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PLoS Computational Biology, ISSN 1553-734X, 01/2015, Volume 11, Issue 1
  The promise of personalized cancer medicine cannot be fulfilled until we gain better understanding of the connections between the genomic makeup of a... 
Drugs | Proteins | Datasets | Mutation | Kinases | Experiments | Cancer
Journal Article
Bioinformatics, ISSN 1367-4803, 05/2014, Volume 30, Issue 21, pp. 3109 - 3114
Motivation: Most approaches used to identify cancer driver genes focus, true to their name, on entire genes and assume that a gene, treated as one entity, has... 
GENOMES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | MUTATIONAL LANDSCAPE | TUMOR TYPES | NETWORKS | SOMATIC MUTATIONS | Neoplasms - genetics | Genes, Neoplasm | Humans | Mutation Rate | Software | Mutation, Missense | Genomics - methods | Neoplasm Proteins - genetics | Index Medicus | Original Papers
Journal Article
by Thorsson, Vesteinn and Thorsson, Vésteinn and Gibbs, Richard A and Gibbs, David L and Brown, Scott D and Wolf, Gregory and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Gao, Jianjiong and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Rao, Arvind and Chen, Chu and Chen, Ken and Chen, Amy and Krasnitz, Alexander and Hu, Jianhong and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert and Holt, Robert A and Rabkin, Charles E and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Jioajiao and Wang, Linghua and Wang, Zhining and Wang, Jing and Wang, Timothy and Wang, Min and Yang, Hannah and Yang, Ian and Yang, Ju Dong and Yang, Liming and Zenklusen, Jean C and Zhang, Lizhi and Zhang, Hongxin and Zhang, Jiexin and Zhang, Hongzheng and Zhang, Jiashan (Julia) and Zhang, Wei and Zhang, Hailei and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Index Medicus | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2015, Volume 43, Issue 1, pp. D968 - D973
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 10/2015, Volume 11, Issue 10
  Despite their importance in maintaining the integrity of all cellular pathways, the role of mutations on protein-protein interaction (PPI) interfaces as... 
Data analysis | Disease | Genomics | Probability | Genomes | Patients | Clinical outcomes | Proteins | Algorithms | Proteomics | Protein expression | Mutation | Tumors | Cancer
Journal Article
Nature methods, ISSN 1548-7091, 8/2017, Volume 14, Issue 8, pp. 782 - 788
Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally most... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2019, Volume 47, Issue D1, pp. D895 - D899
Abstract Our knowledge of cancer genomics exploded in last several years, providing us with detailed knowledge of genetic alterations in almost all cancer... 
VISUALIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN | Database Issue
Journal Article
by Bailey, Matthew and Bailey, Matthew H and Tokheim, Collin and Porta-Pardo, Eduard and Sengupta, Sohini and Bertrand, Denis and Weerasinghe, Amila and Colaprico, Antonio and Wendl, Michael C and Kim, Jaegil and Reardon, Brendan and Ng, Kwok-Shing and Ng, Patrick Kwok-Shing and Jeong, Kang Jin and Cao, Song and Wang, Jioajiao and Wang, Timothy and Wang, Zhining and Wang, Zixing and Wang, Fang and Wang, Linghua and Wang, Jing and Wang, Min and Gao, Qingsong and Gao, Jianjiong and Gao, Galen F and Liu, Xiuping and Liu, Jia and Liu, Wenbin and Liu, Yuexin and Liu, Eric Minwei and Mularoni, Loris and Rubio-Perez, Carlota and Nagarajan, Niranjan and Cortés-Ciriano, Isidro and Zhou, Wanding and Zhou, Daniel Cui and Liang, Wen-Wei and Liang, Han and Hess, Julian M and Hess, Julian and Yellapantula, Venkata D and Tamborero, David and Gonzalez-Perez, Abel and Suphavilai, Chayaporn and Ko, Jia Yu and Khurana, Ekta and Park, Joong-Won and Park, Peter J and Van Allen, Eliezer M and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Ju Dong and Yang, Hannah and Yang, Ian and Yang, Liming and Zenklusen, Jean C and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Zhang, Jiexin and Zhang, Jiashan (Julia) and Zhang, Lizhi and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Sun, Yichao and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Miller, Christopher A and Miller, Judy and Reynolds, Sheila and ... and Canc Genome Atlas Res Network and MC3 Working Grp and MC3 Working Group and Cancer Genome Atlas Research Network
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 371 - 385.e18
Journal Article