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hsp90 heat-shock proteins - metabolism (57) 57
biochemistry & molecular biology (52) 52
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hsp90 (26) 26
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condition-responsive control in microbiological orenzymological processes (18) 18
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specific therapeutic activity of chemical compounds ormedicinal preparations (13) 13
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adenosine triphosphatases - chemistry (12) 12
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Biochemical Journal, ISSN 0264-6021, 2016, Volume 473, Issue 16, pp. 2439 - 2452
Journal Article
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2009, Volume 9, Issue 15, pp. 1352 - 1368
Hsp90 is involved in the maturation and activation of client proteins. Often these are key proteins involved in signal transduction and regulatory pathways... 
Hsp90 | Drug design | Co-chaperones | Heat shock protein | Cancer | ATPASE CYCLE | CHEMISTRY, MEDICINAL | drug design | CRYSTAL-STRUCTURE | ANTICANCER AGENT | ESCHERICHIA-COLI HSP90 | HEAT-SHOCK-PROTEIN | PHASE-II TRIAL | STRUCTURAL BASIS | co-chaperones | N-TERMINAL DOMAIN | MOLECULAR CHAPERONE | cancer | STEROID-RECEPTOR
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1501 - 13
The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like... 
TEL2 | DOMAIN | COCHAPERONE | MECHANISM | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | HUMAN TRANSCRIPTION MACHINERY | DIMERIZATION | PROTEIN-INTERACTION NETWORK | BINDING | REVEALS | Molecular Chaperones - metabolism | Saccharomyces cerevisiae - genetics | Humans | Molecular Chaperones - chemistry | ATPases Associated with Diverse Cellular Activities - chemistry | ATPases Associated with Diverse Cellular Activities - genetics | Saccharomyces cerevisiae - metabolism | ATPases Associated with Diverse Cellular Activities - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Apoptosis Regulatory Proteins - genetics | HSP90 Heat-Shock Proteins - chemistry | Carrier Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Protein Interaction Domains and Motifs | Binding Sites | DNA Helicases - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | DNA Helicases - chemistry | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Apoptosis Regulatory Proteins - chemistry | Molecular Chaperones - genetics | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Cryoelectron Microscopy | Carrier Proteins - genetics | DNA Helicases - metabolism | Animals | Carrier Proteins - metabolism | Protein Conformation, beta-Strand | Escherichia coli - genetics | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | TOR protein | Hsp90 protein | Yeast | RNA polymerase | Kinases | DNA-directed RNA polymerase | 1-Phosphatidylinositol 3-kinase | Proteins | Polymerase | Ribonucleic acids | Scaffolds | Assembly | Adenosine triphosphatase | RNA polymerase II
Journal Article
Journal Article