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Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6388, pp. 490 - 491
Malaria parasites, carried by mosquitoes and transmitted to humans, infect ∼200 million individuals and cause ∼500,000 deaths each year (1). Fifteen years... 
Animals | Mutagenesis | Humans | Plasmodium falciparum - genetics | Genes, Essential | Malaria - genetics | Parasites - genetics | Vector-borne diseases | Malaria | Nucleotide sequence | Genomics | Genes | Blood cells | Erythrocytes | Pharmacology | Genomes | Parasites | Aquatic insects | Blood | Gene sequencing | Organic chemistry | Mosquitoes | Disease transmission | Red blood cells | Natural products | Drug discovery
Journal Article
Journal Article
mBio, 04/2019, Volume 10, Issue 2, p. e00217-19
P. falciparum malaria can cause multiple disease complications that differ by patient age. Previous studies have attempted to address the roles of parasite... 
Plasmodium falciparum | severe malaria | cerebral malaria | machine learning | malaria | var gene | PfEMP1
Journal Article
Infectious Disorders - Drug Targets, ISSN 1871-5265, 2010, Volume 10, Issue 3, pp. 226 - 239
Malaria remains a globally prevalent infectious disease that leads to significant morbidity and mortality. While there are a number of drugs approved for its... 
Plasmodium | Drug discovery | Malaria | Pyrimidine biosynthesis | Dihydroorotate dehydrogenase
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7296, pp. 311 - 315
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2003, Volume 100, Issue 25, pp. 14618 - 14622
Journal Article
Science, ISSN 0036-8075, 4/2002, Volume 296, Issue 5567, pp. 545 - 547
Journal Article
Cellular Microbiology, ISSN 1462-5814, 09/2009, Volume 11, Issue 9, pp. 1340 - 1353
Summary Splenic filtration of infected red blood cells (RBCs) may contribute to innate immunity and variable outcomes of malaria infections. We show that... 
PATHWAYS | SEQUESTRATION | SPLEEN | RING-STAGE | ERYTHROCYTES | ABNORMALITIES | MEMBRANE | MALARIA | MICROBIOLOGY | CAPILLARY OBSTRUCTION | MECHANICAL-PROPERTIES | CELL BIOLOGY | Microfluidic Analytical Techniques | Animals | Cell Shape | Humans | Erythrocytes - cytology | Plasmodium falciparum - growth & development | Erythrocytes - parasitology | Malaria | Original
Journal Article
Journal Article
Science (New York, N.Y.), ISSN 0036-8075, 5/2018, Volume 360, Issue 6388, pp. 490 - 491
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 23, pp. E3270 - E3279
Journal Article
PLoS pathogens, ISSN 1553-7366, 07/2007, Volume 3, Issue 7, pp. e99 - 0948
The clinical outcomes of human infections by Plasmodium falciparum remain highly unpredictable. A complete understanding of the complex interactions between... 
MICROVASCULAR SEQUESTRATION | FALCIPARUM-INFECTED ERYTHROCYTES | INTERCELLULAR-ADHESION MOLECULE-1 | PLASMODIUM-FALCIPARUM | HUMAN CEREBRAL MALARIA | CHONDROITIN SULFATE-A | MICROBIOLOGY | RED-BLOOD-CELLS | ENDOTHELIAL ACTIVATION | MECHANICAL-PROPERTIES | PARASITIZED ERYTHROCYTES | PARASITOLOGY | Microfluidic Analytical Techniques | Cricetinae | Cricetulus | Cell Adhesion Molecules | Phagocytosis - physiology | Plasmodium falciparum - cytology | Cell Movement - physiology | Macrophages - parasitology | Malaria, Falciparum - parasitology | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | Animals | Transfection | Cell Adhesion - physiology | Models, Biological | Blood Flow Velocity | Erythrocytes - metabolism | Plasmodium falciparum - pathogenicity | Host-Parasite Interactions | Plasmodium falciparum - physiology | Erythrocytes - parasitology | CHO Cells | Cell interaction | Medical research | Malaria | Medicine, Experimental | Biological models | Research | Health aspects | Pathology | Plasmodium | Public Health and Epidemiology | Eukaryotes | Immunology | Hematology | Microbiology | Chemical Biology | In Vitro | Infectious Diseases | Cell Biology | Proteins | Disease | Microscopy | Pathogenesis | Erythrocytes | Colleges & universities | Ligands | Digital cameras | Parasites | Experiments | Patients
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 39, pp. 26999 - 27009
Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase ( Pf... 
RHEUMATOID-ARTHRITIS | DESIGN | POTENT | PLASMODIUM-FALCIPARUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | COMPLEXES | PYRIMIDINE BIOSYNTHESIS | INHIBITORS | IDENTIFICATION | PROTEIN FLEXIBILITY | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Protozoan Proteins - antagonists & inhibitors | Triazoles - chemistry | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors | Pyrimidines - chemistry | Pyrimidines - metabolism | Protozoan Proteins - metabolism | Plasmodium falciparum - genetics | Protozoan Proteins - chemistry | Molecular Structure | Binding Sites | Protein Structure, Tertiary | Amino Acid Sequence | Antimalarials - metabolism | Protein Structure, Secondary | Models, Molecular | Pyrimidines - pharmacology | Oxidoreductases Acting on CH-CH Group Donors - chemistry | Antimalarials - pharmacology | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Sequence Homology, Amino Acid | Triazoles - pharmacology | Malaria, Falciparum - parasitology | Triazoles - metabolism | Animals | Hydrogen Bonding | Antimalarials - chemistry | Protein Binding | Index Medicus | MESONS | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | MUTAGENESIS | BASIC BIOLOGICAL SCIENCES | FLEXIBILITY | CRYSTALLOGRAPHY | IN VIVO | 60 APPLIED LIFE SCIENCES | CHEMOTHERAPY | MODIFICATIONS | DIPOLES | AFFINITY | ENZYMES | MALARIA | PLASMODIUM | TARGETS | OPTIMIZATION | OXIDOREDUCTASES | PLASTICITY | Enzyme Catalysis and Regulation
Journal Article