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1. Full Text Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
by Park, Jihwan and Shrestha, Rojesh and Qiu, Chengxiang and Kondo, Ayano and Huang, Shizheng and Werth, Max and Li, Mingyao and Barasch, Jonathan and Suszták, Katalin
Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6390, pp. 758 - 763
Our understanding of kidney disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ's multiple... 
ATLAS | FIBROSIS DEVELOPMENT | RNA-SEQ | ROLES | MULTIDISCIPLINARY SCIENCES | Signal Transduction | Receptors, Notch - metabolism | Humans | Cell Tracking - methods | Gene Expression Profiling - methods | Genetic Markers | Kidney Tubules, Collecting - cytology | Kidney Diseases - genetics | Sequence Analysis, RNA - methods | Kidney Tubules, Collecting - metabolism | Animals | Single-Cell Analysis - methods | Cell Plasticity | Mice | Development and progression | Genetic aspects | Kidney diseases | Kidneys | Transcription | Pathogenesis | Metabolism | Gene expression | Ribonucleic acid--RNA | Disease control | Molecular chains | Gene sequencing | Signal transduction | Signaling | Cell fate | Rodents | Computer applications | Notch protein | Collecting duct | Mutation | Acidosis | Trajectory analysis | Metabolic acidosis
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2. Full Text Towards the understanding of microRNA and environmental factor interactions and their relationships to human diseases
by Qiu, Chengxiang and Chen, Geng and Cui, Qinghua
Scientific Reports, ISSN 2045-2322, 2012, Volume 2, Issue 1, p. 318
Increasing studies have shown that the interactions between microRNAs (miRNAs) and environmental factors (EFs) play critical roles in determining phenotypes... 
PATHOGENESIS | MIRNA | MULTIDISCIPLINARY SCIENCES | LIVER | HYDROGEN-PEROXIDE | EXPRESSION PROFILES | CANCER | Disease - genetics | Humans | MicroRNAs - genetics | Environmental factors | Cancer therapies | Computer applications | MiRNA | Cancer
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3. Full Text Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice
by Beckerman, Pazit and Bi-Karchin, Jing and Park, Ae Seo Deok and Qiu, Chengxiang and Dummer, Patrick D and Soomro, Irfana and Boustany-Kari, Carine M and Pullen, Steven S and Miner, Jeffrey H and Hu, Chien-An A and Rohacs, Tibor and Inoue, Kazunori and Ishibe, Shuta and Saleem, Moin A and Palmer, Matthew B and Cuervo, Ana Maria and Kopp, Jeffrey B and Susztak, Katalin
Nature Medicine, ISSN 1078-8956, 04/2017, Volume 23, Issue 4, pp. 429 - 438
African Americans have a heightened risk of developing chronic and end-stage kidney disease, an association that is largely attributed to two common genetic... 
MEDICINE, RESEARCH & EXPERIMENTAL | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID-BINDING PROTEIN | AUTOPHAGIC CELL-DEATH | DIABETIC-NEPHROPATHY | APOLIPOPROTEIN-L1 | CELL BIOLOGY | TRYPANOLYTIC FACTOR APOL1 | HIV-ASSOCIATED NEPHROPATHY | AFRICAN-AMERICANS | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | CKD | Immunohistochemistry | Lipoproteins, HDL - genetics | Glomerulosclerosis, Focal Segmental - genetics | Humans | Endosomes - metabolism | Genetic Variation | Kidney Glomerulus - ultrastructure | Apolipoproteins - genetics | HEK293 Cells | Renal Insufficiency, Chronic - genetics | Kidney Glomerulus - metabolism | Endocytosis - genetics | Autophagy - genetics | In Situ Nick-End Labeling | Genetic Predisposition to Disease | Podocytes - metabolism | Azotemia - genetics | Mice, Transgenic | Kidney Glomerulus - pathology | Microscopy, Electron | Blotting, Western | Renal Insufficiency, Chronic - pathology | Albuminuria - genetics | Podocytes - ultrastructure | Animals | Alleles | Apolipoprotein L1 | Fluorescent Antibody Technique | Mice | HeLa Cells | Glomerulosclerosis, Focal Segmental - pathology | Genetic aspects | Kidney diseases | Apolipoproteins | Gene expression | Health aspects | Risk factors | albuminuria | pyroptosis | glomerulosclerosis | APOL1 | podocytes
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4. Full Text Human MicroRNA oncogenes and tumor suppressors show significantly different biological patterns: From functions to targets
by Wang, Dong and Qiu, Chengxiang and Zhang, Haijun and Wang, Juan and Cui, Qinghua and Yin, Yuxin
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 7
MicroRNAs (miRNAs) are small noncoding RNAs which play essential roles in many important biological processes. Therefore, their dysfunction is associated with... 
APOPTOSIS | EVOLUTION | DATABASE | LIN-14 | GENES | BIOLOGY | SITES | C-ELEGANS | MIRNAS | CANCER | CELL-DEATH | Neoplasms - metabolism | Neoplasms - genetics | Humans | Gene Expression Regulation | MicroRNAs - metabolism | MicroRNAs - genetics | Genes, Tumor Suppressor | Oncogenes | Evolution, Molecular | Development and progression | MicroRNA | DNA binding proteins | Analysis | Cancer | Transcription factors | Target recognition | Disease | Genomics | Genes | Science | Genomes | Data bases | Cell growth | Cell cycle | Evolution | Informatics | Energy distribution | MiRNA | Suppressors | Free energy | Biological activity | Studies | Acids | Ribonucleic acids | MicroRNAs | Regulation | Cervical cancer | Apoptosis
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5. Full Text TransmiR: A transcription factor microRNA regulation database
by Wang, Juan and Lu, Ming and Qiu, Chengxiang and Cui, Qinghua
Nucleic Acids Research, ISSN 0305-1048, 09/2009, Volume 38, Issue 1, pp. D119 - D122
MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and are therefore important cellular components. As is true for protein-coding... 
TARGETS | PROTEIN EVOLUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALING NETWORK | CELL-DEATH | Computational Biology - methods | Information Storage and Retrieval - methods | Transcription Factors - chemistry | Humans | Computational Biology - trends | Databases, Genetic | MicroRNAs - metabolism | Transcription Factors - genetics | Gene Regulatory Networks | PubMed | Phenotype | Algorithms | Animals | Databases, Protein | MicroRNAs - genetics | Software | Internet | Databases, Nucleic Acid
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6. Full Text The Rice TAL Effector-Dependent Resistance Protein XA10 Triggers Cell Death and Calcium Depletion in the Endoplasmic Reticulum
by Dongsheng Tian and Junxia Wang and Xuan Zeng and Keyu Gu and Chengxiang Qiu and Xiaobei Yang and Zhiyun Zhou and Meiling Goh and Yanchang Luo and Maki Murata-Hori and Frank F. White and Zhongchao Yin
The Plant Cell, ISSN 1040-4651, 1/2014, Volume 26, Issue 1, pp. 497 - 515
The recognition between disease resistance (R) genes in plants and their cognate avirulence (Avr) genes in pathogens can produce a hypersensitive response of... 
Calcium | Cell death | RESEARCH ARTICLES | Genes | HeLa cells | Cell membranes | Plants | Transgenic plants | Rice | Plant cells | Apoptosis | DEFENSE RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDATIVE BURST | BACTERIAL-BLIGHT RESISTANCE | SUBCELLULAR-LOCALIZATION | PLANT SCIENCES | CELL BIOLOGY | DISEASE-SUSCEPTIBILITY GENE | ORYZAE PV. ORYZAE | GATED CATION CHANNEL | HYPERSENSITIVE RESPONSE | CRAC CHANNEL | INNATE IMMUNITY | Amino Acid Sequence | Calcium - metabolism | Oryza - metabolism | Plant Proteins - physiology | Tobacco - metabolism | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Apoptosis - genetics | Plant Proteins - analysis | Tobacco - cytology | Plant Proteins - genetics | Tobacco - genetics | Base Sequence | Cloning, Molecular | HeLa Cells | Disease Resistance - genetics | Intracellular Membranes - metabolism | Oryza - cytology | Plant proteins | Physiological aspects | Research | Endoplasmic reticulum | Health aspects
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7. Full Text HMDD v2.0: A database for experimentally supported human microRNA and disease associations
by Li, Yang and Qiu, Chengxiang and Tu, Jian and Geng, Bin and Yang, Jichun and Jiang, Tianzi and Cui, Qinghua
Nucleic Acids Research, ISSN 0305-1048, 01/2014, Volume 42, Issue 1, pp. D1070 - D1074
The Human microRNA Disease Database (HMDD; available via the Web site at http://cmbi.bjmu.edu.cn/hmdd and http://202.38.126.151/hmdd/tools/hmdd2.html) is a... 
HUMAN CANCERS | BIOGENESIS | SIMILARITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | Disease - genetics | Epigenesis, Genetic | Humans | MicroRNAs - metabolism | MicroRNAs - genetics | Internet | Databases, Nucleic Acid | VI. Genomic variation, diseases and drugs
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8. Full Text The impact of MIR137 on dorsolateral prefrontal-hippocampal functional connectivity in healthy subjects
by Liu, Bing and Zhang, Xiaolong and Hou, Bing and Li, Jin and Qiu, Chengxiang and Qin, Wen and Yu, Chunshui and Jiang, Tianzi
Neuropsychopharmacology, ISSN 0893-133X, 2014, Volume 39, Issue 9, pp. 2153 - 2160
A recent mega-analysis combining genome-wide association study data revealed that a variant of microRNA 137 (MIR137) exhibits the most significant association... 
HUMAN BRAIN | PSYCHIATRY | RESTING-STATE | SCHIZOPHRENIA | NEUROSCIENCES | WORKING-MEMORY PERFORMANCE | MIR-137 | ANTI-CORRELATED NETWORKS | GENETIC RISK | PHARMACOLOGY & PHARMACY | PSYCHOSIS VARIANT | ANATOMICAL CONNECTIVITY | MICRORNA | Genetic Predisposition to Disease | Humans | Male | Risk | Memory, Short-Term - physiology | Neural Pathways - physiology | Young Adult | Homozygote | Magnetic Resonance Imaging | Asian Continental Ancestry Group | Phenotype | Schizophrenia - genetics | China | Adolescent | Brain Mapping | Adult | Female | MicroRNAs - genetics | Hippocampus - physiology | Prefrontal Cortex - physiology | MIR137 | functional connectivity | hippocampus | working memory | Original | dorsolateral prefrontal cortex
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9. Full Text Cytosine methylation predicts renal function decline in American Indians
by Qiu, Chengxiang and Hanson, Robert L and Fufaa, Gudeta and Kobes, Sayuko and Gluck, Caroline and Huang, Jing and Chen, Yong and Raj, Dominic and Nelson, Robert G and Knowler, William C and Susztak, Katalin
Kidney International, ISSN 0085-2538, 06/2018, Volume 93, Issue 6, pp. 1417 - 1431
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes, but the molecular mechanisms by which nephropathy develops are... 
diabetic nephropathy | gene expression | Cell Cycle - genetics | Prognosis | Kidney - pathology | Epigenesis, Genetic | Humans | Middle Aged | Apoptosis - genetics | Male | Diabetic Nephropathies - diagnosis | Kidney Failure, Chronic - ethnology | Case-Control Studies | Albuminuria - physiopathology | DNA Methylation | Diabetic Nephropathies - physiopathology | Renal Insufficiency, Chronic - genetics | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Cytosine | Glomerular Filtration Rate - genetics | Energy Metabolism - genetics | Kidney - physiopathology | Kidney Failure, Chronic - physiopathology | Genetic Predisposition to Disease | Kidney Failure, Chronic - diagnosis | Risk Factors | Albuminuria - ethnology | Diabetic Nephropathies - genetics | Diabetic Nephropathies - ethnology | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Albuminuria - genetics | Kidney Failure, Chronic - genetics | Phenotype | Renal Insufficiency, Chronic - ethnology | Fibrosis | Indians, North American - genetics | CpG Islands | Aged | Renal function | Pathogenesis | Regulatory sequences | Hyperglycemia | Renal insufficiency | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | CpG islands | Creatinine | Kidneys | Epidermal growth factor receptors | DNA probes | Diabetes mellitus | Metabolism | Gene expression | Glomerular filtration rate | Studies | Molecular modelling | Nephropathy | Epigenetics | Diabetes | Kidney diseases | Apoptosis | Diabetic nephropathy
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10. Full Text Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
by Qiu, Chengxiang and Huang, Shizheng and Park, Jihwan and Park, YoSon and Ko, Yi-An and Seasock, Matthew J and Bryer, Joshua S and Xu, Xiang-Xi and Song, Wen-Chao and Palmer, Matthew and Hill, Jon and Guarnieri, Paolo and Hawkins, Julie and Boustany-Kari, Carine M and Pullen, Steven S and Brown, Christopher D and Susztak, Katalin
Nature Medicine, ISSN 1078-8956, 11/2018, Volume 24, Issue 11, pp. 1721 - 1731
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste products, affects 700 million people globally. Genome-wide association... 
FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | ALLELES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANT NEPHROTIC SYNDROME | RISK | LOCI | VARIANT | CELL BIOLOGY | EPITHELIAL-CELLS | PROXIMAL TUBULE | EXPRESSION | GENOME-WIDE ASSOCIATION | Quantitative trait loci | Kidneys | Chronic kidney failure | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Health aspects | Nucleotide sequence | Genes | Genomes | Genetic diversity | Ribonucleic acid--RNA | Gene expression | Renal tubules | Gene sequencing | Proteins | Pathways | Genetic analysis | Kidney diseases | Gene mapping | compartment-specific | renal disease | eQTL
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11. Full Text LncRNADisease: A database for long-non-coding RNA-associated diseases
by Chen, Geng and Wang, Ziyun and Wang, Dongqing and Qiu, Chengxiang and Liu, Mingxi and Chen, Xing and Zhang, Qipeng and Yan, Guiying and Cui, Qinghua
Nucleic Acids Research, ISSN 0305-1048, 01/2013, Volume 41, Issue 1, pp. D983 - D986
In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjm... 
ANRIL | HUMAN MICRORNA | NONCODING RNAS | EXPRESSION | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | Computational Biology - methods | Disease - genetics | RNA, Long Noncoding - chemistry | Humans | Molecular Sequence Annotation | RNA, Long Noncoding - genetics | Internet | Databases, Nucleic Acid | RNA, Long Noncoding - metabolism
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12. Full Text 农村金融发展对城乡收入差距的影响
by 许书杰;于雯;周连秋
经济研究参考, ISSN 2095-3151, 2017, Issue 38, pp. 60 - 63
... 
城乡收入差距 | 农村金融 | 金融资源
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13. Full Text A large-scale analysis of the relationship of synonymous SNPs changing microRNA regulation with functionality and disease
by Wang, Yuchen and Qiu, Chengxiang and Cui, Qinghua
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2015, Volume 16, Issue 10, pp. 23545 - 23555
Historically, owing to not changing amino acid composition of protein sequences, synonymous mutations are commonly assumed to be neutral during evolution and... 
Functionality | Synonymous SNP | MicroRNA | synonymous SNP | EVOLUTION | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | microRNA | functionality | MUTATIONS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | MAMMALS | Haplotypes - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Gene Expression Regulation | Polymorphism, Single Nucleotide - genetics | MicroRNAs - metabolism | MicroRNAs - genetics | Models, Genetic | Mutation | Proteins | Genotype & phenotype | Disease | Genes | Amino acids | Ribonucleic acid--RNA
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14. Full Text 城乡统筹是城乡公平的治本之道
by 邱晓禹 王红利
中国医疗保险, ISSN 1674-3830, 2013, Issue 2, pp. 14 - 15
... 
城乡公平 | 全民医保 | 城乡统筹 | 十八大精神
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15. Full Text Epigenome-wide association studies identify DNA methylation associated with kidney function
by Chu, Audrey Y and Tin, Adrienne and Schlosser, Pascal and Ko, Yi-An and Qiu, Chengxiang and Yao, Chen and Joehanes, Roby and Grams, Morgan E and Liang, Liming and Gluck, Caroline A and Liu, Chunyu and Coresh, Josef and Hwang, Shih-Jen and Levy, Daniel and Boerwinkle, Eric and Pankow, James S and Yang, Qiong and Fornage, Myriam and Fox, Caroline S and Susztak, Katalin and Köttgen, Anna
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1286 - 12
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms... 
SERUM CREATININE | GLOMERULAR-FILTRATION-RATE | POPULATION | METAANALYSIS | WAIST CIRCUMFERENCE | PACKAGE | MULTIDISCIPLINARY SCIENCES | BODY-MASS INDEX | RENAL-DISEASE | LOCI | ATHEROSCLEROSIS RISK | Prospective Studies | Epigenesis, Genetic | Humans | Middle Aged | E1A-Associated p300 Protein - genetics | Male | E1A-Associated p300 Protein - metabolism | Kidney - metabolism | Renal Insufficiency, Chronic - genetics | Trans-Activators - genetics | Female | Glomerular Filtration Rate - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | CCAAT-Enhancer-Binding Protein-beta - genetics | DNA Methylation - genetics | Binding Sites - genetics | Transcription Factors - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Renal Insufficiency, Chronic - physiopathology | CCAAT-Enhancer-Binding Protein-beta - metabolism | Disease Progression | Transcription Factors - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | CpG Islands | Trans-Activators - metabolism | Aged | Heart | Epidermal growth factor receptors | Genomes | Regulatory sequences | Glomerular filtration rate | Studies | Genetic variance | Genotype & phenotype | Enhancers | Fibrosis | Regulatory mechanisms (biology) | DNA methylation | Epigenetics | Methylation | Renal cortex | Binding sites | Deoxyribonucleic acid--DNA | CpG islands | Kidney transplantation | Kidneys | Kidney diseases
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16. Full Text Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming
by Huang, Shizheng and Park, Jihwan and Qiu, Chengxiang and Chung, Ki Wung and Li, Szu-Yuan and Sirin, Yasemin and Han, Seung Hyeok and Taylor, Verdon and Zimber-Strobl, Ursula and Susztak, Katalin
PLoS Biology, ISSN 1544-9173, 09/2018, Volume 16, Issue 9, p. e2005233
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and... 
RENAL FIBROSIS | TO-MESENCHYMAL TRANSITION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | BIOLOGY | INTERSTITIAL FIBROSIS | NOTCH SIGNALING PATHWAY | DIABETIC-NEPHROPATHY | MICE | EXPRESSION | INTESTINAL EPITHELIAL-CELLS
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