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1. Full Text Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
by Gordon Hutchins and Katie Southward and Kelly Handley and Laura Magill and Claire Beaumont and Jens Stahlschmidt and Susan Richman and Philip Chambers and Matthew Seymour and David Kerr and Richard Gray and Philip Quirke
Journal of clinical oncology, ISSN 0732-183X, 04/2011, Volume 29, Issue 10, pp. 1261 - 1270
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Immunohistochemistry | Leucovorin - administration & dosage | MutL Protein Homolog 1 | Recurrence | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Nuclear Proteins - analysis | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | England | Patient Selection | Fluorouracil - administration & dosage | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | DNA Mismatch Repair | Chemotherapy, Adjuvant | Odds Ratio | Colorectal Neoplasms - mortality | Colorectal Neoplasms - enzymology | Risk Assessment | Risk Factors | Proto-Oncogene Proteins - genetics | Treatment Outcome | Adaptor Proteins, Signal Transducing - analysis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | MutS Homolog 2 Protein - analysis | Mutation | Colorectal Neoplasms - pathology | Neoplasm Staging | Adjuvants | Index Medicus
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2. Full Text KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial
by Susan D. Richman and Matthew T. Seymour and Philip Chambers and Faye Elliott and Catherine L. Daly and Angela M. Meade and Graham Taylor and Jennifer H. Barrett and Philip Quirke
Journal of clinical oncology, ISSN 0732-183X, 12/2009, Volume 27, Issue 35, pp. 5931 - 5937
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | MutL Protein Homolog 1 | ras Proteins - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Nuclear Proteins - analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Colorectal Neoplasms - chemistry | Patient Selection | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Camptothecin - administration & dosage | Camptothecin - analogs & derivatives | Precision Medicine | Colorectal Neoplasms - mortality | Risk Assessment | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Treatment Outcome | Adaptor Proteins, Signal Transducing - analysis | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Biomarkers, Tumor - genetics | Mutation | Colorectal Neoplasms - pathology | Index Medicus
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3. Full Text HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials
by Richman, Susan D and Southward, Katie and Chambers, Philip and Cross, Debra and Barrett, Jennifer and Hemmings, Gemma and Taylor, Morag and Wood, Henry and Hutchins, Gordon and Foster, Joseph M and Oumie, Assa and Spink, Karen G and Brown, Sarah R and Jones, Marc and Kerr, David and Handley, Kelly and Gray, Richard and Seymour, Matthew and Quirke, Philip
The Journal of pathology, ISSN 0022-3417, 03/2016, Volume 238, Issue 4, pp. 562 - 570
overexpression, copy number variation | amplification | colorectal cancer | HER2 | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Receptor, ErbB-2 - genetics | Colorectal Neoplasms - genetics | Humans | Receptor, ErbB-2 - metabolism | Male | Clinical Trials as Topic | DNA Copy Number Variations - genetics | Mutation - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Female | Neoplasm Recurrence, Local - genetics | Neoplasm Staging | Gene Expression Regulation, Neoplastic - genetics | Cancer patients | Health aspects | Analysis | Colorectal cancer | Index Medicus | Original Paper | Original Papers
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4. Full Text A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS
by Gollins, Simon and West, Nicholas and Sebag-Montefiore, David and Susnerwala, Shabbir and Falk, Stephen and Brown, Nick and Saunders, Mark and Quirke, Philip and Ray, Ruby and Parsons, Philip and Griffiths, Gareth and Maughan, Tim and Adams, Richard and Hurt, Chris
British journal of cancer, ISSN 0007-0920, 09/2018, Volume 119, Issue 6, pp. 697 - 706
Life Sciences & Biomedicine | Oncology | Science & Technology | Radiotherapy Dosage | Prospective Studies | Drug Administration Schedule | Humans | Middle Aged | Male | Treatment Outcome | Combined Modality Therapy | Oxaliplatin - adverse effects | Rectal Neoplasms - therapy | Feasibility Studies | Patient Compliance - statistics & numerical data | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Radiotherapy, Adjuvant - adverse effects | Neoadjuvant Therapy - methods | Survival Analysis | Adult | Female | Aged | Oxaliplatin - administration & dosage | Rectal Neoplasms - pathology | Chemotherapy, Adjuvant | Neoplasm Staging | Rectal cancer
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5. Full Text Complete Mesocolic Excision With Central Vascular Ligation Produces an Oncologically Superior Specimen Compared With Standard Surgery for Carcinoma of the Colon
by Nicholas P. West and Werner Hohenberger and Klaus Weber and Aristoteles Perrakis and Paul J. Finan and Philip Quirke
Journal of clinical oncology, ISSN 0732-183X, 01/2010, Volume 28, Issue 2, pp. 272 - 278
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colonic Neoplasms - surgery | Ligation | Colonic Neoplasms - blood supply | Mesocolon - surgery | Colonic Neoplasms - pathology | Humans | Colectomy - methods | Anastomosis, Surgical | Female | Male | Adenocarcinoma - blood supply | Adenocarcinoma - surgery | Index Medicus
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6. Full Text Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study
by West, Nicholas P, MBChB and Morris, Eva JA, PhD and Rotimi, Olorunda, FRCPath and Cairns, Alison, FRCPath and Finan, Paul J, FRCS and Quirke, Philip, Prof
The lancet oncology, ISSN 1470-2045, 2008, Volume 9, Issue 9, pp. 857 - 865
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Single-Blind Method | Colectomy - standards | Multivariate Analysis | Adenocarcinoma - pathology | Neoplasm Recurrence, Local - prevention & control | Humans | Mesocolon - pathology | Colectomy - methods | Kaplan-Meier Estimate | Proportional Hazards Models | England | Male | Palliative Care | Colonic Neoplasms - surgery | Mesocolon - surgery | Colonic Neoplasms - pathology | Female | Aged | Retrospective Studies | Quality of Health Care | Adenocarcinoma - surgery | Colon cancer | Research | Oncology, Experimental | Surgery | Cancer | Index Medicus
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7. Full Text Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
by Seymour, Matthew T, Prof and Brown, Sarah R, PhD and Middleton, Gary, Prof and Maughan, Timothy, Prof and Richman, Susan, PhD and Gwyther, Stephen, FRCR and Lowe, Catherine, MA and Seligmann, Jennifer F, MBChB and Wadsley, Jonathan, MBBChir and Maisey, Nick, MD and Chau, Ian, MD and Hill, Mark, MD and Dawson, Lesley, MBChB and Falk, Stephen, MD and O'Callaghan, Ann, MBB Ch BAO and Benstead, Kim, MD and Chambers, Philip, PhD and Oliver, Alfred, LLB and Marshall, Helen, MSc and Napp, Vicky, BSc and Quirke, Phil, Prof
The lancet oncology, ISSN 1470-2045, 2013, Volume 14, Issue 8, pp. 749 - 759
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prospective Studies | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Fluorouracil - therapeutic use | Receptor, Epidermal Growth Factor - metabolism | Time Factors | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Camptothecin - adverse effects | Colorectal Neoplasms - enzymology | Camptothecin - therapeutic use | Drug Administration Schedule | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Treatment Outcome | United Kingdom | Chi-Square Distribution | Disease-Free Survival | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Mutation | Colorectal Neoplasms - pathology | Antimitotic agents | Clinical trials | Care and treatment | Antineoplastic agents | Colorectal cancer | Index Medicus
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8. Full Text Understanding Optimal Colonic Cancer Surgery: Comparison of Japanese D3 Resection and European Complete Mesocolic Excision With Central Vascular Ligation
by Nicholas P. West and Hirotoshi Kobayashi and Keiichi Takahashi and Aristoteles Perrakis and Klaus Weber and Werner Hohenberger and Kenichi Sugihara and Philip Quirke
Journal of clinical oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 15, pp. 1763 - 1769
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Lymph Node Excision | Lymph Nodes - pathology | Colonic Neoplasms - blood supply | Lymph Nodes - surgery | Humans | Japan | Mesocolon - pathology | Middle Aged | Colectomy - methods | Male | Treatment Outcome | Laparoscopy | Mesocolon - blood supply | Colonic Neoplasms - surgery | Ligation | Mesocolon - surgery | Colonic Neoplasms - pathology | Female | Vascular Surgical Procedures | Aged | Dissection | Germany | Index Medicus
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9. Full Text Preoperative Magnetic Resonance Imaging Assessment of Circumferential Resection Margin Predicts Disease-Free Survival and Local Recurrence: 5-Year Follow-Up Results of the MERCURY Study
by Fiona G.M. Taylor and Philip Quirke and Richard J. Heald and Brendan J. Moran and Lennart Blomqvist and Ian R. Swift and David Sebag-Montefiore and Paris Tekkis and Gina Brown and Magnetic Resonance Imaging in Rectal Cancer European Equivalence Study Study Group
Journal of clinical oncology, ISSN 0732-183X, 01/2014, Volume 32, Issue 1, pp. 34 - 43
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Rectal Neoplasms - diagnosis | Predictive Value of Tests | Prognosis | Follow-Up Studies | Humans | Middle Aged | Male | Aged, 80 and over | Adult | Female | Rectal Neoplasms - pathology | Odds Ratio | Rectal Neoplasms - surgery | Europe | Kaplan-Meier Estimate | Proportional Hazards Models | Neoplasm Recurrence, Local - diagnosis | Disease Progression | Rectal Neoplasms - mortality | Disease-Free Survival | Magnetic Resonance Imaging | Confounding Factors (Epidemiology) | Analysis of Variance | Aged | Neoplasm Staging | Research Design | Preoperative Period | Index Medicus | Medicin och hälsovetenskap
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10. Full Text What is the Role of the Neutrophil: Lymphocyte Ratio in Colorectal Cancer?
by Bhattacharjee, Debamita and Quirke, Philip
Turkish journal of colorectal disease, ISSN 2536-4898, 02/2021, Volume 31, Issue 1, pp. 1 - 12
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11. Full Text Validation Study of a Quantitative Multigene Reverse Transcriptase–Polymerase Chain Reaction Assay for Assessment of Recurrence Risk in Patients With Stage II Colon Cancer
by Richard G. Gray and Philip Quirke and Kelly Handley and Margarita Lopatin and Laura Magill and Frederick L. Baehner and Claire Beaumont and Kim M. Clark-Langone and Carl N. Yoshizawa and Mark Lee and Drew Watson and Steven Shak and David J. Kerr
Journal of clinical oncology, ISSN 0732-183X, 12/2011, Volume 29, Issue 35, pp. 4611 - 4619
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colonic Neoplasms - genetics | Gene Expression | Genetic Predisposition to Disease | Prospective Studies | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Male | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Reverse Transcriptase Polymerase Chain Reaction - standards | Colonic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction - methods | Aged, 80 and over | Adult | Female | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | Index Medicus
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12. Full Text Magnetic Resonance Imaging–Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience
by Uday B. Patel and Fiona Taylor and Lennart Blomqvist and Christopher George and Hywel Evans and Paris Tekkis and Philip Quirke and David Sebag-Montefiore and Brendan Moran and Richard Heald and Ashley Guthrie and Nicola Bees and Ian Swift and Kjell Pennert and Gina Brown
Journal of clinical oncology, ISSN 0732-183X, 10/2011, Volume 29, Issue 28, pp. 3753 - 3760
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Prospective Studies | Rectal Neoplasms - surgery | Humans | Middle Aged | Male | Survival Rate | Rectal Neoplasms - radiotherapy | Disease-Free Survival | Magnetic Resonance Imaging | Female | Neoadjuvant Therapy | Aged | Rectal Neoplasms - pathology | Neoplasm Staging | Radiotherapy, Adjuvant | Cohort Studies | Index Medicus | Medicin och hälsovetenskap
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