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Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Index Medicus | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter... 
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | ISOCITRATE DEHYDROGENASE | ONCOMETABOLITE 2-HYDROXYGLUTARATE | SUFFICIENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC PROGENITORS | MUTATION | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 96 - 96
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver... 
PROGENITORS | INTRAHEPATIC CHOLANGIOCARCINOMA | HOMEOSTASIS | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | MUTATION | GROWTH | MICE | PROLIFERATION | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Hepatocyte Nuclear Factor 4 - antagonists & inhibitors | Humans | ras Proteins - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Bile Duct Neoplasms - enzymology | Cell Differentiation - genetics | Neoplasm Metastasis | Hepatocyte Nuclear Factor 4 - biosynthesis | Female | Bile Duct Neoplasms - genetics | Cell Lineage - genetics | Cholangiocarcinoma - enzymology | Disease Models, Animal | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Bile Ducts, Intrahepatic - pathology | Mutant Proteins - genetics | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 4 - genetics | Mutation - genetics | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - genetics | Stem Cells - pathology | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Bile Duct Neoplasms - pathology | Hepatocytes - enzymology | Index Medicus | Càncer | Diferenciació cel·lular | Gallbladder diseases | Metabolisme | Cell diferentiation | Metabolism | Malalties de la vesícula biliar | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2014, Volume 289, Issue 20, pp. 13717 - 13725
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2012, Volume 3, Issue 10, pp. 850 - 855
Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a... 
R132H IDH1 inhibitors | Mutant IDH1 | tumor 2-HG | GLIOMAS | CHEMISTRY, MEDICINAL | MUTATIONS | DIFFERENTIATION | ONCOMETABOLITE 2-HYDROXYGLUTARATE
Journal Article
Blood, ISSN 0006-4971, 09/2017, Volume 130, Issue 11, pp. 1347 - 1356
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2014, Volume 55, Issue 3, pp. 598 - 602
A novel class of 5'-amino-2',5'-dideoxy-2',2'-dif luorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several... 
Analogs | Tetrahedrons | Nucleosides | Derivatives | Displacement
Journal Article
Nature, ISSN 0028-0836, 9/2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in Isocitrate dehydrogenase 1 ( IDH1 ) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly... 
Journal Article