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Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6326, pp. 756 - 760
Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is... 
Glaucoma | Eye | Mitochondria | Vitamin B3 | Neurodegenerative diseases | Rodents | Aging | Nicotinamide | Vulnerability | Gene therapy | Vitamins | Enzymes | Vision | Blindness | Mice | Degeneration
Journal Article
Ophthalmology, ISSN 0161-6420, 2017, Volume 124, Issue 11, pp. 1621 - 1634
Purpose To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). Design Prospective open-label,... 
Ophthalmology | CELLS | CLINICAL-TRIAL | EFFICACY | SAFETY | OPHTHALMOLOGY | EXPRESSION | VECTOR | Yuan (China) | Medical colleges | Care and treatment | Genes | Blindness | Gene therapy
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 12/2007, Volume 179, Issue 7, pp. 1523 - 1537
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1246 - 1261
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5587 - 7
In many human disorders mitochondrial dysfunction is central to degeneration of retinal ganglion cells. As these cells do not regenerate, vision is... 
MICE | THERAPY | GLAUCOMA | MULTIDISCIPLINARY SCIENCES | DELIVERY | Phosphorylation | Gene transfer | Transcription | Optic neuropathy | Transgenic mice | Retina | Mitochondrial DNA | Neuropathy | Retinal ganglion cells | Mitochondria | Oxidative phosphorylation | Rodents | Degeneration | Ganglion cells | Deoxyribonucleic acid--DNA
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1695, pp. 63 - 68
We describe a new method for obtaining user-friendly, robust pattern electroretinograms (PERG) simultaneously from each eye using asynchronous binocular... 
Mouse | Pattern electroretinogram | PERG | Retinal ganglion cell | Electroretinography - methods | Animals | Humans | Bryozoa | Cornea - physiology | Mice | Photic Stimulation
Journal Article
Journal of Glaucoma, ISSN 1057-0829, 02/2018, Volume 27, Issue 5, pp. 1 - 432
PURPOSE:The Water Drinking Test (WDT) is currently used to temporarily elevate intraocular pressure (IOP) and predict peak IOP in glaucoma. This study... 
pattern electroretinogram | systemic blood pressure | water drinking | intraocular pressure | retinal ganglion cell function
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 11779 - 14
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail... 
CASCADE | MICE | RETINAL INJURY | CONTRIBUTES | MULTIDISCIPLINARY SCIENCES | Immunohistochemistry | Sonication | Animal models | Optic nerve | Optic neuropathy | Retina | Inflammation | Leukocytes | Neuropathy | Trauma | CD45 antigen | Visual perception | Microglia | Cell activation | Neurodegeneration | Rodents | Ultrasound
Journal Article
Current Ophthalmology Reports, ISSN 2167-4868, 3/2017, Volume 5, Issue 1, pp. 7 - 13
The clinical management of glaucoma is currently focused on manifest stages of the diseases at which there are congruent losses of visual function and optic... 
Glaucoma | Medicine & Public Health | Glaucoma progression | Retinal ganglion cell function | Body posture | Ophthalmology | Pattern electroretinogram | Intraocular pressure
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5797 - 15
Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play a key role in purinergic signaling in the nervous system in both normal and pathological... 
ADENOSINE RECEPTORS | ACTIVATION | PATTERN-ELECTRORETINOGRAM | HEMICHANNELS | MULTIDISCIPLINARY SCIENCES | NEURONS | CHANNELS | DEATH | ATP RELEASE | GLAUCOMA | FAMILY | Glaucoma | Retinal ganglion cells | Ischemia | Channel gating | Retina | Nervous system | Cell membranes | Membrane channels | Visual perception
Journal Article