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Nucleic acid therapeutics, 06/2019
Antisense oligonucleotides modified with phosphorothioate linkages (PS-ASOs) can enter cells via endocytic pathways and must escape from membraned organelles... 
Journal Article
Nucleic acids research, 09/2019
The rapid RNase H1-dependent mislocalization of heterodimer proteins P54nrb and PSF to nucleoli is an early event in the pathway that explains the effects of... 
Index Medicus
Journal Article
ChemMedChem, ISSN 1860-7179, 09/2014, Volume 9, Issue 9, pp. 2040 - 2044
To ascertain whether increasing hydrophobicity can enhance the activity of second-generation antisense oligonucleotides (ASOs) in muscle, we investigated the... 
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 04/2007, Volume 7, Issue 7, pp. 641 - 649
Chemically modified antisense oligonucleotides are currently progressing in multiple clinical trials. Among several chemical modifications made, modification... 
Antisense oligonucleotides | RNA affinity | DNA decamer duplex | Arabino nucleic acids | RNase H enzyme | SMALL INTERFERING RNA | BIOPHYSICAL PROPERTIES | CHEMISTRY, MEDICINAL | LOCKED NUCLEIC-ACID | CRYSTAL-STRUCTURE | STABILITY | DNA | EXONUCLEASE RESISTANCE | DUPLEXES | CHEMICAL-MODIFICATIONS | MAMMALIAN-CELLS
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 09/2016, Volume 55, Issue 38, pp. 5321 - 5325
RNase H1 cleaves the RNA strand of RNA:DNA hybrids. Replacement of RNA 2'-hydroxyls by fluorine (FRNA) is commonly used to stabilize aptamers and siRNAs.... 
DNA - chemistry | Molecular Mimicry | Bacillus - enzymology | Ribonuclease H - chemistry | Crystallography, X-Ray | Protein Conformation | RNA - chemistry | Fluorine - chemistry | Bacillus (Bacteria) | Research | Structure | Hydrogen bonding | DNA | Index Medicus
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2019, Volume 27, Issue 9, pp. 1547 - 1557
Antisense oligonucleotides (ASOs) are a novel therapeutic approach to target difficult-to-drug protein classes by targeting their corresponding mRNAs.... 
ASOs | HCC | ASGR | CTCs | GalNAc conjugation | N-Acetylgalactosamine | Tumor cells | Hepatocellular carcinoma | Antisense oligonucleotides | Alcohol | Cancer therapies | Studies | Proteins | Liver cancer | Hepatocytes | Medical prognosis | Diethylnitrosamine | Antitumor activity | Tumors | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 6, pp. 555 - 561
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2018, Volume 26, Issue 5, pp. 1228 - 1240
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 03/2017, Volume 45, Issue 5, pp. 2294 - 2306
Journal Article
Nucleic Acids Res, ISSN 0305-1048, 03/2010, Volume 33, Issue (16) ; 2005
Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA.... 
SACCHARIDES | SACCHAROSE | RNA | RESOLUTION | RIBOSE | CRYSTAL STRUCTURE | SULFUR | MATERIALS SCIENCE | IN VIVO | NUCLEIC ACIDS | NUCLEASES | OXYGEN | MODIFICATIONS | NUCLEOTIDES | THERMODYNAMICS | DNA | IN VITRO | ATOMS | RESIDUES | GEOMETRY
Journal Article
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