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Scientific reports, ISSN 2045-2322, 08/2018, Volume 8, Issue 1, pp. 12159 - 1
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. 
Myocardium | Post-transcription | Gene regulation | Dogs | MiRNA
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 04/2018, Volume 83, Issue 7, pp. 3570 - 3581
A ZnCl -catalyzed diastereoselective Joullié-Ugi three-component reaction from 2 H-azirines, isocyanides, and carboxylic acids was established. The protocol... 
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 12, pp. 2143 - 2149
A sequential one-pot approach towards N,N-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides... 
CONVENIENT SYNTHESIS | AMIDINES | SUBSTITUTED GUANIDINES | CHEMISTRY, ORGANIC | BIOLOGICAL-ACTIVITIES | AGENTS | EFFICIENT GUANYLATION | DISUBSTITUTED GUANIDINES | CONCISE SYNTHESIS | SECONDARY-AMINES | CATALYTIC ADDITION | Guanidines | Substrates | Amines
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 08/2018, Volume 212, pp. 38 - 44
A tertiary amine-mediated highly regioselective aromatic nucleophilic substitution (S Ar) protocol was developed in the assemblies of perfluorinated phtalimide... 
Tertiary amine | Regioselective | SNAr | Phtalimide | Aromatic nucleophilic substitution | HALIDES | CHEMISTRY, ORGANIC | ZINC | CHEMISTRY, INORGANIC & NUCLEAR | HETEROARYL CHLORIDES | AMINES | CATALYZED AMINATION | ARYL | Polychlorinated biphenyls | Amines | Ecstasy | Substitutes | Drug addiction | Phthalimide | Regioselectivity | Aromatherapy | Amphetamines | Optimization
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 04/2018, Volume 83, Issue 7, pp. 3570 - 3581
A ZnCl2-catalyzed diastereoselective Joullie Ugi three-component reaction from 2H-azirines, isocyanides, and carboxylic acids was established. The protocol... 
AZIRIDINYL PEPTIDES | MULTICOMPONENT REACTIONS | ASYMMETRIC-SYNTHESIS | 2,4-DISUBSTITUTED OXAZOLES | ENANTIOSELECTIVE SYNTHESIS | N-ACYLAZIRIDINES | CHEMISTRY, ORGANIC | CARBOXYLIC ESTERS | SUBSTITUTED PROLYL PEPTIDES | CYSTEINE PROTEASES | 3+2 CYCLOADDITION
Journal Article
ISSN 1477-0520, 3/2018, Volume 16, Issue 12, pp. 2143 - 2149
A sequential one-pot approach towards N , N ′-disubstituted guanidines from N -chlorophthalimide, isocyanides and amines is reported. This strategy provides... 
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 8, p. 1934
The 8-hydroxyquinoline pharmacophore scaffold has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity, and... 
Betti-reaction | Multicomponent reaction | 8-HQ | 8-hydroxyquinoline | Phenotypic screening | Neurodegeneration | Multitarget directed ligand | HIF1A | Mannich-reaction | Cytoprotection | Mitochondrial membrane potential | CLIOQUINOL | cytoprotection | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial membrane potential | neurodegeneration | multitarget directed ligand | NITROXOLINE | CHEMISTRY, MULTIDISCIPLINARY | NEURODEGENERATIVE DISEASES | MONOAMINE-OXIDASE INHIBITION | DRUGS | A-BETA | phenotypic screening | multicomponent reaction | DERIVATIVES | RASAGILINE | CATHEPSIN-B | Cell Line | Cell Survival - drug effects | Oxyquinoline - pharmacology | Humans | Oxyquinoline - chemical synthesis | Structure-Activity Relationship | Membrane Potential, Mitochondrial - drug effects | Gene Expression Regulation - drug effects | Hypoxia - genetics | Cytoprotection - drug effects | Inhibitory Concentration 50 | Aniline Compounds - chemistry | Cell Death - drug effects | Oxidative Stress - drug effects | Oxyquinoline - chemistry | Aldehydes - chemistry | 8-Hydroxyquinoline | Flow cytometry | Oxidative stress | Animal models | Amines | Toxicity | Central nervous system | Fluorescence | Cytotoxicity | Nervous system | Aldehydes | Assaying | Pyrimidines | Mitochondria | Oxazoles | Formic acid | Chelation | Biocompatibility | Membrane potential | Pyridines | Crystallization | Pharmacology | Gene expression | Hydroxyquinoline | Organic chemistry | Column chromatography | Viability | Scaffolds | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0149832 - e0149832
C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of... 
CANCER-CELLS | APOPTOSIS | UNFOLDED PROTEIN RESPONSE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DOWN-REGULATION | AGENTS | ENDOPLASMIC-RETICULUM STRESS | HUMAN GLIOMA-CELLS | EXPRESSION CHANGES | Neoplasm Transplantation | Curcumin - analogs & derivatives | Cell Proliferation | Receptors, Notch - metabolism | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Rats, Nude | Brain Neoplasms - metabolism | Receptors, Notch - antagonists & inhibitors | Melanoma, Experimental | Inhibitory Concentration 50 | Female | Glioblastoma - metabolism | Transcription, Genetic | Unfolded Protein Response - drug effects | NF-kappa B - antagonists & inhibitors | Signal Transduction | Rats | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Acrylamides - chemistry | Animals | Cell Line, Tumor | Mice | Glioblastoma - drug therapy | Drosophila melanogaster | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Cell proliferation | Protein kinase C | Brain tumors | Brain cancer | Glioblastoma | Cytotoxicity | AKT protein | Kinases | Cancer therapies | Anticancer properties | Proteins | Glioma cells | Transcription activation | Cell cycle | Tumorigenesis | Curcumin | Inhibition | Stress response | Mitoxantrone | NF-κB protein | Drosophila | Gene expression | Signaling | Cell lines | Antitumor activity | Notch protein | Endoplasmic reticulum | Tumors | Apoptosis | Index Medicus
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2017, Volume 18, Issue 10, p. 2105
Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of... 
Curcumin | Caspase-3 | Mitochondrial depolarization | Apoptosis | Endoplasmic reticulum stress | Unfolded protein response | CANCER CELLS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | PROLIFERATION | DEATH | ENDOPLASMIC-RETICULUM STRESS | CHEMISTRY, MULTIDISCIPLINARY | endoplasmic reticulum stress | mitochondrial depolarization | unfolded protein response | THERAPY | PATHWAY | curcumin | caspase-3 | Transcription Factor CHOP - genetics | Unfolded Protein Response - drug effects | Curcumin - analogs & derivatives | Heat-Shock Proteins - metabolism | Humans | Curcumin - pharmacology | Activating Transcription Factor 4 - genetics | Hep G2 Cells | Mitochondrial Membranes - metabolism | Mitochondrial Membranes - drug effects | Heat-Shock Proteins - genetics | Activating Transcription Factor 4 - metabolism | Cell Cycle Checkpoints - drug effects | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Transcription Factor CHOP - metabolism | X-Box Binding Protein 1 - genetics | DNA damage | Cytotoxicity | Hepatocellular carcinoma | Drug development | Depolarization | Analogs | Mitochondria | Pancreatic carcinoma | Protein folding | Cell cycle | Membrane potential | Phosphatidylserine | Deoxyribonucleic acid--DNA | GRP78 protein | Non-small cell lung carcinoma | Caspase | Lung carcinoma | Gene expression | Membrane proteins | Pancreatic cancer | Toxins | Endoplasmic reticulum | Index Medicus
Journal Article
ISSN 1477-0520, 10/2013, Volume 11, Issue 37, pp. 632 - 6327
Pyrazole-based β-aminonitriles and β-amino-carbaldehydes as bifunctional building blocks are introduced in a facile copper( ii )-catalysed one-pot domino... 
Journal Article
Acta Biologica Szegediensis, ISSN 1588-385X, 2015, Volume 59, pp. 51 - 67
Journal Article
Journal Article
The Journal of organic chemistry, 03/2019, Volume 84, Issue 7, pp. 4273 - 4281
A regio- and diastereoselective 1,3-dipolar cycloaddition of 2 H-azirines with azomethine ylides generated in situ from isatins and α-amino acids has been... 
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 1, pp. 15 - 22
Journal Article