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1. Full Text Su1827 - Markers of Systemic Inflammation in Moderate-Severe Ulcerative Colitis: What Level of C-Reactive Protein Constitutes Acute Severe Ulcerative Colitis?
by Croft, Anthony and Lord, Anton and Radford-Smith, Graham L
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-598 - S-598
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2. Full Text Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients
by Yang Wu and Simon Ghaly and Stephen Kerr and Bryce Jackson and Katherine Hanigan and Deborah Martins and Krupa Krishnaprasad and Reme E Mountifield and David C Whiteman and Peter A Bampton and Richard B Gearry and Graham L Radford-Smith and Ian C Lawrance
Digestive Diseases and Sciences, ISSN 0163-2116, 09/2019, pp. 1 - 8
Background Retrospective studies observe an increased risk of keratinocyte carcinomas (KCs) in patients with inflammatory bowel disease (IBD) on thiopurine... 
Inflammatory bowel disease | Ultraviolet radiation | Cosmetics industry | Skin cancer
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3. Full Text Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
by Gharahkhani, Puya and Gharahkhani, Puya and Burdon, Kathryn P and Fogarty, Rhys and Sharma, Shiwani and Hewitt, Alex W and Martin, Sarah and Law, Matthew H and Cremin, Katie and Bailey, Jessica N. Cooke and Loomis, Stephanie J and Pasquale, Louis R and Haines, Jonathan L and Hauser, Michael A and Viswanathan, Ananth C and McGuffin, Peter and Topouzis, Fotis and Foster, Paul J and Graham, Stuart L and Casson, Robert J and Chehade, Mark and White, Andrew J and Zhou, Tiger and Souzeau, Emmanuelle and Landers, John and Fitzgerald, Jude T and Klebe, Sonja and Ruddle, Jonathan B and Goldberg, Ivan and Healey, Paul R and Mills, Richard A and Wang, Jie Jin and Montgomery, Grant W and Martin, Nicholas G and Radford-Smith, Graham and Whiteman, David C and Brown, Matthew A and Wiggs, Janey L and Mackey, David A and Mitchell, Paul and Macgregor, Stuart and Craig, Jamie E and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium 2
Nature genetics, ISSN 1061-4036, 10/2014, Volume 46, Issue 10, pp. 1120 - 1125
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian... 
BIOLOGICAL FUNCTION | GENE | AQUEOUS-HUMOR | ABILITY | GENETICS & HEREDITY | IDENTIFICATION | GENOME-WIDE ASSOCIATION | AFAP-110 | Glaucoma | Genetic aspects | Genetic variation | Health aspects | Risk factors | Studies | Genotype & phenotype | American Recovery & Reinvestment Act 2009-US | Genomes | Gene loci | Chromosomes | Meta-analysis | Index Medicus
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4. Full Text Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
by Franke, Ane and McGovern, Dermot P. B and Barrett, Jeffrey C and Wang, Kai and Radford-Smith, Graham L and Ahmad, Tariq and Lees, Charlie W and Balschun, Tobias and Lee, James and Roberts, Rebecca and Anderson, Carl A and Bis, Joshua C and Bumpstead, Suzanne and Ellinghaus, David and Festen, Eleonora M and Georges, Michel and Green, Todd and Haritunians, Talin and Jostins, Luke and Latiano, Anna and Mathew, Christopher G and Montgomery, Grant W and Prescott, Natalie J and Raychaudhuri, Soumya and Rotter, Jerome I and Schumm, Philip and Sharma, Yashoda and Simms, Lisa A and Taylor, Kent D and Whiteman, David and Wijmenga, Cisca and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and Stronati, Laura and Denson, Ted and de Vos, Martine and D'Inca, Renata and Dubinsky, Marla and Edwards, Cathryn and Florin, Tim and Franchimont, Denis and Gearry, Richard and Glas, Jürgen and van Gossum, Ane and Guthery, Stephen L and Halfvarson, Jonas and Verspaget, Hein W and Hugot, Jean-Pierre and Karban, Amir and Laukens, Debby and Lawrance, Ian and Lemann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and Mowat, Craig and Newman, William and Panés, Julián and Phillips, Anne and Proctor, Deborah D and Regueiro, Miguel and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Seibold, Frank and Steinhart, A. Hillary and Stokkers, Pieter C. F and Torkvist, Leif and Kullak-Ublick, Gerd and Wilson, David and Walters, Thomas and Targan, Stephan R and Brant, Steven R and Rioux, John D and D'Amato, Mauro and Weersma, Rinse K and Kugathasan, Subra and Griffiths, Anne M and Mansfield, John C and Vermeire, Severine and Duerr, Richard H and Silverberg, Mark S and Satsangi, Jack and Schreiber, Stefan and Cho, Judy H and Annese, Vito and Hakonarson, Hakon and Daly, Mark J and Parkes, Miles and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 12, pp. 1118 - 1125
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls... 
COMMON VARIANTS | ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | PROTEIN | NEDD4 FAMILY | GENE | GENETICS & HEREDITY | SEQUENCE VARIANTS | RECEPTOR | IDENTIFICATION | ASSOCIATION | Genetic Variation | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Computational Biology | Genetic Loci - genetics | Crohn Disease - etiology | Genome, Human - genetics | Genetic Linkage | Care and treatment | Methyltransferases | Physiological aspects | Disease susceptibility | Genetic aspects | Crohn's disease | Research | Risk factors | Inflammatory bowel disease | Genetics | Genomics | Meta-analysis | Index Medicus | Medicine | Medicin | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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5. Full Text Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
by Law, Matthew H and Bishop, D Timothy and Lee, Jeffrey E and Brossard, Myriam and Martin, Nicholas G and Moses, Eric K and Song, Fengju and Barrett, Jennifer H and Kumar, Rajiv and Easton, Douglas F and Pharoah, Paul D.P and Swerdlow, Anthony J and Kypreou, Katerina P and Taylor, John C and Harland, Mark and Randerson-Moor, Juliette and Akslen, Lars A and Andresen, Per A and Avril, Marie-Françoise and Azizi, Esther and Scarrà, Giovanna Bianchi and Brown, Kevin M and Dębniak, Tadeusz and Duffy, David L and Elder, David E and Fang, Shenying and Friedman, Eitan and Galan, Pilar and Ghiorzo, Paola and Gillanders, Elizabeth M and Goldstein, Alisa M and Gruis, Nelleke A and Hansson, Johan and Helsing, Per and Hočevar, Marko and Höiom, Veronica and Ingvar, Christian and Kanetsky, Peter A and Chen, Wei V and Landi, Maria Teresa and Lang, Julie and Lathrop, G Mark and Lubiński, Jan and MacKie, Rona M and Mann, Graham J and Molven, Anders and Montgomery, Grant W and Novaković, Srdjan and Olsson, Håkan and Puig, Susana and Puig-Butille, Joan Anton and Qureshi, Abrar A and Radford-Smith, Graham L and Van Der Stoep, Nienke and Van Doorn, Remco and Whiteman, David C and Craig, Jamie E and Schadendorf, Dirk and Simms, Lisa A and Burdon, Kathryn P and Nyholt, Dale R and Pooley, Karen A and Orr, Nick and Stratigos, Alexander J and Cust, Anne E and Ward, Sarah V and Hayward, Nicholas K and Han, Jiali and Schulze, Hans-Joachim and Dunning, Alison M and Bishop, Julia A. Newton and Demenais, Florence and Amos, Christopher I and MacGregor, Stuart and Iles, Mark M and SDH Study Grp and AMFS Investigators and Essen-Heidelberg Investigators and GenoMEL Consortium and ATHENS Melanoma Study Grp and Q-MEGA QTWIN Investigators and SDH Study Group and Q-MEGA and QTWIN Investigators and ATHENS Melanoma Study Group and The SDH Study Group and Surgery (Lund) and Oncology and Pathology, Kamprad Lab and Lund University and EpiHealth: Epidemiology for Health and Kirurgi, Lund and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Lunds universitet and Onkologi och Patologi, Kampradlab
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 987 - 995
Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international... 
STEM-CELLS | PHENOTYPIC CHARACTERISTICS | GENOTYPE IMPUTATION | MEAN TELOMERE LENGTH | FIELD SYNOPSIS | GENETICS & HEREDITY | CANCER-RISK | SEQUENCE VARIANTS | ASSOCIATION | CELL CARCINOMA | SKIN-CANCER | Genetic Predisposition to Disease | Genome-Wide Association Study | Melanoma - genetics | Chromosomes, Human - genetics | Humans | Skin Neoplasms - genetics | Polymorphism, Single Nucleotide | Genetic Loci | Case-Control Studies | Disease susceptibility | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Melanoma | Glaucoma | Statistical analysis | Endometriosis | Genomes | DNA repair | Meta-analysis | Skin cancer | Datasets | Studies | Genotype & phenotype | Quality control | Telomerase | Deoxyribonucleic acid--DNA | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
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6. Full Text Su1938 - Il23R (Interleukin 23 Receptor) R381Q Gene Variant Impacts the Microbial Composition in Non-IBD Healthy Controls
by Zakrzewski, Martha and Simms, Lisa A and Brown, Allison and Appleyard, Mark and Irwin, James and Radford-Smith, Graham L
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-639 - S-639
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7. Full Text The effect on melanoma risk of genes previously associated with telomere length
by Iles, Mark M and Bishop, D Timothy and Taylor, John C and Hayward, Nicholas K and Brossard, Myriam and Cust, Anne E and Dunning, Alison M and Lee, Jeffrey E and Moses, Eric K and Akslen, Lars A and AMFS Investigators, Investigators and Andresen, Per A and Avril, Marie-Françoise and Azizi, Esther and Scarrà, Giovanna Bianchi and Brown, Kevin M and Debniak, Tadeusz and Elder, David E and Friedman, Eitan and Ghiorzo, Paola and Gillanders, Elizabeth M and Goldstein, Alisa M and Gruis, Nelleke A and Hansson, Johan and Harland, Mark and Helsing, Per and Hočevar, Marko and Höiom, Veronica and IBD investigators, investigators and Ingvar, Christian and Kanetsky, Peter A and Landi, Maria Teresa and Lang, Julie and Lathrop, G Mark and Lubiński, Jan and Mackie, Rona M and Martin, Nicholas G and Molven, Anders and Montgomery, Grant W and Novaković, Srdjan and Olsson, Håkan and Puig, Susana and Puig-Butille, Joan Anton and QMEGA and QTWIN Investigators, and QTWIN Investigators and Radford-Smith, Graham L and Randerson-Moor, Juliette and SDH Study Group, Study Group and van der Stoep, Nienke and van Doorn, Remco and Whiteman, David C and MacGregor, Stuart and Pooley, Karen A and Ward, Sarah V and Mann, Graham J and Amos, Christopher I and Pharoah, Paul D P and Demenais, Florence and Law, Matthew H and Newton Bishop, Julia A and Barrett, Jennifer H and GenoMEL Consortium, Consortium and AMFS Investigators and QTWIN Investigator and SDH Study Grp and IBD Investigators and GenoMEL Consortium and QMEGA Investigator and SDH Study Group and QMEGA and QTWIN Investigators and IBD investigators
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 10, p. 1
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated... 
INDIVIDUALS | SURVIVAL | METAANALYSIS | VARIANTS | ONCOLOGY | SUSCEPTIBILITY | DISEASE | CANCER-RISK | LOCI | GENOME-WIDE ASSOCIATION | Predictive Value of Tests | United States | Europe | Humans | RNA - genetics | Telomere-Binding Proteins - genetics | Confounding Factors (Epidemiology) | Telomerase - genetics | Melanoma - genetics | Skin Neoplasms - genetics | Germ-Line Mutation | Ribonucleoproteins - genetics | Zinc Fingers - genetics | Polymorphism, Single Nucleotide | Israel | Australia | DNA Helicases - genetics | Research Design | Telomere - genetics | Molecules | Effects | Causality | Risk factors | Melanoma | Polymorphism | Index Medicus
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8. Full Text NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
by Tye, Hazel and Yu, Chien-Hsiung and Simms, Lisa A and de Zoete, Marcel R and Kim, Man Lyang and Zakrzewski, Martha and Penington, Jocelyn S and Harapas, Cassandra R and Souza-Fonseca-Guimaraes, Fernando and Wockner, Leesa F and Preaudet, Adele and Mielke, Lisa A and Wilcox, Stephen A and Ogura, Yasunori and Corr, Sinead C and Kanojia, Komal and Kouremenos, Konstantinos A and De Souza, David P and McConville, Malcolm J and Flavell, Richard A and Gerlic, Motti and Kile, Benjamin T and Papenfuss, Anthony T and Putoczki, Tracy L and Radford-Smith, Graham L and Masters, Seth L
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3728 - 11
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we... 
ACTIVATION | INTERLEUKIN-18 | CROHNS-DISEASE | COLITIS | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MICROBIOTA | POLYMORPHISM | PYROPTOSIS | SEVERITY | Butyrates - metabolism | Intestinal Mucosa - metabolism | Humans | Clostridiales | Male | Interferon-gamma - metabolism | Inflammatory Bowel Diseases - metabolism | Gene Deletion | Vancomycin - pharmacology | Apoptosis Regulatory Proteins - genetics | Female | Inflammatory Bowel Diseases - drug therapy | Inflammasomes | Signal Transduction | Colon - pathology | Mice, Inbred C57BL | Rectum - metabolism | Gastrointestinal Microbiome | Mice, Transgenic | Apoptosis Regulatory Proteins - metabolism | Animals | T-Lymphocytes - cytology | Adaptor Proteins, Signal Transducing - genetics | Colitis - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-18 - metabolism | Inflammatory bowel diseases | Commensals | Mucosa | Vancomycin | Immunity | Antiinfectives and antibacterials | Interleukin 18 | Inflammatory bowel disease | Receptors | Microorganisms | Intestine | γ-Interferon | Rectum | Colon | Supplementation | Ulcerative colitis | Index Medicus
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9. Full Text Tu1659 - Development and Evaluation of a Risk Assessment Tool to Improve Clinical Triage Accuracy for Colonoscopic Investigations
by Lord, Anton and Simms, Lisa and Brown, Allison and Krishnaprasad, Krupa and Nagler, Belinda N and Croft, Anthony and Appleyard, Mark and Radford-Smith, Graham L
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-985 - S-985
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10. Full Text Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
by Beaudoin, M and Goyette, P and Boucher, G and Lo, K.S and Rivas, M.A and Stevens, C and Alikashani, A and Ladouceur, M and Ellinghaus, D and Torkvist, L and Goel, G and Lagace, C and Annese, V and Bitton, A and Begun, J and Brant, S.R and Bresso, F and Cho, J.H and Duerr, R.H and Halfvarson, J and McGovern, D.P and Radford-Smith, G and Schreiber, S and Schumm, P.L and Sharma, Y and Silverberg, M.S and Weersma, R.K and Quebec, I.B.D.G.C and Consortium, N.I.G and D'Amato, M and Vermeire, S and Franke, A and Lettre, G and Xavier, R.J and Daly, M.J and Rioux, J.D and Jong, D.J. de and Quebec IBD Genetics Consortium and NIDDK IBD Genetics Consortium and Int IBD Genetics Consortium and International IBD Genetics Consortium and Region Örebro län and Örebro universitet and Institutionen för hälsovetenskap och medicin
PLOS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 9, pp. e1003723 - e1003723
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated... 
INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | LIVER | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC-VARIANTS | NUCLEAR FACTOR 4-ALPHA | UBIQUITIN LIGASES | EXPRESSION | INTESTINAL EPITHELIAL-CELLS | GENOME-WIDE ASSOCIATION | Genomics | Genetic aspects | Crohn's disease | Research | Nucleotide sequencing | Ulcerative colitis | DNA sequencing | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Inflammatory bowel disease | Medical research | Hospitals | Genes
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11. Full Text Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
by MacGregor, Stuart and Ong, Jue-Sheng and An, Jiyuan and Han, Xikun and Zhou, Tiger and Siggs, Owen M and Law, Matthew H and Souzeau, Emmanuelle and Sharma, Shiwani and Lynn, David J and Beesley, Jonathan and Sheldrick, Bronwyn and Mills, Richard A and Landers, John and Ruddle, Jonathan B and Graham, Stuart L and Healey, Paul R and White, Andrew J. R and Casson, Robert J and Best, Stephen and Grigg, John R and Goldberg, Ivan and Powell, Joseph E and Whiteman, David C and Radford-Smith, Graham L and Martin, Nicholas G and Montgomery, Grant W and Burdon, Kathryn P and Mackey, David A and Gharahkhani, Puya and Craig, Jamie E and Hewitt, Alex W
Nature Genetics, ISSN 1061-4036, 08/2018, Volume 50, Issue 8, pp. 1067 - 1071
Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness... 
CENTRAL CORNEAL THICKNESS | COMMON VARIANTS | OPEN-ANGLE GLAUCOMA | GENOTYPE IMPUTATION | CLOSURE GLAUCOMA | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | RISK | MUTATIONS | TRAITS | NAIL-PATELLA SYNDROME | Intraocular Pressure - genetics | Humans | Risk Factors | Polymorphism, Single Nucleotide - genetics | Female | Genotype | Male | Genome-Wide Association Study - methods | Glaucoma - genetics | Glaucoma | Genome-wide association studies | Usage | Care and treatment | Genetic aspects | Health aspects | Intraocular pressure | Cornea | Optic nerve | Statistical analysis | Genes | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Risk analysis | Pressure | Loci | Risk factors | Meta-analysis | Consortia | Confidence intervals | Morphology | Blindness | Alleles | Influence | Mutation | Index Medicus
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12. Full Text 633 The Relative Abundances of Dorea and Faecalibacterium spp. in the Mucosa Associated Microbiome of Newly Diagnosed Children With Crohn's Disease Are Differentially Affected by Exclusive Enteral Nutrition
by Grover, Zubin and Kang, Alicia and Morrison, Mark and Radford-Smith, Graham L and Fukuma, Naoki and Simms, Lisa and Lewindon, Peter
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S132 - S133
Gastroenterology and Hepatology
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13. Full Text Sa1964 Weight-Based Dosing of Thiopurines and 6-TGN Concentrations in an Adult Cohort of Patients With Inflammatory Bowel Disease
by McMahon, Anna and Irwin, James and Radford-Smith, Graham L and Sewell, Karen and Howlett, Mariko
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S418 - S418
Gastroenterology and Hepatology | Gastrointestinal diseases
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14. Full Text Anti‐tumour necrosis factor‐α treatment for perianal Crohn's disease in Australia
by Burger, Daniel C and Lawrance, Ian C and Bampton, Peter A and Prosser, Ruth and Croft, Anthony and Gilshenan, Kristen and Radford‐Smith, Graham L and Florin, Timothy H
Medical Journal of Australia, ISSN 0025-729X, 04/2010, Volume 192, Issue 7, pp. 375 - 377
Objective: To examine the prevalence of perianal Crohn's disease (PCD) and the eligibility of PCD patients to access anti‐tumour necrosis factor‐alpha... 
Pharmaceutical preparations | Digestive system diseases | MEDICINE, GENERAL & INTERNAL | INFLAMMATORY-BOWEL-DISEASE | ADALIMUMAB | CHARM TRIAL | QUALITY-OF-LIFE | ACTIVITY INDEX | INFLIXIMAB | MAINTENANCE THERAPY | FISTULAS | Cross-Sectional Studies | Crohn Disease - drug therapy | Humans | Antibodies, Monoclonal - therapeutic use | Retrospective Studies | Australia | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cohort Studies | Index Medicus
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