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PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142006 - e0142006
Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a known topoisomerase II inhibitor induces DNA damage resulting in cell cycle... 
COLON-CANCER | BCL-2 | APOPTOSIS | IN-VITRO | MIR-16 INDUCE | VEGF | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | TUMOR ANGIOGENESIS | ENDOTHELIAL GROWTH-FACTOR | SIGNAL TRANSDUCER | RNA, Small Interfering - genetics | Podophyllotoxin - pharmacology | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Vascular Endothelial Growth Factor A - metabolism | Neovascularization, Pathologic - pathology | Proto-Oncogene Proteins c-bcl-2 - metabolism | MCF-7 Cells | RNA Interference | STAT3 Transcription Factor - metabolism | DNA Damage - drug effects | Cell Survival - drug effects | Etoposide - analogs & derivatives | Human Umbilical Vein Endothelial Cells - drug effects | Etoposide - pharmacology | Models, Molecular | MicroRNAs - biosynthesis | Enzyme Activation - drug effects | Breast Neoplasms - drug therapy | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | MicroRNAs - genetics | Molecular Docking Simulation | Quinazolines - pharmacology | Podophyllotoxin - analogs & derivatives | Cell proliferation | Care and treatment | MicroRNA | Enzyme inhibitors | Genetic aspects | Breast cancer | Neovascularization | Properties | Health aspects | Testing | DNA topoisomerase (ATP-hydrolysing) | Bcl-2 protein | Analogue | DNA damage | Stat3 protein | Etoposide | Carcinogenesis | Studies | Angiogenesis | Carcinogens | Cell growth | Cell cycle | Docking | miRNA | Vascular endothelial growth factor | Deoxyribonucleic acid--DNA | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 04/2015, Volume 120, pp. 102 - 114
Journal Article
Journal of Genetics, ISSN 0022-1333, 9/2019, Volume 98, Issue 3, pp. 1 - 8
In view of the documented association of solute carrier family 19 member 1 (SLC19A1) G80A (R27H) polymorphism with the risk for different types of cancers and... 
Life Sciences | Life Sciences, general | SLC19A1 polymorphism | Plant Genetics and Genomics | Microbial Genetics and Genomics | ligand site analysis | methotrexate | Evolutionary Biology | Animal Genetics and Genomics | homology model | tetrahydrofolate | G80A | GENE | REDUCED FOLATE CARRIER | TRANSPORT ACTIVITY | GENETICS & HEREDITY | COMMON POLYMORPHISMS | ASSOCIATION | Antiporters - chemistry | Humans | Risk Factors | Reduced Folate Carrier Protein - chemistry | Models, Molecular | Reduced Folate Carrier Protein - genetics | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Glycine Hydroxymethyltransferase - metabolism | Case-Control Studies | Polymorphism, Genetic | Protein Structure, Secondary - genetics | Breast Neoplasms - genetics | Computer Simulation | Folic Acid - metabolism | Monosaccharide Transport Proteins - chemistry | Methotrexate - chemistry | Proteins | Phosphates | Systemic lupus erythematosus | Analysis | Oncology, Experimental | Amino acids | Genetic aspects | Research | Methotrexate | Folic acid | Genetic polymorphisms | Cancer | Tetrahydrofolic acid | Statistical analysis | Serine | Phosphate transporter | Glycerol | Homology | Breast cancer | Gene polymorphism | Glycerol-3-phosphate | Ligands | Transmembrane domains | Binding sites | Structure-function relationships | Polymorphism
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159092
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 7/2015, Volume 42, Issue 7, pp. 1211 - 1224
Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study... 
Life Sciences | Serine hydroxymethyltransferase | Catechol- o -amine methyltransferase | Reduced folate carrier1 | Animal Biochemistry | Animal Anatomy / Morphology / Histology | 5-Methyltetrahydrofolate-homocysteine methyltransferase reductase | Cytochrome P4501A1 | Catechol-o-amine methyltransferase | SYSTEMIC-LUPUS-ERYTHEMATOSUS | OXIDATIVE DNA-DAMAGE | GENETIC POLYMORPHISMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL POLYMORPHISMS | CYTOCHROME-P450 1A1 | GREATER-THAN-G | BREAST-CANCER | reductase | CATECHOL ESTROGENS | 5-Methyltetrahydrofolate-homocysteine methyltransferase | CORONARY-ARTERY-DISEASE | PARKINSONS-DISEASE | Multifactor Dimensionality Reduction | Humans | Lupus Erythematosus, Systemic - metabolism | Male | Transferases - genetics | Case-Control Studies | Breast Neoplasms - metabolism | Coronary Artery Disease - pathology | Female | Transferases - metabolism | Parkinson Disease - metabolism | Xenobiotics - metabolism | Carbon - metabolism | Genetic Predisposition to Disease | Parkinson Disease - pathology | Datasets as Topic | Oxidoreductases - metabolism | Oxidoreductases - genetics | Coronary Artery Disease - metabolism | Gene Expression Regulation | Factor Analysis, Statistical | Parkinson Disease - genetics | Metabolic Networks and Pathways - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Epistasis, Genetic | Lupus Erythematosus, Systemic - genetics | Coronary Artery Disease - genetics | Sex Factors | Polymorphism, Single Nucleotide | Lupus Erythematosus, Systemic - pathology | Lupus | Systemic lupus erythematosus | Glutathione transferase | Analysis | Cytochrome P-450 | Models | Coronary heart disease | Folic acid | Studies | Genetics | Breast cancer | Metabolism | Carbon
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 10/2015, Volume 16, Issue 10, pp. 1486 - 1501
In a previous study we reported the role of potent bisindole-PBD conjugate as an inclusion in the arsenal of breast cancer therapeutics. In breast cancer cell... 
docking | tubulin acetylation | p53 dependent genes | p53 acetylation | Akt | histone acetylation | SIRTs | APOPTOSIS | ACTIVATION | PHOSPHORYLATION | SIRT1 | MTOR | ONCOLOGY | SIGNALING PATHWAY | HISTONE H3 | RESISTANCE | INHIBITORS | Sirtuin 1 - metabolism | Breast Neoplasms - genetics | Cell Proliferation | Humans | Tumor Suppressor Protein p53 - metabolism | Female | Sirtuin 1 - genetics | Breast Neoplasms - metabolism
Journal Article
Gene, ISSN 0378-1119, 12/2014, Volume 552, Issue 2, pp. 255 - 264
MicroRNAs are small non-coding RNAs that regulate post-transcriptional mRNA expression by binding to 3′ untranslated region (3′-UTR) of the complementary mRNA... 
mTOR | miR-16 | RPS6KB1 | miR-15 | MDA-MB-231 | MiR-15 | MiR-16 | MTOR | DNA-DAMAGE | DOWN-REGULATION | P53 | EPITHELIAL-MESENCHYMAL TRANSITION | ARREST | OVEREXPRESSION | GENETICS & HEREDITY | PROTEIN S6 KINASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | MicroRNA | Analysis | Cancer cells | Physiological aspects | Protein biosynthesis | Breast cancer | Genetic engineering | Tumor proteins | Gene expression
Journal Article