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1. Full Text Focus on early events: pathogenesis of pulmonary arterial hypertension development
by Rafikova, Olga and Al Ghouleh, Imad and Rafikov, Ruslan
Antioxidants & redox signaling, ISSN 1523-0864, 06/2019
Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature characterized by the proliferation of all vascular wall cell types,... 
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2. Full Text Heme-Driven ROS Production Leads to Increased P38 MAP Kinase Activity and Endothelial Barrier Disruption
by Reavis, Daniel and Zemskov, Evgeny and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. S149 - S150
Heme is involved in a wide number of biological processes including gas exchange, antioxidant defense, signal transduction, as well as energy production within... 
Antioxidants | Heme | Cellular signal transduction | Permeability | Mitogens | Protein kinases | Endothelium
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3. Full Text 352 - Heme-Driven ROS Production Leads to Increased P38 MAP Kinase Activity and Endothelial Barrier Disruption
by Reavis, Daniel and Zemskov, Evgeny and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. S149 - S150
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4. Full Text Abstract 12631: Isolated Pulmonary Endothelial Cells Preserve Gender Specific Sensitivity to Stress
by Rafikova, Olga and Zemskova, Marina and Kurdyukov, Sergey and Rafikov, Ruslan
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A12631 - A12631
IntroductionFemale gender is known to be associated with a higher susceptibility to pulmonary arterial hypertension (PAH). In contrast, male PAH patients have... 
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5. Full Text 39 - Pulmonary hypertension in rats with human mutation of NFU1 is oxygen sensitive
by Niihori, Maki and Eccles, Cody and Zemskova, Marina and Rafikov, Ruslan and Rafikova, Olga
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2018, Volume 128, pp. S34 - S34
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6. Full Text 106 - Bio-Catalysis of Heme Extraction from Extracellular Hemoglobin for Sickle Cell Disease and Hemolysis Treatment
by Sakipov, Serzhan and Kurnikova, Maria and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2015, Volume 87, pp. S56 - S56
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7. Full Text 206 - Targeted Protein Protection from Oxidative/ Nitrosative Post-Translational Modifications Using Shielding Peptides
by Rafikova, Olga and Black, Stephen M and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2015, Volume 87, pp. S94 - S94
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8. Full Text Targeted Protein Protection from Oxidative/ Nitrosative Post-Translational Modifications Using Shielding Peptides
by Rafikova, Olga and Black, Stephen M and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2015, Volume 87, p. S94
Peptides
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9. Full Text Bio-Catalysis of Heme Extraction from Extracellular Hemoglobin for Sickle Cell Disease and Hemolysis Treatment
by Sakipov, Serzhan and Kurnikova, Maria and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2015, Volume 87, p. S56
Hemoglobin | Sickle cell anemia | Catalysis | Drug therapy | Heme
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10. Full Text Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung
by Rafikova, Olga and Srivastava, Anup and Desai, Ankit A and Rafikov, Ruslan and Tofovic, Stevan P
Respiratory Research, ISSN 1465-9921, 04/2018, Volume 19, Issue 1, pp. 69 - 69
Background: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are... 
Metabolomics | Glycolytic switch | Mitochondrial complexes | Protein nitration | Pulmonary hypertension | OXIDATIVE STRESS | SUPEROXIDE | ACTIVATION | CONTRIBUTE | NITRIC-OXIDE SYNTHASE | DEFICIENCY | REACTIVE OXYGEN | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | DYSFUNCTION | EXPRESSION | Glucose metabolism | Analysis | Rattus | Vasoconstriction | Rats | Physiological aspects | Development and progression | Mitochondrial diseases | Succinate dehydrogenase complex | Genetic aspects | Health aspects | Index Medicus | Research
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11. Full Text Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension
by Rafikov, Ruslan and McBride, Matthew L and Zemskova, Marina and Kurdyukov, Sergey and McClain, Nolan and Niihori, Maki and Langlais, Paul R and Rafikova, Olga
American journal of physiology. Lung cellular and molecular physiology, ISSN 1040-0605, 03/2019, Volume 316, Issue 3, pp. L428 - L444
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by progressive pulmonary vascular remodeling. The receptor for advanced glycation end... 
inositol pathway | proliferation | receptor for advanced glycation end products | pulmonary hypertension | glycolysis | ADVENTITIAL FIBROBLASTS | APOPTOSIS | PHYSIOLOGY | MYOINOSITOL BIOSYNTHESIS | TISSUE | CELL-PROLIFERATION | SIGNAL-TRANSDUCTION | PATHOGENESIS | INHIBITION | METABOLISM | RESPIRATORY SYSTEM | ENDOTHELIAL-CELLS | Cell proliferation | Hypertension | Translocation | Systolic pressure | Phosphorylation | Advanced glycosylation end products | Phosphatidylinositol 3,4,5-triphosphate | Pulmonary arteries | Lung diseases | Mass spectroscopy | AKT protein | Glycosylation | Remodeling | Myo-Inositol-1 (or 4)-monophosphatase | Pulmonary artery | 1-Phosphatidylinositol 3-kinase | Phosphatidylinositol | Signaling | Lungs | Rodents | Blood pressure | Ventricle | Mass spectrometry | Apoptosis
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12. Full Text Abstract 12686: Rats With Human Mutation of Fe-S Cluster Scaffold Protein NFU1 Develop Pulmonary Hypertension
by Niihori, Maki and Eccles, Cody A and Zemskova, Marina and Kurdyukov, Sergey and Rafikov, Ruslan and Rafikova, Olga
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A12686 - A12686
IntroductionNFU1 is a mitochondrial protein that is involved in Fe-S clusters biosynthesis and its genetic modifications associated with disorders of... 
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13. Full Text Abstract 12364: The Role of Perivascular Edema in Pulmonary Hypertension
by Eccles, Cody and Srivastava, Anup and Desai, Ankit A and Rafikova, Olga and Rafikov, Ruslan
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A12364 - A12364
BackgroundPulmonary arterial hypertension (PAH) is a progressive condition, characterized by a continued increase in pulmonary pressure that ultimately leads... 
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14. Full Text New cases of glucose-6-phosphate dehydrogenase deficiency in pulmonary arterial hypertension
by Kurdyukov, Sergey and Eccles, Cody A and Desai, Ankit A and Gonzalez-Garay, Manuel and Yuan, Jason X.J and Garcia, Joe G.N and Rafikova, Olga and Rafikov, Ruslan
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, pp. e0203493 - e0203493
Pulmonary Arterial Hypertension (PAH) is a fatal disorder with limited treatment options and reduced life expectancy after diagnosis. Complex genetic... 
SICKLE-CELL-DISEASE | MODEL | HEMOLYSIS | MULTIDISCIPLINARY SCIENCES | Glucose-6-phosphate dehydrogenase deficiency | Complications and side effects | Gene mutations | Research | Diagnosis | Risk factors | Pulmonary hypertension | Index Medicus
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15. Full Text 209 - Inhibition of respiratory chain Complex III irreversibly changes the mitochondria proteomic landscape
by Vasilyev, Mikhail and Eccles, Cody and Langlais, Paul and Rafikova, Olga and Tofovic, Stevan and Rafikov, Ruslan
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2018, Volume 128, pp. S91 - S92
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16. Full Text 72 - The tyrosine nitration of PKG-1α inhibits its regulatory function in the pulmonary endothelium
by Zemskov, Evgeny and Aggarwal, Saurabh and Gross, Christine and Rafikov, Ruslan and Lu, Qing and Black, Stephen
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2018, Volume 128, pp. S46 - S46
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17. Full Text The tyrosine nitration of PKG-1[alpha] inhibits its regulatory function in the pulmonary endothelium
by Zemskov, Evgeny and Aggarwal, Saurabh and Gross, Christine and Rafikov, Ruslan and Lu, Qing and Black, Stephen
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2018, Volume 128, p. S46
Acute respiratory distress syndrome | Tyrosine | Nitration | Blood circulation disorders | Analysis | Phenols | Cyclic adenylic acid | Protein kinases | Endothelium
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18. Full Text Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertension
by Kovacs, Laszlo and Han, Weihong and Rafikov, Ruslan and Bagi, Zsolt and Offermanns, Stefan and Saido, Takaomi C and Black, Stephen M and Su, Yunchao
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 03/2016, Volume 54, Issue 3, pp. 384 - 393
Calpain mediates collagen synthesis and cell proliferation and plays an important role in pulmonary vascular remodeling in pulmonary arterial hypertension... 
Platelet-derived growth factor | Serotonin | Pulmonary hypertension | Vascular smooth muscle cells | SYSTEM | PHOSPHORYLATION | pulmonary hypertension | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | platelet-derived growth factor | H2O2 | PREVENTS | CELL BIOLOGY | OVEREXPRESSION | serotonin | INHIBITION | RESPIRATORY SYSTEM | EPIDERMAL-GROWTH-FACTOR | SMOOTH-MUSCLE-CELLS | vascular smooth muscle cells | Enzyme Activators - pharmacology | Phosphorylation | Calpain - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Hypertension, Pulmonary - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Calpain - genetics | Muscle, Smooth, Vascular - physiopathology | Transfection | RNA Interference | HEK293 Cells | Vascular Remodeling - drug effects | Myocytes, Smooth Muscle - drug effects | Hypertension, Pulmonary - enzymology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Calcium-Binding Proteins - metabolism | Protein Phosphatase 2 - antagonists & inhibitors | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Hypertension, Pulmonary - genetics | Hypoxia - complications | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Pulmonary Artery - enzymology | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | Protein Phosphatase 2 - metabolism | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Hypertension, Pulmonary - pathology | Muscle, Smooth, Vascular - enzymology | Pulmonary Artery - pathology | Calcium-Binding Proteins - genetics | Immunoglobulins | Cytokines | Pulmonary arteries | Smooth muscle | Kinases | Gene expression | Phosphatase | Proteins | Rodents | Sheep | Hypoxia | Extracellular matrix | Scientific imaging | Growth factors | Veins & arteries | Index Medicus | Original Research
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19. Full Text Hemolysis-induced lung vascular leakage contributes to the development of pulmonary hypertension
by Rafikova, Olga and Williams, Elissa R and McBride, Matthew L and Zemskova, Marina and Srivastava, Anup and Nair, Vineet and Desai, Ankit A and Langlais, Paul R and Zemskov, Evgeny and Simon, Marc and Mandarino, Lawrence J and Rafikov, Ruslan
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 09/2018, Volume 59, Issue 3, pp. 334 - 345
Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic... 
Hemoglobin | Edema | Pulmonary arterial hypertension | Endothelial barrier | Heme | ACTIVATION | edema | heme | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | INJURY | endothelial barrier | DISORDERS | HYPOXIA | hemoglobin | CELL BIOLOGY | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | SICKLE-CELL-DISEASE | HEME OXYGENASE-1 | HIF-1-ALPHA | pulmonary arterial hypertension | FREE HEMOGLOBIN | Humans | Middle Aged | Hemoglobins - metabolism | Rats | Male | Hypoxia - complications | Animals | Adult | Female | Vascular Remodeling - physiology | Aged | Lung Diseases - pathology | Lung - blood supply | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Disease Models, Animal | Hemolysis - physiology | Lung | Kinases | Proteins | Signal transduction | Hypoxia-inducible factor 1a | Hemolytic anemia | Haptoglobin | Rodents | Sickle cell disease | Hypertension | Hemolysis | Catheterization | Review boards | Anemia | Heme oxygenase (decyclizing) | Inflammation | Permeability | Gene expression | Endothelial cells | Pulmonary hypertension | Human subjects | Oxygenase | Hsp27 protein | Nitric oxide | Sepsis | Hypoxia | Microvasculature | Intubation | Index Medicus | Original Research
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20. Full Text Characterization of the CLASP2 protein interaction network identifies SOGA1 as a microtubule-associated protein
by Kruse, Rikke and Krantz, James and Barker, Natalie and Coletta, Richard L and Rafikov, Ruslan and Luo, Moulun and Højlund, Kurt and Mandarino, Lawrence J and Langlais, Paul R
Molecular and Cellular Proteomics, ISSN 1535-9476, 10/2017, Volume 16, Issue 10, pp. 1718 - 1735
CLASP2 is a microtubule-associated protein that undergoes insulin-stimulated phosphorylation and co-localization with reorganized actin and GLUT4 at the plasma... 
CORTICAL ACTIN | GOLGI ORGANIZATION | STIMULATED GLUT4 TRANSLOCATION | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMICAL RESEARCH METHODS | GLUCOSE TRANSPORTERS | PURIFICATION-MASS SPECTROMETRY | GTPASE-ACTIVATING PROTEIN | QUANTITATIVE-ANALYSIS | END-TRACKING PROTEINS | AFFINITY-PURIFICATION | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Mice, Inbred C57BL | Glycoproteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | 3T3 Cells - metabolism | GTPase-Activating Proteins - metabolism | GTP-Binding Proteins - genetics | Protein Interaction Maps | Glucosyltransferases - metabolism | Animals | Glycogen - metabolism | Adipocytes - metabolism | Computer Simulation | Proteomics | Mice | GTPase-Activating Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | GTP-Binding Proteins - metabolism | Phosphorylation | Glycogen | Glycogen synthase | Antibodies | Data processing | Mass spectroscopy | Adipocytes | Kinases | Insulin | Proteins | Tubulin | Protein kinase | Actin | Microtubule-associated proteins | Cytoskeleton | Protein-serine/threonine kinase | Circulatory system | Localization | Mass spectrometry | Bioinformatics | Guanosinetriphosphatase | Index Medicus | Research
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