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humans (29) 29
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1. Full Text Prospects for combining targeted and conventional cancer therapy with immunotherapy
by Gotwals, Philip and Cameron, Scott and Cipolletta, Daniela and Cremasco, Viviana and Crystal, Adam and Hewes, Becker and Mueller, Britta and Quaratino, Sonia and Sabatos-Peyton, Catherine and Petruzzelli, Lilli and Engelman, Jeffrey A and Dranoff, Glenn
Nature reviews. Cancer, ISSN 1474-175X, 05/2017, Volume 17, Issue 5, pp. 286 - 301
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - therapy | Animals | Molecular Targeted Therapy - trends | Neoplasms - genetics | Neoplasms - immunology | Humans | Immunotherapy - trends | Combined Modality Therapy | Neoplasms - drug therapy | Chemotherapy | Care and treatment | Immunotherapy | Drug therapy, Combination | Research | Health aspects | Cancer | Index Medicus
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2. Full Text Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
by Luciani, Alessandro and Villella, Valeria Rachela and Esposito, Speranza and Brunetti-Pierri, Nicola and Medina, Diego and Settembre, Carmine and Gavina, Manuela and Pulze, Laura and Giardino, Ida and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Guido, Stefano and Masliah, Eliezer and Spencer, Brian and Quaratino, Sonia and Raia, Valeria and Ballabio, Andrea and Maiuri, Luigi
Nature cell biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Phosphoinositide-3 Kinase Inhibitors | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
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3. Full Text New Approaches in Immunotherapy for the Treatment of Lung Cancer
by Quaratino, Sonia and Forssmann, Ulf and Marschner, Jens-Peter
12/2014, Current Topics in Microbiology and Immunology, ISBN 9783319239095, Volume 405
immunotherapyImmunotherapy | Talactoferrin | NSCLC Patients | Nivolumab | Non-small Cell Lung Cancer (NSCLC) | Lung Neoplasms - immunology | Lung Neoplasms - therapy | Humans | Immunotherapy
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4. Full Text Anti tumour necrosis‐α therapy increases the number of FOXP3+ regulatory T cells in children affected by Crohn’s disease
by Ricciardelli, Ida and Lindley, Keith J and Londei, Marco and Quaratino, Sonia
Immunology, ISSN 0019-2805, 10/2008, Volume 125, Issue 2, pp. 178 - 183
regulatory T cells | anti‐TNF‐α therapy | inflammation | FOXP3 | Crohn’s disease | Anti-TNF-α therapy | Crohn's disease | Inflammation | Regulatory T cells | Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - biosynthesis | Humans | RNA, Messenger - genetics | Antibodies, Monoclonal - therapeutic use | Colon - immunology | Forkhead Transcription Factors - genetics | Crohn Disease - immunology | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - drug effects | Infliximab | Intestinal Mucosa - immunology | Crohn Disease - drug therapy | Reverse Transcriptase Polymerase Chain Reaction - methods | Lymphocyte Count | Child | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | anti-TNF-α therapy | Original
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5. Full Text A first-in-human study of KY1044, a fully human anti-ICOS IgG1 antibody as monotherapy and in combination with atezolizumab in patients with selected advanced malignancies
by Quaratino, Sonia and Sainson, Richard and Thotakura, Anil and Henderson, Simon J and Pryke, Kerstin and Newton, Anthea and Brennan, Nuala and Oelmann, Elisabeth
Journal of clinical oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. TPS2644 - TPS2644
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6. Full Text T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein
by Laurent, Julien and Touvrey, Cedric and Gillessen, Silke and Joffraud, Magali and Vicari, Manuela and Bertrand, Caroline and Ongarello, Stefano and Liedert, Bernd and Gallerani, Elisa and Beck, Joachim and Omlin, Aurelius and Sessa, Cristiana and Quaratino, Sonia and Stupp, Roger and Gnad-Vogt, Ulrike S and Speiser, Daniel E
Journal of translational medicine, ISSN 1479-5876, 01/2013, Volume 11, Issue 1, pp. 5 - 5
Tumor | Cancer-testis antigen | Interleukin-2 | Fusion protein | Lymphocytes | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Immunohistochemistry | Cell Proliferation | DNA - immunology | Lymphocyte Activation | Humans | Recombinant Fusion Proteins - therapeutic use | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Flow Cytometry | Interleukin-2 - immunology | T-Lymphocytes - cytology | Survival Analysis | Lymphocyte Count | Antigens | Care and treatment | Antibodies | Metastasis | T cells | Viral antibodies | Cyclophosphamide | Killer cells | Interleukins | Analysis | DNA | Immunotherapy | Pharmaceutical industry | Drug therapy | Cancer | Studies | Medical research | Flow cytometry | Cytokines | Oncology | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Interleukin 2 receptors | Pharmacodynamics | Translation | Cell survival | CD8 antigen | Clinical trials | Lymphocytes T | CD4 antigen | Metastases | Cell activation | Interleukin 2 | Cell number | Natural killer cells
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7. Full Text Lysosomal accumulation of gliadin p31–43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARγ downregulation in intestinal epithelial cells and coeliac mucosa
by Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Pettoello-Mantovani, Massimo and Guido, Stefano and Cexus, Olivier N and Peake, Nick and Londei, Marco and Quaratino, Sonia and Maiuri, Luigi
Gut, ISSN 0017-5749, 03/2010, Volume 59, Issue 3, pp. 311 - 319
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences
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8. Full Text NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
by van den Heuvel, Michel M and Verheij, Marcel and Boshuizen, Rogier and Belderbos, Jose and Dingemans, Anne-Marie C and De Ruysscher, Dirk and Laurent, Julien and Tighe, Robert and Haanen, John and Quaratino, Sonia
Journal of translational medicine, ISSN 1479-5876, 01/2015, Volume 13, Issue 1, pp. 32 - 32
NHS-IL2 | Phase Ib | Radiotherapy | Lung cancer | Immunotherapy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Carcinoma | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - radiotherapy | Male | Palliative Care | Antineoplastic Agents - therapeutic use | Necrosis | Adenocarcinoma - metabolism | Dose Fractionation | Female | Recombinant Fusion Proteins - administration & dosage | Adenocarcinoma - radiotherapy | Interleukin-2 - metabolism | Mice, Inbred C57BL | Carcinoma, Non-Small-Cell Lung - metabolism | Combined Modality Therapy | Cisplatin - pharmacology | Adenocarcinoma - drug therapy | Animals | Cell Line, Tumor | Aged | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Thyroid diseases | Clinical trials | Antibodies | Metastasis | Lung cancer, Non-small cell | Viral antibodies | Ionizing radiation | Interleukins | Genetically modified organisms | Product development | Pharmaceutical industry | Index Medicus
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9. Full Text Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
by Maiuri, Luigi and Ciacci, Carolina and Ricciardelli, Ida and Vacca, Loredana and Raia, Valeria and Auricchio, Salvatore and Picard, Jean and Osman, Mohamed and Quaratino, Sonia and Londei, Marco
The Lancet (British edition), ISSN 0140-6736, 2003, Volume 362, Issue 9377, pp. 30 - 37
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Duodenum - immunology | Gliadin - immunology | Lymphocyte Activation | Humans | Middle Aged | Cells, Cultured | Immunity, Innate | Disease Progression | Celiac Disease - immunology | Intestinal Mucosa - immunology | Duodenum - pathology | Peptide Fragments - immunology | Adult | T-Lymphocytes - immunology | Intestinal Mucosa - pathology | Causes of | Celiac disease | Care and treatment | Diagnosis | Peptides | Cytokines | Disease | Small intestine | Immune system | Index Medicus | Abridged Index Medicus
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10. Full Text SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation
by Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Raia, Valeria and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Guido, Stefano and Leal, Teresinha and Quaratino, Sonia and Maiuri, Luigi
The Journal of immunology (1950), ISSN 0022-1767, 08/2009, Volume 183, Issue 4, pp. 2775 - 2784
Life Sciences & Biomedicine | Immunology | Science & Technology | Reactive Oxygen Species - metabolism | Cystic Fibrosis - enzymology | Humans | Cystic Fibrosis - pathology | Oxidative Stress - immunology | Respiratory Mucosa - enzymology | Cystic Fibrosis - immunology | Respiratory Mucosa - pathology | Poly-ADP-Ribose Binding Proteins | Animals | Mice, Mutant Strains | Respiratory Mucosa - immunology | Transglutaminases - metabolism | Inflammation Mediators - metabolism | Cell Line, Tumor | Transglutaminases - physiology | Female | Inflammation Mediators - antagonists & inhibitors | Mice | SUMO-1 Protein - metabolism | GTP-Binding Proteins | Protein Inhibitors of Activated STAT - physiology | Transglutaminases - antagonists & inhibitors | Disease Models, Animal | Index Medicus | Abridged Index Medicus
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