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science & technology (22) 22
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1. Full Text FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
by Claussnitzer, Melina and Dankel, Simon N and Kim, Kyoung-Han and Quon, Gerald and Meuleman, Wouter and Haugen, Christine and Glunk, Viktoria and Sousa, Isabel S and Beaudry, Jacqueline L and Puviindran, Vijitha and Abdennur, Nezar A and Liu, Jannel and Svensson, Per-Arne and Hsu, Yi-Hsiang and Drucker, Daniel J and Mellgren, Gunnar and Hui, Chi-Chung and Hauner, Hans and Kellis, Manolis and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
The New England journal of medicine, ISSN 0028-4793, 09/2015, Volume 373, Issue 10, pp. 895 - 907
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Thermogenesis - genetics | Gene Expression | Epigenomics | RNA Editing | Humans | Molecular Sequence Data | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Risk | Mitochondria - metabolism | Obesity - genetics | Obesity - metabolism | Proteins - genetics | Thermogenesis - physiology | Phenotype | Animals | Genetic Engineering | Adipocytes - metabolism | Base Sequence | Alleles | Clustered Regularly Interspaced Short Palindromic Repeats | Mice | Haplotypes | Obesity | Care and treatment | Research | Gene expression | Appetite | CRISPR | Adipose tissue | Physical activity | Body fat | Genomics | Genes | Body weight | Genomes | Adipocytes | Weight control | Conserved sequence | Mitochondria | Thermogenesis | Derepression | Gastrointestinal surgery | Index Medicus | Abridged Index Medicus | IRX3 | Cell and Molecular Biology | GENE-EXPRESSION | BODY-MASS INDEX | RISK | Cell- och molekylärbiologi | ADULT OBESITY | CHILDHOOD | LOCUS | ADIPOSE-TISSUE
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2. Full Text Obesity-associated variants within FTO form long-range functional connections with IRX3
by Smemo, Scott and Tena, Juan J and Kim, Kyoung-Han and Gamazon, Eric R and Sakabe, Noboru J and Gómez-Marín, Carlos and Aneas, Ivy and Credidio, Flavia L and Sobreira, Débora R and Wasserman, Nora F and Lee, Ju Hee and Puviindran, Vijitha and Tam, Davis and Shen, Michael and Son, Joe Eun and Vakili, Niki Alizadeh and Sung, Hoon-Ki and Naranjo, Silvia and Acemel, Rafael D and Manzanares, Miguel and Nagy, Andras and Cox, Nancy J and Hui, Chi-Chung and Gomez-Skarmeta, Jose Luis and Nóbrega, Marcelo A
Nature (London), ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 371 - 375
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Basal Metabolism - genetics | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Humans | Transcription Factors - deficiency | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Zebrafish - embryology | Body Weight - genetics | Obesity - genetics | Promoter Regions, Genetic - genetics | Brain - metabolism | Adipose Tissue - metabolism | Oxo-Acid-Lyases - genetics | Body Mass Index | Introns - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Zebrafish - genetics | Proteins - genetics | Transcription Factors - metabolism | Thinness - genetics | Phenotype | Animals | Hypothalamus - metabolism | Diet | Polymorphism, Single Nucleotide - genetics | Mice | Mixed Function Oxygenases - genetics | Genes, Dominant - genetics | Obesity | Genome-wide association studies | Homeobox genes | Body weight | Genomics | Genetic aspects | Single nucleotide polymorphisms | Properties | Gene expression | Homeotic genes | Brain | Weight control | Rodents | Genomes | Artificial chromosomes | Index Medicus
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3. Full Text Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair
by Yahara, Yasuhito and Barrientos, Tomasa and Tang, Yuning J and Puviindran, Vijitha and Nadesan, Puviindran and Zhang, Hongyuan and Gibson, Jason R and Gregory, Simon G and Diao, Yarui and Xiang, Yu and Qadri, Yawar J and Souma, Tomokazu and Shinohara, Mari L and Alman, Benjamin A
Nature cell biology, ISSN 1465-7392, 01/2020, Volume 22, Issue 1, pp. 49 - 59
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Macrophages - metabolism | Animals | Yolk Sac - metabolism | Homeostasis - physiology | Hematopoiesis - physiology | Hematopoietic Stem Cells - metabolism | Mice | Cell Differentiation - physiology | Osteoclasts - metabolism | Cell Lineage - physiology | Physiological aspects | Homeostasis | Scientific equipment and supplies industry | Macrophages | Statistics | Hematopoietic stem cells | Spleen | Osteoprogenitor cells | Neonates | Bone remodelling | Labelling | CX3CR1 protein | Bone turnover | Ribonucleic acid--RNA | Cell fusion | Parabiosis | Gene sequencing | Monocytes | Biomedical materials | Precursors | Stem cells | Bone marrow | Osteoclasts | Repair | Yolk | Index Medicus
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4. Full Text Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
by Vi, Linda and Baht, Gurpreet S and Soderblom, Erik J and Whetstone, Heather and Wei, Qingxia and Furman, Bridgette and Puviindran, Vijitha and Nadesan, Puviindran and Foster, Matthew and Poon, Raymond and White, James P and Yahara, Yasuhito and Ng, Adeline and Barrientos, Tomasa and Grynpas, Marc and Mosely, M. Arthur and Alman, Benjamin A
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5191 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Stromal Cells - transplantation | Humans | Male | Fractures, Bone - genetics | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Female | Osteoblasts - cytology | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Stromal Cells - metabolism | Rejuvenation | Receptors, LDL - metabolism | Fractures, Bone - metabolism | Macrophages - metabolism | Animals | Fracture Healing | Fractures, Bone - physiopathology | Mice | Fractures, Bone - therapy | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Osteogenesis | Stromal Cells - cytology | Syngeneic grafts | Bone marrow transplantation | Defense contracts | Transplantation | Bone healing | Macrophages | Parabiosis | Proteins | Biomedical materials | Depletion | Osteoblastogenesis | Fractures | Stromal cells | Bone marrow | Healing | Receptor density | Biocompatibility | Repair | Index Medicus
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5. Full Text Intracellular biosynthesis of lipids and cholesterol by Scap and insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
by Tsushima, Hidetoshi and Tang, Yuning J and Puviindran, Vijitha and Hsu, Shu-Hsuan Claire and Nadesan, Puviindran and Yu, Chunying and Zhang, Hongyuan and Mirando, Anthony J and Hilton, Matthew J and Alman, Benjamin A
Development (Cambridge), ISSN 0950-1991, 07/2018, Volume 145, Issue 13, pp. dev162396 - dev162396
Scap | Chondrocyte | Insig | Enchodral | Cholesterol | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Chondrocytes - cytology | Membrane Proteins - genetics | Bone Development - physiology | Hedgehog Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cholesterol - genetics | Mice, Knockout | Animals | Hedgehog Proteins - genetics | Mesenchymal Stem Cells - cytology | Signal Transduction - physiology | Membrane Proteins - metabolism | Mice | Cholesterol - biosynthesis | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | Phenotypes | Mesenchyme | Homeostasis | Lipids | Intracellular signalling | Biosynthesis | Ossification | Dwarfism | Cartilage | Bone growth | Clonal deletion | Hedgehog protein | Chondrocytes | Bone (long) | Intracellular | Chondrogenesis | Index Medicus | 209
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6. Full Text Pharmacologic targeting of β-catenin improves fracture healing in old mice
by Kwak, Yoon Hae and Barrientos, Tomasa and Furman, Bridgette and Zhang, Hazel and Puviindran, Vijitha and Cutcliffe, Hattie and Herfarth, Jonas and Nwankwo, Eugene and Alman, Benjamin A
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 9005 - 9
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proteins | β-catenin | Fractures | Computed tomography | Colonies | Tibia | Mechanical properties | Bone marrow | Bone healing | Osteoblasts | Osteogenesis | Geriatrics | Index Medicus
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7. Full Text Irx3 is required for postnatal maturation of the mouse ventricular conduction system
by Kim, Kyoung-Han and Rosen, Anna and Hussein, Samer M. I and Puviindran, Vijitha and Korogyi, Adam S and Chiarello, Carmelina and Nagy, Andras and Hui, Chi-Chung and Backx, Peter H
Scientific reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, pp. 19197 - 19197
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Brugada Syndrome - genetics | Homeodomain Proteins - metabolism | Homeobox Protein Nkx-2.5 - metabolism | Heart Conduction System - growth & development | Brugada Syndrome - metabolism | Electrocardiography | Homeobox Protein Nkx-2.5 - genetics | Cardiac Conduction System Disease | Heart Ventricles - pathology | Gene Expression | Heart Conduction System - metabolism | Gene Expression Regulation | Connexins - genetics | Models, Molecular | Transcription Factors - genetics | Homeodomain Proteins - genetics | T-Box Domain Proteins - metabolism | Connexins - metabolism | Mice, Knockout | Transcription Factors - metabolism | Animals | Heart Conduction System - physiopathology | Protein Binding | Heart Ventricles - metabolism | Mice | EKG | Cardiac arrhythmia | Conduction | Transcription | Gap junctions | Cardiomyocytes | Connexin 43 | Coronary artery disease | Contraction | Defects | Recruitment | Homeobox | Morphology | Computer applications | Ventricle | Heart diseases | Nkx2.5 protein | Apoptosis | Index Medicus
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8. Full Text Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling
by Li, Danyi and Sakuma, Rui and Vakili, Niki A and Mo, Rong and Puviindran, Vijitha and Deimling, Steven and Zhang, Xiaoyun and Hopyan, Sevan and Hui, Chi-chung
Developmental cell, ISSN 1534-5807, 04/2014, Volume 29, Issue 2, pp. 233 - 240
Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Tibia - physiology | Bone Development - physiology | Homeodomain Proteins - metabolism | Hedgehog Proteins - metabolism | Hindlimb - physiology | Femur - embryology | Tibia - embryology | Transcription Factors - genetics | Limb Buds - embryology | Homeodomain Proteins - genetics | Body Patterning - physiology | Mice, Knockout | Femur - physiology | Transcription Factors - metabolism | Toes - embryology | Animals | Limb Buds - metabolism | Toes - physiology | Hedgehog Proteins - genetics | Gene Expression Regulation, Developmental | Hindlimb - embryology | Signal Transduction - physiology | Mice | Mutation | Children's hospitals | Stem cells | Index Medicus
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9. Full Text Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis
by Tang, Yuning J and Huang, Jianguo and Tsushima, Hidetoshi and Ban, Ga I and Zhang, Hongyuan and Oristian, Kristianne M and Puviindran, Vijitha and Williams, Nerissa and Ding, Xiruo and Ou, Jianhong and Jung, Sin-Ho and Lee, Chang-Lung and Jiao, Yiqun and Chen, Benny J and Kirsch, David G and Alman, Benjamin A
Cell reports (Cambridge), ISSN 2211-1247, 09/2019, Volume 28, Issue 11, pp. 2837 - 2850.e5
sarcoma | lineage tracing | clonal evolution | suppressors of metastasis | cancer metastasis | tumor heterogeneity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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