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integrins (12) 12
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Chemistry – A European Journal, ISSN 0947-6539, 10/2017, Volume 23, Issue 58, p. n/a
Multivalent binding is often used to increase the strength of ligand–receptor interactions. In oncology, the development of multimeric conjugates aims at... 
click chemistry | integrins | peptidomimetics | multivalency | antitumor agents
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 10/2017, Volume 23, Issue 58, pp. 14410 - 14415
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 06/2018, Volume 2018, Issue 23, pp. 2902 - 2909
Two cyclo[DKP‐RGD]‐PTX (PTX = paclitaxel) and two cyclo[RGDfK]‐PTX conjugates containing the Gly‐Phe‐Leu‐Gly (GFLG) linker, which is cleavable by lysosomal... 
Linker technology | Drug delivery | Antitumor agents | Peptidomimetics | Integrins
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 10/2017, Volume 23, Issue 58, pp. 14410 - 14415
This work reports the synthesis of three multimeric RGD peptidomimetic‐paclitaxel conjugates featuring a number of αVβ3 integrin ligands ranging from 2 to 4.... 
click chemistry | integrins | peptidomimetics | multivalency | antitumor agents | Communications | Communication
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2019, Volume 14, Issue 9, pp. 938 - 942
This work reports the synthesis of a series of small‐molecule–drug conjugates containing the αVβ3‐integrin ligand cyclo[DKP‐RGD] or cyclo[DKP‐isoDGR], a... 
integrins | peptidomimetics | drug delivery | auristatins | antitumor agents | Conjugates | Cycloaddition | Internalization | Glioblastoma | Melanoma | Cell lines | Cytotoxicity | Ligands | Tumor cell lines | Chemical synthesis | Viability | Alkynes | Full Paper | Full Papers
Journal Article
ChemMedChem, ISSN 1860-7179, 2019, Volume 14, Issue 9, p. 938
This work reports the synthesis of a series of small-molecule-drug conjugates containing the α β -integrin ligand cyclo[DKP-RGD] or cyclo[DKP-isoDGR], a... 
integrins | peptidomimetics | drug delivery | auristatins | antitumor agents
Journal Article
ChemistryOpen, ISSN 2191-1363, 06/2019, Volume 8, Issue 6, pp. 737 - 742
RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent... 
integrins | cancer | peptidomimetics | drug delivery | antitumor agents | CELLS | DESIGN | INTEGRIN | INVOLVEMENT | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDES | ALPHA(V)BETA | ALPHA-V-BETA-3 | IN-VIVO | BIOLOGICAL EVALUATION | MONOCLONAL-ANTIBODIES | Drugs | Drug delivery systems | Melanoma | Vehicles | Integrins
Journal Article
ChemistryOpen, ISSN 2191-1363, 06/2019, Volume 8, Issue 6, pp. 737 - 742
RGD-cryptophycin and DGR-cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent... 
Binding | Antigens | Conjugates | Drug delivery systems | Peptides | Melanoma | Stockholders | Cytotoxicity | Vitronectin | Cancer therapies | Investigations | Biological activity | Cell adhesion & migration | Ligands | Tumors
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 10/2017, Volume 23, Issue 58
Multivalent binding is often used to increase the strength of ligand-receptor interactions. In oncology, the development of multimeric conjugates aims at... 
Paclitaxel | Integrins | Binding | Antigens | Conjugates | Target recognition
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 10/2017, Volume 23, Issue 58, p. 14410
This work reports the synthesis of three multimeric RGD peptidomimetic-paclitaxel conjugates featuring a number of [alpha].sub.V[beta].sub.3 integrin ligands... 
Carbamates | Paclitaxel | Integrins | Binding | Conjugates | Polyethylene glycol | Spacer | Ligands | Conjugation
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2019, Volume 14, Issue 9, p. 938
This work reports the synthesis of a series of small-molecule-drug conjugates containing the [alpha].sub.V[beta].sub.3-integrin ligand cyclo[DKP-RGD] or... 
Drugs | Drug delivery systems | Gliomas | Analysis | Melanoma | Copper | Integrins | Vehicles
Journal Article
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