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Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 12
Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may contribute to the underlying pathology of synucleinopathies including... 
Neuroimaging | Animal models | Parkinson's disease | Neurodegenerative diseases | Cortex | Central nervous system | Transgenic mice | Retina | Inflammation | Synuclein | Lewy bodies | Atrophy | Pathology | Gliosis | Rodents | Neostriatum | Dementia disorders | Dopamine transporter | Fusion protein | Movement disorders
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 09/2013, Volume 4, Issue 9, pp. 1249 - 1255
Drugs that selectively activate estrogen receptor beta (ER beta) are potentially safer than the nonselective estrogens currently used in hormonal replacement... 
buccal/sublingual administration | Parkinson's disease | gender difference | AC-186 | neuroprotection | selective estrogen receptor beta agonist | PATHWAYS | CHEMISTRY, MEDICINAL | ER-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEX STEROID-HORMONES | NEUROSCIENCES | WOMEN | PAIN | MEN | STRESS | EXPRESSION | MODULATION | BRAIN | Neuroprotective Agents - therapeutic use | Substantia Nigra - pathology | Cyclohexanes - pharmacology | Cytokines - analysis | Nerve Tissue Proteins - analysis | Male | Corpus Striatum - chemistry | Cyclohexanes - therapeutic use | Estrogen Receptor beta - agonists | Neuroprotective Agents - pharmacology | Parkinsonian Disorders - drug therapy | Exploratory Behavior - drug effects | Reflex, Startle - drug effects | Cyclohexanes - chemistry | Female | Molecular Structure | Drug Evaluation, Preclinical | Corpus Striatum - pathology | Phenols - pharmacology | Neuroprotective Agents - chemistry | Substantia Nigra - chemistry | Estradiol - therapeutic use | Ovariectomy | Rats | Parkinsonian Disorders - chemically induced | Tyrosine 3-Monooxygenase - analysis | Rats, Sprague-Dawley | Oxidopamine - toxicity | Rotarod Performance Test | Substantia Nigra - drug effects | Animals | Phenols - therapeutic use | Sex Factors | Corpus Striatum - drug effects | Phenols - chemistry | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | agonist | Medicinska och farmaceutiska grundvetenskaper | selective estrogen receptor beta | Neurovetenskaper
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2017, Volume 49, Issue 6, pp. 834 - 841
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes... 
REGRESSION | METAANALYSIS | METABOLISM | GROWTH | BODY-MASS INDEX | LOCI | WIDE ASSOCIATION | MENDELIAN RANDOMIZATION | TRAITS | INHERITANCE | GENETICS & HEREDITY | Body Mass Index | Genomic Imprinting | Genetic Predisposition to Disease | Genome-Wide Association Study | Age Factors | Membrane Proteins - genetics | Menarche - genetics | Humans | Risk Factors | Intercellular Signaling Peptides and Proteins - genetics | Databases, Genetic | Male | Puberty - genetics | Neoplasms - genetics | Adolescent | Female | Ribonucleoproteins - genetics | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genetic variation | Menarche | Genetic aspects | Gene expression | Health aspects | Carcinogenesis | Risk factors | Enrichment | Transcription | Laboratories | Genomics | Genes | Risk | Genomes | Tissues | Preadipocyte factor 1 | Epidemiology | Variance | Complexity | Body mass index | Mens health | Randomization | Coding | Genetics | Trends | Children | Endometrium | Public health | Age | Medical research | Puberty | Internal medicine | Gynecology | Health risks | Time measurement | Obstetrics | Diseases | Medicine | Studies | Hospitals | Body mass | Womens health | Men | Breast | Links | Heritability | Polygenic inheritance | Prostate cancer | Prostate | Endocrinology | Cancer | InterAct Consortium | AOCS Investigators | PRACTICAL consortium | Endometrial Cancer Association Consortium | Ovarian Cancer Association Consortium | LifeLines Cohort Study | kConFab
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 01/2014, Volume 9, Issue 1, pp. 18 - 18
In dementia with Lewy bodies (DLB) abnormal interactions between [alpha]-synuclein ([alpha]-syn) and beta amyloid (A[beta]) result in selective degeneration of... 
Genetically modified animals | Animal genetic engineering | Pyridine | Cell death | Proteins | Studies | Brain | Pathology | Neurotoxicity | Microscopy | Neurodegeneration | Pathogenesis | Rodents | Cytotoxicity | Dementia | Apoptosis
Journal Article
by Felix, Janine and Bradfield, Jonathan and Poppelaars-Monnereau, Claire and Valk, Ralf and Stergiakouli, Evie and Chesi, Alessana and Gaillard, Romy and Feenstra, Bjarke and Thiering, Elisabeth and Kreiner-Møller, Eskil and Mahajan, Anubha and Pitkänen, Niina and Joro, Raimo and Cavadino, Alana and Huikari, Ville and Franks, Steve and Groen-Blokhuis, Maria and Cousminer, Diana and Marsh, Julie and Lehtimäki, Terho and Curtin, John and Vioque, Jesus and Ahluwalia, Tarunveer Singh and Myhre, Ronny and Price, Thomas and Vilor-Tejedor, Natalia and Yengo, Loic and Grarup, Niels and Ntalla, Ioanna and Ang, Wei and Atalay, Mustafa and Bisgaard, Hans and Blakemore, Alexana and Bonnefond, Amélie and Carstensen, Lisbeth and Eriksson, Johan G and Flexeder, Claudia and Franke, Lude and Geller, Frank and Geserick, Mandy and Hartikainen, A.L and Haworth, Claire M and Hirschhorn, Joel N and Hofman, Albert and Holm, Jens-Christian and Horikoshi, Momoko and Hottenga, Jouke Jan and Huang, Jian and Kadarmideen, Haja N and Kähönen, Mika and Kiess, Wieland and Lakka, Timo and Lewin, Alex and Liang, Liming and Lyytikäinen, Leo-Pekka and Ma, Baoshan and Magnus, Per and McCormack, Shana E and Mcmahon, George and Mentch, Frank and Middeldorp, Christel and Murray, Clare S and Pahkala, Katja and Pers, Tune and Pfäffle, Roland and Postma, Dirkje and Power, Christine and Simpson, Angela and Sengpiel, Verena and Tiesler, Carla and Torrent, Maties and Uitterlinden, Ané and Meurs, Joyce and Vinding, Rebecca and Waage, Johannes and Wardle, Jane and Zeggini, Eleftheria and Zemel, Babette S and Dedoussis, George and Pedersen, Oluf and Froguel, Philippe and Sunyer, Jordi and Plomin, Robert and Jacobsson, Bo and Hansen, Torben and Gonzalez, Juan R and Custovic, Adnan and Raitakari, Olli T and Pennell, Craig and Widén, Elisabeth and Boomsma, Dorret and Koppelman, Gerard and Sebert, Sylvain and Jarvelin, Marjo-Riitta and Hypponen, Elina and McCarthy, Mark and Lindi, Virpi and Harri, Niinikoski and Körner, Antje and Bønnelykke, Klaus and ... and Early Growth Genetics EGG and Early Genetics Lifecourse Epidemi and Bone Mineral Density Childhood and Early Genetics and Lifecourse Epidemiology (EAGLE) consortium and Bone Mineral Density in Childhood Study (BMDCS) and Early Growth Genetics (EGG) Consortium and Bone Mineral Density in Childhood Study BMDCS and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Clinical Sciences, Section for the Health of Women and Children, Department of Obstetrics and Gynecology and Sahlgrenska Academy and Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Human Molecular Genetics, ISSN 0964-6906, 01/2016, Volume 25, Issue 2, pp. 389 - 403
Journal Article
by Taal, Rob and St Pourcain, Beate and Thiering, Eelisabeth and Das, Shikta and Mook-Kanamori, Dennis and Warrington, Nicole and Kaakinen, Marika and Kreiner-Møller, Eskil and Bradfield, Jonathan and Freathy, Rachel and Geller, Frank and Guxens Junyent, Mònica and Cousminer, Diana and Kerkhof, Marjan and Timpson, Nicholas and Ikram, Arfan and Beilin, Lawrence and Bønnelykke, Klaus and Buxton, Jessica and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David and Hofman, Albert and Kemp, John and Kim, Cecilia and Klopp, Norman and Lahti, Jari and Lye, Stephen and Mcmahon, George and Mentch, Frank and Müller-Nurasyid, Martina and O'Reilly, Paul and Prokopenko, Inga and Rivadeneira Ramirez, Fernando and Steegers, Eric and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Breteler, Monique and Debette, Stéphanie and Fornage, Myriam and Gudnason, Vilmunder and Launer, Lenore and Lugt, Aad and Mosley, Thomas and Seshai, Sudha and Smith, Albert V and Vernooij, Meike and Blakemore, Alexana and Chiavacci, Rosetta and Feenstra, Bjarke and Fernandez-Banet, Julio and Grant, Struan and Hartikainen, Anna-Liisa and Heijden, Albert and Iniguez, Carmen and Lathrop, Mark and McArdle, Wendy and Mølgaard, Anne and Newnham, John and Palmer, Lyle and Palotie, Aarno and Pouta, Anneli and Ring, Susan and Sovio, Ulla and Standl, Marie and Uitterlinden, Ané and Wichmann, Erich and Vissing, Nadja and DeCarli, Charles and Duijn, Cornelia and McCarthy, M and Koppelman, Gerard and Estivill, Xavier and Hattersley, Anew and Melbye, Mads and Bisgaard, Hans and Pennell, Craig and Widen, Elisabeth and Hakonarson, Hakon and Davey-Smith, George and Heinrich, Joachim and Jarvelin, Marjo-Riitta and Jaddoe, Vincent and Cohorts Heart Aging Res Genetic Ep and Early Genetics Lifecourse Epidemio and Early Growth Genetics EGG Consorti and Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium and Early Genetics & Lifecourse Epidemiology (EAGLE) consortium and Early Growth Genetics (EGG) Consortium and Early Genetics & Lifecourse Epidemiology (EAGLE) Consortium and The Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium and Mittuniversitetet and Institutionen för samhällsvetenskap and Fakulteten för humanvetenskap
Nature Genetics, ISSN 1061-4036, 05/2012, Volume 44, Issue 5, pp. 532 - 538
textabstractTo identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies... 
INTELLIGENCE | PROTEIN | GENE | FETAL-GROWTH | GENETICS & HEREDITY | BRAIN-DEVELOPMENT | DISORDERS | MUTATIONS | IDENTIFICATION | GENOME-WIDE ASSOCIATION | PARKINSONS-DISEASE | Pregnancy Complications - pathology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | Pregnancy Complications - etiology | Humans | Infant | Male | Head - growth & development | Genetic Loci | Genetic Markers | Head - pathology | Pregnancy | Polymorphism, Single Nucleotide - genetics | Female | Chromosomes, Human, Pair 12 - genetics | Head | Genetic aspects | Genetic variation | Identification and classification | Body size | Confidence intervals | Medical research | Brain | Breastfeeding & lactation | Health services | Prenatal development | Genetics | Epidemiology | Meta-analysis | Malalties | Creixement | Polimorfisme genètic | Cap | Complicacions | Cromosomes humans | Embaràs | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | article; body height; brain growth; child; chromosome 12q; chromosome 12q15; chromosome 12q24; degenerative disease; disease association; female; gene locus; genetic association; genetic variability; head circumference; human; infant; infant head circumference; male; meta analysis; Parkinson disease; preschool child; priority journal; single nucleotide polymorphism
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2018, Volume 8, Issue 1, p. 16165
Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may contribute to the underlying pathology of synucleinopathies including... 
FIBRILS | PROTEIN | TRANSGENIC MODELS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | MICE | ACCUMULATION | PATHOLOGY
Journal Article
Scientific Reports (Nature Publisher Group), 07/2016, Volume 6, p. 29523
  Abnormal α-synuclein (α-syn) accumulation in the CNS may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in... 
Journal Article
Journal Article
by Brownstein, Catherine A and Beggs, Alan H and Homer, Nils and Merriman, Barry and Yu, Timothy W and Flannery, Katherine C and DeChene, Elizabeth T and Towne, Meghan C and Savage, Sarah K and Price, Emily N and Holm, Ingrid A and Luquette, Lovelace J and Lyon, Elaine and Majzoub, Joseph and Neupert, Peter and McCallie, David and Szolovits, Peter and Willard, Huntington F and Mendelsohn, Nancy J and Temme, Renee and Finkel, Richard S and Yum, Sabrina W and Medne, Livija and Sunyaev, Shamil R and Adzhubey, Ivan and Cassa, Christopher A and De Bakker, Paul I.W and Duzkale, Hatice and Dworzyński, Piotr and Fairbrother, William and Francioli, Laurent and Funke, Birgit H and Giovanni, Monica A and Handsaker, Robert E and Lage, Kasper and Lebo, Matthew S and Lek, Monkol and Leshchiner, Ignaty and MacArthur, Daniel G and McLaughlin, Heather M and Murray, Michael F and Pers, Tune H and Polak, Paz P and Raychaudhuri, Soumya and Rehm, Heidi L and Soemedi, Rachel and Stitziel, Nathan O and Vestecka, Sara and Supper, Jochen and Gugenmus, Claudia and Klocke, Bernward and Hahn, Alexander and Schubach, Max and Menzel, Mortiz and Biskup, Saskia and Freisinger, Peter and Deng, Mario and Braun, Martin and Perner, Sven and Smith, Richard J.H and Andorf, Janeen L and Huang, Jian and Ryckman, Kelli and Sheffield, Val C and Stone, Edwin M and Bair, Thomas and Ann Black-Ziegelbein, E and Braun, Terry A and Darbro, Benjamin and DeLuca, Adam P and Kolbe, Diana L and Scheetz, Todd E and Shearer, Aiden E and Sompallae, Rama and Wang, Kai and Bassuk, Alexander G and Edens, Erik and Mathews, Katherine and Moore, Steven A and Shchelochkov, Oleg A and Trapane, Pamela and Bossler, Aaron and Campbell, Colleen A and Heusel, Jonathan W and Kwitek, Anne and Maga, Tara and Panzer, Karin and Wassink, Thomas and Van Daele, Douglas and Azaiez, Hela and Booth, Kevin and Meyer, Nic and Segal, Michael M and Williams, Marc S and Tromp, Gerard and White, Peter and Corsmeier, Donald and Fitzgerald-Butt, Sara and Herman, Gail and Lamb-Thrush, Devon and ... and Science for Life Laboratory, SciLifeLab and Centra and Skolan för bioteknologi (BIO) and KTH and Genteknologi
Genome Biology, ISSN 1474-7596, 2014, Volume 15, Issue 3, pp. R53 - R53
Journal Article