguingly, recent meta-analyses have highlighted an asymmetrical... 
Antidepressant | Depression | Insulin resistance | Inflammation | 5-HT | Endotoxemia | NEUROTROPHIC FACTOR | CO-MORBID DEPRESSION | NEUROBLASTOMA-CELLS | NEUROSCIENCES | ANTIDEPRESSANT MEDICATION USE | CULTURED HIPPOCAMPAL-NEURONS | REGULATED KINASE ERK | SIGNALING PATHWAY | COMORBID DEPRESSION | DIABETES PREVENTION PROGRAM | BEHAVIORAL SCIENCES | INTESTINAL PERMEABILITY | Neurosciences | Serotonin | Antidepressants | Depression, Mental | Psychotherapy | Permeability | Health aspects | Risk factors | Type 2 diabetes | Phenols | Development and progression
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3. Full Text Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons
by Storozhevykh, Tatiana P and Senilova, Yana E and Persiyantseva, Nadezhda A and Pinelis, Vsevolod G and Pomytkin, Igor A
BMC Neuroscience, ISSN 1471-2202, 10/2007, Volume 8, Issue 1, pp. 84 - 84
Background: Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin... 
SIGNAL-TRANSDUCTION | FAT-CELLS | PHOSPHORYLATION | ALZHEIMERS-DISEASE | CRYSTAL-STRUCTURE | PROTEIN-TYROSINE PHOSPHATASES | PLASMA-MEMBRANE | NEUROSCIENCES | GROWTH-FACTOR EXPRESSION | VASCULAR SMOOTH-MUSCLE | KINASE DOMAIN | Insulin - pharmacology | Phosphorylation | Insulin - physiology | Rats, Wistar | Cells, Cultured | Rats | Mitochondria - metabolism | Hydrogen Peroxide - metabolism | Insulin - metabolism | Animals | Cell Respiration - physiology | Neurons - physiology | Receptor, Insulin - metabolism | Neurons - metabolism | Electron Transport - physiology | Receptors | Research | Neurons | Health aspects | Insulin | Krebs cycle
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4. Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice
by Rychikhin, V M and Sariev, A K and Pomytkin, I A
Eksperimental'naia i klinicheskaia farmakologiia, ISSN 0869-2092, 2013, Volume 76, Issue 3, p. 10
The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced... 
Convulsants - adverse effects | Anticonvulsants - pharmacology | Pipecolic Acids - pharmacology | Dose-Response Relationship, Drug | Pentylenetetrazole - adverse effects | Animals | Epilepsy - chemically induced | Time Factors | Choline - analogs & derivatives | Choline - pharmacology | Convulsants - pharmacology | Epilepsy - drug therapy | Mice | Succinates - pharmacology | Pentylenetetrazole - pharmacology | Disease Models, Animal
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5. Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice
by Rychikhin, V.M and Sariev, A.K and Pomytkin, I.A
Eksperimental'naia i klinicheskaia farmakologiia, ISSN 0869-2092, 2013, Volume 76, Issue 3, pp. 10 - 12
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6. Full Text 2017 TERMIS - Americas Conference & Exhibition Charlotte, NC December 3–6, 2017
by Heo, S and Bursac, N and Walker, B. W and Yu, C. H and Sani, E. Shirzaei and Kimball, W and Sapru, S and Naskar, D and Kundu, B and Ghosh, A. K and Mandal, M and Reis, R. L and Reis, R. L and Mi, H and Turng, L and Musson, D. S and Naot, D and da Silva, L. P and Bastos, A. R and Costa, J. B and Oliveira, J. M and Oliveira, J. M and Correlo, V. M and Reis, R. L and Reis, R. L and Cornish, J and Estevez, M and Sreeram, A and Cuskey, S and Fedorchak, N and Ashton, R and Milbreta, U and Pinese, C and Park, J and Wetzel, I and Cho, H and Robles, U. Aregueta and Gilmour, A and Goding, J and Lovell, N. H and Martens, P. J and Green, R. A and Zirretta, L and Stapp, D and Grundeen, S and Kaplan, D. L and Maximova, N. V and Krasheninnikov, M. E and Klabukov, I. D and Pomytkin, I. A and Lyundup, A. V and Sproul, E. P and Nandi, S and Roosa, C. A and Brown, A. C and Brown, A. C and Gandhi, A and Attar, P and Korn, S and Lam, K and Lam, K and Saini, S and Hyoju, S and Zaborina, O and Alverdy, J and Teymour, F and Papavasiliou, G and Beyer, S and Walus, K and Thain, K and Pan, S and Mohamed, T and De Riccardis, G and Alexander, P. G and Raimondi, M. T and Tuan, R. S and Lerman, M. J and Kingsbury, T. J and Civin, C. I and Fisher, J. P and Fisher, J. P and Felder, M and Williams, C and Sikavitsas, V and Suzuki, K and Komura, H and Lankford, S. K and Andersson, K and Tedeschi, A. M and Gjinovci, A and Russo, S and Camilli, C and Cossu, G and Mantero, S and De Coppi, P and Badylak, S. F and Badylak, S. F and Badylak, S. F and Zakhem, E and Bohl, J and ...
Tissue Engineering Part A, ISSN 1937-3341, 12/2017, Volume 23, Issue S1, pp. S-1 - S-159
Cardiomyocytes (CM) in the adult mammalian heart have limited capacity to proliferate following injury. [...]therapies to induce endogenous regeneration of the... 
Abstracts | Biodegradation | Heart | Hydrogels | Tissue engineering | Cardiomyocytes | Metastasis | Biopolymers | Cell adhesion & migration | Biomaterials | Medicine | Musculoskeletal system | Biomedical materials | Stem cells | Cell cycle | Biocompatibility | Hypoxia | Growth factors | Binding sites | Cancer | Tumors
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7. Full Text Relationship between natural concentration of heavy water isotopologs and rate of H2O2 generation by mitochondria
by Pomytkin, I A and Kolesova, O E
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 11/2006, Volume 142, Issue 5, pp. 570 - 572
Relationship between natural concentration of heavy water isotope homologs in natural water and the kinetics of H2O2 generation by isolated rat liver... 
Pathology | Biomedicine | hydrogen peroxide | Internal Medicine | succinic acid | Michaelis-Mentain | Laboratory Medicine | heavy water isotopologs | Biomedicine general | Cell Biology | mitochondrion | Mitochondrion | Succinic acid | Heavy water isotopologs | Hydrogen peroxide | MEDICINE, RESEARCH & EXPERIMENTAL | Animals | Deuterium Oxide - metabolism | Rats, Wistar | Mitochondria, Liver - metabolism | Succinic Acid - metabolism | Rats | Male | Deuterium Oxide - analysis | Hydrogen Peroxide - metabolism
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8. Full Text Methylnaloxone suppresses the development of withdrawal syndrome in morphine-dependent rats
by Sudakov, S K and Rusakova, I V and Trigub, M M and Pomytkin, I A
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 5/2007, Volume 143, Issue 5, pp. 608 - 610
We studied the effect of peripheral opioid receptor antagonist methylnaloxone on the development of withdrawal syndrome in morphine-dependent rats.... 
Pathology | Biomedicine | peripheral opioid receptors | Internal Medicine | methylnaloxone | Laboratory Medicine | morphine withdrawal syndrome | Biomedicine general | Cell Biology | physical dependence | Methylnaloxone | Physical dependence | Morphine withdrawal syndrome | Peripheral opioid receptors | MEDICINE, RESEARCH & EXPERIMENTAL | Animals | Rats, Wistar | Rats | Male | Opioid-Related Disorders - physiopathology | Substance Withdrawal Syndrome | Morphine - adverse effects | Oxymorphone - pharmacology
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9. Full Text Study of the Effect of Preconditioning with Succinic Acid Salt of Choline (1:2) on the Disturbances of Energy Metabolism in the Brain during Ischemia by 31P NMR In vivo
by Pomytkin, I and Semenova, N
Doklady Biochemistry & Biophysics, ISSN 1607-6729, 07/2005, Volume 403, Issue 1-6, pp. 289 - 292
(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT] 
Life Sciences | Biochemistry, general | Biophysics/Biomedical Physics | Phosphorus Isotopes | Magnetic Resonance Spectroscopy - methods | Rats, Wistar | Brain Ischemia - metabolism | Rats | Male | Brain Ischemia - prevention & control | Succinylcholine - administration & dosage | Brain - drug effects | Brain - metabolism | Brain - blood supply | Ischemic Preconditioning - methods | Phosphates - metabolism | Animals | Energy Metabolism - drug effects | Brain | Biochemistry | Biophysics | Ischemia | Acids | Metabolism
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10. Full Text Effect of Insulin on the Rate of Hydrogen Peroxide Generation in Mitochondria
by Pomytkin, I A and Kolesova, O E
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 6/2003, Volume 135, Issue 6, pp. 541 - 542
We studied the effect of insulin on H2O2 generation by mitochondria in rat liver and heart. Insulin markedly increased the rate of H2O2 generation, which was... 
Biochemistry, general | Pathology | Biophysics/Biomedical Physics | Medicine & Public Health | insulin | hydrogen peroxide | Oncology | succinic acid | Pharmacology/Toxicology | succinate dehydrogenase | mitochondrion | Mitochondrion | Succinic acid | Succinate dehydrogenase | Hydrogen peroxide | Insulin | MEDICINE, RESEARCH & EXPERIMENTAL | Rats, Wistar | Liver - metabolism | Oxidants - metabolism | Rats | Male | Mitochondria - metabolism | Hydrogen Peroxide - metabolism | Insulin - metabolism | Animals | Succinic Acid - metabolism | Myocardium - metabolism | Succinate Dehydrogenase - metabolism | Enzyme Activation
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11. Full Text Development of new corrosion-resistant and wear-resistant materials for use in agressive hydrogen medium
by Slys, I.G and Berezanskaya, V.I and Kossko, I.A and Pomytkin, A.P
International Journal of Hydrogen Energy, ISSN 0360-3199, 2001, Volume 26, Issue 5, pp. 531 - 536
Sulphidized chromium exceeds similar double-amorphous alloys with sulphur content up to 30% and chemical heat coatings by its corrosive, mechanical and... 
Agressive hydrogen medium | Sulphidized chromium | Corrosion | Wear resistant | Corrosion resistant | Friction coefficient | Container with fusible gate | Coating | Surface strength | surface strength | ENVIRONMENTAL SCIENCES | corrosion | coating | ENERGY & FUELS | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | wear resistant | corrosion resistant | agressive hydrogen medium | sulphidized chromium | container with fusible gate | friction coefficient
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12. Full Text Key Role of Succinate Dehydrogenase in Insulin-Induced Inactivation of Protein Tyrosine Phosphatases
by Pomytkin, I A and Kolesova, O E
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 6/2002, Volume 133, Issue 6, pp. 568 - 570
We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an... 
Biochemistry, general | succinate | Pathology | Biophysics/Biomedical Physics | Medicine & Public Health | insulin | protein tyrosine phosphatase | hydrogen peroxide | Oncology | Pharmacology/Toxicology | succinate dehydrogenase | Succinate dehydrogenase | Hydrogen peroxide | Protein tyrosine phosphatase | Insulin | Succinate | MEDICINE, RESEARCH & EXPERIMENTAL | MITOCHONDRIA | HYDROGEN-PEROXIDE | Insulin - pharmacology | Succinate Dehydrogenase - drug effects | Rats, Wistar | Mitochondria, Liver - metabolism | Rats | Male | Protein Tyrosine Phosphatases - metabolism | Malonates - pharmacology | Mitochondria, Liver - enzymology | Hydrogen Peroxide - metabolism | Animals | Succinic Acid - pharmacology | Succinate Dehydrogenase - metabolism
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13. Full Text Reactions of polyhalogenopyridines. 12. Reactions of 4-pentafluoroethylthio-2,3, 5,6-tetrafluoropyridine with nucleophilic agents
by Efremov, I.V and Sipyagin, A.M and Pomytkin, I.A
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 1996, Volume 32, Issue 7, pp. 796 - 799
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14. Full Text Reaction of polyhalopyridines 4. Reaction of mercaptopolychloropyridines with fluorine-containing xenon compounds
by Sipyagin, A.M and Pomytkin, I.A and Pal'tsun, S.V and Aleinikov, N.N
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 01/1994, Volume 30, Issue 1, pp. 52 - 55
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15. Reactions of polyhalopyridines .12. Reactions of 4-pentafluoroethylthio-2,3,5,6-tetrafluoropyridine with nucleophilic agents
by Efremov, IV and Sipyagin, AM and Pomytkin, IA
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, ISSN 0132-6244, 07/1996, Issue 7, pp. 932 - 935
CHEMISTRY, ORGANIC
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16. Full Text 10. Perfluoroalkylation of bis(tetrafluoro-4-pyridyl) disulfide
by Enshov, V.S and Enshov, V.S and Kashtanov, S.A and Kashtanov, S.A and Efremov, I.V and Efremov, I.V and Pomytkin, I.A and Pomytkin, I.A and Sipyagin, A.M and Sipyagin, A.M and Alcinikov, N.N and Alcinikov, N.N
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 1995, Volume 31, Issue 12, pp. 1483 - 1483
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17. Full Text Bis(tetramethylammonium), bis(tetrabutylammonium), and bis(tetraphenylarsonium) dihydrohexaoxoxenonates(VIII)
by Aleinikov, N.N and Kashtanov, S.A and Pomytkin, I.A and Sipyagin, A.M
Russian Chemical Bulletin, ISSN 1066-5285, 1995, Volume 44, Issue 1, pp. 180 - 181
Bis(tetramethylammonium), bis(tetrabutylammonium), and bis(tetraphenylarsonium) dihydrohexaoxoxenonates(VIII) were obtained in an aqueous solution and in... 
decomposition, rate constant | bis(tetramethylammonium) dihydrohexaoxoxenonate(VIII), bis(tetrabutylammonium) dihydrohexaoxoxenonate(VIII), bis(tetraphenylarsonium) dihydrohexaoxoxenonate(VIII), preparation | RATE CONSTANT | DECOMPOSITION | CHEMISTRY | BIS(TETRAMETHYLAMMONIUM) DIHYDROHEXAOXOXENONATE(VIII) BIS(TETRABUTYLAMMONIUM) DIHYDROHEXAOXOXENONATE(VIII) BIS(TETRAPHENYLARSONIUM) DIHYDROHEXAOXOXENONATE(VIII) | PREPARATION
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18. Full Text Reactions of polyhalopyridines 5. Reaction of 2,3,5,6-tetrachloro-4-trifluoromethylthiopyridine with nucleophilic reagents
by Sipyagin, A.M and Pal'tsun, S.V and Pomytkin, I.A and Aleinikov, N.N
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 01/1994, Volume 30, Issue 1, pp. 56 - 59
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19. Full Text Reactions of polyhalopyridines. 9. Perfluoroalkylation of 2,3,5,6-tetrafluoro-4-mercaptopyridine with compounds of xenon containing fluorine
by Sipyagin, A.M and Efremov, I.V and Pomytkin, I.A and Kashtanov, S.A and Aleinikov, N.N
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 09/1994, Volume 30, Issue 9, pp. 1121 - 1122
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20. POLYHALOPYRIDINE REACTIONS .5. REACTIONS OF 4-TRIFLUOROMETHYLTHIO-2,3,5,6-TETRACHLOROPYRIDINE WITH NUCLEOPHILIC AGENTS
by SIPYAGIN, AM and PALTSUN, SV and POMYTKIN, IA and ALEINIKOV, NN
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, ISSN 0132-6244, 01/1994, Issue 1, pp. 63 - 67
CHEMISTRY, ORGANIC
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