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humans (14) 14
animals (9) 9
genetics (8) 8
genetics & heredity (8) 8
genetic variation (7) 7
human genome (7) 7
pan troglodytes - genetics (7) 7
index medicus (6) 6
models, genetic (6) 6
mutation (6) 6
evolution, molecular (5) 5
further section (5) 5
genes (5) 5
male (5) 5
polymorphism, genetic (5) 5
evolution (4) 4
genetic aspects (4) 4
genome, human (4) 4
genomes (4) 4
genomics (4) 4
haplotypes (4) 4
linkage disequilibrium (4) 4
multidisciplinary sciences (4) 4
recombination, genetic (4) 4
research (4) 4
biochemistry & molecular biology (3) 3
biology (3) 3
dna (3) 3
dna polymorphism (3) 3
dna-sequences (3) 3
estimates (3) 3
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female (3) 3
genetic recombination (3) 3
human (3) 3
linkage disequilibrium - genetics (3) 3
linkage-disequilibrium (3) 3
meiotic recombination (3) 3
phylogeny (3) 3
research article (3) 3
selection, genetic (3) 3
sequence analysis, dna (3) 3
analysis (2) 2
article (2) 2
base sequence (2) 2
biological diversity (2) 2
cancer (2) 2
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chromosome mapping (2) 2
computer simulation (2) 2
deoxyribonucleic acid (2) 2
diagnosis (2) 2
dna - genetics (2) 2
dna, mitochondrial - genetics (2) 2
drosophila (2) 2
experiments (2) 2
gastroenterology and hepatology (2) 2
gene loci (2) 2
genetic research (2) 2
genetics, population (2) 2
genome (2) 2
genome - genetics (2) 2
genotype (2) 2
haplotype reconstruction (2) 2
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hominids (2) 2
hotspot (2) 2
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natural-selection (2) 2
nucleotide diversity (2) 2
pan paniscus - genetics (2) 2
patterns (2) 2
phenotype (2) 2
physiological aspects (2) 2
population (2) 2
positive selection (2) 2
predictive value of tests (2) 2
primates (2) 2
recombination, genetic - genetics (2) 2
single nucleotide polymorphisms (2) 2
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active transfer strategies for informing clinical practice through information technologies (1) 1
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african continental ancestry group - genetics (1) 1
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1. Full Text Analysis of one million base pairs of Neanderthal DNA
by Green, Richard E and Krause, Johannes and Ptak, Susan E and Briggs, Adrian W and Ronan, Michael T and Simons, Jan F and Du, Lei and Egholm, Michael and Rothberg, Jonathan M and Paunovic, Maja and Pääbo, Svante
Nature, ISSN 0028-0836, 11/2006, Volume 444, Issue 7117, pp. 330 - 336
Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes... 
MODERN HUMAN ORIGINS | MODERN HUMANS | MITOCHONDRIAL GENOME | MULTIDISCIPLINARY SCIENCES | ANCESTRAL POPULATION SIZES | ARTIFACTS | ANCIENT DNA | ENZYMATIC AMPLIFICATION | DIVERSITY | DIVERGENCE TIMES | MTDNA SEQUENCE | DNA - genetics | Animals | DNA, Mitochondrial - genetics | DNA - analysis | Humans | Population Density | Polymorphism, Genetic - genetics | DNA, Mitochondrial - analysis | Phylogeny | Hominidae - genetics | Sequence Analysis, DNA | Fossils | Deoxyribonucleic acid | DNA | Genomics | Paleontology | Hominids
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2. Full Text The bonobo genome compared with the chimpanzee and human genomes
by Prüfer, Kay and Munch, Kasper and Hellmann, Ines and Akagi, Keiko and Miller, Jason R and Walenz, Brian and Koren, Sergey and Sutton, Granger and Kodira, Chinnappa and Winer, Roger and Knight, James R and Mullikin, James C and Meader, Stephen J and Ponting, Chris P and Lunter, Gerton and Higashino, Saneyuki and Hobolth, Asger and Dutheil, Julien and Karakoç, Emre and Alkan, Can and Sajjadian, Saba and Catacchio, Claudia Rita and Ventura, Mario and Marques-Bonet, Tomas and Eichler, Evan E and André, Claudine and Atencia, Rebeca and Mugisha, Lawrence and Junhold, Jörg and Patterson, Nick and Siebauer, Michael and Good, Jeffrey M and Fischer, Anne and Ptak, Susan E and Lachmann, Michael and Symer, David E and Mailund, Thomas and Schierup, Mikkel H and Andrés, Aida M and Kelso, Janet and Pääbo, Svante
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7404, pp. 527 - 531
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many... 
RETROTRANSPOSITION | LANDSCAPE | PRIMATES | MULTIDISCIPLINARY SCIENCES | SEQUENCE | Species Specificity | Humans | Genome - genetics | Pan troglodytes - genetics | Molecular Sequence Data | Genotype | Phylogeny | Pan paniscus - genetics | Genome, Human - genetics | Phenotype | Animals | DNA Transposable Elements - genetics | Gene Duplication - genetics | Genetic Variation - genetics | Evolution, Molecular
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3. Full Text Fine-scale recombination patterns differ between chimpanzees and humans
by Patil, Nila and Ptak, Susan E and Koehler, Kathrin and Frazer, Kelly A and Hinds, David A and Nickel, Birgit and Pääbo, Svante and Przeworski, Molly and Ballinger, Dennis G
Nature Genetics, ISSN 1061-4036, 04/2005, Volume 37, Issue 4, pp. 429 - 434
Recombination rates seem to vary extensively along the human genome. Pedigree analysis suggests that rates vary by an order of magnitude when measured at the... 
HAPLOTYPE RECONSTRUCTION | DNA-SEQUENCES | HUMAN GENOME | CROSSOVERS | GENETICS & HEREDITY | SITES | LINKAGE-DISEQUILIBRIUM | HOTSPOT | MAJOR HISTOCOMPATIBILITY COMPLEX | SAMPLES | MEIOTIC RECOMBINATION | Genetic Variation | Haplotypes | Genetics, Population | Animals | Recombination, Genetic | Computer Simulation | Humans | Pan troglodytes - genetics | Chromosome Mapping | Genome | Linkage Disequilibrium | Polymorphism, Genetic | Physiological aspects | Genetic aspects | Research | Human genome | Chimpanzees | Simulation methods
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4. Full Text A Neutral Explanation for the Correlation of Diversity with Recombination Rates in Humans
by Hellmann, Ines and Ebersberger, Ingo and Ptak, Susan E and Pääbo, Svante and Przeworski, Molly
The American Journal of Human Genetics, ISSN 0002-9297, 2003, Volume 72, Issue 6, pp. 1527 - 1535
One of the most striking findings to emerge from the study of genomic patterns of variation is that regions with lower recombination rates tend to have lower... 
VARIABILITY | DNA-SEQUENCES | MUTATION-RATE | HUMAN GENOME | POLYMORPHISMS | GENE | DROSOPHILA-MELANOGASTER | STRAND-BREAK REPAIR | GENETICS & HEREDITY | SACCHAROMYCES-CEREVISIAE | MAP | Multivariate Analysis | Humans | Pan troglodytes - genetics | Linear Models | Polymorphism, Genetic | Genetic Variation | Animals | Papio - genetics | Recombination, Genetic | Statistics, Nonparametric | Models, Genetic | Mutation | Genome, Human | Genetic research | Genetic aspects | Drosophila | Biological diversity
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5. Full Text Bonobos fall within the genomic variation of Chimpanzees
by Fischer, Anne and Prüfer, Kay and Good, Jeffrey M and Halbwax, Michel and Wiebe, Victor and André, Claudine and Atencia, Rebeca and Mugisha, Lawrence and Ptak, Susan E and Pääbo, Svante
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21605
To gain insight into the patterns of genetic variation and evolutionary relationships within and between bonobos and chimpanzees, we sequenced 150,000 base... 
GENETIC-STRUCTURE | DEMOGRAPHIC HISTORY | MIXED MODELS | NUCLEOTIDE DIVERSITY | DNA POLYMORPHISM | MULTIDISCIPLINARY SCIENCES | SPECIES TREES | HUMANS | POPULATIONS | PATTERNS | MULTIPLE SEQUENCE ALIGNMENT | Genetic Variation | Animals | DNA, Mitochondrial - genetics | Humans | Genome - genetics | Pan troglodytes - genetics | Male | Phylogeny | Pan paniscus - genetics | Sequence Analysis, DNA | Evolution, Molecular | Chimpanzees | Genomics | Genomes | Nucleotide sequence | Base pairs | Biological evolution | Principal components analysis | Mitochondrial DNA | Genetic diversity | Monkeys & apes | Mitochondria | Hypotheses | Phylogenetics | Population | Mutation | Variation | Bioinformatics | Speciation | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
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6. Full Text Evidence for population growth in humans is confounded by fine-scale population structure
by Ptak, Susan E and Przeworski, Molly
Trends in Genetics, ISSN 0168-9525, 2002, Volume 18, Issue 11, pp. 559 - 563
Although many studies have reported human polymorphism data, there has been no analysis of the effect of sampling design on the patterns of variability... 
Human | allele frequency spectrum | polymorphism | population structure | single nucleotide polymorphisms | Tajima's D | LINKAGE DISEQUILIBRIUM | MITOCHONDRIAL | DNA POLYMORPHISM | SIZE | GENES | GENETICS & HEREDITY | SINGLE-NUCLEOTIDE POLYMORPHISMS | Predictive Value of Tests | Models, Genetic | Population Growth | Humans | Polymorphism, Genetic
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7. Full Text Absence of the TAP2 human recombination hotspot in chimpanzees
by Ptak, Susan E and Roeder, Amy D and Stephens, Matthew and Gilad, Yoav and Pääbo, Svante and Przeworski, Molly
PLoS Biology, ISSN 1544-9173, 2004, Volume 2, Issue 6, pp. 849 - 855
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is... 
HAPLOTYPE RECONSTRUCTION | DNA-SEQUENCES | HUMAN GENOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | NATURAL-SELECTION | BIOLOGY | LINKAGE-DISEQUILIBRIUM | MAJOR HISTOCOMPATIBILITY COMPLEX | STATISTICAL-METHOD | HUMAN-SPERM | MEIOTIC RECOMBINATION | COLD SPOTS | Humans | Pan troglodytes - genetics | Linkage Disequilibrium - genetics | Molecular Sequence Data | Mutation - genetics | Sequence Analysis, DNA | ATP-Binding Cassette, Sub-Family B, Member 3 | Genetic Variation | Haplotypes - genetics | Animals | ATP-Binding Cassette Transporters - genetics | Base Sequence | Computer Simulation | Polymorphism, Single Nucleotide - genetics | Recombination, Genetic - genetics | Models, Genetic | Evolution, Molecular | Primates | Evolution | Genetics | Gene Therapy | Homo (Human) | Genomics | Haplotypes | Sperm | Gene loci | Genomes | Genetic recombination | Experiments | Estimates
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8. Full Text Linkage Disequilibrium Extends Across Putative Selected Sites in FOXP2
by Ptak, Susan E and Enard, Wolfgang and Wiebe, Victor and Hellmann, Ines and Krause, Johannes and Lachmann, Michael and Pääbo, Svante
Molecular Biology and Evolution, ISSN 0737-4038, 10/2009, Volume 26, Issue 10, pp. 2181 - 2184
Polymorphism data in humans suggest that the gene encoding the transcription factor FOXP2, which influences speech and language development, has been subject... 
Human | Evolution | Linkage disequilibrium | Selection | FOXP2 | LANGUAGE | MODERN HUMANS | INHERITED SPEECH | BIOCHEMISTRY & MOLECULAR BIOLOGY | DARWINIAN SELECTION | evolution | SWEEPS | SIGNATURE | EVOLUTIONARY BIOLOGY | selection | POSITIVE SELECTION | GENETICS & HEREDITY | STANDING GENETIC-VARIATION | HITCHHIKING | human | linkage disequilibrium | Linkage Disequilibrium - genetics | Amino Acid Sequence | Amino Acid Substitution - genetics | Forkhead Transcription Factors - genetics | Humans | Amino acids | Evolutionary biology | Molecular biology | Gene expression | Hominids
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9. Full Text Why do human diversity levels vary at a megabase scale?
by Hellmann, Ines and Prüfer, Kay and Ji, Hongkai and Zody, Michael C and Pääbo, Svante and Ptak, Susan E
Genome Research, ISSN 1088-9051, 09/2005, Volume 15, Issue 9, pp. 1222 - 1231
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural... 
BACKGROUND SELECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PATTERNS | DNA-SEQUENCE VARIATION | X-LINKED LOCI | MUTATION-RATES | HUMAN GENOME | POSITIVE SELECTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | RECOMBINATION RATES | LINKAGE-DISEQUILIBRIUM | HITCHHIKING | Humans | Pan troglodytes - genetics | Selection, Genetic | Linear Models | DNA - genetics | Genetic Variation | DNA - chemistry | Animals | Base Composition | Recombination, Genetic | CpG Islands | Models, Genetic | Mutation | Genome, Human | Evolution, Molecular | Genetic research | Research | Gene mutations | Biological diversity | Letters
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10. Insights into recombination from patterns of linkage disequilibrium in humans
by Susan E Ptak and Kristian Voelpel and Molly Przeworski
Genetics, ISSN 0016-6731, 05/2004, Volume 167, Issue 1, p. 387
  An ability to predict levels of linkage disequilibrium (LD) between linked markers would facilitate the design of association studies and help to distinguish... 
Genotype & phenotype | Genetic linkage | Evolution | Genetics
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11. Insights Into Recombination From Patterns of Linkage Disequilibrium in Humans
by Ptak, Susan E and Voelpel, Kristian and Przeworski, Molly
Genetics, ISSN 0016-6731, 05/2004, Volume 167, Issue 1, pp. 387 - 397
An ability to predict levels of linkage disequilibrium (LD) between linked markers would facilitate the design of association studies and help to distinguish... 
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12. Why do human diversity levels vary at a megabase scale?
by Hellmann, Ines and Pruefer, Kay and Ji, Hongkai and Zody, Michael C and Paeaebo, Svante and Ptak, Susan E
Genome Research, ISSN 1088-9051, 09/2005, Volume 15, Issue 9, pp. 1222 - 1231
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural... 
Journal Article
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13. Full Text Insights Into Recombination From Patterns of Linkage Disequilibrium in Humans
by Ptak, Susan E and Voelpel, Kristian and Przeworski, Molly
Genetics, ISSN 0016-6731, 05/2004, Volume 167, Issue 1, pp. 387 - 397
An ability to predict levels of linkage disequilibrium (LD) between linked markers would facilitate the design of association studies and help to distinguish... 
HUMAN GENOME | MODELS | HAPLOTYPE BLOCKS | GENETICS & HEREDITY | FINITE POPULATION | GENE CONVERSION | HOT-SPOTS | HOTSPOT | CROSSOVER | SINGLE NUCLEOTIDE POLYMORPHISMS | MEIOTIC RECOMBINATION | Genetics, Population | Demography | Humans | Genotype | Chromosome Mapping | Models, Statistical | Gene Conversion | Databases as Topic | Linkage Disequilibrium | Polymorphism, Genetic | Genetic Variation | Recombination, Genetic | Models, Genetic | Mutation | Genome, Human | Evolution, Molecular | Genetics | Research
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14. How intron splicing affects the deletion and insertion profile in Drosophila melanogaster
by Susan E Ptak and Dmitri A Petrov
Genetics, ISSN 0016-6731, 11/2002, Volume 162, Issue 3, p. 1233
  Studies of "dead-on-arrival" transposable elements in Drosophila melanogaster found that deletions outnumber insertions ~8:1 with a median size for deletions... 
Insects | Genes | Genetics | Mutation
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15. Full Text Absence of the TAP2 Human Recombination Hotspot in Chimpanzees
: e155
by Susan E Ptak and Amy D Roeder and Matthew Stephens and Yoav Gilad and Svante Pääbo and Molly Przeworski
PLoS Biology, ISSN 1544-9173, 06/2004, Volume 2, Issue 6
  Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is... 
Haplotypes | Sperm | Gene loci | Genomes | Genetic recombination | Experiments | Estimates
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16. On the evolution of polygyny: a theoretical examination of the polygyny threshold model
by Susan E. Ptak and Michael Lachmann
Behavioral Ecology, ISSN 1045-2249, 03/2003, Volume 14, Issue 2, p. 201
  The polygyny threshold model states that if costs incurred are less than the benefits gained from mating polygynously in terms of breeding-situation quality,... 
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17. Full Text The bonobo genome comparedwith the chimpanzee and human genomes
by Kay Prüfer and Kasper Munch and Ines Hellmann and Keiko Akagi and Jason R Miller and Brian Walenz and Sergey Koren and Granger Sutton and Chinnappa Kodira and Roger Winer and James R Knight and James C Mullikin and Stephen J Meader and Chris P Ponting and Gerton Lunter and Saneyuki Higashino and Asger Hobolth and Julien Dutheil and Emre Karakoc and Can Alkan and Saba Sajjadian and Claudia Rita Catacchio and Mario Ventura and Tomas Marques-Bonet and Evan E Eichler and Claudine André and Rebeca Atencia and Lawrence Mugisha and Jörg Junhold and Nick Patterson and Michael Siebauer and Jeffrey M Good and Anne Fischer and Susan E Ptak and Michael Lachmann and David E Symer and Thomas Mailund and Mikkel H Schierup and Aida M Andrés and Janet Kelso and Svante Pääbo
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7404, p. 527
  Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in... 
Genomics | Genetics | Genomes | Females | Monkeys & apes | Cell adhesion & migration
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18. Full Text Combining Sperm Typing and Linkage Disequilibrium Analyses Reveals Differences in Selective Pressures or Recombination Rates Across Human Populations
by Clark, Vanessa J and Ptak, Susan E and Tiemann, Irene and Qian, Yudong and Coop, Graham and Stone, Anne C and Przeworski, Molly and Arnheim, Norman and Rienzo, Anna Di
Genetics, ISSN 0016-6731, 02/2007, Volume 175, Issue 2, pp. 795 - 804
A previous polymorphism survey of the type 2 diabetes gene CAPN10 identified a segment showing an excess of polymorphism levels in all population samples,... 
DIABETES-MELLITUS | GENETIC-VARIATION | CLASS-II REGION | HUMAN GENOME | CARNIVORE CONNECTION | NUCLEOTIDE DIVERSITY | DNA POLYMORPHISM | GENETICS & HEREDITY | HAPLOTYPE STRUCTURE | SEGREGATING SITES | CROSSOVER HOT-SPOTS | Haplotypes | Humans | Pan troglodytes - genetics | Selection, Genetic | Linkage Disequilibrium - genetics | Male | Spermatozoa - metabolism | Polymorphism, Genetic | Animals | Base Pairing | Base Sequence | Recombination, Genetic - genetics | Models, Genetic | African Continental Ancestry Group - genetics | Spermatozoa - classification | Type 2 diabetes | Spermatozoa | Genetic aspects | Research | Genetic polymorphisms | Studies | Genes | Ratings & rankings | Population | Genetic recombination | Molecular biology | Estimates | Investigations
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19. Full Text How Intron Splicing Affects the Deletion and Insertion Profile in Drosophila melanogaster
by Ptak, Susan E and Petrov, Dmitri A
Genetics, ISSN 0016-6731, 11/2002, Volume 162, Issue 3, pp. 1233 - 1244
Studies of "dead-on-arrival" transposable elements in Drosophila melanogaster found that deletions outnumber insertions similar to8:1 with a median size for... 
RECOMBINATION | EXON | REPAIR | CYCLOBUTANE PYRIMIDINE DIMERS | MOLECULAR EVOLUTION | NATURAL-SELECTION | GENES | GENETICS & HEREDITY | DNA LOSS | GENOME SIZE | PSEUDOGENES | RNA Splicing - physiology | Sequence Deletion | Data Interpretation, Statistical | Animals | Introns - genetics | RNA Splice Sites - genetics | RNA Splicing - genetics | Selection, Genetic | Drosophila melanogaster - genetics | Genetic aspects | Chromosome deletion | Introns | Drosophila | Analysis
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20. Analysis of one million base pairs of Neanderthal DNA
by Green, Richard E and Krause, Johannes and Ptak, Susan E and Briggs, Adrian W and Ronan, Michael T and Simons, Jan F and Du, Lei and Egholm, Michael and Rothberg, Jonathan M and Paunovic, Maja and Paeaebo, Svante
Nature, ISSN 0028-0836, 11/2006, Volume 444, Issue 7117, pp. 330 - 336
Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes... 
Journal Article
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