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1. Full Text No evidence of disease activity (NEDA-3) and disability improvement after alemtuzumab treatment for multiple sclerosis: a 36-month real-world study
by Prosperini, Luca and Annovazzi, Pietro and Boffa, Laura and Buscarinu, Maria Chiara and Gallo, Antonio and Matta, Manuela and Moiola, Lucia and Musu, Luigina and Perini, Paola and Avolio, Carlo and Barcella, Valeria and Bianco, Assunta and Farina, Deborah and Ferraro, Elisabetta and Pontecorvo, Simona and Granella, Franco and Grimaldi, Luigi M. E and Laroni, Alice and Lus, Giacomo and Patti, Francesco and Pucci, Eugenio and Pasca, Matteo and Sarchielli, Paola and Italian Alemtuzumab Study Grp and Italian Alemtuzumab Study Group and the Italian Alemtuzumab Study Group
Journal of Neurology, ISSN 0340-5354, 12/2018, Volume 265, Issue 12, pp. 2851 - 2860
In this retrospective, multicenter, real-world study we collected clinical and magnetic resonance imaging (MRI) data of all patients (n = 40) with... 
Neurology | Neurosciences | Multiple sclerosis | Outcome measurement | Medicine & Public Health | Alemtuzumab | Neuroradiology | THERAPY | EFFICACY | 5-YEAR FOLLOW-UP | NATALIZUMAB | CLINICAL-PRACTICE | INTERFERON BETA-1A | STATUS SCALE | CLINICAL NEUROLOGY | Alemtuzumab - adverse effects | Follow-Up Studies | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Male | Treatment Outcome | Magnetic Resonance Imaging | Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging | Adult | Female | Immunologic Factors - adverse effects | Retrospective Studies | Alemtuzumab - therapeutic use | Immunologic Factors - therapeutic use | Research | Drug therapy | Patient outcomes | Nuclear magnetic resonance--NMR | Magnetic resonance imaging | Clinical trials | Monoclonal antibodies | Remission | Patients
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2. Full Text The dual task-cost of standing balance affects quality of life in mildly disabled MS people
by Castelli, Letizia and De Luca, Francesca and Marchetti, Maria Rita and Sellitto, Giovanni and Fanelli, Fulvia and Prosperini, Luca
Neurological Sciences, ISSN 1590-1874, 5/2016, Volume 37, Issue 5, pp. 673 - 679
The aim of this study was to explore the correlations between the dual-task cost (DTC) of standing balance and quality of life (QoL) in mildly disabled... 
Neurology | Multiple sclerosis | Medicine & Public Health | Dual-task | Neurosurgery | Psychiatry | Balance | Neuroradiology | Quality of life | Cognitive-motor interference | DISABILITY STATUS | POPULATION | DEPRESSION | MULTIPLE-SCLEROSIS PATIENTS | FATIGUE | PERFORMANCE | POSTURAL CONTROL | NEUROSCIENCES | POSTUROGRAPHY | CLINICAL NEUROLOGY | IMPAIRMENT | INDIVIDUALS | Disability Evaluation | Severity of Illness Index | Multiple Sclerosis - psychology | Cross-Sectional Studies | Humans | Middle Aged | Sensation Disorders - etiology | Male | Walking - physiology | Multiple Sclerosis - complications | Young Adult | Adolescent | Statistics, Nonparametric | Quality of Life | Adult | Female | Surveys and Questionnaires | Postural Balance - physiology | Disabled persons
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3. Full Text Early diagnosis of progressive multifocal leucoencephalopathy: Longitudinal lesion evolution
by Scarpazza, Cristina and Signori, Alessio and Prosperini, Luca and Sormani, Maria Pia and Cosottini, Mirco and Capra, Ruggero and Gerevini, Simonetta and Altieri, Marta and Amato, Maria Pia and Artusi, Carlo Alberto and Bandini, Fabio and Barcella, Valeria and Bertolotto, Antonio and Morra, Vincenzo Brescia and Capobianco, Marco and Cavaletti, Guido and Cavalla, Paola and Centonze, Diego and Chiusole, Maurizia and Clerico, Marinella and Cordioli, Cinzia and D'Aleo, Giangaetano and De Luca, Giovanna and De Riz, Milena and De Rossi, Nicola and Deotto, Luciano and Durelli, Luca and Falcini, Mario and Ferrante, Claudio and Ferrari, Ernesta and Fusco, Maria Luisa and Gasperini, Claudio and Ghezzi, Angelo and Grimaldi, Luigi and Guidotti, Mario and Laroni, Alice and Lugaresi, Alessandra and Moiola, Lucia and Naldi, Paola and Pane, Chiara and Palmeri, Barbara and Perrone, Patrizia and Pizzorno, Matteo and Pozzilli, Carlo and Rezzonico, Monica and Rottoli, Maria Rosa and Rovaris, Marco and Salemi, Giuseppe and Salvetti, Marco and Santuccio, Giuseppe and Scarpini, Elio and Sessa, Edoardo and Solaro, Claudio and Stenta, Gianola and Tabiadon, Giulietta and Tortorella, Carla and Trojano, Maria and Valentino, Paola and Rottoli, Maira Rosa and Italian PML Grp and Italian PML Group
Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, 2018, Volume 90, Issue 3, pp. 261 - 267
Objective Early diagnosis of natalizumab-related progressive multifocal leucoencephalopathy (NTZ-PML) in multiple sclerosis has been deemed a major priority by... 
STATEMENT | SURVIVAL | SURGERY | ASYMPTOMATIC PML | MRI | PSYCHIATRY | MS | GUIDELINES | NATALIZUMAB-ASSOCIATED PML | RISK | CLINICAL NEUROLOGY | PLASMA | MULTIPLE-SCLEROSIS | Neurology | Multiple sclerosis | Nuclear magnetic resonance--NMR | Brain research | Surveillance | Laboratories | Medical diagnosis | Patients | Psychiatry
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4. Full Text A Low-Cost Cognitive Rehabilitation With a Commercial Video Game Improves Sustained Attention and Executive Functions in Multiple Sclerosis
: A Pilot Study
by De Giglio, Laura and De Luca, Francesca and Prosperini, Luca and Borriello, Giovanna and Bianchi, Valentina and Pantano, Patrizia and Pozzilli, Carlo
Neurorehabilitation and Neural Repair, ISSN 1545-9683, 6/2015, Volume 29, Issue 5, pp. 453 - 461
Objective. To evaluate the effectiveness of a home-based cognitive rehabilitation (CR) program based on the video game Dr Kawashima’s Brain Training (DKBT;... 
multiple sclerosis | cognitive impairment | neurorehabilitation | TASK | MRI FINDINGS | FATIGUE | HANDEDNESS | CLINICAL NEUROLOGY | IMPAIRMENT | TRIAL | MOOD | REHABILITATION | SCALE | DYSFUNCTION | Disability Evaluation | Cognitive Therapy - methods | Humans | Middle Aged | Attention Deficit Disorder with Hyperactivity - rehabilitation | Multiple Sclerosis - rehabilitation | Male | Cognition Disorders - rehabilitation | Executive Function - physiology | Multiple Sclerosis - complications | Neuropsychological Tests | Young Adult | Pilot Projects | Cognition Disorders - etiology | Adolescent | Statistics, Nonparametric | Attention Deficit Disorder with Hyperactivity - etiology | Quality of Life | Adult | Female | Video Games - psychology
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5. Full Text Task-dependent deterioration of balance underpinning cognitive-postural interference in MS
by Prosperini, Luca and Castelli, Letizia and De Luca, Francesca and Fabiano, Francesca and Ferrante, Ilaria and De Giglio, Laura
Neurology, ISSN 0028-3878, 09/2016, Volume 87, Issue 11, pp. 1085 - 1092
OBJECTIVE:To investigate which concurrent cognitive task (if any) had the most detrimental effect on balance control of patients with multiple sclerosis (MS).... 
STATIC POSTUROGRAPHY | WALKING | MULTIPLE-SCLEROSIS | PERFORMANCE | STANDING BALANCE | DUAL-TASKING | PEOPLE | DIFFERENTIAL CEREBELLAR | DIGIT MODALITIES TEST | MOTOR INTERFERENCE | CLINICAL NEUROLOGY | Multiple Sclerosis - psychology | Reproducibility of Results | Cross-Sectional Studies | Humans | Middle Aged | Attention | Male | Cognition | Motor Activity | Neuropsychological Tests | Multiple Sclerosis - physiopathology | Female | Executive Function | Postural Balance
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6. Full Text Multiple sclerosis: Changes in thalamic resting-State functional connectivity induced by A homebased cognitive rehabilitation program
by De Giglio, Laura and Tona, Francesca and De Luca, Francesca and Petsas, Nikolaos and Prosperini, Luca and Bianchi, Valentina and Pozzilli, Carlo and Pantano, Patrizia
Radiology, ISSN 0033-8419, 07/2016, Volume 280, Issue 1, pp. 202 - 211
Purpose: To investigate thalamic connectivity changes after use of a video game-based cognitive rehabilitation program, as thalamic damage and alterations in... 
TRIAL | ATTENTION | PERSISTENCE | DYSFUNCTION | DEFICITS | PROJECTIONS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PREFRONTAL CORTEX | BRAIN | EXECUTIVE FUNCTIONS | IMPAIRMENT
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7. Full Text "Better explanations" in multiple sclerosis diagnostic workup: A 3-year longitudinal study
by Calabrese, Massimiliano and Gasperini, Claudio and Tortorella, Carla and Schiavi, Gianmarco and Frisullo, Giovanni and Ragonese, Paolo and Fantozzi, Roberta and Prosperini, Luca and Annovazzi, Pietro and Cordioli, Cinzia and Di Filippo, Massimiliano and Ferraro, Diana and Gajofatto, Alberto and Malucchi, Simona and Lo Fermo, Salvatore and De Luca, Giovanna and Stromillo, Maria L and Cocco, Eleonora and Gallo, Antonio and Paolicelli, Damiano and Lanzillo, Roberta and Tomassini, Valentina and Pesci, Ilaria and Rodegher, Maria E and Solaro, Claudio and RIREMS Grp and RIREMS group (Rising Italian Researchers in Multiple Sclerosis)
Neurology, ISSN 0028-3878, 05/2019, Volume 92, Issue 22, pp. e2527 - e2537
Background The exclusion of other diseases that canmimicmultiple sclerosis (MS) is the cornerstone of current diagnostic criteria. However, data on the... 
DIFFERENTIAL-DIAGNOSIS | MRI CRITERIA | CONVERSION | GUIDELINES | CONSENSUS | SPECTRUM | CLASSIFICATION CRITERIA | CLINICAL NEUROLOGY
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8. Full Text Beyond clinical changes: Rehabilitation-induced neuroplasticity in MS
by Prosperini, Luca and Di Filippo, Massimiliano
Multiple Sclerosis Journal, ISSN 1352-4585, 9/2019, Volume 25, Issue 10, pp. 1348 - 1362
Background: Neural plasticity represents the substrate by which the damaged central nervous system (CNS) re-learns lost behaviors in response to... 
Multiple sclerosis | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS PATIENTS | MRI | quantitative MRI | NEUROSCIENCES | EXERCISE | CLINICAL NEUROLOGY | COGNITIVE REHABILITATION | functional MRI | rehabilitation | CONNECTIVITY | CORPUS-CALLOSUM | animal model | FUNCTIONAL BRAIN ACTIVITY | WORKING-MEMORY | PLASTICITY | Neuroimaging | Enrichment | Animal models | Nuclear magnetic resonance--NMR | Immunomodulation | Central nervous system | Cognitive ability | Plasticity (neural) | Plasticity (functional) | Functional magnetic resonance imaging | Rehabilitation | Structure-function relationships
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9. Full Text Balance worsening associated with nabiximols in multiple sclerosis
by Castelli, Letizia and Prosperini, Luca and Pozzilli, Carlo
Multiple Sclerosis Journal, ISSN 1352-4585, 1/2019, Volume 25, Issue 1, pp. 113 - 117
We performed a dual-task experiment to explore the effect of nabiximols on postural control in 22 patients with multiple sclerosis. They were assessed with... 
Multiple sclerosis | nabiximols | spasticity | balance | outcome measurement | OROMUCOSAL SPRAY | NEUROSCIENCES | CANNABINOIDS | CLINICAL NEUROLOGY | Patients | Posture
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10. Full Text Long-term assessment of No Evidence of Disease Activity with natalizumab in relapsing multiple sclerosis
by Prosperini, Luca and Fanelli, Fulvia and Pozzilli, Carlo
Journal of the Neurological Sciences, ISSN 0022-510X, 2015, Volume 364, pp. 145 - 147
Abstract In this study we assessed the proportion of patients with relapsing multiple sclerosis (R-MS) who had No Evidence of Disease Activity (NEDA-3),... 
Neurology | Multiple sclerosis | Disease-modifying treatments | Natalizumab | No Evidence of Disease Activity | Disability Evaluation | Severity of Illness Index | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Male | Treatment Outcome | Chi-Square Distribution | Magnetic Resonance Imaging | Antibodies, Monoclonal, Humanized - blood | Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging | Natalizumab - therapeutic use | Adult | Female | Imaging, Three-Dimensional | Longitudinal Studies | Immunologic Factors - therapeutic use | Diagnostic imaging | Diagnosis
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11. Full Text Effect of dalfampridine on information processing speed impairment in multiple sclerosis
by De Giglio, Laura and De Luca, Francesca and Gurreri, Flavia and Ferrante, Ilaria and Prosperini, Luca and Borriello, Giovanna and Quartuccio, Esmeralda and Gasperini, Claudio and Pozzilli, Carlo
Neurology, ISSN 0028-3878, 08/2019, Volume 93, Issue 8, pp. e733 - e746
OBJECTIVETo test a possible benefit of dalfampridine on information processing speed (IPS), a key function for cognitive impairment (CogIm) in multiple... 
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12. Full Text Natalizumab-related progressive multifocal leukoencephalopathy in multiple sclerosis: Findings from an Italian independent registry
by Prosperini, Luca and De Rossi, Nicola and Scarpazza, Cristina and Moiola, Lucia and Cosottini, Mirco and Gerevini, Simonetta and Capra, Ruggero and Italian PML Study Grp and Italian PML study group and on behalf of the Italian PML study group
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168376
Background The monoclonal antibody natalizumab (NTZ) is a highly effective treatment for patients with multiple sclerosis (MS). However, this drug is... 
TREATED MS PATIENTS | PATTERN | RECONSTITUTION INFLAMMATORY SYNDROME | MRI | RECOMMENDATIONS | MULTIDISCIPLINARY SCIENCES | DISABILITY | RISK | PATIENT | PML-IRIS | Multiple Sclerosis - mortality | Humans | Middle Aged | Natalizumab - adverse effects | Male | Multiple Sclerosis - diagnostic imaging | Survival Rate | Leukoencephalopathy, Progressive Multifocal - mortality | Disease-Free Survival | Leukoencephalopathy, Progressive Multifocal - chemically induced | Magnetic Resonance Imaging | JC Virus | Natalizumab - administration & dosage | Adult | Female | Leukoencephalopathy, Progressive Multifocal - diagnostic imaging | Retrospective Studies | Leukoencephalopathy, Progressive Multifocal - physiopathology | Multiple Sclerosis - drug therapy | Development and progression | Care and treatment | Multiple sclerosis | Drug therapy | Leukoencephalopathy, Progressive multifocal | Prevalence studies (Epidemiology) | Pictures | Neuroimaging | Brain | Nuclear magnetic resonance--NMR | Change detection | Central nervous system | Cognitive ability | Opportunist infection | Gadolinium | Cerebrospinal fluid | Leukoencephalopathy | Progressive multifocal leukoencephalopathy | Demographics | Restoration | Human immunodeficiency virus--HIV | Diagnosis | Age | Deoxyribonucleic acid--DNA | Immune system | Survival | Patients | Neurology | Magnetic resonance imaging | Monoclonal antibodies | Data collection | Psychiatry | Sociodemographics | Deoxyribonucleic acid | Nuclear magnetic resonance | NMR | HIV | DNA | Human immunodeficiency virus
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13. Full Text Isoprostanes in clinically isolated syndrome and early multiple sclerosis as biomarkers of tissue damage and predictors of clinical course
by Sbardella, Emilia and Greco, Anita and Stromillo, Maria L and Prosperini, Luca and Puopolo, Maria and Cefaro, Luca Ausili and Pantano, Patrizia and De Stefano, Nicola and Minghetti, Luisa and Pozzilli, Carlo
Multiple Sclerosis Journal, ISSN 1352-4585, 4/2013, Volume 19, Issue 4, pp. 411 - 417
Background: Isoprostanes (IsoP) are sensitive biomarkers of oxidative stress. Their cerebrospinal-fluid (CSF) level is increased in several neurological... 
Biomarkers | Multiple sclerosis | Prognosis | MRI | OXIDATIVE STRESS | ATROPHY | biomarkers | prognosis | WHITE-MATTER CHANGES | LESIONS | CLINICAL NEUROLOGY | DISEASE-ACTIVITY | SPECTROSCOPY | DISABILITY | AXONAL-INJURY | EXPRESSION | PROGRESSION | Isoprostanes - cerebrospinal fluid | Area Under Curve | Multiple Sclerosis - cerebrospinal fluid | Humans | Demyelinating Diseases - cerebrospinal fluid | Male | Magnetic Resonance Imaging | Spinal Cord - pathology | Multiple Sclerosis - pathology | Adult | Female | ROC Curve | Biomarkers - cerebrospinal fluid | Demyelinating Diseases - pathology
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14. Full Text To do or not to do? plasma exchange and timing of steroid administration in progressive multifocal leukoencephalopathy
by Scarpazza, Cristina and Prosperini, Luca and De Rossi, Nicola and Moiola, Lucia and Sormani, Maria Pia and Gerevini, Simonetta and Capra, Ruggero and Italian PML Grp and Italian PML group
Annals of Neurology, ISSN 0364-5134, 11/2017, Volume 82, Issue 5, pp. 697 - 705
ObjectiveTo retrospectively analyze the effect of plasma exchange (PLEX; yes = PLEX+, no = PLEX-) and steroids administration timing (prophylactically [proST]... 
PATHOGENESIS | MULTIPLE-SCLEROSIS | RECONSTITUTION INFLAMMATORY SYNDROME | NATALIZUMAB TREATMENT | RECOMMENDATIONS | JC VIRUS | DISEASE | INFECTION | PML-IRIS | NEUROSCIENCES | CLINICAL NEUROLOGY | LYMPHOCYTES | Disability Evaluation | Immune Reconstitution Inflammatory Syndrome - prevention & control | Leukoencephalopathy, Progressive Multifocal - therapy | Humans | Immune Reconstitution Inflammatory Syndrome - complications | Leukoencephalopathy, Progressive Multifocal - drug therapy | Male | Young Adult | Immune Reconstitution Inflammatory Syndrome - drug therapy | Immune Reconstitution Inflammatory Syndrome - therapy | Adult | Female | Plasma Exchange - adverse effects | Retrospective Studies | Steroids - therapeutic use | Databases, Factual | Leukoencephalopathy, Progressive Multifocal - complications | Steroids - adverse effects | Medical services | Immune reconstitution | Data processing | Inflammation | Variance analysis | Patients | Leukoencephalopathy | Steroid hormones | Steroids | Progressive multifocal leukoencephalopathy | Latency
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15. Full Text Investigating the phenomenon of "cognitive-motor interference" in multiple sclerosis by means of dual-task posturography
by Prosperini, Luca and Castelli, Letizia and Sellitto, Giovanni and De Luca, Francesca and De Giglio, Laura and Gurreri, Flavia and Pozzilli, Carlo
Gait and Posture, ISSN 0966-6362, 03/2015, Volume 41, Issue 3, pp. 780 - 785
Background: Two simultaneously performed tasks may compete for common brain network resources in patients with multiple sclerosis (MS), suggesting the... 
Posturography | Multiple sclerosis | Cognition | Balance | Attention | Dual-task cost | DISABILITY STATUS | SPORT SCIENCES | FAR TRANSFER | GAIT | PERFORMANCE | POSTURAL CONTROL | NEUROSCIENCES | IMPAIRMENT | BALANCE DISORDERS | PREDICTING ACCIDENTAL FALLS | IMPACT | PEOPLE | ORTHOPEDICS | Cross-Sectional Studies | Humans | Male | Gait - physiology | Psychomotor Performance - physiology | Case-Control Studies | Walking - physiology | Attention - physiology | Multiple Sclerosis - physiopathology | Cognition - physiology | Adult | Female | Postural Balance - physiology | Investigations
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