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ectoenzymes (8) 8
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Molecular Medicine, ISSN 1076-1551, 10/2016, Volume 22, Issue 1, pp. 694 - 704
Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes... 
MULTIPLE-MYELOMA | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | PHYSIOLOGY | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ECTOENZYMES | HYPOXIA | SUPPRESSION | CELL BIOLOGY | ENZYMES | CD38 | MONOCLONAL-ANTIBODIES
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 04/2018, Volume 9, p. 196
Cytokine-induced killer (CIK) cells, a heterogeneous T cell population obtained by in vitro differentiation of peripheral blood mononuclear cells (PBMC),... 
Adenosine | CD73 | P1 receptors | CIK | CD39 | CD38 | Hypoxia | CD203a/PC-1 | SYSTEM | hypoxia | PHYSIOLOGY | INNATE | CIK CELLS | RELEASE | CANCER | adenosine | MICROENVIRONMENT | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | MYELOMA | LYMPHOCYTES | Cellular proteins | Killer cells | Genetic aspects | Immune response | Cytokines | Health aspects
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 03/2017, Volume 8, p. 305
Ectoenzymes are cell surface molecules, which represent functional bridges between the environment and the cytoplasm. One set of ectoenzymes-CD39, CD38,... 
Adenosine | Ectoenzymes | Multiple myeloma therapy | Microvesicles | PHYSIOLOGY | microvesicles | IMMUNOLOGY | SUPPRESSION | CANCER | adenosine | multiple myeloma therapy | T-CELL PROLIFERATION | METABOLISM | PATHWAY | INFLAMMATION | CD38 | ectoenzymes | ANTIBODIES TARGETING CD38 | EXPRESSION | Physiological aspects | Care and treatment | Cellular immunity | Enzyme kinetics | Health aspects | Multiple myeloma
Journal Article
OncoImmunology, ISSN 2162-4011, 09/2013, Volume 2, Issue 9, p. e26246
The tumor microenvironment is characterized by of high levels of extracellular nucleotides that are metabolized through the dynamic and sequential action of... 
adenosine | NAD | PC-1 | ectonucleotidases | CD203a | CD38 | + | Adenosine | Ectonucleotidases | EXTRACELLULAR-PRECURSORS | IMMUNITY | CD73 | CRYSTAL-STRUCTURE | IMMUNOLOGY | MOLECULES | NAD(+) METABOLISM | ONCOLOGY | INFLAMMATION | NAD(+) | RECEPTORS | EXPRESSION | CELL-ACTIVATION | Original Research
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2019, Volume 202, Issue 3, pp. 724 - 735
This study investigates the mechanism(s) underlying the immunoregulatory activities of placenta-derived human amnion epithelial cells (hAEC). The working... 
INHIBITION | DENDRITIC CELLS | METABOLISM | MACROPHAGES | IMMUNOGLOBULIN | RECEPTOR | ECTOENZYMES | MECHANISMS | TNF-ALPHA | IMMUNOLOGY | T-CELLS
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 2064 - 2064
Abstract Development of human multiple myeloma (MM) in the bone niche derives from multiple factors. Besides cells and soluble factors, hypoxia triggers... 
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 28, pp. 25602 - 25618
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2959 - 2959
Abstract The relationship between multiple myeloma (MM) cells and osteoblast (OB)s and osteoclast (OCL)s into the bone marrow (BM) niche has a critical role in... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 1849 - 1849
Abstract Daratumumab (DARA) is an anti-CD38 human mAb in phase III clinical trials in myeloma patients. DARA binding induces killing of tumor cells via... 
Journal Article