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1992, ISBN 9780471933243, xii, 209
Book
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22271
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 11, pp. 4321 - 4326
Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in... 
Genomics | Melanoma | Cell lines | Small interfering RNA | Melanocytes | Genetic mutation | Oncogenes | Tumors | Apoptosis | Cancer | METASTATIC MELANOMA | SURVIVAL ONCOGENE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATION | SENSITIVITY | MITF | MALIGNANT-MELANOMA | B-RAF | CELL-LINES | CANCER | Inhibitor of Apoptosis Proteins - genetics | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Male | Melanocytes - metabolism | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Melanoma - genetics | Melanocytes - pathology | Inhibitor of Apoptosis Proteins - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Microphthalmia-Associated Transcription Factor - metabolism | Melanoma - pathology | Gene Amplification - drug effects | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Transformation, Neoplastic | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Microphthalmia-Associated Transcription Factor - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Gene mutations | Physiological aspects | Genetic aspects | Research | Gene expression | Computational biology | Biological Sciences | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
by Panfilio, Kristen A and Vargas Jentzsch, Iris M and Benoit, Joshua B and Erezyilmaz, Deniz and Suzuki, Yuichiro and Colella, Stefano and Robertson, Hugh M and Poelchau, Monica F and Waterhouse, Robert M and Ioannidis, Panagiotis and Weirauch, Matthew T and Hughes, Daniel S. T and Murali, Shwetha C and Werren, John H and Jacobs, Chris G. C and Duncan, Elizabeth J and Armisén, David and Vreede, Barbara M. I and Baa-Puyoulet, Patrice and Berger, Chloé S and Chang, Chun-che and Chao, Hsu and Chen, Mei-Ju M and Chen, Yen-Ta and Childers, Christopher P and Chipman, Ariel D and Cridge, Andrew G and Crumière, Antonin J. J and Dearden, Peter K and Didion, Elise M and Dinh, Huyen and Doddapaneni, Harsha Vardhan and Dolan, Amanda and Dugan, Shannon and Extavour, Cassandra G and Febvay, Gérard and Friedrich, Markus and Ginzburg, Neta and Han, Yi and Heger, Peter and Holmes, Christopher J and Horn, Thorsten and Hsiao, Yi-min and Jennings, Emily C and Johnston, J. Spencer and Jones, Tamsin E and Jones, Jeffery W and Khila, Abderrahman and Koelzer, Stefan and Kovacova, Viera and Leask, Megan and Lee, Sandra L and Lee, Chien-Yueh and Lovegrove, Mackenzie R and Lu, Hsiao-ling and Lu, Yong and Moore, Patricia J and Munoz-Torres, Monica C and Muzny, Donna M and Palli, Subba R and Parisot, Nicolas and Pick, Leslie and Porter, Megan L and Qu, Jiaxin and Refki, Peter N and Richter, Rose and Rivera-Pomar, Rolando and Rosendale, Andrew J and Roth, Siegfried and Sachs, Lena and Santos, M. Emília and Seibert, Jan and Sghaier, Essia and Shukla, Jayendra N and Stancliffe, Richard J and Tidswell, Olivia and Traverso, Lucila and van der Zee, Maurijn and Viala, Séverine and Worley, Kim C and Zdobnov, Evgeny M and Gibbs, Richard A and Richards, Stephen
Genome biology, ISSN 1474-760X, 2019, Volume 20, Issue 1, pp. 64 - 26
Journal Article
Nature chemical biology, ISSN 1552-4469, 2015, Volume 11, Issue 6, pp. 432 - 437
Journal Article
The Journal of infectious diseases, ISSN 0022-1899, 7/2013, Volume 208, Issue 2, pp. 340 - 345
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2016, Volume 388, Issue 10043, pp. 498 - 503
Journal Article
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2016, Volume 388, Issue 10041, pp. 239 - 247
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 5, p. e0197082
WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a... 
PROTEIN METHYLTRANSFERASES | H3K36 METHYLATION | POTENT | LYSINE METHYLTRANSFERASE | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | T(4/14) MULTIPLE-MYELOMA | SELECTIVE INHIBITORS | CHEMICAL PROBE | MOLECULAR-BASIS | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - chemistry | Peptides - chemistry | Histones - chemistry | Norleucine - pharmacology | Humans | Protein Conformation - drug effects | Enzyme Inhibitors - pharmacology | Peptides - genetics | Neoplasms - enzymology | Repressor Proteins - genetics | Crystallography, X-Ray | Norleucine - chemistry | Repressor Proteins - antagonists & inhibitors | Neoplasms - drug therapy | Histone-Lysine N-Methyltransferase - chemistry | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Histones - genetics | Enzyme Inhibitors - chemistry | Norleucine - analogs & derivatives | Lysine - chemistry | PR-SET Domains - genetics | Histones | Research | Methyltransferases | Peptides | Pediatrics | Enzymes | Hematology | Norleucine | Leukemia | Peptide inhibitors | Proteins | Histone H4 | Inhibitors | Lysine | Epigenetics | Histone methyltransferase | Mutation | Solid tumors | Drug discovery | Methylation | Histone H3 | Cancer | Crystal structure | protein structure | lysine | methyltransferases | histones | BASIC BIOLOGICAL SCIENCES | enzymes | enzyme inhibitors | protein structure databases | enzyme structure
Journal Article