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1. Full Text Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
by Luciani, Alessandro and Villella, Valeria Rachela and Brunetti-Pierri, Nicola and Masliah, Eliezer and Spencer, Brian and Pulze, Laura and Ballabio, Andrea and Gavina, Manuela and Medina, Diego and Raia, Valeria and Esposito, Speranza and Guido, Stefano and Quaratino, Sonia and Giardino, Ida and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Settembre, Carmine and Maiuri, Luigi
Nature Cell Biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a life-threatening genetic... 
APOPTOSIS | UNFOLDED PROTEIN RESPONSE | BECLIN 1 | DOWN-REGULATION | ENDOPLASMIC-RETICULUM | MICE | GENE-TRANSFER | TISSUE TRANSGLUTAMINASE | NEURODEGENERATIVE DISEASES | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
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2. Full Text T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein
by Laurent, Julien and Touvrey, Cedric and Gillessen, Silke and Joffraud, Magali and Vicari, Manuela and Bertrand, Caroline and Ongarello, Stefano and Liedert, Bernd and Gallerani, Elisa and Beck, Joachim and Omlin, Aurelius and Sessa, Cristiana and Quaratino, Sonia and Stupp, Roger and Gnad-Vogt, Ulrike S and Speiser, Daniel E
Journal of Translational Medicine, ISSN 1479-5876, 01/2013, Volume 11, Issue 1, pp. 5 - 5
Background: EMD 521873 (Selectikine or NHS-IL2LT) is a fusion protein consisting of modified human IL-2 which binds specifically to the high-affinity IL-2... 
Tumor | Cancer-testis antigen | Interleukin-2 | Fusion protein | Lymphocytes | MEDICINE, RESEARCH & EXPERIMENTAL | CYTOKINES | CYCLOPHOSPHAMIDE | INFILTRATING LYMPHOCYTES | IL-2 | ANTITUMOR-ACTIVITY | IDENTIFICATION | IMMUNOTHERAPY | COLORECTAL-CANCER | HIGH-DOSE INTERLEUKIN-2 | CARCINOMA | Immunohistochemistry | Cell Proliferation | DNA - immunology | Lymphocyte Activation | Humans | Recombinant Fusion Proteins - therapeutic use | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Flow Cytometry | Interleukin-2 - immunology | T-Lymphocytes - cytology | Survival Analysis | Lymphocyte Count | Antigens | Care and treatment | Antibodies | Metastasis | T cells | Viral antibodies | Cyclophosphamide | Killer cells | Interleukins | Analysis | DNA | Immunotherapy | Pharmaceutical industry | Drug therapy | Cancer | Studies | Medical research | Flow cytometry | Cytokines | Oncology | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Interleukin 2 receptors | Pharmacodynamics | Translation | Cell survival | CD8 antigen | Clinical trials | Lymphocytes T | CD4 antigen | Metastases | Cell activation | Interleukin 2 | Cell number | Natural killer cells
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3. Full Text A first-in-human study of KY1044, a fully human anti-ICOS IgG1 antibody as monotherapy and in combination with atezolizumab in patients with selected advanced malignancies
by Quaratino, Sonia and Sainson, Richard and Thotakura, Anil and Henderson, Simon J and Pryke, Kerstin and Newton, Anthea and Brennan, Nuala and Oelmann, Elisabeth
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. TPS2644 - TPS2644
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4. Full Text Anti tumour necrosis-α therapy increases the number of FOXP3 + regulatory T cells in children affected by Crohn's disease
by Ricciardelli, Ida and Lindley, Keith J and Londei, Marco and Quaratino, Sonia
Immunology, ISSN 0019-2805, 10/2008, Volume 125, Issue 2, pp. 178 - 183
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing... 
Anti-TNF-α therapy | Crohn's disease | Inflammation | Regulatory T cells | FOXP3 | RHEUMATOID-ARTHRITIS | TOLERANCE | IMMUNOLOGY | LAMINA PROPRIA | SUPPRESSION | regulatory T cells | anti-TNF-alpha therapy | INFLAMMATORY-BOWEL-DISEASE | inflammation | BIOLOGY | TNF-ALPHA | INFLIXIMAB | Forkhead Transcription Factors - biosynthesis | Humans | RNA, Messenger - genetics | Antibodies, Monoclonal - therapeutic use | Colon - immunology | Forkhead Transcription Factors - genetics | Crohn Disease - immunology | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - drug effects | Infliximab | Intestinal Mucosa - immunology | Crohn Disease - drug therapy | Reverse Transcriptase Polymerase Chain Reaction - methods | Lymphocyte Count | Child | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | anti-TNF-α therapy | Original
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5. Full Text Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
by Maiuri, Luigi and Ciacci, Carolina and Ricciardelli, Ida and Vacca, Loredana and Raia, Valeria and Auricchio, Salvatore and Picard, Jean and Osman, Mohamed and Quaratino, Sonia and Londei, Marco
The Lancet, ISSN 0140-6736, 2003, Volume 362, Issue 9377, pp. 30 - 37
The adaptive immune system is central to the development of coeliac disease. Adaptive immune responses are, however, controlled by a preceding activation of... 
CHALLENGE | MEDICINE, GENERAL & INTERNAL | GLUTEN | DENDRITIC CELLS | MESSENGER-RNA | INTERLEUKIN-15 | MACROPHAGES | ORGAN-CULTURE | TOXICITY | BLOOD MONOCYTES | EXPRESSION | Duodenum - immunology | Gliadin - immunology | Lymphocyte Activation | Humans | Middle Aged | Cells, Cultured | Immunity, Innate | Disease Progression | Celiac Disease - immunology | Intestinal Mucosa - immunology | Duodenum - pathology | Peptide Fragments - immunology | Adult | T-Lymphocytes - immunology | Intestinal Mucosa - pathology | Causes of | Celiac disease | Care and treatment | Diagnosis | Peptides | Cytokines | Disease | Small intestine | Immune system | Index Medicus | Abridged Index Medicus
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6. Full Text Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARγ downregulation in intestinal epithelial cells and coeliac mucosa
by Maiuri, Luigi and Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Pettoello-Mantovani, Massimo and Guido, Stefano and Cexus, Olivier N and Peake, Nick and Londei, Marco and Quaratino, Sonia
Gut, ISSN 0017-5749, 03/2010, Volume 59, Issue 3, pp. 311 - 319
Background An unresolved question in coeliac disease is to understand how some toxic gliadin peptides, in particular p31-43, can initiate an innate response... 
PATHOGENIC T-CELLS | ACTIVATED RECEPTOR-GAMMA | ACID | PERMEABILITY | INFLAMMATION | ULCERATIVE-COLITIS | DISEASE | STORAGE DISORDERS | CROSS-LINKING | ROSIGLITAZONE | GASTROENTEROLOGY & HEPATOLOGY
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7. Full Text NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
by van den Heuvel, Michel M and Verheij, Marcel and Boshuizen, Rogier and Belderbos, Jose and Dingemans, Anne-Marie C and De Ruysscher, Dirk and Laurent, Julien and Tighe, Robert and Haanen, John and Quaratino, Sonia
Journal of Translational Medicine, ISSN 1479-5876, 01/2015, Volume 13, Issue 1, pp. 32 - 32
Background: NHS-IL2 (selectikine, EMD 521873, MSB0010445) consists of human NHS76 (antibody specific for necrotic DNA) fused to genetically modified human... 
NHS-IL2 | Phase Ib | Radiotherapy | Immunotherapy | Lung cancer | INTERLEUKIN-2 | MEDICINE, RESEARCH & EXPERIMENTAL | CARBOPLATIN | GEFITINIB | SAFETY | VACCINE | COMBINATION | EMD 521873 SELECTIKINE | RADIATION | PACLITAXEL | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Carcinoma | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - radiotherapy | Male | Palliative Care | Antineoplastic Agents - therapeutic use | Necrosis | Adenocarcinoma - metabolism | Dose Fractionation | Female | Recombinant Fusion Proteins - administration & dosage | Adenocarcinoma - radiotherapy | Interleukin-2 - metabolism | Mice, Inbred C57BL | Carcinoma, Non-Small-Cell Lung - metabolism | Combined Modality Therapy | Cisplatin - pharmacology | Adenocarcinoma - drug therapy | Animals | Cell Line, Tumor | Aged | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Thyroid diseases | Clinical trials | Antibodies | Metastasis | Lung cancer, Non-small cell | Viral antibodies | Ionizing radiation | Interleukins | Genetically modified organisms | Product development | Pharmaceutical industry | Index Medicus
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8. Full Text Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARγ down-regulation
by Maiuri, Luigi and Luciani, Alessandro and Giardino, Ida and Raia, Valeria and Villella, Valeria R and D'Apolito, Maria and Pettoello-Mantovani, Massimo and Guido, Stefano and Ciacci, Carolina and Cimmino, Mariano and Cexus, Olivier N and Londei, Marco and Quaratino, Sonia
Journal of Immunology, ISSN 0022-1767, 2008, Volume 180, Issue 11, pp. 7697 - 7705
Cystic fibrosis (CF), the most common life-threatening inherited disease in Caucasians, is due to mutations in the CF transmembrane conductance regulator... 
BREAST-CANCER CELLS | PROTEIN | INHIBITION | AGGRESOMES | RECEPTOR-GAMMA | EPITHELIAL-CELLS | DISEASE | AIRWAY INFLAMMATION | KAPPA-B | IMMUNOLOGY | CROSS-LINKS
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9. Full Text Unexpected Role of Surface Transglutaminase Type II in Celiac Disease
by Maiuri, Luigi and Ciacci, Carolina and Ricciardelli, Ida and Vacca, Loredana and Raia, Valeria and Rispo, Antonio and Griffin, Martin and Issekutz, Thomas and Quaratino, Sonia and Londei, Marco
Gastroenterology, ISSN 0016-5085, 11/2005, Volume 129, Issue 5, pp. 1400 - 1413
In celiac disease (CD), transglutaminase type II (TG2) has 2 fundamental roles: (1) as the autoantigen recognized by highly specific autoantibodies and (2) the... 
MIGRATION | APOPTOSIS | IN-VITRO | GLIADIN | ENZYME | STRUCTURAL BASIS | BARRIER FUNCTION | FIBRONECTIN | T-CELL EPITOPE | GASTROENTEROLOGY & HEPATOLOGY | TISSUE TRANSGLUTAMINASE | Up-Regulation | CD8-Positive T-Lymphocytes - pathology | Intestine, Small - pathology | Humans | Middle Aged | Substrate Specificity | Transglutaminases - immunology | Intestine, Small - enzymology | Gliadin - metabolism | Celiac Disease - immunology | Intestinal Mucosa - immunology | Intestinal Mucosa - enzymology | Antigens, Surface - metabolism | Adult | Intestine, Small - immunology | Organ Culture Techniques | Cell Line | GTP-Binding Proteins - immunology | Epithelial Cells - pathology | Antibodies, Monoclonal | Celiac Disease - pathology | Biopsy | Transglutaminases - metabolism | Epithelial Cells - enzymology | CD8-Positive T-Lymphocytes - immunology | Celiac Disease - metabolism | Apoptosis | GTP-Binding Proteins - metabolism | Intestinal Mucosa - pathology | Autoimmunity | Enzymes | Autoantibodies | Peptides | Oncology, Experimental | Flexible response (Strategy) | Research | T cells | Deterrence (Strategy) | Muscle proteins | Celiac disease | Actin | Analysis | Fluorescein | Monoclonal antibodies | Antigenic determinants | Cancer | Index Medicus | Abridged Index Medicus
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10. Full Text SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation
by Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Raia, Valeria and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Guido, Stefano and Leal, Teresinha and Quaratino, Sonia and Maiuri, Luigi
The Journal of Immunology, ISSN 0022-1767, 08/2009, Volume 183, Issue 4, pp. 2775 - 2784
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CIF transmembrane conductance regulator (CFTR) gene. CF is characterized by chronic... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | KAPPA-B ACTIVATION | PROTEIN | SUMO | BRONCHIAL EPITHELIAL-CELLS | PPAR-GAMMA | IMMUNOLOGY | CYSTIC-FIBROSIS AIRWAYS | NEURODEGENERATIVE DISEASES | CFTR | HUNTINGTON-DISEASE | Reactive Oxygen Species - metabolism | Cystic Fibrosis - enzymology | Humans | Cystic Fibrosis - pathology | Oxidative Stress - immunology | Respiratory Mucosa - enzymology | Cystic Fibrosis - immunology | Respiratory Mucosa - pathology | Poly-ADP-Ribose Binding Proteins | Animals | Mice, Mutant Strains | Respiratory Mucosa - immunology | Transglutaminases - metabolism | Inflammation Mediators - metabolism | Cell Line, Tumor | Transglutaminases - physiology | Female | Inflammation Mediators - antagonists & inhibitors | Mice | SUMO-1 Protein - metabolism | GTP-Binding Proteins | Protein Inhibitors of Activated STAT - physiology | Transglutaminases - antagonists & inhibitors | Disease Models, Animal | Index Medicus | Abridged Index Medicus
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11. Full Text Interleukin 15 mediates epithelial changes in celiac disease
by Maiuri, Luigi and Ciacci, Carolina and Auricchio, Salvatore and Brown, Virginia and Quaratino, Sonia and Londei, Marco
Gastroenterology, ISSN 0016-5085, 10/2000, Volume 119, Issue 4, pp. 996 - 1006
: Villous atrophy and crypt proliferation are key epithelial features of untreated celiac disease. We tried to define whether cytokines such as interleukin... 
RHEUMATOID-ARTHRITIS | IN-VITRO | MESSENGER-RNA | WHEAT PEPTIDE CHALLENGE | ULCERATIVE-COLITIS | VITRO GLIADIN CHALLENGE | SMALL-INTESTINE | NECROSIS-FACTOR-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | CRYPT-CELL HYPERPLASIA | Humans | Middle Aged | Interleukin-7 - pharmacology | Male | Intestinal Mucosa - drug effects | Interleukin-4 - pharmacology | Jejunum | Celiac Disease - immunology | Intestinal Mucosa - immunology | DNA Fragmentation | Adult | Female | Organ Culture Techniques | Celiac Disease - genetics | Duodenum | Antibodies, Monoclonal - pharmacology | Interleukin-15 - analysis | Reverse Transcriptase Polymerase Chain Reaction | Celiac Disease - pathology | Interleukin-15 - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Interleukin-15 - genetics | Biopsy | Adolescent | Interleukin-2 - pharmacology | Gliadin - pharmacology | Cytokines - pharmacology | Interferon-gamma - pharmacology | Intestinal Mucosa - pathology | Immunohistochemistry | Monoclonal antibodies | Celiac disease | Interleukins | Biological response modifiers | Index Medicus | Abridged Index Medicus
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12. Full Text Erratum: SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation (Journal of Immunology (2009) 183 ( 2775-2784))
by Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Raia, Valeria and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Guido, Stefano and Leal, Teresinha and Quaratino, Sonia and Maiuri, Luigi
Journal of Immunology, ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5347 - 5349
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13. Full Text Correction: SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation
by Luciani, Alessandro and Villella, Valeria Rachela and Vasaturo, Angela and Giardino, Ida and Raia, Valeria and Pettoello-Mantovani, Massimo and D'Apolito, Maria and Guido, Stefano and Leal, Teresinha and Quaratino, Sonia and Maiuri, Luigi
The Journal of Immunology, ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5347 - 5349
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14. Full Text Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice
by Pang, Yun Yun and Bartok, Istvan and Maiuri, Luigi and Londei, Marco and Badami, Ester and Dyson, Julian and Kioussis, Dimitris and Quaratino, Sonia
Nature Medicine, ISSN 1078-8956, 09/2004, Volume 10, Issue 9, pp. 920 - 926
Thyroid autoimmune disorders comprise more than 30% of all organ-specific autoimmune diseases and are characterized by autoantibodies and infiltrating T cells.... 
MEDICINE, RESEARCH & EXPERIMENTAL | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | THYROID-DISEASE | CELIAC-DISEASE | CELL BIOLOGY | EPITOPE | THYMIC SELECTION | HLA | EXPRESSION | TRANSGENIC MICE | Humans | Thyroxine - blood | Thyroiditis, Autoimmune - etiology | Flow Cytometry | T-Lymphocytes - metabolism | DNA Fragmentation | Radioimmunoassay | Iodide Peroxidase - metabolism | Statistics, Nonparametric | Thyroiditis, Autoimmune - physiopathology | Receptors, Antigen, T-Cell - immunology | Antibodies, Monoclonal - immunology | In Situ Nick-End Labeling | Receptors, Antigen, T-Cell - metabolism | Models, Molecular | Mice, Transgenic | Epitopes | Thyrotropin - metabolism | Chromium Radioisotopes | Autoantibodies - immunology | Models, Immunological | Animals | T-Lymphocytes - immunology | Major Histocompatibility Complex - immunology | Mice | Index Medicus
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15. Full Text Models of autoimmune thyroiditis
by Quaratino, Sonia
Drug Discovery Today: Disease Models, ISSN 1740-6757, 2004, Volume 1, Issue 4, pp. 417 - 423
Autoimmune thyroiditis is an organ-specific autoimmune disease characterized by both B-cell and T-cell responses. Despite extensive research to underpin the... 
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16. Full Text Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPAR  downregulation in intestinal epithelial cells and coeliac mucosa
by Luciani, A and Villella, V. R and Vasaturo, A and Giardino, I and Pettoello-Mantovani, M and Guido, S and Cexus, O. N and Peake, N and Londei, M and Quaratino, S and Maiuri, L
Gut, ISSN 0017-5749, 03/2010, Volume 59, Issue 3, pp. 311 - 319
  Background An unresolved question in coeliac disease is to understand how some toxic gliadin peptides, in particular p31-43, can initiate an innate response... 
Celiac disease | Lysosomes | Physiological aspects | Development and progression | Natural immunity | Transglutaminases | Research | Inflammatory bowel disease | Oxidative stress | Disease | Peptides | Cytokines | Rodents | Cystic fibrosis | Inflammation | Gene expression | Small intestine
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