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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10108
Background: Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However,... 
BREAST-CANCER | INTRACAROTID INFUSION | LUNG-CANCER | BARRIER PERMEABILITY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NITRIC-OXIDE | ACTIVATED POTASSIUM CHANNELS | BLOOD-BRAIN | BRADYKININ ANALOG | CHEMOTHERAPY | Neoplasm Transplantation | Sulfones - therapeutic use | Triazines - therapeutic use | Humans | Brain Neoplasms - pathology | Phosphodiesterase 5 Inhibitors | Breast Neoplasms | Sulfones - pharmacology | Lung Neoplasms | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Antibodies, Monoclonal, Humanized | Endocytosis | Biological Transport | Imidazoles - therapeutic use | Triazines - pharmacology | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Antineoplastic Agents | Phosphodiesterase Inhibitors - pharmacology | Treatment Outcome | Imidazoles - pharmacology | Piperazines - therapeutic use | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Piperazines - pharmacology | Phosphodiesterase Inhibitors - administration & dosage | Animals | Antibodies, Monoclonal - administration & dosage | Mice, Nude | Vardenafil Dihydrochloride | Mice | Trastuzumab | Drugs | Drug delivery systems | Biological products | Lung cancer | Brain tumors | Permeability | Metastasis | Vehicles | Dextran | Brain research | Analysis | Monoclonal antibodies | Drug therapy | Health aspects | Cancer | Brain | Drug abuse | Clathrin | Animal models | Physicians | Brain cancer | Nervous system | Drug delivery | Neurosurgery | Molecular weight | Bearing | Metastases | Angiogenesis | Blood-brain barrier | Phosphodiesterase | Caveolae | Oral administration | Breast cancer | Survival | ErbB-2 protein | Endothelial cells | Inhibitors | Acids | Microscopy | Medical prognosis | Coronary vessels | Breast | Transport | Potassium | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 2019, Volume 79, Issue 6, pp. 1239 - 1251
Journal Article
Neuroimage, ISSN 1053-8119, 2011, Volume 54, Issue 1, pp. S106 - S124
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, pp. 18143 - 18148
Effective treatment of brain neurological disorders such as Alzheimer’s disease, multiple sclerosis, or tumors should be possible with drug delivery through... 
Glioma | Antineoplastics | Brain neoplasms | Cell membranes | Drug design | Liposomes | Polymers | Blood brain barrier | Tumors | Endosomes | Glioma treatment | Blood-brain barrier | Laminin-411 | Endosomal escape | Polymalic acid | blood-brain barrier | laminin-411 | GENE DELIVERY | ANGIOGENESIS | PERMEABILITY | MULTIDISCIPLINARY SCIENCES | BARRIER | endosomal escape | glioma treatment | PEPTIDE | CHEMOTHERAPY | LAMININ-8 | polymalic acid | IN-VIVO | MALIGNANT GLIOMAS | HPMA COPOLYMER | Polymers - administration & dosage | Brain Neoplasms - pathology | Brain Neoplasms - drug therapy | Endosomes - metabolism | Nanoparticles | Polymers - therapeutic use | Animals | Mice, Nude | Malates - pharmacokinetics | Polymers - pharmacokinetics | Mice | Infusions, Intravenous | Malates - administration & dosage | Malates - therapeutic use | Blood-Brain Barrier | Hydrogen-Ion Concentration | Drugs | Care and treatment | Drug delivery systems | Brain tumors | Malic acid | Dosage and administration | Research | Vehicles | Multiple sclerosis | Intravenous administration | Neurodegenerative diseases | Biodegradability | Tumor cells | Antisense oligonucleotides | Esters | endosomes | Drug delivery | Leucine | Drug development | pH effects | Neurological diseases | Angiogenesis | Glioma cells | Monoclonal antibodies | nanotechnology | Alzheimer's disease | Cytoplasm | Biological Sciences | Physical Sciences | blood–brain barrier
Journal Article
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3850 - 13
Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was... 
SYSTEM | INTERLEUKIN-2 | PROTEIN | IMMUNOTHERAPY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | BLOCKADE | IDENTIFICATION | GLIOBLASTOMA ERADICATION | ANAPHYLAXIS | DELIVERY | Antineoplastic Agents, Immunological - administration & dosage | Biopolymers - chemistry | Antineoplastic Agents, Immunological - pharmacokinetics | Humans | Brain Neoplasms - pathology | Immunoconjugates - pharmacokinetics | Physarum polycephalum - chemistry | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Cell Line, Tumor - transplantation | Immunoconjugates - administration & dosage | Brain Neoplasms - immunology | Glioma - pathology | Female | Disease Models, Animal | Glioma - immunology | Treatment Outcome | Permeability | Brain Neoplasms - drug therapy | CTLA-4 Antigen - immunology | Immunoconjugates - chemistry | Blood-Brain Barrier - metabolism | Malates - chemistry | Animals | Polymers - chemistry | Mice | Programmed Cell Death 1 Receptor - immunology | CTLA-4 Antigen - antagonists & inhibitors | Glioma - drug therapy | Nanoconjugates - chemistry | Brain | PD-1 protein | CD8 antigen | Brain tumors | Brain cancer | Glioblastoma | Antibodies | Cytotoxicity | Activation | Lymphocytes T | Macrophages | Biopolymers | Blood | Bearing | CTLA-4 protein | Blood-brain barrier | Lymphocytes | Malic acid | Movement disorders | Immune system | Antigens | Cell survival | Immune response | Immunoregulation | Inhibitors | Immune checkpoint | Immunoconjugates | Glioma | Cell death | Tumors | Apoptosis
Journal Article
MACROMOLECULAR BIOSCIENCE, ISSN 1616-5187, 09/2015, Volume 15, Issue 9, pp. 1212 - 1217
Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (A) plaques in... 
SURVIVAL | MATERIALS SCIENCE, BIOMATERIALS | POLYMER SCIENCE | PROTEIN | Alzheimer disease | MRI | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | nanoimaging agent | BREAST-CANCER-TREATMENT | polymalic acid | POLY(BETA-L-MALIC ACID) | curcumin | Rare earth metals | Malic acid | Magnetic resonance imaging | Alzheimer's disease | Contrast media | Alzheimers disease
Journal Article
Journal of Computer-Aided Molecular Design, ISSN 0920-654X, 4/2013, Volume 27, Issue 4, pp. 347 - 363
P-glycoprotein (P-gp) is a plasma membrane efflux transporter belonging to ATP-binding cassette superfamily, responsible for multidrug resistance in tumor... 
P-glycoprotein | Chemistry | Physical Chemistry | Caco-2 | Molecular modeling | Molecular dynamics | MDR | Animal Anatomy / Morphology / Histology | Computer Applications in Chemistry | Substrate binding | CYSTEINE-SCANNING MUTAGENESIS | MULTIDRUG TRANSPORTER | DRUG-BINDING | CROSS-LINKING ANALYSIS | BACTERIAL ABC TRANSPORTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE-BINDING | NBD DIMER | ATP-BINDING CASSETTE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | CONFORMATIONAL-CHANGES | BIOPHYSICS | TRANSMEMBRANE DOMAINS | Caco-2 Cells | Caenorhabditis elegans - chemistry | Caenorhabditis elegans - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Caenorhabditis elegans Proteins - metabolism | Substrate Specificity | Crystallography, X-Ray | Drug Resistance, Neoplasm | Molecular Dynamics Simulation | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Thermodynamics | Animals | Models, Biological | Computer Simulation | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Structural Homology, Protein | Care and treatment | Chemical properties | Permeability | Drug resistance | Analysis | Cancer | Models | Glycoproteins | Substrates | Anticancer properties
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31070
Treatment options for triple negative breast cancer (TNBC) are generally limited to cytotoxic chemotherapy. Recently, anti-epidermal growth factor receptor... 
GROWTH-FACTOR RECEPTOR | APOPTOSIS | IN-VITRO | TRANSFERRIN | MULTIDISCIPLINARY SCIENCES | ANTISENSE | ANTIBODY | TUMOR-CELLS | POLYMALIC ACID | LIPOSOMES | DELIVERY | Receptor, Epidermal Growth Factor - genetics | Receptors, Estrogen - metabolism | Humans | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Breast Neoplasms - therapy | Receptor, Epidermal Growth Factor - metabolism | Nanoparticles - therapeutic use | Oligonucleotides, Antisense - therapeutic use | Female | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Blotting, Western | Xenograft Model Antitumor Assays | Malates - chemistry | Animals | Biopolymers - therapeutic use | Breast Neoplasms - genetics | Mice, Nude | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Polymers - chemistry | Mice | Drugs | Chemotherapy | Drug delivery systems | Biological products | Epidermal growth factor | Monoclonal antibodies | Malic acid | Breast cancer | Vehicles | Cancer | Phosphorylation | Transferrin | Downstream effects | Physicians | Cytotoxicity | Confocal microscopy | AKT protein | Drug delivery | Leucine | Confocal | Kinases | Biopolymers | Cancer therapies | Accumulation | Western blotting | Synthesis | Polyethylene glycol | Bioaccumulation | Video compression | Inhibition | Epidermal growth factor receptors | Antisense oligonucleotides | MPEG encoders | Microscopy | Breast
Journal Article