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Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 5, pp. 462 - 466
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 20, pp. 8188 - 8193
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2016, Volume 48, Issue 3, pp. 273 - 282
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 723 - 726
Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived... 
MEDICINE, RESEARCH & EXPERIMENTAL | PTEN LOSS | EVEROLIMUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Immunohistochemistry | Genomic Instability | Neoplasm Transplantation | Phosphoproteins - drug effects | Phosphorylation | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | DNA Repair - genetics | Carrier Proteins - drug effects | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Brain Neoplasms - secondary | Caspase 3 - drug effects | Female | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Everolimus - pharmacology | Brain Neoplasms - genetics | Morpholines - pharmacology | Brain Neoplasms - drug therapy | Mice, SCID | Breast Neoplasms - drug therapy | Remission Induction | Xenograft Model Antitumor Assays | Magnetic Resonance Imaging | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Breast Neoplasms - pathology | Aminopyridines - pharmacology | Mice | Ki-67 Antigen - drug effects | Complications and side effects | Care and treatment | Brain tumors | Development and progression | Breast cancer | Genetic aspects | Metastasis | Phosphotransferases | Health aspects | Brain cancer | Rodents
Journal Article
Current treatment options in oncology, 06/2018, Volume 19, Issue 8, p. 41
In recent years, large-scale genomic studies have expanded our knowledge regarding genomic drivers in tumors of the central nervous system. While... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 2017, Volume 19, Issue 6, pp. 774 - 785
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 18, pp. 8083 - 8092
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. B66 - B66
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2015, Volume 17, Issue 10, pp. 1344 - 1355
Journal Article
Nature medicine, ISSN 1078-8956, 7/2016, Volume 22, Issue 7, pp. 723 - 726
Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 05/2015, Volume 17, Issue 5, pp. 697 - 707
Background. Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM,... 
apoptosis | glioblastoma | exportin 1 | SINE | patient-derived xenograft | GLIOMAS | NUCLEAR EXPORT | CRM1 | CLINICAL NEUROLOGY | ONCOLOGY | CONCOMITANT | KPT-330 | RADIOTHERAPY | EXPRESSION | Apoptosis - drug effects | Humans | Macaca fascicularis | Male | Antineoplastic Agents - therapeutic use | Thiazoles - therapeutic use | Acrylamides - pharmacokinetics | Thiazoles - pharmacokinetics | Dose-Response Relationship, Drug | Oxadiazoles - pharmacology | Triazoles - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Triazoles - therapeutic use | Hydrazines - pharmacology | Hydrazines - therapeutic use | Hydrazines - pharmacokinetics | Treatment Outcome | Brain Neoplasms - drug therapy | Rats, Sprague-Dawley | Oxadiazoles - therapeutic use | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Cell Cycle Checkpoints - drug effects | Cell Differentiation - drug effects | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Acrylamides - therapeutic use | Mice | Thiazoles - pharmacology | Glioblastoma - drug therapy | Karyopherins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Basic and Translational Investigations
Journal Article