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1. Full Text Methodology and reporting characteristics of studies using interrupted time series design in healthcare
by Hudson, J and Fielding, S and Ramsay, CR
BMC MEDICAL RESEARCH METHODOLOGY, ISSN 1471-2288, 07/2019, Volume 19, Issue 1, pp. 137 - 7
BackgroundRandomised controlled trials (RCTs) are considered the gold standard when evaluating the causal effects of healthcare interventions. When RCTs cannot... 
Quasi-experimental | Healthcare interventions | Interrupted time series | HEALTH CARE SCIENCES & SERVICES | Medical research | Evaluation | Usage | Medicine, Experimental | Time-series analysis | Evidence-based medicine | Methods
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2. Full Text Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins
by Brittenden, Julie and Cooper, David and Dimitrova, Maria and Scotland, Graham and Cotton, Seonaidh C and Elders, Andrew and MacLennan, Graeme and Ramsay, Craig R and Norrie, John and Burr, Jennifer M and Campbell, Marion K and Campbell, Bruce and Bachoo, Paul and Chetter, Ian and Gough, Michael and Earnshaw, Jonothan and Lees, Tim and Scott, Julian and Baker, Sara A and Tassie, Emma and Francis, Jill
The New England Journal of Medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 912 - 922
In a randomized trial, 798 patients with varicose veins were assigned to undergo laser ablation, foam sclerotherapy, or surgery. At 5 years, disease-specific... 
HIGH LIGATION | MEDICINE, GENERAL & INTERNAL | ENDOVENOUS LASER-ABLATION | COST-EFFECTIVENESS | CONVENTIONAL SURGERY | CLINICAL-TRIAL | GUIDED FOAM SCLEROTHERAPY | GREAT SAPHENOUS-VEIN | FOLLOW-UP | QUALITY-OF-LIFE | HEALTH | Treatment outcome | Usage | Care and treatment | Safety and security measures | Analysis | Varicose veins | Health aspects | Sclerotherapy | Quality of life
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3. Full Text Optical coherence tomography for the monitoring of neovascular age-related macular degeneration: A systematic review
by Castillo, Mayret M and Mowatt, Graham and Elders, Andrew and Lois, Noemi and Fraser, Cynthia and Hernández, Rodolfo and Amoaku, Winfried and Burr, Jennifer M and Lotery, Andrew and Ramsay, Craig R and Azuara-Blanco, Augusto
Ophthalmology, ISSN 0161-6420, 02/2015, Volume 122, Issue 2, pp. 399 - 406
Topic To compare the accuracy of optical coherence tomography (OCT) with alternative tests for monitoring neovascular age-related macular degeneration (nAMD)... 
DOMAIN | LEAKAGE | VERTEPORFIN | PHOTODYNAMIC THERAPY | OPHTHALMOLOGY | LASER PHOTOCOAGULATION | CHOROIDAL NEOVASCULARIZATION | FLUORESCEIN ANGIOGRAPHY | RANIBIZUMAB | ACCURACY | Wet Macular Degeneration - diagnosis | Reproducibility of Results | Tomography, Optical Coherence - methods | Humans | Sensitivity and Specificity | Diagnostic Techniques, Ophthalmological
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4. Full Text Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study
by Virgili, Gianni and Michelessi, Manuele and Cook, Jonathan and Boachie, Charles and Burr, Jennifer and Banister, Katie and Garway-Heath, David F and Bourne, Rupert R A and Asorey Garcia, Almudena and Ramsay, Craig R and Azuara-Blanco, Augusto
British Journal of Ophthalmology, ISSN 0007-1161, 05/2018, Volume 102, Issue 5, pp. 604 - 610
Background/AimsTo assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting... 
diagnostic tests/investigation | imaging | glaucoma | OPHTHALMOLOGY | SPECTRUM BIAS | GDX VCC | TECHNOLOGIES | NERVE-FIBER LAYER | ABILITY | Glaucoma | Hypertension | Automation | Optic nerve | Medical imaging | Optics | Medical diagnosis | Evidence-based medicine | Studies | Accuracy | Lasers | Tomography | Ophthalmology
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5. Full Text DELTA 2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
by Cook, Jonathan A and Julious, Steven A and Sones, William and Hampson, Lisa V and Hewitt, Catherine and Berlin, Jesse A and Ashby, Deborah and Emsley, Richard and Fergusson, Dean A and Walters, Stephen J and Wilson, Edward C.F and MacLennan, Graeme and Stallard, Nigel and Rothwell, Joanne C and Bland, Martin and Brown, Louise and Ramsay, Craig R and Cook, Andrew and Armstrong, David and Altman, Doug and Vale, Luke D
BMJ (Online), ISSN 0959-8146, 2018, Volume 363, p. k3750
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6. Full Text Clear lens extraction for the management of primary angle closure glaucoma: surgical technique and refractive outcomes in the EAGLE cohort
by Day, Alexander C and Cooper, David and Burr, Jennifer and Foster, Paul J and Friedman, David S and Gazzard, Gus and Che-Hamzah, Jemaima and Aung, Tin and Ramsay, Craig R and Azuara-Blanco, Augusto
British Journal of Ophthalmology, ISSN 0007-1161, 12/2018, Volume 102, Issue 12, pp. 1658 - 1662
BackgroundTo describe the surgical technique and refractive outcomes following clear lens extraction (CLE) in the Effectiveness, in Angle-closure Glaucoma, of... 
clinical trial | treatment surgery | optics and refraction | lens and zonules | glaucoma | VISUAL-ACUITY | BENCHMARK STANDARDS | NATIONAL OPHTHALMOLOGY DATABASE | RISK-FACTORS | OPHTHALMOLOGY | ROYAL-COLLEGE | ELECTRONIC MULTICENTER AUDIT | EXCHANGE | CATARACT-SURGERY | ACCURACY | Cataracts | Surgical outcomes | Biometrics | Glaucoma | Medical personnel | Accuracy | Ethnicity | Cornea | Lasers | Surgeons | Ophthalmology | Eye surgery
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7. Full Text "Better" clinical decisions do not necessarily require more time to make
by McCleary, N and Francis, JJ and Campbell, MK and Ramsay, CR and Eccles, MP and Treweek, S and Allan, J
JOURNAL OF CLINICAL EPIDEMIOLOGY, ISSN 0895-4356, 02/2017, Volume 82, pp. 173 - 174
  Quicker decisions were more likely to be appropriate [Spearman [rho] (1,022) = -0.408, P < 0.001], and each unit decrease in perceived difficulty was... 
Patient scenario | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Clinical decision making | Upper respiratory tract infection | HEALTH CARE SCIENCES & SERVICES | Cognition | Primary care | Antibiotic prescribing | Clinical Competence | Humans | General Practice - standards | Male | Respiratory Tract Infections - drug therapy | Respiratory Tract Infections - diagnosis | Anti-Bacterial Agents - therapeutic use | Practice Patterns, Physicians' - statistics & numerical data | Time Factors | Clinical Decision-Making | Sensitivity and Specificity | Female | General Practice - trends | Drug Utilization - statistics & numerical data | General Practitioners - statistics & numerical data | Decision making | Management decisions | Quality
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8. Full Text Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop
by Cook, Jonathan A and Julious, Steven A and Sones, William and Hampson, Lisa V and Hewitt, Catherine and Berlin, Jesse A and Ashby, Deborah and Emsley, Richard and Fergusson, Dean A and Walters, Stephen J and Wilson, Edward CF and MacLennan, Graeme and Stallard, Nigel and Rothwell, Joanne C and Bland, Martin and Brown, Louise and Ramsay, Craig R and Cook, Andrew and Armstrong, David and Altman, Douglas and Vale, Luke D
Health Technology Assessment, ISSN 1366-5278, 10/2019, Volume 23, Issue 60, pp. 1 - 88
Background The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central... 
randomised controlled trials | research design | peer review | sample size | minimal clinically important difference
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9. Full Text Consensus on outcome measures for glaucoma effectiveness trials: Results from a delphi and nominal group technique approaches
by Ismail, Rehab and Azuara-Blanco, Augusto and Ramsay, Craig R
Journal of Glaucoma, ISSN 1057-0829, 2016, Volume 25, Issue 6, pp. 539 - 546
Purpose: Comparing the relative effectiveness of interventions across glaucoma trials can be problematic due to differences in definitions of outcomes. We... 
consensus | measures | consensus meeting | outcomes | glaucoma | RCTs | NGT | Delphi | DESIGN | FDA | FUTURE | RESEARCH COMMUNITY | OPHTHALMOLOGY | COSMIN | Nerve Fibers - pathology | Outcome Assessment (Health Care) - methods | Visual Fields - physiology | Tomography, Optical Coherence | Humans | Intraocular Pressure - physiology | Male | Randomized Controlled Trials as Topic | Retinal Ganglion Cells - pathology | Delphi Technique | Tonometry, Ocular | Female | Glaucoma - therapy | Surveys and Questionnaires | Glaucoma - physiopathology
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10. Full Text ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
by Sterne, Jonathan AC and Hernán, Miguel A and Reeves, Barnaby C and Savović, Jelena and Berkman, Nancy D and Viswanathan, Meera and Henry, David and Altman, Douglas G and Ansari, Mohammed T and Boutron, Isabelle and Carpenter, James R and Chan, An-Wen and Churchill, Rachel and Deeks, Jonathan J and Hróbjartsson, Asbjørn and Kirkham, Jamie and Jüni, Peter and Loke, Yoon K and Pigott, Theresa D and Ramsay, Craig R and Regidor, Deborah and Rothstein, Hannah R and Sandhu, Lakhbir and Santaguida, Pasqualina L and Schünemann, Holger J and Shea, Beverly and Shrier, Ian and Tugwell, Peter and Turner, Lucy and Valentine, Jeffrey C and Waddington, Hugh and Waters, Elizabeth and Wells, George A and Whiting, Penny F and Higgins, Julian PT
BMJ, ISSN 0959-8146, 10/2016, Volume 355, p. i4919
Non-randomised studies of the effects of interventions are critical to many areas of healthcare evaluation, but their results may be biased. It is therefore... 
MEDICINE, GENERAL & INTERNAL | SYSTEMATIC REVIEWS | QUALITY | HEALTH-CARE | RANDOMIZED-TRIALS | MEDICINE | Pilot Projects | Confounding Factors (Epidemiology) | Bias | Humans | Observational Studies as Topic | Risk | Statistics as Topic - instrumentation | Clinical Trials as Topic
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11. Full Text Core outcomes in periodontal trials: Study protocol for core outcome set development
by Lamont, Thomas J and Clarkson, Jan E and Ricketts, David N.J and Heasman, Peter A and Ramsay, Craig R
Trials, ISSN 1745-6215, 09/2017, Volume 18, Issue 1, pp. 436 - 4
Background: There are a large number of clinical outcome measures used to assess the effectiveness of prevention and management strategies of periodontal... 
Periodontics | Clinical trial | Dentistry | Review | Delphi technique | Outcomes | MEDICINE, RESEARCH & EXPERIMENTAL | DISEASE | ORAL-HEALTH | PROGRESSION | Periodontal Diseases - therapy | Preventive Dentistry - methods | Periodontal Diseases - diagnosis | Humans | Treatment Outcome | Secondary Care | Consensus | Stakeholder Participation | Periodontics - methods | Delphi Technique | Endpoint Determination | Biomedical Research - methods | Primary Health Care | Clinical Trials as Topic - methods | Research Design | Prevention | Practice guidelines (Medicine) | Clinical trials | Periodontal disease | Care and treatment | Analysis
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12. Full Text Outcome Measures in Glaucoma: A Systematic Review of Cochrane Reviews and Protocols
by Ismail, Rehab and Azuara-Blanco, Augusto and Ramsay, Craig R
Journal of Glaucoma, ISSN 1057-0829, 09/2015, Volume 24, Issue 7, pp. 533 - 538
PURPOSE:In clinical trials, the selection of appropriate outcomes is crucial for the assessment of whether one intervention is better than another. Selection... 
Cochrane reviews | outcome measures | glaucoma | variations | heterogeneity | QUALITY | CLINICAL-TRIALS | OPHTHALMOLOGY | Intraocular Pressure - physiology | Glaucoma - therapy | Outcome Assessment (Health Care) | Humans | Glaucoma - physiopathology | Randomized Controlled Trials as Topic
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13. Full Text The use of Latin squares and related block designs in implementation research
by Steen, Ian Nicholas and Campbell, Marion K and Eccles, Martin P and Grimshaw, Jeremy M and Ramsay, Craig R and Russell, Ian T
Journal of Clinical Epidemiology, ISSN 0895-4356, 2014, Volume 67, Issue 12, pp. 1299 - 1301
  In practice, the implementation studies that have used this design have involved multiple centers in each block; by modeling differences between centers as... 
Internal Medicine | GENERALIZED LINEAR-MODELS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | Biomedical Research - methods | Research Design | Humans | Medical colleges | Usage | Studies | Variables | Journals | Cardiovascular disease | Web sites | Estimates | Generalized linear models
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14. Full Text DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
by Cook, Jonathan A and Julious, Steven A and Sones, William and Hampson, Lisa V and Hewitt, Catherine and Berlin, Jesse A and Ashby, Deborah and Emsley, Richard and Fergusson, Dean A and Walters, Stephen J and Wilson, Edward C. F and Maclennan, Graeme and Stallard, Nigel and Rothwell, Joanne C and Bland, Martin and Brown, Louise and Ramsay, Craig R and Cook, Andrew and Armstrong, David and Altman, Doug and Vale, Luke D
Trials, ISSN 1745-6215, 12/2018, Volume 19, Issue 1, pp. 1 - 8
A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target... 
Medicine, Experimental | Medical research | Usage | Analysis | Statistical sampling
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15. Full Text Interventions to improve antibiotic prescribing practices for hospital inpatients (updated protocol)
by Davey, Peter and Scott, Claire L and Brown, Erwin and Charani, Esmita and Michie, Susan and Ramsay, Craig R and Marwick, Charis A
Cochrane Database of Systematic Reviews, ISSN 1465-1858, 02/2017, Volume 2017, Issue 2
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