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BMC MEDICAL RESEARCH METHODOLOGY, ISSN 1471-2288, 07/2019, Volume 19, Issue 1, pp. 137 - 7
BackgroundRandomised controlled trials (RCTs) are considered the gold standard when evaluating the causal effects of healthcare interventions. When RCTs cannot... 
Quasi-experimental | Healthcare interventions | Interrupted time series | HEALTH CARE SCIENCES & SERVICES | Medical research | Evaluation | Usage | Medicine, Experimental | Time-series analysis | Evidence-based medicine | Methods
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 912 - 922
In a randomized trial, 798 patients with varicose veins were assigned to undergo laser ablation, foam sclerotherapy, or surgery. At 5 years, disease-specific... 
HIGH LIGATION | MEDICINE, GENERAL & INTERNAL | ENDOVENOUS LASER-ABLATION | COST-EFFECTIVENESS | CONVENTIONAL SURGERY | CLINICAL-TRIAL | GUIDED FOAM SCLEROTHERAPY | GREAT SAPHENOUS-VEIN | FOLLOW-UP | QUALITY-OF-LIFE | HEALTH | Treatment outcome | Usage | Care and treatment | Safety and security measures | Analysis | Varicose veins | Health aspects | Sclerotherapy | Quality of life
Journal Article
British Journal of Ophthalmology, ISSN 0007-1161, 05/2018, Volume 102, Issue 5, pp. 604 - 610
Background/AimsTo assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting... 
diagnostic tests/investigation | imaging | glaucoma | OPHTHALMOLOGY | SPECTRUM BIAS | GDX VCC | TECHNOLOGIES | NERVE-FIBER LAYER | ABILITY | Glaucoma | Hypertension | Automation | Optic nerve | Medical imaging | Optics | Medical diagnosis | Evidence-based medicine | Studies | Accuracy | Lasers | Tomography | Ophthalmology
Journal Article
British Journal of Ophthalmology, ISSN 0007-1161, 12/2018, Volume 102, Issue 12, pp. 1658 - 1662
BackgroundTo describe the surgical technique and refractive outcomes following clear lens extraction (CLE) in the Effectiveness, in Angle-closure Glaucoma, of... 
clinical trial | treatment surgery | optics and refraction | lens and zonules | glaucoma | VISUAL-ACUITY | BENCHMARK STANDARDS | NATIONAL OPHTHALMOLOGY DATABASE | RISK-FACTORS | OPHTHALMOLOGY | ROYAL-COLLEGE | ELECTRONIC MULTICENTER AUDIT | EXCHANGE | CATARACT-SURGERY | ACCURACY | Cataracts | Surgical outcomes | Biometrics | Glaucoma | Medical personnel | Accuracy | Ethnicity | Cornea | Lasers | Surgeons | Ophthalmology | Eye surgery
Journal Article
Health Technology Assessment, ISSN 1366-5278, 10/2019, Volume 23, Issue 60, pp. 1 - 88
Background The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central... 
randomised controlled trials | research design | peer review | sample size | minimal clinically important difference
Journal Article
Journal of Glaucoma, ISSN 1057-0829, 09/2015, Volume 24, Issue 7, pp. 533 - 538
PURPOSE:In clinical trials, the selection of appropriate outcomes is crucial for the assessment of whether one intervention is better than another. Selection... 
Cochrane reviews | outcome measures | glaucoma | variations | heterogeneity | QUALITY | CLINICAL-TRIALS | OPHTHALMOLOGY | Intraocular Pressure - physiology | Glaucoma - therapy | Outcome Assessment (Health Care) | Humans | Glaucoma - physiopathology | Randomized Controlled Trials as Topic
Journal Article
Journal of Clinical Epidemiology, ISSN 0895-4356, 2014, Volume 67, Issue 12, pp. 1299 - 1301
  In practice, the implementation studies that have used this design have involved multiple centers in each block; by modeling differences between centers as... 
Internal Medicine | GENERALIZED LINEAR-MODELS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | Biomedical Research - methods | Research Design | Humans | Medical colleges | Usage | Studies | Variables | Journals | Cardiovascular disease | Web sites | Estimates | Generalized linear models
Journal Article
Trials, ISSN 1745-6215, 12/2018, Volume 19, Issue 1, pp. 1 - 8
A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target... 
Medicine, Experimental | Medical research | Usage | Analysis | Statistical sampling
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1465-1858, 02/2017, Volume 2017, Issue 2
Journal Article