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1. Full Text Landscape potential for the adoption of crop cultivation: Role of local soil properties and groundwater table rise during 6000–5400 BP in Flevoland (central Netherlands)
by van den Biggelaar, Don F.A.M and Kluiving, Sjoerd J and Bohncke, Sjoerd J.P and van Balen, Ronald T and Kasse, Cornelis and Prins, Maarten A and Kolen, Jan
Quaternary International, ISSN 1040-6182, 05/2015, Volume 367, pp. 77 - 95
This paper presents a new perspective for the temporal variation of crop cultivation adoption during the period 6000–5400 BP in Flevoland (central Netherlands)... 
Groundwater level rise | Crop cultivation | Flevoland | Swifterbant culture | Pleistocene surface mapping | DELTA | SOUTHERN NORTH-SEA | LEVEL RISE | BELGIUM | WESTERN-EUROPE | CLIMATE AEOLIAN SAND | SIZE DISTRIBUTIONS | GEOGRAPHY, PHYSICAL | GEOSCIENCES, MULTIDISCIPLINARY | EVOLUTION | LAGOON | Water, Underground | Archaeology | Hydrology | Sandy soils | Sediments (Geology)
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2. Full Text Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
by Büller, Harry R and Bethune, Claudette and Bhanot, Sanjay and Gailani, David and Monia, Brett P and Raskob, Gary E and Segers, Annelise and Verhamme, Peter and Weitz, Jeffrey I and FXI-ASO TKA Investigators
The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 3, pp. 232 - 240
Enoxaparin is used to prevent deep-vein thrombosis in patients undergoing total knee arthroplasty. In this study, an antisense oligonucleotide against factor... 
MEDICINE, GENERAL & INTERNAL | COAGULATION-FACTOR XI | INHIBITION | BLOOD-COAGULATION | BLEEDING RISK | THROMBOEMBOLISM | DEFICIENCY | Anticoagulants - administration & dosage | Humans | Middle Aged | Clinical Protocols | Postoperative Complications - prevention & control | Male | Oligonucleotides - adverse effects | Enoxaparin - adverse effects | Factor XI - antagonists & inhibitors | Enoxaparin - administration & dosage | Adult | Arthroplasty, Replacement, Knee | Female | Venous Thrombosis - prevention & control | Factor XI - analysis | Length of Stay | Oligonucleotides, Antisense - adverse effects | Anticoagulants - adverse effects | Blood Coagulation - drug effects | Partial Thromboplastin Time | Oligonucleotides, Antisense - administration & dosage | Aged | Blood Coagulation - physiology | Hemorrhage - chemically induced | Oligonucleotides - administration & dosage | Knee | Coagulation factors | Arthroplasty (knee) | Surgery | Antisense oligonucleotides | Joint surgery | Preventive medicine | Thromboembolism | Drug therapy | Thrombosis | Bleeding | Index Medicus | Abridged Index Medicus
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3. Full Text Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
by Warren, Helen R and Evangelou, Evangelos and Cabrera, Claudia P and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surenan, Praveen and Liu, Chunyu and Cook, James P and Kraja, Aldi T and nos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P Segura and O'Reilly, Paul F and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E Shyong and Said, M Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T and Padmanabhan, Sandosh and Mägi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J L and Metspalu, Anes and Shields, Denis C and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tõnu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C and Chasman, Daniel I and Hottenga, J.J and de Geus, Eco and Willemsen, Gonneke and Boomsma, D.I and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 403 - 415
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic,... 
Journal Article | genome-wide association studies | hypertension | Medical and Health Sciences | Medicin och hälsovetenskap
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4. Full Text The Primary Care PTSD Screen for DSM-5 (PC-PTSD-5): Development and Evaluation Within a Veteran Primary Care Sample
by Prins, Annabel and Bovin, Michelle J and Smolenski, Derek J and Marx, Brian P and Kimerling, Rachel and Jenkins-Guarnieri, Michael A and Kaloupek, Danny G and Schnurr, Paula P and Kaiser, Anica Pless and Leyva, Yani E and Tiet, Quyen Q
Journal of General Internal Medicine, ISSN 0884-8734, 10/2016, Volume 31, Issue 10, pp. 1206 - 1211
Posttraumatic Stress Disorder (PTSD) is associated with increased health care utilization, medical morbidity, and tobacco and alcohol use. Consequently,... 
PTSD | primary health care | screening | DSM-5 | POSTTRAUMATIC-STRESS-DISORDER | DEPRESSION | CHECKLIST | PC-PTSD | RELIABILITY | PREVALENCE | NEUROPSYCHIATRIC INTERVIEW MINI | MEDICINE, GENERAL & INTERNAL | HEALTH CARE SCIENCES & SERVICES | VALIDITY | TRAUMA | Diagnostic and Statistical Manual of Mental Disorders | Primary Health Care - methods | United States | Humans | Middle Aged | Veterans - psychology | Patient Preference | Mass Screening - methods | Socioeconomic Factors | Neuropsychological Tests | Young Adult | Patient Acceptance of Health Care | Sensitivity and Specificity | Stress Disorders, Post-Traumatic - diagnosis | Aged, 80 and over | Adult | Aged | Resveratrol | Post-traumatic stress disorder | Health care | Mental disorders | Medical services | Posttraumatic stress disorder | Patients | Trauma | Primary care | Morbidity | Acceptability | Alcohols | Screening | Accuracy | Tobacco | Post traumatic stress disorder | Diagnostic systems | PTSD Assessment Instruments | Veterans | Americans | PTSD (DSM-5) | Primary Health Care | Adults | Diagnostic Validity | Original Research
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5. Full Text Comprehensive molecular characterization of human colon and rectal cancer
by Muzny, Donna M and Bainbridge, Matthew N and Chang, Kyle and Dinh, Huyen H and Drummond, Jennifer A and Fowler, Gerald and Kovar, Christie L and Lewis, Lora R and Morgan, Margaret B and Newsham, Irene F and Reid, Jeffrey G and Santibanez, Jireh and Shinbrot, Eve and Trevino, Lisa R and Wu, Yuan-Qing and Wang, Min and Gunaratne, Preethi and Donehower, Lawrence A and Creighton, Chad J and Wheeler, David A and Gibbs, Richard A and Lawrence, Michael S and Voet, Douglas and Jing, Rui and Cibulskis, Kristian and Sivachenko, Andrey and Stojanov, Petar and McKenna, Aaron and Lander, Eric S and Gabriel, Stacey and Ding, Li and Fulton, Robert S and Koboldt, Daniel C and Wylie, Todd and Walker, Jason and Dooling, David J and Fulton, Lucinda and Delehaunty, Kim D and Fronick, Catrina C and Demeter, Ryan and Mardis, Elaine R and Wilson, Richard K and Chu, Andy and Chun, Hye-Jung E and Mungall, Andrew J and Pleasance, Erin and Gordon Robertson, A and Stoll, Dominik and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron S. N and Chuah, Eric and Coope, Robin J. N and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Schein, Jacqueline E and Slobodan, Jared R and Tam, Angela and Thiessen, Nina and Varhol, Richard and Zeng, Thomas and Zhao, Yongjun and Jones, Steven J. M and Marra, Marco A and Bass, Adam J and Ramos, Alex H and Saksena, Gordon and Cherniack, Andrew D and Schumacher, Stephen E and Tabak, Barbara and Carter, Scott L and Pho, Nam H and Nguyen, Huy and Onofrio, Robert C and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Meyerson, Matthew and Protopopov, Alexei and Hadjipanayis, Angela and Lee, Eunjung and Xi, Ruibin and Yang, Lixing and Ren, Xiaojia and Sathiamoorthy, Narayanan and Chen, Peng-Chieh and Haseley, Psalm and Xiao, Yonghong and Lee, Semin and Seidman, Jonathan and Chin, Lynda and Park, Peter J and ... and Cancer Genome Atlas Network and The Cancer Genome Atlas Network
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7407, pp. 330 - 337
To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number,... 
INTESTINAL EPITHELIUM | CELLS | ONCOGENE | HUMAN BREAST | GENE | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | WTX | DIFFERENTIATION | SOMATIC MUTATIONS | WILMS-TUMOR | Colonic Neoplasms - genetics | DNA Methylation | Exome - genetics | Rectal Neoplasms - genetics | Humans | Mutation Rate | Gene Expression Profiling | Polymorphism, Single Nucleotide | Mutation - genetics | Sequence Analysis, DNA | DNA Copy Number Variations | Genetic aspects | Colon cancer | Diagnosis | Research | Colorectal cancer | Cancer
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6. Full Text Genetics of coronary artery disease: Genome-wide association studies and beyond
by Prins, Bram P and Lagou, Vasiliki and Asselbergs, Folkert W and Snieder, Harold and Fu, Jingyuan
Atherosclerosis, ISSN 0021-9150, 2012, Volume 225, Issue 1, pp. 1 - 10
Abstract Genome-wide association (GWA) studies on coronary artery disease (CAD) have been very successful, identifying a total of 32 susceptibility loci so... 
Cardiovascular | Heritability | Genome-wide association study | Coronary artery disease | Systems genetics | 2-LOCUS LINKAGE ANALYSIS | MYOCARDIAL-INFARCTION | UMCG Approved | LP(A) LIPOPROTEIN | HEART-DISEASE | RARE VARIANTS | CARDIOVASCULAR-DISEASE | MISSING HERITABILITY | COMPLEX DISEASES | SUSCEPTIBILITY LOCUS | SINGLE-NUCLEOTIDE POLYMORPHISMS | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | DNA METHYLATION | PERIPHERAL VASCULAR DISEASE | TRAITS | EXPRESSION | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Humans | Coronary Artery Disease - genetics | Proteomics | Genotype | Risk | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Systems Biology | Medical research | Genomics | Atherosclerosis | Medical genetics | Physiological aspects | Medicine, Experimental | Genetic aspects | Disease susceptibility | Cardiology | Chromosomes | Coronary heart disease
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7. Full Text Poor replication of candidate genes for major depressive disorder using genome-wide association data
by Bosker, F. J and Hartman, C. A and Nolte, I. M and Prins, B. P and Terpstra, P and Posthuma, D and van Veen, T and Willemsen, G and DeRijk, R. H and de Geus, E. J and Hoogendijk, W. J and Sullivan, P. F and Penninx, B. W and Boomsma, D. I and Snieder, H and Nolen, W. A
Molecular Psychiatry, ISSN 1359-4184, 05/2011, Volume 16, Issue 5, pp. 516 - 532
Data from the Genetic Association Information Network ( GAIN) genome-wide association study (GWAS) in major depressive disorder (MDD) were used to explore... 
replication | FUNCTIONAL POLYMORPHISM | ALZHEIMERS-DISEASE | GLUCOCORTICOID-RECEPTOR GENE | ANTIDEPRESSANT TREATMENT | PROMOTER POLYMORPHISM | SEROTONIN TRANSPORTER GENE | UMCG Approved | major depressive disorder | candidate genes | MOOD DISORDERS | INCREASED RISK | KOREAN POPULATION | genome-wide association study | single-nucleotide polymorphisms | ALPHA-GENE | PROTEIN | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | HAPLOTYPE ANALYSIS | SNP | UNIPOLAR DEPRESSION | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Tumor Necrosis Factor-alpha - genetics | Computational Biology | Genotype | Neuropeptide Y - genetics | Nerve Tissue Proteins - genetics | Linkage Disequilibrium | Peptidyl-Dipeptidase A - genetics | PubMed - statistics & numerical data | Depressive Disorder, Major - genetics | Norepinephrine Plasma Membrane Transport Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Odds Ratio | Genetic aspects | Research | Single nucleotide polymorphisms | Major depressive disorder | Risk factors
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8. Full Text Genomic atlas of the human plasma proteome
by Sun, Benjamin B and Maranville, Joseph C and Peters, James E and Stacey, David and Staley, James R and Blackshaw, James and Burgess, Stephen and Jiang, Tao and Paige, Ellie and Surendran, Praveen and Oliver-Williams, Clare and Kamat, Mihir A and Prins, Bram P and Wilcox, Sheri K and Zimmerman, Erik S and Chi, An and Bansal, Narinder and Spain, Sarah L and Wood, Angela M and Morrell, Nicholas W and Bradley, John R and Janjic, Nebojsa and Roberts, David J and Ouwehand, Willem H and Todd, John A and Soranzo, Nicole and Suhre, Karsten and Paul, Dirk S and Fox, Caroline S and Plenge, Robert M and Danesh, John and Runz, Heiko and Butterworth, Adam S
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7708, pp. 73 - 79
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control... 
MULTIVARIABLE MENDELIAN RANDOMIZATION | INFLAMMATORY-BOWEL-DISEASE | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | PLEIOTROPIC GENETIC-VARIANTS | SUMMARIZED DATA | INTERACTION NETWORKS | WIDE ASSOCIATION | PAGETS-DISEASE | COMPLEX TRAITS | REGULATORY VARIATION | Physiological aspects | Methods | Proteomics | Blood plasma | Drugs | Integrated approach | Blood & organ donations | Architecture | Therapeutic applications | Cardiovascular disease | Genomes | Genetic diversity | Drug development | Gene expression | Loci | Blood donors | Biological activity | Quantitative trait loci | Proteins | Plasma proteins | Acids | Genetic analysis | Biomarkers | Genetic factors | Bioinformatics
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