Protein Science, ISSN 0961-8368, 09/2018, Volume 27, Issue 9, pp. 1624 - 1635
The ankyrin repeat (AR) structure is a common protein–protein interaction motif and ankyrin repeat proteins comprise a vast family across a large array of...
amide exchange | structure prediction | repeat protein | homology model | Deuterium Exchange Measurement | Humans | Mass Spectrometry | Models, Molecular | I-kappa B Proteins - chemistry | Protein Conformation | Ankyrin Repeat | Proto-Oncogene Proteins - chemistry | Deuterium | Exchanging | Spectroscopy | Structural members | Homology | Mass spectroscopy | Augmented reality | Proteins | Domains | Modelling | Scientific imaging | Ankyrin | Mass spectrometry | Protein structure | Hydrogen ion concentration | Crystal structure | Full‐Length Papers | Full‐Length Paper
amide exchange | structure prediction | repeat protein | homology model | Deuterium Exchange Measurement | Humans | Mass Spectrometry | Models, Molecular | I-kappa B Proteins - chemistry | Protein Conformation | Ankyrin Repeat | Proto-Oncogene Proteins - chemistry | Deuterium | Exchanging | Spectroscopy | Structural members | Homology | Mass spectroscopy | Augmented reality | Proteins | Domains | Modelling | Scientific imaging | Ankyrin | Mass spectrometry | Protein structure | Hydrogen ion concentration | Crystal structure | Full‐Length Papers | Full‐Length Paper
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 221a - 221a
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2015, Volume 112, Issue 37, pp. 11553 - 11558
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, p. 221
Journal Article
Protein Science, ISSN 0961-8368, 09/2018, Volume 27, Issue 9, pp. 1624 - 1635
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, p. 62
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2015, Volume 112, Issue 37, p. 11553
Cooperativity in human glucokinase (GCK), the body's primary glucose sensor and a major determinant of glucose homeostatic diseases, is fundamentally...
Proteins | Homeostasis | Glucose | Binding sites
Proteins | Homeostasis | Glucose | Binding sites
Journal Article
Biochemistry, ISSN 0006-2960, 05/2019, Volume 58, Issue 21, pp. 2555 - 2563
The NFκB transcription factor family members RelA, p50, and cRel form homo and heterodimers that are inhibited by IκBα, IκBβ, and IκBε. These NFκB family...
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 62a - 63a
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2017, Volume 429, Issue 7, p. 999
We recently discovered that I[kappa]B[alpha] enhances the rate of release of nuclear factor kappa B (NF[kappa]B) from DNA target sites in a process we have...
Molecular dynamics | DNA
Molecular dynamics | DNA
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2018, Volume 25, Issue 8, pp. 687 - 697
The bromodomain and extra-terminal motif (BET) protein BRD4 binds to acetylated histones at enhancers and promoters via its bromodomains (BDs) to regulate...
RECRUITMENT | RECOGNITION | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | HISTONE ACETYLTRANSFERASE | CELL BIOLOGY | BIOPHYSICS | GENE-EXPRESSION | NF-KAPPA-B | BINDING | BROMODOMAIN PROTEIN BRD4 | BET BROMODOMAINS | Genetic transcription | RNA processing | Analysis | Protein-protein interactions | Protein binding | Chromatin | BRG1 protein | Transcription elongation | p53 Protein | Gene regulation | Colorectal carcinoma | Gene expression | Proteins | Enhancers | Transcription activation | Histones | Docking | Elongation
RECRUITMENT | RECOGNITION | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | HISTONE ACETYLTRANSFERASE | CELL BIOLOGY | BIOPHYSICS | GENE-EXPRESSION | NF-KAPPA-B | BINDING | BROMODOMAIN PROTEIN BRD4 | BET BROMODOMAINS | Genetic transcription | RNA processing | Analysis | Protein-protein interactions | Protein binding | Chromatin | BRG1 protein | Transcription elongation | p53 Protein | Gene regulation | Colorectal carcinoma | Gene expression | Proteins | Enhancers | Transcription activation | Histones | Docking | Elongation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2015, Volume 112, Issue 37, pp. 11553 - 11558
Cooperativity in human glucokinase (GCK), the body’s primary glucose sensor and a major determinant of glucose homeostatic diseases, is fundamentally different...
monomeric cooperativity | intrinsic disorder | diabetes | allostery | glucokinase | CONFORMATIONAL ENTROPY | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | MODEL | ENZYME | STRUCTURAL BASIS | KINETIC COOPERATIVITY | DYNAMICS | PROTEINS | BINDING | HUMAN PANCREATIC GLUCOKINASE | Allosteric Regulation - genetics | Catalytic Domain | Gene Library | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Humans | Mutagenesis | Allosteric Site | Glucose - chemistry | Hyperinsulinism - genetics | Ligands | Catalysis | Mutation | Enzyme Activation - genetics | Glucokinase - chemistry | Hexokinase - chemistry | Glucose metabolism | Observations | Phosphotransferases | Health aspects | Binding sites (Biochemistry) | Biological Sciences
monomeric cooperativity | intrinsic disorder | diabetes | allostery | glucokinase | CONFORMATIONAL ENTROPY | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | MODEL | ENZYME | STRUCTURAL BASIS | KINETIC COOPERATIVITY | DYNAMICS | PROTEINS | BINDING | HUMAN PANCREATIC GLUCOKINASE | Allosteric Regulation - genetics | Catalytic Domain | Gene Library | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Humans | Mutagenesis | Allosteric Site | Glucose - chemistry | Hyperinsulinism - genetics | Ligands | Catalysis | Mutation | Enzyme Activation - genetics | Glucokinase - chemistry | Hexokinase - chemistry | Glucose metabolism | Observations | Phosphotransferases | Health aspects | Binding sites (Biochemistry) | Biological Sciences
Journal Article
G3: Genes, Genomes, Genetics, ISSN 2160-1836, 2015, Volume 5, Issue 5, pp. 719 - 740
The Muller F element (4.2 Mb, similar to 80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low...
Melting characteristics | Evolution of heterochromatin | Transposons | Gene size | Codon bias | codon bias | RNA INTERFERENCE | DINE-1 TRANSPOSABLE ELEMENTS | melting characteristics | transposons | CODON USAGE BIAS | DOT CHROMOSOME | evolution of heterochromatin | gene size | TANDEM REPEATS | HIGHLY ABUNDANT | GENETICS & HEREDITY | SEQUENCED GENOMES | MELANOGASTER CHROMOSOME-4 | HETEROCHROMATIN FORMATION | ROLLING-CIRCLE TRANSPOSONS | Polytene Chromosomes | Species Specificity | Exons | Introns | Genomics | Molecular Sequence Annotation | Computational Biology | Selection, Genetic | Drosophila melanogaster - genetics | DNA Transposable Elements | Heterochromatin | Animals | Codon | Gene Rearrangement | Repetitive Sequences, Nucleic Acid | Drosophila Proteins - genetics | Genome | Drosophila - genetics | Evolution, Molecular
Melting characteristics | Evolution of heterochromatin | Transposons | Gene size | Codon bias | codon bias | RNA INTERFERENCE | DINE-1 TRANSPOSABLE ELEMENTS | melting characteristics | transposons | CODON USAGE BIAS | DOT CHROMOSOME | evolution of heterochromatin | gene size | TANDEM REPEATS | HIGHLY ABUNDANT | GENETICS & HEREDITY | SEQUENCED GENOMES | MELANOGASTER CHROMOSOME-4 | HETEROCHROMATIN FORMATION | ROLLING-CIRCLE TRANSPOSONS | Polytene Chromosomes | Species Specificity | Exons | Introns | Genomics | Molecular Sequence Annotation | Computational Biology | Selection, Genetic | Drosophila melanogaster - genetics | DNA Transposable Elements | Heterochromatin | Animals | Codon | Gene Rearrangement | Repetitive Sequences, Nucleic Acid | Drosophila Proteins - genetics | Genome | Drosophila - genetics | Evolution, Molecular
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2017, Volume 429, Issue 7, pp. 999 - 1008
We recently discovered that IκBα enhances the rate of release of nuclear factor kappa B (NFκB) from DNA target sites in a process we have termed molecular...
transcription regulation | amide hydrogen/deuterium exchange | Rel homology domain | allostery | IκB kinase | COMPLEX | DISSOCIATION | INTERFACE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALING MODULE | ANKYRIN REPEAT DOMAIN | BETA | Models, Biological | Humans | Mass Spectrometry | NF-KappaB Inhibitor alpha - metabolism | Models, Molecular | Protein Binding | NF-kappa B - metabolism | Protein Conformation | NF-kappa B - chemistry | DNA - metabolism
transcription regulation | amide hydrogen/deuterium exchange | Rel homology domain | allostery | IκB kinase | COMPLEX | DISSOCIATION | INTERFACE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALING MODULE | ANKYRIN REPEAT DOMAIN | BETA | Models, Biological | Humans | Mass Spectrometry | NF-KappaB Inhibitor alpha - metabolism | Models, Molecular | Protein Binding | NF-kappa B - metabolism | Protein Conformation | NF-kappa B - chemistry | DNA - metabolism
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 4, pp. 887 - 895
Total internal reflection fluorescence-based single-molecule Förster resonance energy transfer (FRET) measurements were previously carried out on the ankyrin...
DNA-BINDING | COMPLEX | INHIBITION | BIOPHYSICS | FLUORESCENCE | CRYSTAL-STRUCTURE | DYNAMICS | RESONANCE ENERGY-TRANSFER | MECHANISMS | TRANSCRIPTION FACTOR | PROTEIN-STRUCTURE PREDICTION | NF-KappaB Inhibitor alpha - metabolism | Amides - chemistry | Protein Binding | NF-kappa B - metabolism | Ankyrin Repeat | NF-kappa B - chemistry | Molecular Dynamics Simulation | NF-KappaB Inhibitor alpha - chemistry | Protein
DNA-BINDING | COMPLEX | INHIBITION | BIOPHYSICS | FLUORESCENCE | CRYSTAL-STRUCTURE | DYNAMICS | RESONANCE ENERGY-TRANSFER | MECHANISMS | TRANSCRIPTION FACTOR | PROTEIN-STRUCTURE PREDICTION | NF-KappaB Inhibitor alpha - metabolism | Amides - chemistry | Protein Binding | NF-kappa B - metabolism | Ankyrin Repeat | NF-kappa B - chemistry | Molecular Dynamics Simulation | NF-KappaB Inhibitor alpha - chemistry | Protein
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 4, p. 887
Total internal reflection fluorescence-based single-molecule Forster resonance energy transfer (FRET) measurements were previously carried out on the ankyrin...
Molecules | Hydrogen | Fluorescence | Mass spectrometry | Crystallography | Crystal structure
Molecules | Hydrogen | Fluorescence | Mass spectrometry | Crystallography | Crystal structure
Journal Article
Ophthalmology, ISSN 0161-6420, 07/2018, Volume 125, Issue 7, pp. 1054 - 1063
To assess systemic vascular endothelial growth factor (VEGF)-A levels after treatment with intravitreous aflibercept, bevacizumab, or ranibizumab....
METAANALYSIS | PHARMACOKINETICS | BEVACIZUMAB | INJECTION | OPHTHALMOLOGY | RETINOPATHY | SERUM | RANIBIZUMAB | PREMATURITY | DEGENERATION
METAANALYSIS | PHARMACOKINETICS | BEVACIZUMAB | INJECTION | OPHTHALMOLOGY | RETINOPATHY | SERUM | RANIBIZUMAB | PREMATURITY | DEGENERATION
Journal Article