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United States Patent and Trademark Office, 01/1901
The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified... 
Journal Article
Journal of the Chemical Society, Chemical Communications, ISSN 0022-4936, 1994, Issue 11, pp. 1357 - 1358
The designed ribodinucleotide 1 containing a proximal imidazole, in the presence of ZnCl2, undergoes self hydrolysis faster than unmodified r(UpA); like its... 
CATALYSIS | RNA CLEAVAGE | PHOSPHORYL-TRANSFER | RECOGNITION | MECHANISM | COMPLEXES | CHEMISTRY | K DY CHEMISTRY | BOVINE PANCREATIC RIBONUCLEASE | HISTAMINE | ETHYLENEDIAMINE | IMIDAZOLE
Journal Article
Tetrahedron, ISSN 0040-4020, 1994, Volume 50, Issue 40, pp. 11699 - 11708
Studies on self cleavage of dinucleotides (2-5) containing conjugated imidazole and ethylenediamine chains indicated that the imidazole conjugated... 
PHOSPHORYL-TRANSFER | RNA | RECOGNITION | BASIC POLYPEPTIDES | COMPLEXES | CHEMISTRY, ORGANIC | ION | BOVINE PANCREATIC RIBONUCLEASE | ETHYLENEDIAMINE | IMIDAZOLE | HYDROLYTIC CLEAVAGE
Journal Article
Tetrahedron, ISSN 0040-4020, 1994, Volume 50, Issue 40, pp. 11699 - 11708
Journal Article
Journal of the Chemical Society, Chemical Communications, ISSN 0022-4936, 1994, Issue 17, p. 2022
Journal Article
Journal of the Chemical Society, Chemical Communications, ISSN 0022-4936, 1994, Issue 17, p. 2021
Journal Article
Chemistry & Biology, ISSN 1074-5521, 1996, Volume 3, Issue 8, pp. 671 - 678
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 08/1996, Issue 15, pp. 1793 - 1794
Formation of chimeric duplexes is investigated between DNA bearing exclusively 2',5'-phosphodiester linkages and DNA or RNA bearing 3',5'-linkages;... 
FORMS | LINKAGES | ADENOSINE | CHEMISTRY | OLIGORIBONUCLEOTIDES | DUPLEXES | TEMPLATE-DIRECTED SYNTHESIS | ASSOCIATION | BINDING | OLIGONUCLEOTIDES
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1996, Volume 6, Issue 7, pp. 815 - 818
A novel bifurcated nucleoside that bears an adenine group trimethylene linked to the 5-position of uracil, 5-(omega-adenylpropyl)-2'-deoxyuridine, has been... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 07/1997, Volume 109, Issue 13-14, pp. 1523 - 1525
Journal Article
Angewandte Chemie International Edition in English, ISSN 1433-7851, 08/1997, Volume 36, Issue 1314, pp. 1522 - 1523
Journal Article
Nucleosides and Nucleotides, ISSN 0732-8311, 06/1999, Volume 18, Issue 6-7, pp. 1737 - 1746
Chemical modifications to improve the efficacy of an antisense oligonucleotide are designed to increase the binding affinity to target RNA, to enhance the... 
Journal Article
Nucleosides and Nucleotides, ISSN 0732-8311, 06/1999, Volume 18, Issue 6-7, pp. 1419 - 1420
We have synthesized the novel 2′-O-AOE- and MIOE-5-methyluridine and -adenosine nucleosides and successfully incorporated them into oligonucleotides. The... 
Journal Article
Nucleosides and Nucleotides, ISSN 0732-8311, 06/1999, Volume 18, Issue 6-7, pp. 1199 - 1201
A new protecting group, 2-cyanoethyloxycarbonyl, or CEOC, has been developed for amino groups and utilized in synthesizing modified oligonucleotides.... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 1999, Volume 40, Issue 4, pp. 661 - 664
The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target... 
CONSEQUENCES | CHEMISTRY, ORGANIC
Journal Article
Nucleosides and Nucleotides, ISSN 0732-8311, 06/1999, Volume 18, Issue 6-7, pp. 1381 - 1382
Oligonucleotides with modifications at the carbohydrate 2′-position offer potential second-generation drug candidates 1 . ISIS 13312, a chimeric compound... 
Journal Article
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