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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2014, Volume 111, Issue 11, pp. 4055 - 4060
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 2018, Volume 19, Issue 12, p. 4074
Small G-proteins are structurally-conserved modules that function as molecular on-off switches. They function in many different cellular processes with... 
LRRK2 | Small GTPase | Intramolecular mechanism | Roc
Journal Article
Materials Horizons, ISSN 2051-6347, 03/2019, Volume 6, Issue 3, pp. 604 - 611
The development of sensors for monitoring hazardous materials in security and environmental applications has been increasing in the last few years. In... 
CHEMISTRY, MULTIDISCIPLINARY | MATERIALS SCIENCE, MULTIDISCIPLINARY | BIOSENSOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, p. 9593
  Multiple system atrophy (MSA) is a sporadic orphan neurodegenerative disorder. No treatment is currently available to slow down the aggressive... 
Proteins | Pathology | Neurotoxicity | Cellular biology | Neurodegeneration | Epilepsy
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, p. E6572
  The transcription factor T-bet (Tbox protein expressed in T cells) is one of the master regulators of both the innate and adaptive immune responses. It plays... 
Lymphocytes | Fluorescence | Protein expression | Genomes | Biological assays | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, p. 9587
  The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare... 
Proteins | Pathology | Pathogenesis | Neurons | Parkinsons disease | Mutation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2014, Volume 111, Issue 30, p. 11007
  Pharmacological chaperones are small molecules that bind to proteins and stabilize them against thermal denaturation or proteolytic degradation, as well as... 
Proteins | Molecules | Parkinsons disease | Pharmacology | Binding sites | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 34, pp. 9593 - 9598
Multiple system atrophy (MSA) is a sporadic orphan neurodegenerative disorder. No treatment is currently available to slow down the aggressive... 
Multiple system atrophy | Alpha-synuclein | Caspase-1 | Truncation | PROTEOLYTIC CLEAVAGE | HUMAN ALPHA-SYNUCLEIN | MULTIDISCIPLINARY SCIENCES | multiple system atrophy | alpha-synuclein | IN-VITRO | PROLYL OLIGOPEPTIDASE INHIBITOR | MOUSE MODEL | ANIMAL-MODELS | MICE | caspase-1 | truncation | LEWY BODIES | AGGREGATION | PARKINSONS-DISEASE | Neurons - pathology | Oligodendroglia - metabolism | Tyrosine 3-Monooxygenase - metabolism | Substantia Nigra - pathology | para-Aminobenzoates - pharmacology | Humans | Caspase 1 - metabolism | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Oligodendroglia - drug effects | Protein Aggregates - genetics | Proteolysis | Multiple System Atrophy - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Neurons - drug effects | Corpus Striatum - pathology | Disease Models, Animal | Protein Aggregates - drug effects | Signal Transduction | Multiple System Atrophy - pathology | Dipeptides - pharmacology | Gene Expression Regulation | Mice, Transgenic | Clinical Trials as Topic | Multiple System Atrophy - genetics | alpha-Synuclein - chemistry | Oligodendroglia - pathology | Tyrosine 3-Monooxygenase - genetics | Substantia Nigra - drug effects | Animals | Caspase 1 - genetics | Corpus Striatum - drug effects | Multiple System Atrophy - drug therapy | Mice | alpha-Synuclein - metabolism | Atrophy | Physiological aspects | Neural circuitry | Health aspects | Life Sciences | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2014, Volume 111, Issue 11, p. 4055
  Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase... 
Parkinsons disease | Biochemistry | Kinases
Journal Article
Nature, ISSN 0028-0836, 10/2003, Volume 425, Issue 6961, pp. 977 - 980
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 44, p. 17820
  Bacillus subtilis GabR is a transcription factor that regulates gamma-aminobutyric acid (GABA) metabolism. GabR is a member of the understudied MocR/GabR... 
Proteins | Molecular structure | Gram-positive bacteria | Metabolism | Binding sites | Cells
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 43, p. 17797
A heterologously expressed form of the human Parkinson disease-associated protein α-synuclein with a 10-residue N-terminal extension is shown to form a stable... 
Proteins | Nuclear magnetic resonance--NMR | Molecular structure | Parkinsons disease | Lipids
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. 803 - 804
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. 803 - 804
Journal Article
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