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index medicus (18) 18
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1. Full Text FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
by Claussnitzer, Melina and Dankel, Simon N and Kim, Kyoung-Han and Quon, Gerald and Meuleman, Wouter and Haugen, Christine and Glunk, Viktoria and Sousa, Isabel S and Beaudry, Jacqueline L and Puviindran, Vijitha and Abdennur, Nezar A and Liu, Jannel and Svensson, Per-Arne and Hsu, Yi-Hsiang and Drucker, Daniel J and Mellgren, Gunnar and Hui, Chi-Chung and Hauner, Hans and Kellis, Manolis and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
The New England Journal of Medicine, ISSN 0028-4793, 09/2015, Volume 373, Issue 10, pp. 895 - 907
In this study, the authors used epigenetics, allelic activity, motif conservation, and other techniques to dissect the regulatory circuitry and mechanistic... 
MEDICINE, GENERAL & INTERNAL | IRX3 | GENE-EXPRESSION | BODY-MASS INDEX | RISK | ADULT OBESITY | CHILDHOOD | LOCUS | ADIPOSE-TISSUE | Thermogenesis - genetics | Gene Expression | Epigenomics | RNA Editing | Humans | Molecular Sequence Data | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Risk | Mitochondria - metabolism | Obesity - genetics | Obesity - metabolism | Proteins - genetics | Thermogenesis - physiology | Phenotype | Animals | Genetic Engineering | Adipocytes - metabolism | Base Sequence | Alleles | Clustered Regularly Interspaced Short Palindromic Repeats | Mice | Haplotypes | Obesity | Care and treatment | Research | Gene expression | Appetite | CRISPR | Adipose tissue | Physical activity | Body fat | Genomics | Genes | Body weight | Genomes | Adipocytes | Weight control | Conserved sequence | Mitochondria | Thermogenesis | Derepression | Gastrointestinal surgery | Cell and Molecular Biology | Cell- och molekylärbiologi
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2. Full Text Obesity-associated variants within FTO form long-range functional connections with IRX3
by Smemo, Scott and Tena, Juan J and Kim, Kyoung-Han and Gamazon, Eric R and Sakabe, Noboru J and Gómez-Marín, Carlos and Aneas, Ivy and Credidio, Flavia L and Sobreira, Débora R and Wasserman, Nora F and Lee, Ju Hee and Puviindran, Vijitha and Tam, Davis and Shen, Michael and Son, Joe Eun and Vakili, Niki Alizadeh and Sung, Hoon-Ki and Naranjo, Silvia and Acemel, Rafael D and Manzanares, Miguel and Nagy, Andras and Cox, Nancy J and Hui, Chi-Chung and Gomez-Skarmeta, Jose Luis and Nóbrega, Marcelo A
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 371 - 375
Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes... 
ELEMENTS | BROWSER | DATABASE | MULTIDISCIPLINARY SCIENCES | MASS | TISSUE | GENE-EXPRESSION | NEURONS | REVEAL | CHILDHOOD | VERTEBRATE | Basal Metabolism - genetics | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Humans | Transcription Factors - deficiency | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Zebrafish - embryology | Body Weight - genetics | Obesity - genetics | Promoter Regions, Genetic - genetics | Brain - metabolism | Adipose Tissue - metabolism | Oxo-Acid-Lyases - genetics | Body Mass Index | Introns - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Zebrafish - genetics | Proteins - genetics | Transcription Factors - metabolism | Thinness - genetics | Phenotype | Animals | Hypothalamus - metabolism | Diet | Polymorphism, Single Nucleotide - genetics | Mice | Mixed Function Oxygenases - genetics | Genes, Dominant - genetics | Obesity | Genome-wide association studies | Homeobox genes | Body weight | Genomics | Genetic aspects | Single nucleotide polymorphisms | Properties | Gene expression | Homeotic genes | Brain | Weight control | Rodents | Genomes | Artificial chromosomes
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3. Full Text Mutant IDH is sufficient to initiate enchondromatosis in mice
by Makoto Hirata and Masato Sasaki and Rob A. Cairns and Satoshi Inoue and Vijitha Puviindran and Wanda Y. Li and Bryan E. Snow and Lisa D. Jones and Qingxia Wei and Shingo Sato and Yuning J. Tang and Puviindran Nadesan and Jason Rockel and Heather Whetstone and Raymond Poon and Angela Weng and Stefan Gross and Kimberly Straley and Camelia Gliser and Yingxia Xu and Jay Wunder and Tak W. Mak and Benjamin A. Alman
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2015, Volume 112, Issue 9, pp. 2829 - 2834
Enchondromas are benign cartilage tumors and precursors to malignant chondrosarcomas. Somatic mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2)... 
Isocitrate dehydrogenase | Hedgehog | Cartilage tumor | MAFFUCCI SYNDROME | isocitrate dehydrogenase | CHONDROCYTES | MULTIDISCIPLINARY SCIENCES | CRE RECOMBINASE | FREQUENT MUTATION | CELL-PROLIFERATION | INDIAN HEDGEHOG | CARTILAGE TUMORS | hedgehog | OLLIER-DISEASE | GROWTH-PLATE | BONE | cartilage tumor | Chondrocytes - pathology | Isocitrate Dehydrogenase - biosynthesis | Enchondromatosis - enzymology | Humans | Isocitrate Dehydrogenase - genetics | Mutation, Missense | Collagen Type II - genetics | Gene Expression Regulation, Enzymologic | Chondrocytes - enzymology | Animals | Mice, Mutant Strains | Glutarates - adverse effects | Mice | Glutarates - pharmacology | Enchondromatosis - pathology | Enchondromatosis - genetics | Amino Acid Substitution | Collagen Type II - biosynthesis | Development and progression | Dysplasia | Bone diseases | Health aspects | Biological Sciences
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4. Full Text Pharmacologic targeting of β-catenin improves fracture healing in old mice
by Kwak, Yoon Hae and Barrientos, Tomasa and Furman, Bridgette and Zhang, Hazel and Puviindran, Vijitha and Cutcliffe, Hattie and Herfarth, Jonas and Nwankwo, Eugene and Alman, Benjamin A
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 9005 - 9
beta-catenin protein needs to be precisely regulated for effective fracture repair. The pace of fracture healing slows with age, associated with a transient... 
REPAIR | INHIBITION | MECHANICAL-PROPERTIES | MULTIDISCIPLINARY SCIENCES | GROWTH | AGE | Proteins | β-catenin | Fractures | Computed tomography | Colonies | Tibia | Mechanical properties | Bone marrow | Bone healing | Osteoblasts | Osteogenesis | Geriatrics
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5. Full Text Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
by Vi, Linda and Baht, Gurpreet S and Soderblom, Erik J and Whetstone, Heather and Wei, Qingxia and Furman, Bridgette and Puviindran, Vijitha and Nadesan, Puviindran and Foster, Matthew and Poon, Raymond and White, James P and Yahara, Yasuhito and Ng, Adeline and Barrientos, Tomasa and Grynpas, Marc and Mosely, M. Arthur and Alman, Benjamin A
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5191 - 12
The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for... 
INACTIVATION | GENE | REGENERATION | MULTIDISCIPLINARY SCIENCES | FRACTURE REPAIR | TISSUE | NEWLY SYNTHESIZED PROTEINS | DIFFERENTIATION | BETA-CATENIN | RECEPTOR-RELATED PROTEIN-1 | AGE | Stromal Cells - transplantation | Humans | Male | Fractures, Bone - genetics | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Female | Osteoblasts - cytology | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Stromal Cells - metabolism | Rejuvenation | Receptors, LDL - metabolism | Fractures, Bone - metabolism | Macrophages - metabolism | Animals | Fracture Healing | Fractures, Bone - physiopathology | Mice | Fractures, Bone - therapy | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Osteogenesis | Stromal Cells - cytology | Syngeneic grafts | Bone marrow transplantation | Defense contracts | Transplantation | Bone healing | Macrophages | Parabiosis | Proteins | Biomedical materials | Depletion | Osteoblastogenesis | Fractures | Stromal cells | Bone marrow | Healing | Receptor density | Biocompatibility | Repair | Recombinant
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6. Full Text Intracellular biosynthesis of lipids and cholesterol by Scap and insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
by Tsushima, Hidetoshi and Tang, Yuning J and Puviindran, Vijitha and Hsu, Shu-Hsuan Claire and Nadesan, Puviindran and Yu, Chunying and Zhang, Hongyuan and Mirando, Anthony J and Hilton, Matthew J and Alman, Benjamin A
Development (Cambridge), ISSN 0950-1991, 07/2018, Volume 145, Issue 13, pp. dev162396 - dev162396
During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated... 
Scap | Chondrocyte | Insig | Enchodral | Cholesterol | RECEPTOR | DEVELOPMENTAL BIOLOGY | MODEL | METABOLISM | PATHWAY | OSTEOARTHRITIS | PROTEINS | PLATE | EXPRESSION | Chondrocytes - cytology | Membrane Proteins - genetics | Bone Development - physiology | Hedgehog Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cholesterol - genetics | Mice, Knockout | Animals | Hedgehog Proteins - genetics | Mesenchymal Stem Cells - cytology | Signal Transduction - physiology | Membrane Proteins - metabolism | Mice | Cholesterol - biosynthesis | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | Phenotypes | Mesenchyme | Homeostasis | Lipids | Intracellular signalling | Biosynthesis | Ossification | Dwarfism | Cartilage | Bone growth | Clonal deletion | Hedgehog protein | Chondrocytes | Bone (long) | Intracellular | Chondrogenesis | 209
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7. Full Text Iroquois homeobox gene 3 establishes fast conduction in the cardiac His–Purkinje network
by Shan-Shan Zhang and Kyoung-Han Kim and Anna Rosen and James W. Smyth and Rui Sakuma and Paul Delgado-Olguín and Mark Davis and Neil C. Chi and Vijitha Puviindran and Nathalie Gaborit and Tatyana Sukonnik and John N. Wylie and Koroboshka Brand-Arzamendi and Gerrie P. Farman and Jieun Kim and Robert A. Rose and Phillip A. Marsden and Yonghong Zhu and Yu-Qing Zhou and Lucile Miquerol and R. Mark Henkelman and Didier Y. R. Stainier and Robin M. Shaw and Chi-chung Hui and Benoit G. Bruneau and Peter H. Backx
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 33, pp. 13576 - 13581
Rapid electrical conduction in the His–Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light... 
Heart | Conduction | Messenger RNA | Gap junctions | Genes | Imaging | Electrocardiography | Evolution | Bundle branch block | Gene expression | Development | Electrophysiology | Transcription factor | Transcription Factors - physiology | Bundle of His - physiology | Heart Conduction System | Gene Expression Regulation | Connexins - genetics | Gap Junctions | Heart Ventricles | Animals | Transcription, Genetic | Mice | Homeodomain Proteins - physiology | Genes, Homeobox | Purkinje Fibers - physiology | Connexin 43 - genetics | Morphogenesis | Cardiovascular system | Transcription factors | Homeobox genes | Physiological aspects | Research | Homeotic genes | Biological Sciences | transcription factor | development | electrophysiology
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8. Full Text Hedgehog inhibits [beta]-catenin activity in synovial joint development and osteoarthritis
by Rockel, Jason S and Yu, Chunying and Whetstone, Heather and Craft, April M and Reilly, Katherine and Ma, Henry and Tsushima, Hidetoshi and Puviindran, Vijitha and Jazrawe, Mushriq Al and Keller, Gordon M and Alman, Benjamin A
Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, p. 1649
Both the WNT/[beta]-catenin and hedgehog signaling pathways are important in the regulation of limb development, chondrocyte differentiation, and degeneration... 
Analysis | Fibroblast growth factors | Research | Cell differentiation | Osteoarthritis | Health aspects | Risk factors | Studies | Morphogenesis | Cloning | Bones | Arthritis | Gene expression | Experiments
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9. Full Text Antagonistic and Cooperative Actions of Kif7 and Sufu Define Graded Intracellular Gli Activities in Hedgehog Signaling
by Law, Kelvin King Lo and Makino, Shigeru and Mo, Rong and Zhang, Xiaoyun and Puviindran, Vijitha and Hui, Chi-chung
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e50193
Graded Hedgehog (Hh) signaling governs the balance of Gli transcriptional activators and repressors to specify diverse ventral cell fates in the spinal cord.... 
SUPPRESSOR | PROGENITOR-CELL IDENTITY | SHH | RETINOIC ACID | PROTEIN | FLOOR PLATE | MULTIDISCIPLINARY SCIENCES | VERTEBRATE NEURAL-TUBE | MOUSE | NEURONAL FATE | SPINAL-CORD | Hedgehog Proteins - metabolism | Repressor Proteins - genetics | Blotting, Western | Kinesin - metabolism | Mice, Knockout | Microscopy, Confocal | Spinal Cord - embryology | Animals | In Situ Hybridization | Analysis of Variance | Kruppel-Like Transcription Factors - metabolism | Fluorescent Antibody Technique | Kinesin - genetics | Signal Transduction - physiology | Mice | Zinc Finger Protein GLI1 | Spinal Cord - cytology | Cell Differentiation - physiology | Repressor Proteins - metabolism | Spinal cord | Transcription factors | Transcription | Genomics | Genes | Intracellular signalling | Biology | Cell fate | Repressors | Hedgehog protein | Rodents | Stem cells | Intracellular
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10. Full Text Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis
by Tang, Yuning J and Huang, Jianguo and Tsushima, Hidetoshi and Ban, Ga I and Zhang, Hongyuan and Oristian, Kristianne M and Puviindran, Vijitha and Williams, Nerissa and Ding, Xiruo and Ou, Jianhong and Jung, Sin-Ho and Lee, Chang-Lung and Jiao, Yiqun and Chen, Benny J and Kirsch, David G and Alman, Benjamin A
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 11, pp. 2837 - 2850.e5
Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor... 
sarcoma | lineage tracing | clonal evolution | suppressors of metastasis | cancer metastasis | tumor heterogeneity | GENE-MUTATIONS | INACTIVATION | IMPACT | RETINOIC ACID | CANCER METASTASIS | INTRATUMOR HETEROGENEITY | EXPRESSION | SOFT-TISSUE SARCOMA | PRINCIPLES | STEM | CELL BIOLOGY
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11. Full Text Irx3 is required for postnatal maturation of the mouse ventricular conduction system
by Kim, Kyoung-Han and Rosen, Anna and Hussein, Samer M. I and Puviindran, Vijitha and Korogyi, Adam S and Chiarello, Carmelina and Nagy, Andras and Hui, Chi-Chung and Backx, Peter H
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 19197
The ventricular conduction system (VCS) orchestrates the harmonious contraction in every heartbeat. Defects in the VCS are often associated with... 
ENDOTHELIN-CONVERTING ENZYME-1 | PATHWAY | MULTIDISCIPLINARY SCIENCES | CONGENITAL HEART-DISEASE | IN-VIVO | MUTATIONS | HOLT-ORAM-SYNDROME | NKX2-5 | TBX5 | MOTIF | TRANSCRIPTION-FACTORS | Brugada Syndrome - genetics | Homeodomain Proteins - metabolism | Homeobox Protein Nkx-2.5 - metabolism | Heart Conduction System - growth & development | Brugada Syndrome - metabolism | Electrocardiography | Homeobox Protein Nkx-2.5 - genetics | Cardiac Conduction System Disease | Heart Ventricles - pathology | Gene Expression | Heart Conduction System - metabolism | Gene Expression Regulation | Connexins - genetics | Models, Molecular | Transcription Factors - genetics | Homeodomain Proteins - genetics | T-Box Domain Proteins - metabolism | Connexins - metabolism | Mice, Knockout | Transcription Factors - metabolism | Animals | Heart Conduction System - physiopathology | Protein Binding | Heart Ventricles - metabolism | Mice | EKG | Cardiac arrhythmia | Conduction | Transcription | Gap junctions | Cardiomyocytes | Connexin 43 | Coronary artery disease | Contraction | Defects | Recruitment | Homeobox | Morphology | Computer applications | Ventricle | Heart diseases | Nkx2.5 protein | Apoptosis
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12. Full Text T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor
by Makino, Shigeru and Zhulyn, Olena and Mo, Rong and Puviindran, Vijitha and Zhang, Xiaoyun and Murata, Takuya and Fukumura, Ryutaro and Ishitsuka, Yuichi and Kotaki, Hayato and Matsumaru, Daisuke and Ishii, Shunsuke and Hui, Chi-Chung and Gondo, Yoichi
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0119455 - e0119455
Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be... 
SUPPRESSOR | SHH | ACTIVATION | LIMB DEVELOPMENT | SONIC HEDGEHOG | BETA-TRCP | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | DEGRADATION | INDEPENDENT REGULATION | NEGATIVE REGULATOR | Polydactyly - genetics | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Repressor Proteins - genetics | Mutation, Missense | Polydactyly - embryology | Threonine - metabolism | Kruppel-Like Transcription Factors - chemistry | Isoleucine - metabolism | Nerve Tissue Proteins - metabolism | Nerve Tissue Proteins - chemistry | Animals | Kruppel-Like Transcription Factors - metabolism | Body Patterning | Mice | Protein Stability | Extremities - growth & development | Repressor Proteins - metabolism | Physiological aspects | Transcription factors | Cellular signal transduction | Genetic aspects | Research | Gene mutations | Regulations | Genomics | Biology | Genomes | Kinases | Embryos | Defects | Limb buds | Proteins | Signal transduction | Signaling | Ethyl nitrosourea | Hospitals | Mutagenesis | Insects | Hedgehog protein | Morphology | Alleles | Polydactyly | Stem cells | Genetics | Mutation | Index Medicus
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13. Full Text Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis
by Rockel, Jason S and Yu, Chunying and Whetstone, Heather and Craft, April M and Reilly, Katherine and Ma, Henry and Tsushima, Hidetoshi and Puviindran, Vijitha and Al-Jazrawe, Mushriq and Keller, Gordon M and Alman, Benjamin A
Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1649 - 1663
Both the WNT/β-catenin and hedgehog signaling pathways are important in the regulation of limb development, chondrocyte differentiation, and degeneration of... 
ADAMTS4 Protein - genetics | Chondrocytes - immunology | Humans | Wnt Signaling Pathway - immunology | Fibroblast Growth Factors - genetics | Synovial Membrane - immunology | Fibroblast Growth Factors - immunology | beta Catenin - immunology | Hedgehog Proteins - genetics | Transcription Factor 7-Like 2 Protein - immunology | Osteoarthritis - pathology | Disease Models, Animal | Chondrocytes - pathology | Transcription Factor 7-Like 2 Protein - genetics | Osteoarthritis - immunology | ADAMTS4 Protein - immunology | Synovial Membrane - metabolism | Osteoarthritis - genetics | beta Catenin - genetics | Mice, Knockout | Animals | Wnt Signaling Pathway - genetics | Down-Regulation - immunology | Mice | Hedgehog Proteins - immunology
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