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SCIENCE, ISSN 0036-8075, 02/2016, Volume 351, Issue 6273, pp. 617 - 621
Journal Article
Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 452 - 455
Journal Article
by Hernandez, Adrian F and Green, Fiona and Green, Jennifer B and Janmohamed, Salim and D'Agostino, Ralph B and Granger, Christopher B and Jones, Michael and Jones, Nigel P and Leiter, Lawrence A and Rosenberg, Anne E and Rosenberg, Anne and Sigmon, Kristina and Sigmon, Kristina N and Somerville, Matthew and Somerville, Matthew C and Thorpe, Karl and Thorpe, Karl M and McMurray, John J V and McMurray, John J.V and Del Prato, Stefano and Califf, Robert M and Holman, Rury and DeMets, David and Riddle, Matthew and Goodman, Shaun and McGuire, Darren and Alexander, Karen and Devore, Adam and Melloni, Chiara and Patel, Chetan and Patel, Rajesh and Patel, Vickas and Patel, Prashant and Patel, Rajivkumar and Kong, David and Bloomfield, Gerald and Roe, Matthew and Tricoci, Pierluigi and Harrison, Rob and Harrison, Lindsay and Lopes, Renato and Mathews, Robin and Mehta, Anand and Mehta, Rajendra and Schuyler Jones, William and Vemulapalli, Sreekanth and Povsic, Thomas and Eapen, Zubin and Dombrowski, Keith and Kolls, Brad and Jordan, Dedrick and Ambrosy, Andrew and Greene, Deb and Greene, Stephen and Mandawat, Aditya and Shavadia, Jay and Cooper, John and Cooper, Lauren and Sharma, Abhinav and Sharma, Richa and Guimaraes, Patricia and Friedman, Daniel and Wilson, Matt and Wilson, Tim and Endsley, Patricia and Gentry, Tracy and Collier, Jeannie and Perez, Kathleen and James, Kourtnei and James, Rachel and Roush, Jennifer and Pope, Connie and Howell, Christina and Johnson, Megan and Johnson, David and Johnson, Andrew and Bailey, Matt and Cole, Joanna and Akers, Teresa and Vandyne, Beth and Thomas, Betsy and Rich, Jenny and Bartone, Susan and Beaulieu, Gail and Brown, Judith and Brown, Kim and Chau, Tuan and Christian, Tamra and Coker, Rebecca and Haddock, Trevorlyn and Jenkins, Wendy and Haque, Ghazala and Marquess, Marsha and Pesarchick, Jean and Rethaford, Renee and Stone, Allegra and Al Kawas, Firas and Anderson, Michelle and Enns, Robert and Sinay, Isaac and ... and Harmony Outcomes Comm Investigator and Harmony Outcomes committees and investigators
The Lancet, ISSN 0140-6736, 10/2018, Volume 392, Issue 10157, pp. 1519 - 1529
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular... 
MEDICINE, GENERAL & INTERNAL | RISK | METAANALYSIS | MELLITUS | SAFETY | RECEPTOR AGONISTS | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Stroke - prevention & control | Double-Blind Method | Drug Administration Schedule | Glucagon-Like Peptide 1 - administration & dosage | Glucagon-Like Peptide 1 - analogs & derivatives | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Stroke - etiology | Hypoglycemic Agents - administration & dosage | Injections, Subcutaneous | Adult | Female | Aged | Myocardial Infarction - prevention & control | Diabetes Mellitus, Type 2 - drug therapy | Myocardial Infarction - etiology | Diabetes Mellitus, Type 2 - complications | Glucagon-Like Peptide 1 - therapeutic use | Myocardial infarction | Diabetic retinopathy | Heart attacks | Peptides | Glucagon | Medical services | Clinical trials | Cardiovascular disease | Thyroid gland | Incidence | Thyroid carcinoma | Randomization | Motivation | Hemoglobin | Diuretics | Diabetes mellitus (non-insulin dependent) | Glucagon-like peptide 1 | Thyroid | Cerebral infarction | Stroke | Diabetes mellitus | Pancreatitis | Health risks | Risk reduction | Disease control | Patients | Organic chemistry | Interactive systems | Pancreatic cancer | Fatalities | Infarction | Diabetes | Cardiovascular diseases | Health risk assessment
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 119a - 119a
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 2, pp. 562a - 562a
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2018, Volume 9, Issue 4, pp. 354 - 358
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening... 
tirasemtiv | imidazo[4,5-b]pyrazin-2-one | troponin | Amyotrophic lateral sclerosis (ALS) | skeletal muscle activator | CHEMISTRY, MEDICINAL | SAFETY | HUMANS | AMYOTROPHIC-LATERAL-SCLEROSIS | POTENTIAL THERAPEUTIC APPROACH | YOUNG | CARDIAC MYOSIN | CONTRACTION | TOLERABILITY | DISEASE
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2010, Volume 1, Issue 9, pp. 472 - 477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit... 
cardiac myosin | small molecule enzyme activator | Omecamtiv mecarbil | systolic heart failure | MORTALITY | CHROMATOGRAPHIC ANALYSIS | CHEMISTRY, MEDICINAL | HUMAN SERUM-ALBUMIN | HEART-FAILURE | PROTEIN BINDING | CARBAMAZEPINE BINDING
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A14467 - A14467
IntroductionHCM is a heritable disease of heart muscle associated with increased risk of heart failure and sudden death. Mutations in genes encoding sarcomere... 
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 1877 - 1877
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 5604 - 5604
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2010, Volume 98, Issue 3, p. 151
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2009, Volume 96, Issue 3, pp. 231a - 231a
Journal Article
Science (Washington), ISSN 0036-8075, 03/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling... 
Heart | Cascades | Myosin | Activation | Mathematical models | Catalysis | Failure | Ejection
Journal Article
Journal of Cardiac Failure, ISSN 1071-9164, 2006, Volume 12, Issue 6, pp. S86 - S86
Journal Article
by Bukeirat, Faisal A and Rahman, Rubayat and Farhat, Mirna H and Shamseddine, Ali I and Barada, Kassem A and Lever, Eric L and Kumar, Anshu X and Conkling, Brandon A and Sing, James T and Erickson, Richard A and Qayed, Emad and Cai, Qiang and Leung, Joseph W and Lim, Brian and Hasyagar, Chhaya and Wilson, Robert and Leung, Felix W and Sundaram, Uma and Pomakov, Ognian A and Mehboob, Shahid and Gutierrez, Rebeck and Ransibrahmanakul, Kanat and Stevens, Tyler and Zuccaro, Gregory and Dumot, John A and Vargo, John J and Alkaade, Samer and Balci, Numan C and Momtahen, Amir J and Burton, Frank R and Shahzad, Atif and Jasti, Sirisha and Aytaman, Ayse and Fruchter, Gerald and Nachnani, Jagdish S and Campbell, Donald R and Naik, Ami K and Alishahi, Yasmin and Bilal, Muhammad and Wan, Jim Y and Tombazzi, Claudio R and Nozawa, Satoshi and Kimura, Fumio and Shimizu, Hiroaki and Yoshidome, Hiroyuki and Ohtsuka, Masayuki and Kato, Atsushi and Yoshitomi, Hideyuki and Furukawa, Katsunori and Mitsuhashi, Noboru and Takeuchi, Dan and Suda, Kousuke and Takano, Shigetsugu and Miyazaki, Masaru and Sohagia, Amit B and Masood, Raja and Rehan, Rafiq and Hertan, Hiliary and Kiyici, Nejat and Norkus, Edward and Nawaz, Arif Amir and Sarwar, Shahid and Hussain, Salwa and Batul, Atiqa and Shahid, Khubaib and Kochhar, Rakesh and Ahammed, Mahiuddin S.K and Chakraborti, Arunaloke and Ray, Pallab and Dutta, Usha and Wig, Jai Dev and Vege, Santhi Swaroop and Farnell, Michael B and Kendrick, Michael K and Que, Florencia G and Sabater, Enrique A and Bjarnason, Haraldur and Callstrom, Matthew R and Deeds, Michael and Anderson, Jarret and Armstrong, Adam and Chari, Suresh T and Kudva, Yogish C and Chava, Soujanya and Griffin, Timothy and Rigaux, Johanne and Poreddy, Vijay and Al-Kawas, Firas and Torres, Victor J
The American Journal of Gastroenterology, ISSN 0002-9270, 09/2007, Volume 102, Issue s2, pp. S174 - S199
157Clinical Outcomes, Survival Benefits, and Long-Term Stent Patency in Patients with Malignant Biliary Obstruction: A Systematic Review and Meta-Analysis... 
Journal Article
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