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Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 22, pp. 5562 - 5573
Purpose: This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic... 
TUMOR-INFILTRATING LYMPHOCYTES | GAIN-OF-FUNCTION | ADOPTIVE TRANSFER | ONCOLOGY | GENES | MUTANT P53 | ANTIGENS | PATIENT | RECEPTORS | CARCINOMA | CHEMOTHERAPY
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 08/2019, Volume 9, Issue 8, pp. 1022 - 1035
Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers.... 
TUMOR-INFILTRATING LYMPHOCYTES | AUTOLOGOUS T-CELLS | MELANOMA | ONCOLOGY | IMMUNOTHERAPY | INTRATUMOR HETEROGENEITY | ANTIGENS | RECEPTORS | BLOCKADE | TRANSFER THERAPY | Index Medicus
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2016, Volume 24, pp. S155 - S155
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 23, pp. 2255 - 2262
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3981 - 3991
Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated... 
CD4+T CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TCR | THERAPY | RECOGNITION | ANTI-CTLA-4 | MUTATIONAL LANDSCAPE | CD4(+) | ANTIGENS | BLOCKADE | Humans | Middle Aged | Neoplasm Proteins - immunology | Molecular Sequence Data | Male | Antigen-Antibody Reactions | Epitopes - immunology | Exome | Melanoma - genetics | Peptide Fragments - immunology | Adult | Female | Receptor, ErbB-2 - immunology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Transcription Factors - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | DNA-Binding Proteins - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Interferon-gamma Release Tests | Cells, Cultured | HLA-A1 Antigen - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Epitopes - genetics | Nuclear Proteins - immunology | Melanoma - secondary | HLA-A2 Antigen - chemistry | Algorithms | Genes, erbB-2 | Melanoma - immunology | Adolescent | RNA, Neoplasm - genetics | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | HLA-A1 Antigen - immunology | DNA, Neoplasm - genetics | Mutation | Antigens, Neoplasm - classification | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | T cells | Lymphocytes | Identification and classification | Health aspects | Tumors | Antigens | Peptides | Cloning | Melanoma | T cell receptors | Metastasis | Cancer therapies | Patients | Studies | Immunotherapy | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2016, Volume 22, Issue 4, pp. 433 - 438
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2006, Volume 281, Issue 41, pp. 30503 - 30511
Journal Article
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6334, pp. 200 - 205
Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor antigens targeted in successful treatments remain poorly defined.... 
TRIAL | CELLS | THERAPY | KK-LC-1 | RECURRENT | MULTIDISCIPLINARY SCIENCES | CERVICAL-CANCER | IDENTIFICATION | BLOCKADE | CARCINOMA | LYMPHOCYTES | Human papillomavirus 18 - immunology | Carcinoma, Squamous Cell - virology | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Human papillomavirus 16 - immunology | T-Lymphocytes - transplantation | Papillomavirus Infections - therapy | Female | Oncogene Proteins, Viral - genetics | Uterine Cervical Neoplasms - therapy | Antigens, Neoplasm - genetics | Immunotherapy, Adoptive - methods | Papillomavirus Infections - complications | DNA-Binding Proteins - immunology | Antigens, Neoplasm - immunology | Carcinoma, Squamous Cell - therapy | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Repressor Proteins - genetics | DNA-Binding Proteins - genetics | Repressor Proteins - immunology | Uterine Cervical Neoplasms - virology | T-Lymphocytes - immunology | Oncogene Proteins, Viral - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Antigens | Care and treatment | Health aspects | Immunotherapy | Methods | Cancer | Human papillomavirus | Immune response | Lymphocytes | Cell death | T cell receptors | Lymphocytes T | Immune system | Tumors | Harnesses | Index Medicus | Landscapes | Regression | Strategy | Human behavior
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. LB-48 - LB-48
Journal Article
The Journal of investigative dermatology, ISSN 0022-202X, 2/2014, Volume 134, Issue 2, pp. 452 - 460
Patients with advanced metastatic melanoma have poor prognosis and the genetics underlying its pathogenesis are poorly understood. High throughput sequencing... 
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 33, pp. 13481 - 13486
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 06/2019, Volume 202, Issue 12, pp. 3458 - 3467
Immune checkpoint inhibitors are effective in treating a variety of malignancies, including metastatic bladder cancer. A generally accepted hypothesis suggests... 
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2011, Volume 43, Issue 11, pp. 1119 - 1126
G protein-coupled receptors (GPCRs), the largest human gene family, are important regulators of signaling pathways. However, knowledge of their genetic... 
CELLS | INHIBITION | GLUTAMATE | METALLOPROTEINASE | GENETICS & HEREDITY | PHASE-II | BRAF | CANCER | REVEALS | Receptors, G-Protein-Coupled - genetics | Mutation | Exons | Melanoma - genetics | Humans | Proteins | Studies | Signal transduction | Phosphorylation | Cell growth | Cloning | Genetic testing | Index Medicus
Journal Article