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1. Full Text Long‐Read Single Molecule Real‐Time Full Gene Sequencing of Cytochrome P450‐2D6
by Qiao, Wanqiong and Yang, Yao and Sebra, Robert and Mendiratta, Geetu and Gaedigk, Andrea and Desnick, Robert J and Scott, Stuart A
Human Mutation, ISSN 1059-7794, 03/2016, Volume 37, Issue 3, pp. 315 - 323
ABSTRACT The cytochrome P450‐2D6 (CYP2D6) enzyme metabolizes ∼25% of common medications, yet homologous pseudogenes and copy number variants (CNVs) make... 
pharmacogenomics | CYP2D6 | gene duplication | single molecule real‐time (SMRT) sequencing | long‐read sequencing | pharmacogenetics | Pacific Biosciences | Pharmacogenetics | Single molecule real-time (SMRT) sequencing | Long-read sequencing | Gene duplication | Pharmacogenomics | ALLELE | DEFECT | CODEINE THERAPY | IDENTIFICATION | long-read sequencing | LOCUS | CYP2C19 GENOTYPES | AMPLIFICATION | single molecule real-time (SMRT) sequencing | GENETICS & HEREDITY | CYP2D6 GENE | DEBRISOQUINE | PHARMACOGENETICS IMPLEMENTATION CONSORTIUM | Cytochrome P-450 CYP2D6 - genetics | Genotype | Gene Frequency - genetics | Humans | Alleles | Nucleotide sequencing | Analysis | Genes | Cytochrome P-450 | DNA sequencing | Cytochrome | Enzymes | Genotype & phenotype | Metabolism | Polymorphism | Index Medicus | single-molecule real-time (SMRT) sequencing
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2. Full Text Acute Intermittent Porphyria: Predicted Pathogenicity of HMBS Variants Indicates Extremely Low Penetrance of the Autosomal Dominant Disease
by Chen, Brenden and Solis‐Villa, Constanza and Hakenberg, Jörg and Qiao, Wanqiong and Srinivasan, Ramakrishnan R and Yasuda, Makiko and Balwani, Manisha and Doheny, Dana and Peter, Inga and Chen, Rong and Desnick, Robert J
Human Mutation, ISSN 1059-7794, 11/2016, Volume 37, Issue 11, pp. 1215 - 1222
ABSTRACT Acute intermittent porphyria results from hydroxymethylbilane synthase (HMBS) mutations that markedly decrease HMBS enzymatic activity. This dominant... 
in silico prediction | disease penetrance | in vitro expression | allele frequency | allele prevalence | MISSENSE VARIANTS | POPULATION | PORPHOBILINOGEN DEAMINASE GENE | STABILITY CHANGES | AMINO-ACID SUBSTITUTIONS | SEQUENCE VARIANTS | CLINICAL CONSEQUENCES | HYDROXYMETHYLBILANE SYNTHASE GENE | GENETICS & HEREDITY | PROTEIN MUTATIONS | WEB SERVER | Genetic Variation | European Continental Ancestry Group - genetics | Computer Simulation | Gene Frequency | Humans | Porphyria, Acute Intermittent - genetics | Female | Male | Penetrance | Porphyria, Acute Intermittent - ethnology | Sequence Analysis, DNA | Porphyria | Career development | Enzymes | Medical research | Algorithms | Gene mutations | Medicine, Experimental | Genes | Mutation
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3. Full Text Surface vs. solution hybridization: effects of salt, temperature, and probe typeElectronic supplementary information (ESI) available: Experimental methods; ΔH° and ΔS° tables; and results of surface chemistry studies. See DOI: 10.1039/c5cc06674c
by Qiao, Wanqiong and Chiang, Hao-Chun and Xie, Hui and Levicky, Rastislav
ISSN 1359-7345, 11/2015, Volume 51, Issue 97, pp. 17245 - 17248
Hybridization thermodynamics on solid supports are compared with those in solution for two types of hybridization probe, DNA and uncharged morpholino... 
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4. Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection
by Qiao, Wanqiong and Martis, Suparna and Mendiratta, Geetu and Shi, Lisong and Botton, Mariana R and Yang, Yao and Gaedigk, Andrea and Vijzelaar, Raymon and Edelmann, Lisa and Kornreich, Ruth and Desnick, Robert J and Scott, Stuart A
Pharmacogenomics, ISSN 1462-2416, 01/2019, Volume 20, Issue 1, pp. 9 - 20
Aim: To comprehensively interrogate CYP2D6 by integrating genotyping, copy number analysis and novel strategies to identify CYP2D6*36 and characterize CYP2D6... 
Pharmacogenetics | Copy number variation | Genotyping | MLPA | CYP2D6 | FREQUENCIES | genotyping | DNA REFERENCE MATERIALS | CYP2C19 | LOCUS | CYP2D636 | GENOTYPES | CONSORTIUM CPIC GUIDELINE | copy number variation | GENE | PHARMACOLOGY & PHARMACY | ASHKENAZI | ASSOCIATION | pharmacogenetics
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5. Full Text Kinetic Mechanisms in Morpholino–DNA Surface Hybridization
by Liu, Yatao and Irving, Damion and Qiao, Wanqiong and Ge, Dongbiao and Levicky, Rastislav
Journal of the American Chemical Society, ISSN 0002-7863, 08/2011, Volume 133, Issue 30, pp. 11588 - 11596
Morpholinos (MOs) are DNA analogues whose uncharged nature can bring fundamental advantages to surface hybridization technologies such as DNA microarrays, by... 
GOLD ELECTRODES | LABEL-FREE | PROBE DENSITY | FLUORESCENCE SPECTROSCOPY | PEPTIDE-NUCLEIC-ACID | OLIGONUCLEOTIDE HYBRIDIZATION | SINGLE-STRANDED-DNA | CHEMISTRY, MULTIDISCIPLINARY | SEQUENTIAL ADSORPTION | PLASMON RESONANCE | MELTING CURVES | DNA - chemistry | Nucleic Acid Hybridization | Peptide Nucleic Acids - chemistry | Kinetics | Surface Properties | Morpholines - chemistry | Oligomers | Usage | DNA microarrays | Research | Structure | Nucleic acid hybridization
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6. Full Text Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6
: Human Mutation
by Qiao, Wanqiong and Yang, Yao and Sebra, Robert and Mendiratta, Geetu and Gaedigk, Andrea and Desnick, Robert J and Scott, Stuart A
Human Mutation, ISSN 1059-7794, 03/2016, Volume 37, Issue 3, pp. 315 - 323
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7. Surface vs. solution hybridization: effects of salt, temperature, and probe type
by Qiao, Wanqiong and Chiang, Hao-Chun and Xie, Hui and Levicky, Rastislav
Chemical Communications: Chem Comm, ISSN 1359-7345, 11/2015, Volume 51, Issue 97, pp. 17245 - 17248
Hybridization thermodynamics on solid supports are compared with those in solution for two types of hybridization probe, DNA and uncharged morpholino... 
Thermodynamics | Deoxyribonucleic acid | Oligonucleotides | Affinity | Trends | Strength | Gene sequencing
Journal Article
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8. Full Text Surface vs. solution hybridization: Effects of salt, temperature, and probe type
by Qiao, Wanqiong and Chiang, Hao-Chun and Xie, Hui and Levicky, Rastislav
Chemical Communications, ISSN 1359-7345, 10/2015, Volume 51, Issue 97, pp. 17245 - 17248
Hybridization thermodynamics on solid supports are compared with those in solution for two types of hybridization probe, DNA and uncharged morpholino... 
LABEL-FREE | PNA | SPECTROSCOPY | NUCLEIC-ACID | DISCRIMINATION | MICROARRAYS | DNA HYBRIDIZATION | CHEMISTRY, MULTIDISCIPLINARY | IMMOBILIZATION | PLASMON RESONANCE | MELTING CURVES | Molecular Probes | Salts - chemistry | Thermodynamics | Temperature | Surface Properties | Solutions - chemistry
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9. Full Text Cytogenomic identification and long-read single molecule real-time (SMRT) sequencing of a Bardet-Biedl Syndrome 9 (BBS9) deletion
by Reiner, Jennifer and Pisani, Laura and Qiao, Wanqiong and Singh, Ram and Yang, Yao and Shi, Lisong and Khan, Wahab A and Sebra, Robert and Cohen, Ninette and Babu, Arvind and Edelmann, Lisa and Jabs, Ethylin Wang and Scott, Stuart A
npj Genomic Medicine, ISSN 2056-7944, 12/2018, Volume 3, Issue 1, pp. 3 - 5
Bardet-Biedl syndrome (BBS) is a recessive disorder characterized by heterogeneous clinical manifestations, including truncal obesity, rod-cone dystrophy,... 
BARDET-BIEDL-SYNDROME | MUTATIONS | GENE | CILIA | COPY NUMBER | GENETICS & HEREDITY | Mutation
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10. Full Text Quantitative and multiplexed DNA methylation analysis using long-read single-molecule real-time bisulfite sequencing (SMRT-BS)
by Yang, Yao and Sebra, Robert and Pullman, Benjamin S and Qiao, Wanqiong and Peter, Inga and Desnick, Robert J and Geyer, C. Ronald and DeCoteau, John F and Scott, Stuart A
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16, Issue 1, p. 350
Background: DNA methylation has essential roles in transcriptional regulation, imprinting, X chromosome inactivation and other cellular processes, and aberrant... 
Third generation sequencing | Pacific Bioscience | Bisulfite sequencing | DNA methylation | Long-read sequencing | Single-molecule real-time (SMRT) sequencing | CpG islands | PCR-BIAS | DESIGN | 5-METHYLCYTOSINE | RESOLUTION | IDENTIFICATION | GENOMES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REGIONS | GENETICS & HEREDITY | SCALE | EPIGENOME-WIDE ASSOCIATION | SEQ | Time Factors | Humans | Polymerase Chain Reaction | Cell Line, Tumor | DNA Methylation - drug effects | Sequence Analysis, DNA - methods | Sulfites - pharmacology | Genome, Human - genetics | Genetic research | Genetic transcription | Research | Nucleotide sequencing | Innovations | DNA sequencing | Genetic aspects | Instrument industry | Laws, regulations and rules | Analysis | Biotechnology industry
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11. Full Text Acute Intermittent Porphyria: Predicted Pathogenicity ofHMBSVariants Indicates Extremely Low Penetrance of the Autosomal Dominant Disease
: HUMAN MUTATION
by Chen, Brenden and Solis-Villa, Constanza and Hakenberg, Jörg and Qiao, Wanqiong and Srinivasan, Ramakrishnan R and Yasuda, Makiko and Balwani, Manisha and Doheny, Dana and Peter, Inga and Chen, Rong and Desnick, Robert J
Human Mutation, ISSN 1059-7794, 11/2016, Volume 37, Issue 11, pp. 1215 - 1222
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12. Full Text Charge-neutral morpholino microarrays for nucleic acid analysis
by Qiao, Wanqiong and Kalachikov, Sergey and Liu, Yatao and Levicky, Rastislav
Analytical Biochemistry, ISSN 0003-2697, 03/2013, Volume 434, Issue 2, pp. 207 - 214
A principal challenge in microarray experiments is to facilitate hybridization between probe strands on the array with complementary target strands from... 
Immobilization | PNA | Morpholinos | Microarrays | DNA | Surface hybridization | CHEMISTRY, ANALYTICAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | ARRAYS | PROBES | GLASS | ZIP-CODE MICROARRAY | KINETICS | MISMATCH DISCRIMINATION | DNA SURFACE HYBRIDIZATION | DNA - chemistry | Molecular Probes - chemistry | Oligonucleotide Array Sequence Analysis | DNA - analysis | Surface Properties | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Chemistry Techniques, Analytical - methods | Morpholinos - chemistry | DNA microarrays | Surface active agents | Adsorption | immobilization | surface hybridization | morpholinos | microarrays
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13. Full Text Morpholino-dna interaction study on morpholino microarray
by Qiao, Wanqiong
01/2014, ISBN 9781321057980
Although technologies based on surface hybridization to DNA monolayers continue to be widely and successfully used, their performance is constrained by the... 
Engineering | Chemical engineering | Biomedical engineering
Dissertation
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14. Full Text Exome sequencing of extreme clopidogrel response phenotypes identifies B4GALT2 as a determinant of on‐treatment platelet reactivity
by Scott, SA and Collet, J‐P and Baber, U and Yang, Y and Peter, I and Linderman, M and Sload, J and Qiao, W and Kini, AS and Sharma, SK and Desnick, RJ and Fuster, V and Hajjar, RJ and Montalescot, G and Hulot, J‐S
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2016, Volume 100, Issue 3, pp. 287 - 294
Interindividual variability in platelet aggregation is common among patients treated with clopidogrel and both high on‐treatment platelet reactivity (HTPR) and... 
VARIABILITY | PERCUTANEOUS CORONARY INTERVENTION | PRETREATMENT | PHARMACOLOGY & PHARMACY | SIALIC-ACID | AFRICAN-AMERICANS | WHOLE-EXOME | POLYMORPHISM | GENETIC VARIANT | CYP2C19 | ANTIPLATELET THERAPY | Ticlopidine - pharmacology | Humans | Middle Aged | Cytochrome P-450 CYP2C19 - genetics | Genotype | Male | Galactosyltransferases - genetics | Coronary Artery Disease - drug therapy | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Exome | Phenotype | Pilot Projects | Platelet Aggregation Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacology | Ticlopidine - administration & dosage | Adult | Female | Aged | Blood Platelets - drug effects | Drug Therapy, Combination | Usage | Care and treatment | Exome sequencing | Clopidogrel | Dosage and administration | Research | Diagnosis | Patients | Health aspects | Blood platelet disorders | B4GALT2 | exome sequencing | pharmacogenomics | pharmacodynamics | platelet aggregation
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15. Full Text Bisulfite-modified target DNA array for aberrant methylation analysis
by Zhou, Dongrui and Qiao, Wanqiong and Yang, Liguo and Lu, Zuhong
Analytical Biochemistry, ISSN 0003-2697, 2006, Volume 351, Issue 1, pp. 26 - 35
Aberrant DNA methylation of CpG islands is among the earliest and most frequent alterations in cancer. It is of great importance to develop simple and... 
Array | Molecular markers | Nylon membrane | IGFBP7 gene | Methylation analysis | CHEMISTRY, ANALYTICAL | HYPERMETHYLATION | MICROARRAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | P16(INK4A) | nylon membrane | BREAST-CANCER CELLS | HIGH-SENSITIVITY | array | GENES | LEUKEMIA | PROMOTER | methylation analysis | molecular markers | CPG ISLANDS | TUMORIGENESIS | DNA - chemistry | DNA Methylation | Nucleic Acid Hybridization | Base Sequence | Polymerase Chain Reaction | DNA Primers | Sulfites - chemistry | Sulfites | DNA microarrays | Nylon | DNA | Oncology, Experimental | Genetic research | Research | Methylation | Cancer
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16. Morpholino-dna interaction study on morpholino microarray
by Qiao, Wanqiong
01/2014, ISBN 9781321057980, Volume 75, Issue 11
Although technologies based on surface hybridization to DNA monolayers continue to be widely and successfully used, their performance is constrained by the... 
Backbone | Analytical chemistry | Thermodynamics | Deoxyribonucleic acid | Fluorescence | Affinity | Gene expression | Molybdenum
Book Chapter
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17. Morpholino-dna interaction study on morpholino microarray
by Qiao, Wanqiong
01/2014, ISBN 9781321057980, Volume 75, Issue 11
Although technologies based on surface hybridization to DNA monolayers continue to be widely and successfully used, their performance is constrained by the... 
Book Chapter
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18. Detection of Unlabeled Nucleic Acids by Changing Solubility of Surface-Associating Probes
by QIAO WANQIONG and LIU YATAO and LEVICKY RASTISLAV
05/2015
Provided are methods and devices for detection of unlabeled nucleic acids. The detection methods are based on change of solubility of hydrophobic probes upon... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR
Patent
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19. Full Text Microarray-based methylation analysis using dual-color fluorescence hybridization
by Zhou, Dongrui and Qiao, Wanqiong and Wan, Yuan and Lu, Zuhong
Journal of Biochemical and Biophysical Methods, ISSN 0165-022X, 2006, Volume 66, Issue 1, pp. 33 - 43
Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations in cancer. It is of great importance to develop simple,... 
Molecular markers | IGFBP7 | Dual-color fluorescence hybridization | Microarray | Methylation analysis | DNA METHYLATION | dual-color fluorescence hybridization | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | P16(INK4A) | ABERRANT METHYLATION | BREAST-CANCER CELLS | microarray | BIOPHYSICS | GENES | methylation analysis | molecular markers | CPG ISLANDS | Molecular Probes | Nucleic Acid Hybridization - methods | Oligonucleotide Array Sequence Analysis - methods | Humans | Fluorescence | Molecular Sequence Data | Breast Neoplasms - chemistry | DNA Methylation | Breast Neoplasms - genetics | Base Sequence | Female | DNA, Neoplasm - analysis | Tumor Cells, Cultured | DNA microarrays | Methylation | Analysis
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