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by Gaulton, Kyle J and Ferreira, Teresa and Lee, Yeji and Raimondo, Anne and Mägi, Reedik and Reschen, Michael E and Mahajan, Anubha and Locke, Adam and Rayner, N. William and Robertson, Neil and Scott, Robert A and Prokopenko, Inga and Scott, Laura J and Green, Todd and Sparso, Thomas and Thuillier, Dorothee and Yengo, Loic and Grallert, Harald and Wahl, Simone and Frånberg, Mattias and Strawbridge, Rona J and Kestler, Hans and Chheda, Himanshu and Eisele, Lewin and Gustafsson, Stefan and Steinthorsdottir, Valgerdur and Thorleifsson, Gudmar and Qi, Lu and Karssen, Lennart C and van Leeuwen, Elisabeth M and Willems, Sara M and Li, Man and Chen, Han and Fuchsberger, Christian and Kwan, Phoenix and Ma, Clement and Linderman, Michael and Lu, Yingchang and Thomsen, Soren K and Rundle, Jana K and Beer, Nicola L and van de Bunt, Martijn and Chalisey, Anil and Kang, Hyun Min and Voight, Benjamin F and Abecasis, Gonçalo R and Almgren, Peter and Baldassarre, Damiano and Balkau, Beverley and Benediktsson, Rafn and Blüher, Matthias and Boeing, Heiner and Bonnycastle, Lori L and Bottinger, Erwin P and Burtt, Noël P and Carey, Jason and Charpentier, Guillaume and Chines, Peter S and Cornelis, Marilyn C and Couper, David J and Crenshaw, Anew T and van Dam, Rob M and Doney, Alex S. F and Dorkhan, Mozhgan and Edkins, Sarah and Eriksson, Johan G and Esko, Tonu and Eury, Elodie and Fadista, João and Flannick, Jason and Fontanillas, Pierre and Fox, Caroline and Franks, Paul W and Gertow, Karl and Gieger, Christian and Gigante, Bruna and Gottesman, Omri and Grant, George B and Grarup, Niels and Groves, Christopher J and Hassinen, Maija and Have, Christian T and Herder, Christian and Holmen, Oddgeir L and Hreidarsson, Astradur B and Humphries, Steve E and Hunter, David J and Jackson, Anne U and Jonsson, Anna and Jørgensen, Marit E and Jørgensen, Torben and Kao, Wen-Hong L and Kerrison, Nicola D and Kinnunen, Leena and Klopp, Norman and Kong, Augustine and Kovacs, Peter and Kraft, Peter and Kravic, Jasmina and Langford, Cordelia and ... and DIAbet Genetics Replication Meta-A and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten and Stockholms universitet and Science for Life Laboratory (SciLifeLab)
Nature genetics, ISSN 1061-4036, 2015, Volume 47, Issue 12, pp. 1415 - +
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct... 
TRANSCRIPTION FACTORS | COMMON VARIANTS | HUMAN PANCREATIC-ISLETS | GLUCOSE-HOMEOSTASIS | GENOTYPE IMPUTATION | LARGE-SCALE ASSOCIATION | INSULIN-SECRETION | GENETICS & HEREDITY | GLYCEMIC TRAITS | BETA-CELL | WIDE ASSOCIATION | Hepatocyte Nuclear Factor 3-beta - metabolism | Receptor, Melatonin, MT2 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Liver - pathology | Hepatocyte Nuclear Factor 3-beta - genetics | Islets of Langerhans - pathology | Diabetes Mellitus, Type 2 - genetics | Genomics | Humans | Liver - metabolism | Molecular Sequence Annotation | Gene Expression Regulation | Chromosome Mapping | Genetic Loci | Case-Control Studies | Chromatin Immunoprecipitation | Islets of Langerhans - metabolism | Polymorphism, Single Nucleotide - genetics | Receptor, Melatonin, MT2 - metabolism | Binding Sites | Type 2 diabetes | Quantitative trait loci | Chromosome mapping | Genetic susceptibility | Genetic research | Development and progression | Genetic aspects | Research | Identification and classification | Methods | Studies | Haplotypes | Genealogy | Biomedical research | Genomes | Localization | Meta-analysis | Genetik | Basic Medicine | Medical Genetics | Medicinsk genetik | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Genetics | Natural Sciences
Journal Article
Addiction, ISSN 0965-2140, 03/2019, Volume 114, Issue 3, pp. 404 - 405
Abuse-deterrent formulations (ADFs) of pharmaceutical opioids have limited capacity to reduce extra-medical use and harm; their impact is likely restricted to... 
overdose | tamper | stigma | Abuse deterrent formulation | opioid | dependence | extra‐medical use | injecting | pharmacoepidemiology | post‐marketing | extra-medical use | post-marketing | PSYCHIATRY | SUBSTANCE ABUSE | Drug abuse | Formulations | Substance abuse treatment | Abuse | Narcotics | Opioids | Addictions
Journal Article
Journal Article
Addiction, ISSN 0965-2140, 03/2019, Volume 114, Issue 3, pp. 389 - 399
Background and aims Opioid formulations with properties to deter abuse (abuse-deterrent formulations; ADFs) have been developed as one response to the... 
UNITED-STATES | DIVERSION | EXTRAMEDICAL USE | SUBSTANCE-ABUSE | IMPACT | OXYCONTIN | PSYCHIATRY | EXTENDED-RELEASE OXYCODONE | PHARMACOEPIDEMIOLOGY | SUBSTANCE ABUSE | NONMEDICAL USE | REDUCED ABUSE | Formulations | Drug abuse | Transparency | Substance abuse treatment | Narcotics | Abuse | Weight | Marketing | Studies | Safety engineering | Opioids | Conflicts of interest | Research design | Pharmaceuticals
Journal Article
by Horwitz, Steven and O'Connor, Owen A and O'Connor, Owen and Pro, Barbara and Illidge, Tim and Fanale, Michelle and Advani, Ranjana and Bartlett, Nancy and Bartlett, Nancy L and Christensen, Jacob Haaber and Morschhauser, Franck and Domingo-Domenech, Eva and Rossi, Giuseppe and Kim, Won Seog and Feldman, Tatyana and Lennard, Anne and Belada, David and Illés, Árpád and Tobinai, Kensei and Tsukasaki, Kunihiro and Yeh, Su-Peng and Shustov, Andrei and Hüttmann, Andreas and Savage, Kerry and Savage, Kerry J and Yuen, Sam and Iyer, Swaminathan and Zinzani, Pier Luigi and Hua, Zhaowei and Little, Meredith and Rao, Shangbang and Woolery, Joseph and Manley, Thomas and Trümper, Lorenz and Aboulafia, David and Alpdogan, Onder and Ando, Kiyoshi and Arcaini, Luca and Baldini, Luca and Bellam, Naresh and Yehuda, Dina Ben and Benedetti, Fabio and Borchman, Peter and Bordessoule, Dominique and Brice, Pauline and Briones, Javier and Caballero, Dolores and Carella, Angelo Michele and Chang, Hung and Cheong, June Weon and Cho, Seok-Goo and Choi, Ilseung and Choquet, Sylvain and Colita, Andrei and Congui, Angela Giovanna and D'amore, Francesco and Dang, Nam and Davison, Kelly and de Guibert, Sophie and Brown, Peter de Nully and Delwail, Vincent and Demeter, Judit and di Raimondo, Francesco and Do, Young Rok and Domingo, Eva and Douvas, Michael and Dreyling, Martin and Ernst, Thomas and Fay, Keith and Ferrero, Silvia Fernandez and Flinn, Ian Winchester and Forero-Torres, Andres and Fox, Christopher and Friedberg, Jonathan and Fukuhara, Noriko and Garcia-Marco, Jose and Cruz, Jorge Gayoso and Codina, Jose Gomez and Gressin, Remy and Grigg, Andrew and Gurion, Ronit and Haioun, Corinne and Hajek, Roman and Hanel, Mathias and Hatake, Kiyohiko and Hensen, Robert and Horowitz, Netanel and Huttmann, Andreas and Illes, Arpad and Ishizawa, Kenichi and Islas-Ohlmayer, Miguel and Jacobsen, Eric and Janakiram, Murali and Jurczak, Wojciech and Kaminski, Mark and Kato, Koji and Kirgner, Ilya and Kuo, Ching-Yuan and Lazaroiu, Mihaela Cornelia and Du, Katell Le and ... and ECHELON 2 Study Grp and ECHELON-2 Study Group
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10168, pp. 229 - 240
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2018, Volume 50, Issue 8, p. 1122
The molecular mechanisms underpinning susceptibility loci for type 2 diabetes (T2D) remain poorly understood. Coding variants in peptidylglycine... 
Type 2 diabetes | Pancreatic beta cells | Genetic aspects | Research | Gene expression | Risk factors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 3037 - 3041
Journal Article