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Publication DateAging clinical and experimental research, ISSN 1720-8319, 03/2019
Clinical research is an essential step in the successful translation of knowledge from basic research into concrete clinical applications, yet many people are...
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Loading RightsJAMA, ISSN 0098-7484, 01/2013, Volume 309, Issue 3, pp. 249 - 256
IMPORTANCE Monitoring of residual gastric volume is recommended to prevent ventilator-associated pneumonia (VAP) in patients receiving early enteral nutrition....
BODY POSITION | ICU PATIENTS | MEDICINE, GENERAL & INTERNAL | MULTICENTER | INTENSIVE-CARE-UNIT | GUIDELINES | NUTRITION SUPPORT | COLONIZATION | INTOLERANCE | CRITICALLY-ILL PATIENTS | NOSOCOMIAL PNEUMONIA | Intensive Care Units | Monitoring, Physiologic - standards | Humans | Middle Aged | Pneumonia, Ventilator-Associated - prevention & control | Organ Size | Male | Risk | Enteral Nutrition | Respiration, Artificial | Intention to Treat Analysis | Stomach - anatomy & histology | Female | Aged | Ventilators | Pneumonia | Enteral nutrition | Health risk assessment | Effectiveness studies
BODY POSITION | ICU PATIENTS | MEDICINE, GENERAL & INTERNAL | MULTICENTER | INTENSIVE-CARE-UNIT | GUIDELINES | NUTRITION SUPPORT | COLONIZATION | INTOLERANCE | CRITICALLY-ILL PATIENTS | NOSOCOMIAL PNEUMONIA | Intensive Care Units | Monitoring, Physiologic - standards | Humans | Middle Aged | Pneumonia, Ventilator-Associated - prevention & control | Organ Size | Male | Risk | Enteral Nutrition | Respiration, Artificial | Intention to Treat Analysis | Stomach - anatomy & histology | Female | Aged | Ventilators | Pneumonia | Enteral nutrition | Health risk assessment | Effectiveness studies
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Loading RightsThe New England Journal of Medicine, ISSN 0028-4793, 03/2018, Volume 378, Issue 9, pp. 809 - 818
Septic shock is characterized by a dysregulated host response to infection and is associated with a mortality of 45 to 50%. In this multicenter, randomized,...
TRIAL | MEDICINE, GENERAL & INTERNAL | SURVIVING SEPSIS CAMPAIGN | GLUCOCORTICOID-RECEPTOR | MANAGEMENT | THERAPY | INTERNATIONAL CONSENSUS DEFINITIONS | ACTIVATED PROTEIN-C | GUIDELINES | CORTICOSTEROIDS | Recurrence | Humans | Middle Aged | Hydrocortisone - therapeutic use | Male | Simplified Acute Physiology Score | Shock, Septic - therapy | Cause of Death | Anti-Inflammatory Agents - adverse effects | Shock, Septic - drug therapy | Anti-Inflammatory Agents - therapeutic use | Female | Drug Therapy, Combination | Double-Blind Method | Renal Replacement Therapy | Shock, Septic - complications | Treatment Outcome | Combined Modality Therapy | Shock, Septic - mortality | Fludrocortisone - adverse effects | Respiration, Artificial | Hydrocortisone - adverse effects | Fludrocortisone - therapeutic use | Survival Analysis | Organ Dysfunction Scores | Aged | Treatment outcome | Safety and security measures | Analysis | Septic shock | Dosage and administration | Hydrocortisone | Drug therapy | Shock | Mortality | Clinical trials | Infections | Hormones | Investigations | Clinical outcomes | Cortisone | Drug administration | Hyperglycemia | Ventilation | Sepsis | Blood pressure | Life Sciences
TRIAL | MEDICINE, GENERAL & INTERNAL | SURVIVING SEPSIS CAMPAIGN | GLUCOCORTICOID-RECEPTOR | MANAGEMENT | THERAPY | INTERNATIONAL CONSENSUS DEFINITIONS | ACTIVATED PROTEIN-C | GUIDELINES | CORTICOSTEROIDS | Recurrence | Humans | Middle Aged | Hydrocortisone - therapeutic use | Male | Simplified Acute Physiology Score | Shock, Septic - therapy | Cause of Death | Anti-Inflammatory Agents - adverse effects | Shock, Septic - drug therapy | Anti-Inflammatory Agents - therapeutic use | Female | Drug Therapy, Combination | Double-Blind Method | Renal Replacement Therapy | Shock, Septic - complications | Treatment Outcome | Combined Modality Therapy | Shock, Septic - mortality | Fludrocortisone - adverse effects | Respiration, Artificial | Hydrocortisone - adverse effects | Fludrocortisone - therapeutic use | Survival Analysis | Organ Dysfunction Scores | Aged | Treatment outcome | Safety and security measures | Analysis | Septic shock | Dosage and administration | Hydrocortisone | Drug therapy | Shock | Mortality | Clinical trials | Infections | Hormones | Investigations | Clinical outcomes | Cortisone | Drug administration | Hyperglycemia | Ventilation | Sepsis | Blood pressure | Life Sciences
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Loading RightsNature Reviews Gastroenterology and Hepatology, ISSN 1759-5045, 01/2015, Volume 12, Issue 2, pp. 98 - 107
Bleeding from stress-related mucosal disease in critically ill patients remains an important clinical management issue. Although only a small proportion (1-6%)...
COST-EFFECTIVENESS ANALYSIS | CLOSTRIDIUM-DIFFICILE INFECTION | COMMUNITY-ACQUIRED PNEUMONIA | ULCER BLEEDING PROPHYLAXIS | RISK-FACTORS | INDUCED GASTRIC-LESIONS | INTENSIVE-CARE-UNIT | PROTON PUMP INHIBITORS | HISTAMINE-2 RECEPTOR ANTAGONISTS | GASTROENTEROLOGY & HEPATOLOGY | PEPTIC-ULCER | Enteral Nutrition - methods | Proton Pump Inhibitors - adverse effects | Stomach Ulcer - complications | Humans | Risk Factors | Peptic Ulcer Hemorrhage - prevention & control | Stress, Physiological | Critical Illness - therapy | Proton Pump Inhibitors - therapeutic use | Peptic Ulcer Hemorrhage - etiology | Stomach Ulcer - prevention & control | Psychological aspects | Prognosis | Mucositis | Critically ill | Research | Stress (Psychology) | Risk factors | Diseases
COST-EFFECTIVENESS ANALYSIS | CLOSTRIDIUM-DIFFICILE INFECTION | COMMUNITY-ACQUIRED PNEUMONIA | ULCER BLEEDING PROPHYLAXIS | RISK-FACTORS | INDUCED GASTRIC-LESIONS | INTENSIVE-CARE-UNIT | PROTON PUMP INHIBITORS | HISTAMINE-2 RECEPTOR ANTAGONISTS | GASTROENTEROLOGY & HEPATOLOGY | PEPTIC-ULCER | Enteral Nutrition - methods | Proton Pump Inhibitors - adverse effects | Stomach Ulcer - complications | Humans | Risk Factors | Peptic Ulcer Hemorrhage - prevention & control | Stress, Physiological | Critical Illness - therapy | Proton Pump Inhibitors - therapeutic use | Peptic Ulcer Hemorrhage - etiology | Stomach Ulcer - prevention & control | Psychological aspects | Prognosis | Mucositis | Critically ill | Research | Stress (Psychology) | Risk factors | Diseases
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Loading RightsShock, ISSN 1073-2322, 06/2018, Volume 49, Issue 6, pp. 625 - 630
Septic shock is the primary cause of death in intensive care units, with about 20% of patients dying in the first 3 days. To design future trials focused on...
Life Sciences | Human health and pathology
Life Sciences | Human health and pathology
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Loading RightsAmerican Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2012, Volume 186, Issue 1, pp. 65 - 71
Rationale: Although the outcome of sepsis benefits from the prompt administration of appropriate antibiotics on correct diagnosis, the assessment of infection...
CD64 | Sepsis | Diagnostic biomarkers | STREM-1 | Procalcitonin | ADULT PATIENTS | SCORE | diagnostic biomarkers | MARKERS | procalcitonin | ACCURACY | PLASMA | RESPIRATORY SYSTEM | SOLUBLE TRIGGERING RECEPTOR | sTREM-1 | NEUTROPHIL CD64 EXPRESSION | INFECTION | SERUM PROCALCITONIN | sepsis | MYELOID CELLS-1 | CRITICAL CARE MEDICINE | Calcitonin Gene-Related Peptide | Predictive Value of Tests | Calcitonin - blood | Prospective Studies | Protein Precursors - blood | Humans | Critical Illness | Membrane Glycoproteins - blood | Sepsis - diagnosis | Logistic Models | Biomarkers - blood | Triggering Receptor Expressed on Myeloid Cells-1 | Receptors, IgG - analysis | Myeloid Cells - metabolism | ROC Curve | Receptors, Immunologic - blood
CD64 | Sepsis | Diagnostic biomarkers | STREM-1 | Procalcitonin | ADULT PATIENTS | SCORE | diagnostic biomarkers | MARKERS | procalcitonin | ACCURACY | PLASMA | RESPIRATORY SYSTEM | SOLUBLE TRIGGERING RECEPTOR | sTREM-1 | NEUTROPHIL CD64 EXPRESSION | INFECTION | SERUM PROCALCITONIN | sepsis | MYELOID CELLS-1 | CRITICAL CARE MEDICINE | Calcitonin Gene-Related Peptide | Predictive Value of Tests | Calcitonin - blood | Prospective Studies | Protein Precursors - blood | Humans | Critical Illness | Membrane Glycoproteins - blood | Sepsis - diagnosis | Logistic Models | Biomarkers - blood | Triggering Receptor Expressed on Myeloid Cells-1 | Receptors, IgG - analysis | Myeloid Cells - metabolism | ROC Curve | Receptors, Immunologic - blood
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Loading RightsCritical Care Medicine, ISSN 0090-3493, 04/2016, Volume 44, Issue 4, pp. 764 - 772
OBJECTIVES:To assess whether early thrombocytopenia during septic shock is associated with an increased risk of death at day 28 and to identify risk factors...
septic shock | intensive care | thrombocytopenia | prognosis | SOLUBLE THROMBOMODULIN | INTENSIVE-CARE UNITS | IMMATURE PLATELET FRACTION | IMPAIRS HOST-DEFENSE | MICROPARTICLES | ACUTE PHYSIOLOGY | DYSFUNCTION | CRITICALLY-ILL PATIENTS | EPIDEMIOLOGY | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Severity of Illness Index | Prognosis | Prospective Studies | Hospital Mortality | Thrombocytopenia - etiology | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Shock, Septic - complications | Male | Shock, Septic - mortality | Platelet Count | Shock, Septic - blood | Adult | Female | Thrombocytopenia - diagnosis | Aged | France | Life Sciences | Human health and pathology
septic shock | intensive care | thrombocytopenia | prognosis | SOLUBLE THROMBOMODULIN | INTENSIVE-CARE UNITS | IMMATURE PLATELET FRACTION | IMPAIRS HOST-DEFENSE | MICROPARTICLES | ACUTE PHYSIOLOGY | DYSFUNCTION | CRITICALLY-ILL PATIENTS | EPIDEMIOLOGY | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Severity of Illness Index | Prognosis | Prospective Studies | Hospital Mortality | Thrombocytopenia - etiology | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Shock, Septic - complications | Male | Shock, Septic - mortality | Platelet Count | Shock, Septic - blood | Adult | Female | Thrombocytopenia - diagnosis | Aged | France | Life Sciences | Human health and pathology
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Loading RightsTrials, ISSN 1745-6215, 07/2014, Volume 15, Issue 1, pp. 270 - 270
Background: One of the most dreaded complications of septic shock is acute kidney injury. It occurs in around 50% of patients, with a mortality rate of about...
Septic shock | Intensive care | Renal replacement therapy | Severe acute kidney injury | MEDICINE, RESEARCH & EXPERIMENTAL | INTERNATIONAL CONSENSUS CONFERENCE | septic shock | renal replacement therapy | MANAGEMENT | intensive care | CONTINUOUS VENOVENOUS HEMOFILTRATION | severe acute kidney injury | FAILURE | RIFLE | RECOVERY | HEMODIALYSIS | CRITICALLY-ILL PATIENTS | CLINICAL-OUTCOMES | SEVERE SEPSIS | Humans | Renal Replacement Therapy - methods | Clinical Protocols | Shock, Septic - diagnosis | Shock, Septic - therapy | Time Factors | France | Length of Stay | Severity of Illness Index | Intensive Care Units | Time-to-Treatment | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Renal Replacement Therapy - mortality | Shock, Septic - mortality | Respiration, Artificial | Acute Kidney Injury - mortality | Acute Kidney Injury - diagnosis | Intention to Treat Analysis | Quality of Life | Acute Kidney Injury - therapy | Research Design | Renal Replacement Therapy - adverse effects | Medical care | Analysis | Quality management
Septic shock | Intensive care | Renal replacement therapy | Severe acute kidney injury | MEDICINE, RESEARCH & EXPERIMENTAL | INTERNATIONAL CONSENSUS CONFERENCE | septic shock | renal replacement therapy | MANAGEMENT | intensive care | CONTINUOUS VENOVENOUS HEMOFILTRATION | severe acute kidney injury | FAILURE | RIFLE | RECOVERY | HEMODIALYSIS | CRITICALLY-ILL PATIENTS | CLINICAL-OUTCOMES | SEVERE SEPSIS | Humans | Renal Replacement Therapy - methods | Clinical Protocols | Shock, Septic - diagnosis | Shock, Septic - therapy | Time Factors | France | Length of Stay | Severity of Illness Index | Intensive Care Units | Time-to-Treatment | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Renal Replacement Therapy - mortality | Shock, Septic - mortality | Respiration, Artificial | Acute Kidney Injury - mortality | Acute Kidney Injury - diagnosis | Intention to Treat Analysis | Quality of Life | Acute Kidney Injury - therapy | Research Design | Renal Replacement Therapy - adverse effects | Medical care | Analysis | Quality management
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Loading RightsCritical Care, ISSN 1364-8535, 04/2013, Volume 17, Issue 2, pp. R65 - R65
Introduction: To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive...
MORTALITY | INFLAMMATORY RESPONSE SYNDROME | GOAL-DIRECTED THERAPY | RISK-FACTORS | SCORE | ACUTE PHYSIOLOGY | ADULTS | SURVIVING SEPSIS | DYSFUNCTION | SEVERE SEPSIS | CRITICAL CARE MEDICINE | France - epidemiology | Intensive Care Units | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Shock, Septic - epidemiology | Male | Mortality - trends | Shock, Septic - diagnosis | Shock, Septic - mortality | Aged, 80 and over | Female | Aged | Cohort Studies | Infection | Care and treatment | Prognosis | Critically ill | Analysis | Immunotherapy | Mortality | Septic shock | France | Epidemiology | Life Sciences | Human health and pathology | Tissues and Organs | Research
MORTALITY | INFLAMMATORY RESPONSE SYNDROME | GOAL-DIRECTED THERAPY | RISK-FACTORS | SCORE | ACUTE PHYSIOLOGY | ADULTS | SURVIVING SEPSIS | DYSFUNCTION | SEVERE SEPSIS | CRITICAL CARE MEDICINE | France - epidemiology | Intensive Care Units | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Shock, Septic - epidemiology | Male | Mortality - trends | Shock, Septic - diagnosis | Shock, Septic - mortality | Aged, 80 and over | Female | Aged | Cohort Studies | Infection | Care and treatment | Prognosis | Critically ill | Analysis | Immunotherapy | Mortality | Septic shock | France | Epidemiology | Life Sciences | Human health and pathology | Tissues and Organs | Research
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Loading RightsAmerican journal of respiratory and critical care medicine, ISSN 1073-449X, 09/2019, Volume 200, Issue 5, pp. 646 - 647
Hemodynamic instability is a frequent issue in brain-injured patients, and even more so in cases involving multiple trauma. [...]RRT-associated hemodynamic...
Kidneys | Traumatic brain injury | Renal replacement therapy | Patients
Kidneys | Traumatic brain injury | Renal replacement therapy | Patients
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Loading RightsCirculation, ISSN 0009-7322, 07/2015, Volume 132, Issue 3, pp. 182 - 193
Background Targeted temperature management is recommended after out-of-hospital cardiac arrest. Whether advanced internal cooling is superior to basic external...
endovascular procedures | heart arrest | hypothermia | prognosis | therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | SAFETY | INDUCTION | CARE | THERAPEUTIC HYPOTHERMIA | SURFACE | PERIPHERAL VASCULAR DISEASE | COMATOSE SURVIVORS | Single-Blind Method | Hypothermia, Induced - mortality | Prospective Studies | Survival Rate - trends | Follow-Up Studies | Humans | Middle Aged | Male | Out-of-Hospital Cardiac Arrest - mortality | Out-of-Hospital Cardiac Arrest - diagnosis | Endovascular Procedures - mortality | Body Temperature | Out-of-Hospital Cardiac Arrest - therapy | Endovascular Procedures - methods | Hypothermia, Induced - methods | Female | Aged | Disease Management | Clinical trials | Usage | Management | Risk factors | Cardiac arrest | Hypothermia | Index Medicus | Abridged Index Medicus
endovascular procedures | heart arrest | hypothermia | prognosis | therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | SAFETY | INDUCTION | CARE | THERAPEUTIC HYPOTHERMIA | SURFACE | PERIPHERAL VASCULAR DISEASE | COMATOSE SURVIVORS | Single-Blind Method | Hypothermia, Induced - mortality | Prospective Studies | Survival Rate - trends | Follow-Up Studies | Humans | Middle Aged | Male | Out-of-Hospital Cardiac Arrest - mortality | Out-of-Hospital Cardiac Arrest - diagnosis | Endovascular Procedures - mortality | Body Temperature | Out-of-Hospital Cardiac Arrest - therapy | Endovascular Procedures - methods | Hypothermia, Induced - methods | Female | Aged | Disease Management | Clinical trials | Usage | Management | Risk factors | Cardiac arrest | Hypothermia | Index Medicus | Abridged Index Medicus
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Loading RightsThe New England Journal of Medicine, ISSN 0028-4793, 10/2018, Volume 379, Issue 15, pp. 1431 - 1442
A multicenter, randomized, controlled trial compared early with delayed strategies of renal-replacement therapy in patients with early-stage septic shock who...
INTERNATIONAL CONSENSUS CONFERENCE | MEDICINE, GENERAL & INTERNAL | HEMOFILTRATION | INITIATION | SEPTIC SHOCK | ORGAN FAILURE | CRITICALLY-ILL PATIENTS | Time-to-Treatment | Humans | Middle Aged | Renal Replacement Therapy | Shock, Septic - complications | Male | Acute Kidney Injury - mortality | Acute Kidney Injury - complications | Treatment Failure | Survival Analysis | Kidney Failure, Chronic - classification | Female | Acute Kidney Injury - therapy | Aged | Kidney Failure, Chronic - etiology | Sepsis | Care and treatment | Patient outcomes | Acute renal failure | Creatinine | Urine | End-stage renal disease | Intensive care | Kidneys | Mortality | Body weight | Septic shock | Metabolism | Patients | Design | Anuria | Classification | Renal failure | Kidney diseases | Health risk assessment | Life Sciences
INTERNATIONAL CONSENSUS CONFERENCE | MEDICINE, GENERAL & INTERNAL | HEMOFILTRATION | INITIATION | SEPTIC SHOCK | ORGAN FAILURE | CRITICALLY-ILL PATIENTS | Time-to-Treatment | Humans | Middle Aged | Renal Replacement Therapy | Shock, Septic - complications | Male | Acute Kidney Injury - mortality | Acute Kidney Injury - complications | Treatment Failure | Survival Analysis | Kidney Failure, Chronic - classification | Female | Acute Kidney Injury - therapy | Aged | Kidney Failure, Chronic - etiology | Sepsis | Care and treatment | Patient outcomes | Acute renal failure | Creatinine | Urine | End-stage renal disease | Intensive care | Kidneys | Mortality | Body weight | Septic shock | Metabolism | Patients | Design | Anuria | Classification | Renal failure | Kidney diseases | Health risk assessment | Life Sciences
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Loading RightsSHOCK, ISSN 1073-2322, 10/2019, Volume 52, Issue 4, pp. e22 - e30
BACKGROUND:In septic shock, both systemic vasodilatation and glomerular arteriole dilatation are responsible for the drop in glomerular filtration observed in...
Complications and side effects | Prognosis | Kidney function tests | Physiological aspects | Septic shock | Hemodynamics | Health aspects | Acute renal failure | Risk factors | Life Sciences | Hematology | Human health and pathology
Complications and side effects | Prognosis | Kidney function tests | Physiological aspects | Septic shock | Hemodynamics | Health aspects | Acute renal failure | Risk factors | Life Sciences | Hematology | Human health and pathology
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Loading RightsInternational Journal of Cardiology, ISSN 0167-5273, 11/2018, Volume 270, pp. 189 - 189
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Loading RightsAmerican journal of respiratory and critical care medicine, ISSN 1073-449X, 05/2019, Volume 199, Issue 9, pp. 1066 - 1075
Acute kidney injury (AKI) affects many ICU patients and is responsible for increased morbidity and mortality. Although lifesaving in many situations, renal...
Studies | Hypotheses | Intensive care | Kidneys | Respiratory distress syndrome | Medical prognosis | Mortality | Clinical trials | Critical care | Renal replacement therapy | Metabolism
Studies | Hypotheses | Intensive care | Kidneys | Respiratory distress syndrome | Medical prognosis | Mortality | Clinical trials | Critical care | Renal replacement therapy | Metabolism
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Loading RightsJAMA, ISSN 0098-7484, 10/2017, Volume 318, Issue 15, pp. 1450 - 1459
IMPORTANCE: The high mortality rate in critically ill elderly patients has led to questioning of the beneficial effect of intensive care unit (ICU) admission...
MEDICINE, GENERAL & INTERNAL | MULTICENTER | BENEFIT | ADMISSION | OLDER | ICU | ILLNESS | FRAILTY | QUALITY-OF-LIFE | France - epidemiology | Critical Care - standards | Hospital Mortality | Outcome Assessment (Health Care) | Humans | Intensive Care Units - statistics & numerical data | Male | Activities of Daily Living | Critical Illness - mortality | Time Factors | Aged, 80 and over | Quality of Life | Female | Aged | Patient Admission - statistics & numerical data | Triage | Program Evaluation | Health Status | Critical Care Outcomes | Intensive care units | Hospitals | Critically ill | Mortality | Analysis | Management | France | Health aspects | Risk factors | Admission and discharge | Elderly people | Intensive care | Activities of daily living | Clinical trials | Risk | Cachexia | Patients | Quality of life | Randomization | Older people | Death | Elderly | Emergency medical services | Nutritional status | Chronic illnesses | Cancer | Geriatrics | Life Sciences | Human health and pathology | Caring for the Critically Ill Patient | Online First | Research | Original Investigation
MEDICINE, GENERAL & INTERNAL | MULTICENTER | BENEFIT | ADMISSION | OLDER | ICU | ILLNESS | FRAILTY | QUALITY-OF-LIFE | France - epidemiology | Critical Care - standards | Hospital Mortality | Outcome Assessment (Health Care) | Humans | Intensive Care Units - statistics & numerical data | Male | Activities of Daily Living | Critical Illness - mortality | Time Factors | Aged, 80 and over | Quality of Life | Female | Aged | Patient Admission - statistics & numerical data | Triage | Program Evaluation | Health Status | Critical Care Outcomes | Intensive care units | Hospitals | Critically ill | Mortality | Analysis | Management | France | Health aspects | Risk factors | Admission and discharge | Elderly people | Intensive care | Activities of daily living | Clinical trials | Risk | Cachexia | Patients | Quality of life | Randomization | Older people | Death | Elderly | Emergency medical services | Nutritional status | Chronic illnesses | Cancer | Geriatrics | Life Sciences | Human health and pathology | Caring for the Critically Ill Patient | Online First | Research | Original Investigation
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