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1. Full Text Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress
by Rainbolt, T. Kelly and Lebeau, Justine and Puchades, Cristina and Wiseman, R. Luke
Cell reports (Cambridge), ISSN 2211-1247, 03/2016, Volume 14, Issue 9, pp. 2041 - 2049
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Mitochondria - enzymology | ATPases Associated with Diverse Cellular Activities | Proteolysis | Adenosine Triphosphate - metabolism | Humans | Membrane Potential, Mitochondrial | Metalloendopeptidases - metabolism | Mitochondrial Proteins | Peptide Hydrolases - metabolism | Index Medicus
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2. Full Text Lining up for quality control: linear ubiquitin and proteotoxicity
by Wiseman, R Luke
The EMBO journal, ISSN 0261-4189, 05/2019, Volume 38, Issue 9, p. n/a
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ubiquitin | Proteasome Endopeptidase Complex | Ubiquitination | Proteins | Neurological diseases | Immunology | Neurodegenerative diseases | Pathogenesis | Quality control | Inflammation | Index Medicus | Neuroscience | Post-translational Modifications, Proteolysis & Proteomics | Views
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3. Full Text Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy
by Plate, Lars and Wiseman, R. Luke
Trends in cell biology, ISSN 0962-8924, 2017, Volume 27, Issue 10, pp. 722 - 737
Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Activating Transcription Factor 6 - metabolism | Secretory Pathway - physiology | Animals | Proteostasis - physiology | Humans | Signal Transduction - physiology | Biological Transport - physiology | Proteome - metabolism | Unfolded Protein Response - physiology | Repressor Proteins - metabolism | Endoplasmic Reticulum Stress - physiology | Studies | Proteins | Signal transduction | Signaling | Pathways | Protein folding | Etiology | Aging | Activation | Proteomes | Endoplasmic reticulum | Index Medicus
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4. Full Text Targeting protein aggregation for the treatment of degenerative diseases
by Eisele, Yvonne S and Monteiro, Cecilia and Fearns, Colleen and Encalada, Sandra E and Wiseman, R. Luke and Powers, Evan T and Kelly, Jeffery W
Nature reviews. Drug discovery, ISSN 1474-1776, 11/2015, Volume 14, Issue 11, pp. 759 - 780
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Neurodegenerative Diseases - pathology | Humans | Treatment Outcome | Protein Transport - drug effects | Structure-Activity Relationship | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Protein Aggregation, Pathological - drug therapy | Prealbumin - antagonists & inhibitors | Biological Factors - therapeutic use | Animals | Prealbumin - metabolism | Protein Aggregation, Pathological - pathology | Protein Folding - drug effects | Prealbumin - chemistry | Biological Factors - pharmacology | Protein Aggregation, Pathological - metabolism | Degeneration (Pathology) | Care and treatment | Amyloidosis | Genetic aspects | Research | Index Medicus
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5. Full Text Small molecule strategies to harness the unfolded protein response: Where do we go from here?
by Grandjean, Julia M.D and Luke Wiseman, R
The Journal of biological chemistry, ISSN 0021-9258, 11/2020, Volume 295, Issue 46, pp. 15692 - 15711
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Index Medicus | small molecule | high-throughput screening (HTS) | stress response | JBC Reviews | modulation | unfolded protein response (UPR) | endoplasmic reticulum stress (ER stress) | endoplasmic reticulum (ER) | proteostasis
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6. Full Text Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
by Shoulders, Matthew D and Ryno, Lisa M and Genereux, Joseph C and Moresco, James J and Tu, Patricia G and Wu, Chunlei and Yates, John R and Su, Andrew I and Kelly, Jeffery W and Wiseman, R. Luke
Cell reports (Cambridge), ISSN 2211-1247, 04/2013, Volume 3, Issue 4, pp. 1279 - 1292
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Transcription, Genetic - drug effects | Trimethoprim - pharmacology | Humans | Endoplasmic Reticulum - metabolism | Transcriptome - drug effects | Unfolded Protein Response | Regulatory Factor X Transcription Factors | Doxorubicin - toxicity | X-Box Binding Protein 1 | Hep G2 Cells | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Prealbumin - metabolism | Protein Folding - drug effects | HEK293 Cells | Proteomics | Index Medicus
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7. Full Text PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress
by Romine, Isabelle C and Wiseman, R. Luke
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 410 - 410
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amyloidogenesis | Proteins | Thapsigargin | Cell survival | Protein folding | Secretion | Transthyretin | Aging | Endoplasmic reticulum | Index Medicus
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