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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1461 - 15
Ammonia can be utilised as an alternative nitrogen source to glutamine to support cell proliferation. However, the underlying molecular mechanisms and whether... 
TARGET | APOPTOSIS | ACTIVATED PROTEIN-KINASE | METABOLISM | GLUTAMINE | MULTIDISCIPLINARY SCIENCES | BIOLOGY | GROWTH | AUTOPHAGY | STRESS | CANCER | Cell proliferation | Glutamate dehydrogenase | Starvation | Glucose | Tumor cell lines | Nitrogen | Kinases | Ammonia | Cell growth | Cell activation | Molecular modelling | Cell lines | Supplementation | Glutamine | Cancer
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 06/2019, Volume 16, pp. 770 - 777
The human proinsulin gene ( ) contains a thymine-to-adenine variant ( ) located in the 3′ splice site (3′ ss) recognition motif of the first intron. The... 
G quadruplex | type 1 diabetes | polymorphism | 3′ splice site | transcription | proinsulin gene
Journal Article
Cell Research, ISSN 1001-0602, 02/2016, Volume 26, Issue 2, p. 266
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 18, pp. 7169 - 7176
Eukaryotic elongation factor 2 kinase (eEF2K) negatively regulates the elongation stage of mRNA translation and is activated under different stress conditions... 
proteasome | MECHANISM | translation elongation factor | eukaryotic elongation factor 2 kinase (eEF2K) | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein synthesis | apoptosis | elongation | heat shock protein (HSP) | molecular chaperone | mRNA translation | INHIBITION | DEGRADATION | cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 2016, Volume 473, Issue 24, pp. 4651 - 4664
Journal Article
Science, ISSN 0036-8075, 11/2007, Volume 318, Issue 5852, pp. 926 - 927
A mitochondrial membrane protein links two parts of a signaling pathway that is central to cell growth and proliferation. 
Amino acids | Cell growth | Perspectives | Insulin | Drug interactions | Oncogenes | INSULIN | TSC | TOR | MULTIDISCIPLINARY SCIENCES | GROWTH | KINASE | FKBP38 | PROTEINS
Journal Article
British Journal of Cancer, ISSN 0007-0920, 07/2019, Volume 121, Issue 1, pp. 37 - 50
BACKGROUNDActivating mutations in KRAS frequently occur in colorectal cancer (CRC) patients, leading to resistance to EGFR-targeted therapies.METHODSTo better... 
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2019
Hepatocellular carcinoma (HCC) is an aggressive malignancy with increasing mortality in China. Angiogenesis is crucial for tumor formation, development and... 
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 03/2019, Volume 23, Issue 3, pp. 187 - 199
Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are switched on by the oncogenic MAPK (ERK) signalling pathway. They... 
eIF4E | mRNA translation | metastasis | transformation | MNKs | oncology | Cancer | MAMMALIAN TARGET | ANDROGEN RECEPTOR | FACTOR EIF-4E | ACTIVATED PROTEIN-KINASE | NUCLEAR EXPORT | INITIATION-FACTOR 4E | CELL-CYCLE PROGRESSION | MESSENGER-RNA | EIF4E PHOSPHORYLATION | CAP-DEPENDENT TRANSLATION | PHARMACOLOGY & PHARMACY
Journal Article
Current Biology, ISSN 0960-9822, 03/2019, Volume 29, Issue 5, pp. 737 - 749.e5
Maintaining accuracy during protein synthesis is crucial to avoid producing misfolded and/or non-functional proteins. The target of rapamycin complex 1 (TORC1)... 
eEF2K | Caenorhabditis elegans | eEF2 | caloric restriction | tRNA | lifespan | mTOR | elongation | translation fidelity | FACTOR 2 KINASE | INACTIVATION | FIREFLY LUCIFERASE | FIDELITY | PHOSPHORYLATION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFER-RNA | CANCER | EXPRESSION | MTOR | CELL BIOLOGY | Proteins | Physiological aspects | Protein biosynthesis | Codon | Genetic translation | Transfer RNA
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 10/2016, Volume 41, Issue 10, p. 847
  The eukaryotic translation initiation factor (eIF) 4E, which binds to the 5'-cap of mRNA, undergoes phosphorylation on a single conserved serine, executed by... 
Eukaryotes | Phosphorylation | Metastasis | Ribonucleic acid--RNA | Kinases | Cancer
Journal Article
Cold Spring Harbor perspectives in biology, 06/2018
Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is regulated by extracellular stimuli such as hormones and by the levels of... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, pp. 735 - 751
The mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate eukaryotic initiation factor 4E (eIF4E) and play important roles... 
Mnk | Selective inhibitor | Thieno[2,3-d]pyrimidine | eIF4E inhibition | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | INITIATION-FACTOR 4E | DISCOVERY | TRANSLATIONAL CONTROL | POTENT | INTERACTING KINASES | EXPRESSION | BINDING | EIF4E | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 08/2017, Volume 66, Issue 2, pp. 481 - 497
Journal Article
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