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science & technology (114) 114
life sciences & biomedicine (90) 90
humans (77) 77
animals (42) 42
genomes (33) 33
stem cells (32) 32
gene targeting (28) 28
biotechnology & applied microbiology (27) 27
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homologous recombination (23) 23
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gene therapy (21) 21
biochemistry & molecular biology (20) 20
cell biology (20) 20
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genetic aspects (16) 16
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fundamental and applied biological sciences. psychology (14) 14
molecular biology (14) 14
transplantation (14) 14
base sequence (13) 13
gene editing (13) 13
genetic therapy - methods (13) 13
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dna repair (12) 12
gene editing - methods (12) 12
gene expression (12) 12
genetic engineering - methods (12) 12
genome editing (12) 12
genomics (12) 12
zinc fingers (12) 12
abridged index medicus (11) 11
cells, cultured (11) 11
gene targeting - methods (11) 11
genes (11) 11
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dependovirus - genetics (9) 9
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science (9) 9
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cas9 (8) 8
dna (8) 8
dna breaks, double-stranded (8) 8
flow cytometry (8) 8
green fluorescent proteins - genetics (8) 8
pluripotency (8) 8
transfection (8) 8
analysis (7) 7
anemia, sickle cell - genetics (7) 7
anemia, sickle cell - therapy (7) 7
biology (7) 7
cancer (7) 7
cells (7) 7
crispr-cas9 genome editing (7) 7
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deoxyribonucleases - metabolism (7) 7
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1. Genome editing
: the next step in gene therapy
by Cathomen, Toni, Herausgeber and Hirsch, Matthew, Herausgeber and Porteus, Matthew, Herausgeber
2016, Advances in experimental medicine and biology, ISBN 9781493935079, Volume 895, xvi, 263 pages
Gene therapy | Genetic engineering | Human genetics
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2. Full Text A New Class of Medicines through DNA Editing
by Porteus, Matthew H
The New England journal of medicine, ISSN 0028-4793, 03/2019, Volume 380, Issue 10, pp. 947 - 959
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Care and treatment | Genetic disorders | Research | T cells | CRISPR | Enzymes | Genetic counseling | Genes | Committees | Clinical trials | Genomes | Deoxyribonucleic acid--DNA | Immune system | Index Medicus | Abridged Index Medicus
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3. Full Text An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
by Daniel E. Bauer and Sophia C. Kamran and Samuel Lessard and Jian Xu and Yuko Fujiwara and Carrie Lin and Zhen Shao and Matthew C. Canver and Elenoe C. Smith and Luca Pinello and Peter J. Sabo and Jeff Vierstra and Richard A. Voit and Guo-Cheng Yuan and Matthew H. Porteus and John A. Stamatoyannopoulos and Guillaume Lettre and Stuart H. Orkin
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2013, Volume 342, Issue 6155, pp. 253 - 257
Chromatin | Erythroblasts | Genetic variation | Transgenic animals | Lymphocytes | REPORTS | Cell lines | Alleles | Genomes | Erythroid cells | Gene expression | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Fetal Hemoglobin - biosynthesis | Humans | Precursor Cells, B-Lymphoid - metabolism | Genetic Variation | Chromatin Immunoprecipitation | Hemoglobinopathies - genetics | Nuclear Proteins - genetics | Gene Targeting | Genome-Wide Association Study | Cells, Cultured | Erythroid Cells - metabolism | Gene Expression Regulation | Chromosome Mapping | Transcription Factors - genetics | Hemoglobinopathies - therapy | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Genetic Engineering | Enhancer Elements, Genetic | Fetal Hemoglobin - genetics | Cell Line, Tumor | Mice | Chromatin - genetics | Hemoglobin | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | Genetic diversity | Developmental biology | Fetuses | Erythrocytes | Index Medicus
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4. Full Text Chimeric Nucleases Stimulate Gene Targeting in Human Cells
by Matthew H. Porteus and David Baltimore
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2003, Volume 300, Issue 5620, pp. 763 - 763
Gene targeting | Somatic cells | DNA | Embryonic stem cells | Binding sites | Zinc | Brevia | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Cell Line | Gene Targeting - methods | Green Fluorescent Proteins | Zinc Fingers | Humans | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Nuclear Localization Signals | Deoxyribonucleases, Type II Site-Specific - genetics | Recombinant Fusion Proteins - metabolism | Deoxyribonucleases, Type II Site-Specific - metabolism | Deoxyribonucleases, Type II Site-Specific - chemistry | Transfection | Recombination, Genetic | Saccharomyces cerevisiae Proteins | Luminescent Proteins - genetics | Mutation | Dimerization | Genetic disorders | Research | Molecular genetics | Genes | Cells | Index Medicus
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5. Full Text Towards a new era in medicine: Therapeutic genome editing
by Porteus, Matthew H
Genome Biology, ISSN 1474-7596, 12/2015, Volume 16, Issue 1, pp. 286 - 286
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Gene Targeting - methods | Animals | Genome | Humans | Genetic Therapy - methods | CRISPR | Genetic disorders | Infectious diseases | Yeast | Disease | Nucleotide sequence | Genes | Stem cells | Genomes | Genetic engineering | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Review
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6. Full Text A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
by Vakulskas, Christopher A and Dever, Daniel P and Rettig, Garrett R and Turk, Rolf and Jacobi, Ashley M and Collingwood, Michael A and Bode, Nicole M and McNeill, Matthew S and Yan, Shuqi and Camarena, Joab and Lee, Ciaran M and Park, So Hyun and Wiebking, Volker and Bak, Rasmus O and Gomez-Ospina, Natalia and Pavel-Dinu, Mara and Sun, Wenchao and Bao, Gang and Porteus, Matthew H and Behlke, Mark A
Nature medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1216 - 1224
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Anemia, Sickle Cell - therapy | Antigens, CD34 - metabolism | Base Sequence | Escherichia coli | Humans | HEK293 Cells | Hematopoietic Stem Cells - metabolism | Ribonucleoproteins - metabolism | Mutation - genetics | Gene Editing | Anemia, Sickle Cell - genetics | CRISPR-Associated Protein 9 - genetics | Care and treatment | Sickle cell anemia | Gene mutations | Genetic aspects | Research | T cells | Health aspects | Hematopoietic stem cells | CD34 antigen | Fidelity | CRISPR | CCR5 protein | Genomes | Lymphocytes T | Progenitor cells | Hemopoiesis | Gene targeting | Lymphocytes | Cells (biology) | Stem cells | Point mutation | Mutation | Sickle cell disease | Genetic modification | Index Medicus
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7. Full Text Activation of proto-oncogenes by disruption of chromosome neighborhoods
by Hnisz, Denes and Weintrau, Abraham S and Day, Daniel S and Valton, Anne-Laure and Bak, Rasmus O and Li, Charles H and Goldmann, Johanna and Lajoie, Bryan R and Fan, Zi Peng and Sigova, Alla A and Reddy, Jessica and Borges-Rivera, Diego and Lee, Tong Ihn and Jaenisch, Rudolf and Porteus, Matthew H and Dekker, Job and Young, Richard A
Science (American Association for the Advancement of Science), ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1454 - 1458
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Sequence Deletion | Translocation, Genetic | Proto-Oncogenes - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Humans | Transcriptional Activation | Chromosome Aberrations | HEK293 Cells | Chromosome Mapping | Gene Expression Regulation, Leukemic | Mutation | Genetic aspects | Research | Oncology, Experimental | Oncogenes | Cancer | Gene expression | Chromosomes | Genomics | Index Medicus
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8. Full Text CRISPR/Cas9 genome editing in human hematopoietic stem cells
by Bak, Rasmus O and Dever, Daniel P and Porteus, Matthew H
Nature protocols, ISSN 1754-2189, 02/2018, Volume 13, Issue 2, pp. 358 - 376
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Hematopoiesis | Genetic research | Genotype | Genetic engineering | Genetic aspects | Models | Research | Hematopoietic stem cells | Testing | CRISPR | Flow cytometry | Hematology | Homologous recombination | Immunodeficiency | Stem cell transplantation | Editing | Thalassemia | Homology | Transplantation | Genomes | Maintenance | Optimization | Cytometry | Researchers | Gene targeting | Allografts | Stem cells | Mutation | Protocol | Sickle cell disease | Cassettes | Index Medicus
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9. Full Text Gene targeting using zinc finger nucleases
by Porteus, Matthew H and Carroll, Dana
Nature biotechnology, ISSN 1087-0156, 08/2005, Volume 23, Issue 8, pp. 967 - 973
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | DNA - genetics | Genetic Engineering - methods | Deoxyribonucleases - genetics | Gene Targeting - methods | Zinc Fingers | DNA Damage - genetics | Recombination, Genetic - genetics | DNA - metabolism | DNA Repair - genetics | Deoxyribonucleases - metabolism | Index Medicus
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