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Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 869 - 873
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2013, Volume 23, Issue 5, pp. 603 - 617
Journal Article
Cancer Research, ISSN 0008-5472, 01/2006, Volume 66, Issue 1, pp. 283 - 289
Journal Article
Cancer Research, ISSN 0008-5472, 10/2007, Volume 67, Issue 19, pp. 9591 - 9596
Fanconi anemia (FA) is a rare autosomal recessive disease characterized by a greatly increased risk of cancer among those diagnosed with the syndrome. The... 
BREAST-CANCER | ONCOLOGY | PATHWAY | SUSCEPTIBILITY | FREQUENCY | MUTATIONS | LEUKEMIA | DNA-REPAIR | PROTEINS | LARGE INTRAGENIC DELETIONS | REGISTRY IFAR | Genetic Predisposition to Disease | Breast Neoplasms - genetics | Neoplasms - genetics | Humans | Female | Heterozygote | Male | Fanconi Anemia - genetics
Journal Article
Journal Article