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Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 9, pp. 1612 - 1621
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. SCI-47 - SCI-47
There is a clinical need to identify novel treatments for lymphoid malignancies. Effective immunotherapy promotes the killing of cancer cells by cytotoxic T... 
Journal Article
Journal of Nuclear Materials, ISSN 0022-3115, 10/2018, Volume 509, p. 667
The assessment of the post-cracking behaviour of the reactor core components requires knowledge of the fracture properties, such as the fracture toughness,... 
Geometry | Trepanning | Materials testing | Properties (attributes) | Reactors | Graphite | Irradiated | Fracture toughness
Journal Article
Journal of Nuclear Materials, ISSN 0022-3115, 10/2018, Volume 509, pp. 667 - 678
The assessment of the post-cracking behaviour of the reactor core components requires knowledge of the fracture properties, such as the fracture toughness, ,... 
Irradiated graphite | Dose | Density | Work of fracture | ENERGY | BRITTLE MATERIALS | CRACK-PROPAGATION | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | NUCLEAR GRAPHITE | WORK-OF-FRACTURE | NUCLEAR SCIENCE & TECHNOLOGY | AGR MODERATOR BRICKS
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 237 - 237
Abstract Immune checkpoint blockade has demonstrated potential to reactivate anti-tumor immunity and regress tumors. However, response rates in B-cell... 
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 05/2018, Volume 103, Issue 5, pp. 855 - 866
MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR‐181 family is important in T cell... 
T lymphocytes | BRK1 | microRNA | F‐actin | F-actin | SIGNAL-TRANSDUCTION | ACTIVATION | MECHANISM | MICRORNAS | IMMUNOLOGY | HEMATOLOGY | WAVE COMPLEX | CELL BIOLOGY
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 675 - 675
Abstract Immunotherapy has demonstrated potential to reactivate or transfer T cell immunity and regress tumors, offering hope to relapsed or refractory diffuse... 
Journal Article
British Journal of Haematology, ISSN 0007-1048, 01/2016, Volume 172, Issue 1, pp. 7 - 8
The article by Giudice et al, cited in this Editorial Comment, is published in issue 172:3 (http://onlinelibrary.wiley.com/doi/10.1111/bjh.13859/). 
chronic lymphocytic leukaemia | clonal evolution | relapse | genetic heterogeneity | Clonal evolution | Relapse | Chronic lymphocytic leukaemia | Genetic heterogeneity | PATHOGENESIS | HEMATOLOGY | genetic hetero-geneity | Female | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Mutation | Humans | Tumors
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 236 - 236
Abstract The targeted therapy ibrutinib inhibits B cell receptor signaling (BTK inhibitor) and has yielded high response rates and durable remissions in... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4400 - 4400
Abstract Using next-generation sequencing (NGS), we recently documented the clonal architecture of the T cell repertoire in treatment-naive chronic lymphocytic... 
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2009, Volume 106, Issue 15, pp. 6250 - 6255
Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models... 
DRUG | CD4 | PEPTIDES | THERAPY | MULTIDISCIPLINARY SCIENCES | MOUSE | LENALIDOMIDE | CD28 | IMMUNOLOGICAL SYNAPSE | EXPRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 06/2007, Volume 67, Issue 11, pp. 5275 - 5284
Journal Article
Blood, ISSN 0006-4971, 08/2012, Volume 120, Issue 7, pp. 1412 - 1421
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 1738 - 1738
Abstract Immunomodulatory drugs (IMiDs®) such as lenalidomide and immune checkpoint blockade (ICB) antibodies can enhance autologous anti-tumor T cell immunity... 
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | LYTIC FUNCTION | IMMUNOTHERAPY | ACTIN POLYMERIZATION | GENE-EXPRESSION | LENALIDOMIDE | MALIGNANCIES | CANCER | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors
Journal Article
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