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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 50, pp. 21401 - 21406
Journal Article
Nature, ISSN 0028-0836, 11/2008, Volume 456, Issue 7220, pp. 350 - 356
Nuclear receptors are multi- domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-... 
RESPONSE ELEMENT | DOMAIN | LIGAND-BINDING | MECHANISM | PROLIFERATOR-ACTIVATED RECEPTORS | MULTIDISCIPLINARY SCIENCES | REV-ERB-ALPHA | RETINOID-X-RECEPTOR | ALLOSTERIC CONTROL | IDENTIFICATION | HYDROGEN-EXCHANGE
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2007, Volume 14, Issue 12, pp. 1207 - 1213
The nuclear receptors REV-ERB alpha (encoded by NR1D1) and REV-ERB beta (NR1D2) have remained orphans owing to the lack of identified physiological ligands.... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA-AMINOLEVULINATE SYNTHASE | ROR-ALPHA | MEMBER | CELL BIOLOGY | CIRCADIAN CLOCK | BIOPHYSICS | GENE-EXPRESSION | E-REGION | MOLECULAR-CLONING | TARGET GENE | TRANSCRIPTIONAL REGULATION | BINDING
Journal Article
Circulation Research, ISSN 0009-7330, 11/2013, Volume 113, Issue 11, pp. 1231 - 1241
Journal Article
Circulation Research, ISSN 0009-7330, 08/2014, Volume 115, Issue 5, pp. 504 - 517
RATIONALE:Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment... 
gene action regulation | intercellular signaling peptides and proteins | macrophages | genetic therapy | angiogenesis effect | osteopontin | muscle, skeletal | cytokines | peripheral arterial disease | PGC-1alpha protein, mouse | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | CARDIAC & CARDIOVASCULAR SYSTEMS | TUMOR PROGRESSION | EXERCISE PERFORMANCE | INTERMITTENT CLAUDICATION | VEGF GENE-THERAPY | CELL-MIGRATION | REGIONAL ANGIOGENESIS | PERIPHERAL VASCULAR DISEASE | PERIPHERAL ARTERIAL-DISEASE | HEMATOLOGY | ENDOTHELIAL GROWTH-FACTOR | MOLECULAR-MECHANISMS | Osteopontin - genetics | Osteopontin - deficiency | Human Umbilical Vein Endothelial Cells - metabolism | Diabetes Mellitus - genetics | Humans | Muscle, Skeletal - metabolism | Ischemia - genetics | Osteopontin - metabolism | Vascular Endothelial Growth Factor A - metabolism | Mice, 129 Strain | Muscle Fibers, Skeletal - metabolism | Time Factors | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adenoviridae - genetics | Chemokine CCL2 - metabolism | Disease Models, Animal | Muscle, Skeletal - blood supply | Vascular Endothelial Growth Factor Receptor-1 - genetics | Cell Line | Signal Transduction | Mice, Inbred C57BL | Cell Communication | Diabetes Mellitus - metabolism | Ischemia - metabolism | Ischemia - therapy | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Ischemia - physiopathology | Transcription Factors - genetics | Regional Blood Flow | Macrophage Activation | Mice, Knockout | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Diabetes Mellitus - physiopathology | Diabetes Mellitus - therapy | Mice | Genetic Vectors | Neovascularization, Physiologic | Cell Movement | Genetic Therapy - methods | Index Medicus | secreted phosphoprotein 1 | Angiogenesis | peripheral artery disease | gene regulation | PGC-1 | gene therapy | skeletal muscle | growth factors and cytokines
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 12/2009, Volume 106, Issue 50, p. 21401
Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause of limb amputations. Exercise remains the single best... 
Exercise | Muscles | Physiological aspects | Genetic aspects | Genetic transcription | Research | Neovascularization | Properties | Vascular endothelial growth factor | Proteins | Musculoskeletal system | Angiogenesis | Rodents | Vein & artery diseases | Metabolism | Gene expression
Journal Article
Nature, ISSN 0028-0836, 11/2008, Volume 456, Issue 7220, p. 350
  Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome... 
Research | DNA binding proteins | Properties | Structure | DNA-ligand interactions | Proteins | Studies | Interfaces | E coli | Neurons | Data collection | Binding sites | Deoxyribonucleic acid--DNA
Journal Article
Skeletal Muscle, ISSN 2044-5040, 01/2014, Volume 4, Issue 1
Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional... 
Analysis | Animal genetic engineering
Journal Article
Nature, ISSN 0028-0836, 12/2008, Volume 456, Issue 7220, pp. np - np
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome... 
Journal Article
Skeletal Muscle, ISSN 2044-5040, 01/2014, Volume 4, Issue 1, pp. 2 - 2
Background: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the... 
mdx | PGC-1β | Duchenne Muscle Dystrophy | PGC-1α | Neuromuscular junction | Utrophin | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | PGC-1 beta | ACTIVATED RECEPTOR-GAMMA | PGC-1 alpha | MOUSE | DEFICIENT MICE | MDX MICE | CELL BIOLOGY | SKELETAL-MUSCLE | PGC-1 COACTIVATORS | GENE-EXPRESSION | DUCHENNE MUSCULAR-DYSTROPHY | NEUROMUSCULAR-JUNCTION
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2007, Volume 14, Issue 12, pp. 1207 - 1213
  The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands.... 
Circadian rhythms | Physiological aspects | Hormone receptors | Research | Identification and classification | Heme | Molecular biology | Mammals | Metabolism | Genes | Cells
Journal Article
01/2008, ISBN 1109043864
Nuclear receptors are transcription factors that use lipophilic molecules as ligand and regulate several signaling pathways essential for differentiation,... 
Pharmacology
Dissertation
01/2008, ISBN 1109043864, Volume 70, Issue 2
Nuclear receptors are transcription factors that use lipophilic molecules as ligand and regulate several signaling pathways essential for differentiation,... 
Book Chapter
Thesis (Ph. D.)--University of Virginia, 2008. Includes bibliographical references. Also available online through Digital Dissertations. 
Dissertation
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