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1994, ISBN 2890055892, 123
Book
Pharmacogenomics Journal, ISSN 1470-269X, 04/2019, Volume 19, Issue 2, pp. 147 - 156
Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate... 
CYP2C9 | BSMI | VDR | FACTOR 4-ALPHA | GENETICS & HEREDITY | VITAMIN-D-RECEPTOR | RISK | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | METABOLIZING-ENZYMES | ASSOCIATION | EXPRESSION | Anticoagulants - administration & dosage | Humans | Middle Aged | Warfarin - metabolism | Warfarin - adverse effects | Male | Receptors, Calcitriol - genetics | Warfarin - administration & dosage | Vitamin K - metabolism | Dose-Response Relationship, Drug | Vitamin K - genetics | Aged, 80 and over | Pregnane X Receptor - genetics | Adult | Female | CCAAT-Enhancer-Binding Proteins - genetics | Genome-Wide Association Study | Quebec - epidemiology | Anticoagulants - metabolism | GATA4 Transcription Factor - genetics | Genotype | Hepatocyte Nuclear Factor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Calcitriol - metabolism | Anticoagulants - adverse effects | Cytochrome P-450 CYP2C9 - genetics | Estrogen Receptor alpha - genetics | Alleles | Receptors, Glucocorticoid - genetics | Retinoid X Receptor alpha - genetics | Polymorphism, Single Nucleotide - genetics | Blood Coagulation - genetics | Aged | Cytochrome | Warfarin | Genes | Variability | Retinoid X receptor α | Single-nucleotide polymorphism | Gene expression | Metabolism | Homozygotes | ESR1 protein | Vitamin D | Drug metabolism | Cytochromes | Hepatocyte nuclear factor 4
Journal Article
by Webb, Thomas R., PhD and Erdmann, Jeanette, PhD and Stirrups, Kathleen E., PhD and Stitziel, Nathan O., MD, PhD and Masca, Nicholas G.D., PhD and Jansen, Henning, MD and Kanoni, Stavroula, PhD and Nelson, Christopher P., PhD and Ferrario, Paola G., PhD and König, Inke R., PhD and Eicher, John D., PhD and Johnson, Andrew D., PhD and Hamby, Stephen E., PhD and Betsholtz, Christer, PhD and Ruusalepp, Arno, MD, PhD and Franzén, Oscar, PhD and Schadt, Eric E., MD, PhD and Björkegren, Johan L.M., MD, PhD and Weeke, Peter E., MD, PhD and Auer, Paul L., PhD and Schick, Ursula M., PhD and Lu, Yingchang, MD, PhD and Zhang, He, PhD and Dube, Marie-Pierre, PhD and Goel, Anuj, MSc and Farrall, Martin, MD and Peloso, Gina M., PhD and Won, Hong-Hee, PhD and Do, Ron, PhD and van Iperen, Erik, MSc and Kruppa, Jochen, PhD and Mahajan, Anubha, PhD and Scott, Robert A., PhD and Willenborg, Christina, PhD and Braund, Peter S., PhD and van Capelleveen, Julian C., MD and Doney, Alex S.F., MD, PhD and Donnelly, Louise A., PhD and Asselta, Rosanna, PhD and Merlini, Pier A., MD and Duga, Stefano, PhD and Marziliano, Nicola, PhD and Denny, Josh C., MD, MS and Shaffer, Christian, BS and El-Mokhtari, Nour Eddine, MD and Franke, Andre, PhD and Heilmann, Stefanie, PhD and Hengstenberg, Christian, MD and Hoffmann, Per, PhD and Holmen, Oddgeir L., MD and Hveem, Kristian, MD, PhD and Jansson, Jan-Håkan, MD, PhD and Jöckel, Karl-Heinz, PhD and Kessler, Thorsten, MD and Kriebel, Jennifer, PhD and Laugwitz, Karl L., MD and Marouli, Eirini, MSc and Martinelli, Nicola, MD, PhD and McCarthy, Mark I., MD and Van Zuydam, Natalie R., PhD and Meisinger, Christa, MD, MPH and Esko, Tõnu, PhD and Mihailov, Evelin, MSc and Escher, Stefan A., PhD and Alver, Maris, MSc and Moebus, Susanne, PhD and Morris, Andrew D., MD and Virtamo, Jarma, MD, PhD and Nikpay, Majid, PhD and Olivieri, Oliviero, MD and Provost, Sylvie, MSc and AlQarawi, Alaa, BSc and Robertson, Neil R., MSc and Akinsansya, Karen O., PhD and Reilly, Dermot F., PhD and Vogt, Thomas F., PhD and Yin, Wu, PhD and Asselbergs, Folkert W., MD, PhD and Kooperberg, Charles, PhD and Jackson, Rebecca D., MD and Stahl, Eli, PhD and Müller-Nurasyid, Martina, PhD and Strauch, Konstantin, PhD and Varga, Tibor V., PhD and Waldenberger, Melanie, PhD and Zeng, Lingyao, MSc and Chowdhury, Rajiv, MD, PhD and Salomaa, Veikko, MD, PhD and Ford, Ian, PhD and Jukema, J. Wouter, MD, PhD and Amouyel, Philippe, MD, PhD and Kontto, Jukka, MSSc and Nordestgaard, Børge G., MD, DMSc and Ferrières, Jean, MD and Saleheen, Danish, MBBS, PhD and Sattar, Naveed, PhD and Surendran, Praveen, PhD and Wagner, Aline, MD, PhD and Young, Robin, PhD and Howson, Joanna M.M., PhD and ... and Wellcome Trust Case Control and MORGAM Investigators and Myocardial Infarction Genetics and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 823 - 836
Abstract Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show... 
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Medical Genetics | Medicinsk genetik | Clinical Medicine | Cardiac and Cardiovascular Systems | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Paediatrics & Child Health, ISSN 1205-7088, 05/2018, Volume 23, Issue suppl_1, pp. e31 - e32
Abstract BACKGROUND Nursing workload evaluation tools are designed to determine adequate staffing for a given shift. Only retrospective tools that do not... 
Studies | Pediatrics | Intensive care | Workloads | Nursing | Statistical analysis | Abstracts
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A18405 - A18405
Background and AimThe marked inter-individual variability in warfarin dose requirement is mainly attributed to the variants of the main target genes across the... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 4113 - 4113
Abstract BACKGROUND. The most frequently mutated genes documented in blood cells of aging individuals are known epigenetic regulator genes such as TET2 and... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 4106 - 4106
Abstract BACKGROUND. Recent studies using whole genome approaches have shown that acquired mutations in genes such as DNMT3A, TET2, ASXL1, JAK2 and TP53 are... 
Journal Article
Journal Article
Epigenetics and Chromatin, ISSN 1756-8935, 06/2016, Volume 9, Issue 1, p. 25
Background: Prenatal alcohol exposure is the leading preventable cause of behavioral and cognitive deficits, which may affect between 2 and 5 % of children in... 
METAANALYSIS | TISSUE | REGIONS | GENETICS & HEREDITY | GENE-EXPRESSION | ISLANDS | EXPOSURE | CONSUMPTION | BRAIN | INSIGHTS | FEATURES | Fetal alcohol syndrome | Epigenetic inheritance | Analysis | Genomics | Effect of alcohol on | Fetus | Genetic aspects | Research | Diagnosis
Journal Article
INQUIRY: The Journal of Health Care Organization, Provision, and Financing, ISSN 0046-9580, 1/2016, Volume 53, Issue 1, p. C1
Journal Article