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humans (49) 49
male (38) 38
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peripheral vascular disease (24) 24
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hypertension (18) 18
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hypertension - drug therapy (14) 14
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blood-pressure (9) 9
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expression (8) 8
atrial natriuretic peptide (7) 7
obesity (7) 7
rats (7) 7
receptors, atrial natriuretic factor - genetics (7) 7
atrial natriuretic factor - blood (6) 6
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gene expression (6) 6
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italy (6) 6
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hypertension - complications (5) 5
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antihypertensive agents - therapeutic use (4) 4
body mass index (4) 4
dentistry, oral surgery & medicine (4) 4
echocardiography (4) 4
follow-up studies (4) 4
further section (4) 4
genetic variation (4) 4
genetics (4) 4
kallikreins - urine (4) 4
mortality (4) 4
natriuresis (4) 4
nifedipine (4) 4
prospective studies (4) 4
renin (4) 4
renin - metabolism (4) 4
reproducibility of results (4) 4
risk factors (4) 4
treatment outcome (4) 4
adipose (3) 3
adipose tissue - metabolism (3) 3
aged, 80 and over (3) 3
analysis (3) 3
angiotensin-ii (3) 3
angiotensinogen (3) 3
atrial natriuretic factor - administration & dosage (3) 3
blood glucose - analysis (3) 3
calcium antagonists (3) 3
calcium channel blockers - therapeutic use (3) 3
cardiac & cardiovascular systems (3) 3
cardiology (3) 3
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dentistry (3) 3
dihydropyridines - therapeutic use (3) 3
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endocrinology & metabolism (3) 3
gene expression regulation (3) 3
growth factors (3) 3
hypertension - urine (3) 3
kallikrein (3) 3
left-ventricular mass (3) 3
medicine & public health (3) 3
metabolic syndrome - complications (3) 3
natriuretic peptide receptors (3) 3
natriuretic peptides (3) 3
nifedipine - therapeutic use (3) 3
obesity - metabolism (3) 3
pharmacotherapy (3) 3
polymerase chain reaction (3) 3
prognosis (3) 3
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1. Full Text A Manual of Guidelines to Score the Modified Cumulative Illness Rating Scale and Its Validation in Acute Hospitalized Elderly Patients
by Salvi, Fabio and Miller, Mark D and Grilli, Annalisa and Giorgi, Raffaella and Towers, Adele L and Morichi, Valeria and Spazzafumo, Liana and Mancinelli, Lucia and Espinosa, Emma and Rappelli, Alessandro and Dessì‐Fulgheri, Paolo
Journal of the American Geriatrics Society, ISSN 0002-8614, 10/2008, Volume 56, Issue 10, pp. 1926 - 1931
OBJECTIVES: To update previous guidelines to score the Cumulative Illness Rating Scale (CIRS) and test their usefulness in hospitalized elderly patients.... 
illness severity | CIRS | mortality | guidelines | comorbidity | Comorbidity | Mortality | Guidelines | Illness severity | illness severity mortality | POPULATION | OLDER-ADULTS | cIRS | COMPREHENSIVE GERIATRIC ASSESSMENT | FRAILTY | GERIATRICS & GERONTOLOGY | FAMILY-PRACTICE | DISEASE | DISABILITY | GERONTOLOGY | INDEX | Geriatric Assessment | Severity of Illness Index | Reproducibility of Results | Patient Readmission | Humans | Male | Hospitalization | Female | Aged | Psychological Tests | Observer Variation | Aged patients | Illnesses | Internal medicine | Older people | Ratings & rankings | Predictions
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2. Full Text Renin–angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans
by Sarzani, Riccardo and Salvi, Fabio and Dessì-Fulgheri, Paolo and Rappelli, Alessandro
Journal of Hypertension, ISSN 0263-6352, 05/2008, Volume 26, Issue 5, pp. 831 - 843
The obesity pandemic is closely related to hypertension and metabolic syndrome. Visceral adipose tissue plays a key role in the metabolic and cardiovascular... 
Hypertension | Adipocyte | Obesity | Renin | Angiotensin | Aldosterone | Metabolic syndrome | Lipolysis | MITOCHONDRIAL BIOGENESIS | aldosterone | HEART-FAILURE | MEDIATED UP-REGULATION | DIET-INDUCED OBESITY | BLOOD-PRESSURE | LOW-CALORIE DIET | metabolic syndrome | HUMAN ADIPOSE-TISSUE | renin | INSULIN-RESISTANCE | adipocyte | angiotensin | BODY-MASS INDEX | PERIPHERAL VASCULAR DISEASE | lipolysis | hypertension | PLASMA-ALDOSTERONE LEVELS | obesity | Natriuretic Peptides - physiology | Humans | Metabolic Syndrome - physiopathology | Hypertension - complications | Obesity - physiopathology | Renin-Angiotensin System - physiology | Adipocytes - physiology | Lipolysis - physiology | Hypertension - physiopathology | Metabolic Syndrome - complications
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3. Full Text The association of left ventricular hypertrophy with metabolic syndrome is dependent on body mass index in hypertensive overweight or obese patients
by Guerra, Federico and Mancinelli, Lucia and Angelini, Luca and Fortunati, Marco and Rappelli, Alessandro and Dessí-Fulgheri, Paolo and Sarzani, Riccardo
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, p. e16630
Background: Overweight (Ow) and obesity (Ob) influence blood pressure (BP) and left ventricular hypertrophy (LVH). It is unclear whether the presence of... 
HEART | MORTALITY | IMPACT | CONTROL RATES | MANAGEMENT | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | WEIGHT-LOSS | SCIENTIFIC STATEMENT | GENDER-DIFFERENCES | Body Mass Index | Hypertension | Obesity | Humans | Hypertrophy, Left Ventricular - etiology | Risk Factors | Male | Metabolic Syndrome - complications | Overweight | Stroke Volume | Aged, 80 and over | Female | Aged | Type 2 diabetes | Body mass index | Care and treatment | Usage | Heart enlargement | Risk factors | Heart | Adipose tissue | Body weight | ISO standards | Medical services | Cardiovascular disease | Males | Metabolic syndrome | Mens health | Blood pressure | Age | Heart failure | Young adults | Internal medicine | Septum | Metabolic diseases | Triglycerides | Wall thickness | Patients | Medicine | Geometry | Weight control | Hospitals | Body mass | Womens health | Body size | Diabetes | Ventricle | Females | Metabolic disorders | Hypertrophy | Ejection
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4. Full Text Treatment of Isolated Systolic Hypertension: The SHELL Study Results
by MALACCO, ETTORE and MANCIA, GIUSEPPE and RAPPELLI, ALESSANDRO and MENOTTI, ALESSANDRO and ZUCCARO, M. STEFANO and COPPINI, ALESSANDRO and SHELL Invest
Blood Pressure, ISSN 0803-7051, 2003, Volume 12, Issue 3, pp. 160 - 167
Objective: Our aim was to compare the effect of lacidipine and chlorthalidone on cardiovascular outcome as a primary parameter and blood pressure as a... 
Diuretic | Isolated Systolic Hypertension | Dihydropyridine | Hydrochlorothiazide | Mortality | Calcium Channel Blocker | mortality | diuretic | isolated systolic hypertension | dihydropyridine | calcium channel blocker | hydrochlorothiazide | Calcium channel blocker | Isolated systolic hypertension | PLACEBO | ACTIVE TREATMENT | PROTOCOL | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | DIASTOLIC BLOOD-PRESSURE
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5. Full Text Hypertension and obesity after the menopause
by Rappelli, Alessandro
Journal of Hypertension, ISSN 0263-6352, 05/2002, Volume 20, Issue 2, pp. S26 - S28
It is well known that in pre-menopausal women the incidence of cardiovascular events is lower than in men of the same age and that after the menopause... 
Natriuretic peptide receptors | Obesity-related hypertension | Adipose tissue | ANP | obesity-related hypertension | ATRIAL-NATRIURETIC-PEPTIDE | natriuretic peptide receptors | adipose tissue | PERIPHERAL VASCULAR DISEASE | RECEPTORS | EXPRESSION | ADIPOSE-TISSUE
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6. Full Text A double-blind randomized trial comparing implants with laser-microtextured and machined collar surfaces: Microbiologic and clinical results
by Guarnieri, Renzo and Rappelli, Giorgio and Piemontese, Matteo and Procaccini, Maurizio and Quaranta, Alessandro
International Journal of Oral and Maxillofacial Implants, ISSN 0882-2786, 2016, Volume 31, Issue 5, pp. 1117 - 1125
Purpose: The purpose of this study was to compare the clinical outcome of and determine the differences in periodonto-pathogenic microbiota around two types of... 
Implant | Microbiology | Bacteria | DENTAL IMPLANTS | bacteria | CONNECTIVE-TISSUE ATTACHMENT | microbiology | MARGINAL BONE LEVEL | HISTOLOGIC EVIDENCE | implant | SOFT-TISSUE | IN-VITRO | DENTISTRY, ORAL SURGERY & MEDICINE | INITIAL SUBGINGIVAL COLONIZATION | RADIOGRAPHIC EVALUATION | PARTIALLY EDENTULOUS PATIENTS | DEFINED BIOMATERIAL SURFACES | Double-Blind Method | Gingival Diseases - microbiology | Bacterial Infections - etiology | Humans | Middle Aged | Dental Implants - microbiology | Male | Prevotella intermedia - isolation & purification | Aggregatibacter actinomycetemcomitans - isolation & purification | Jaw, Edentulous, Partially - rehabilitation | Porphyromonas gingivalis - isolation & purification | Dental Prosthesis Design | Tannerella forsythia - isolation & purification | Dental Etching - methods | Lasers | Gingival Diseases - etiology | Adult | Female | Aged | Treponema denticola - isolation & purification | Real-Time Polymerase Chain Reaction | Bacterial Infections - microbiology
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7. Full Text Technical and biological complications related to crown to implant ratio: A systematic review
by Quaranta, Alessandro and Piemontese, Matteo and Rappelli, Giorgio and Sammartino, Gilberto and Procaccini, Maurizio
Implant Dentistry, ISSN 1056-6163, 2014, Volume 23, Issue 2, pp. 180 - 187
Aim:To review the occurrence of prosthetic failure and biological complications with respect to the crown to implant (C/I) ratio.Methods:Accurate search was... 
perimplantitis | radiographic assessment | prosthetic failure | implant failure | crown to implant ratio | bone resorption | SUPPORTED RESTORATIONS | OBSERVATION PERIOD | SHORT DENTAL IMPLANTS | STRESS-DISTRIBUTION | SINGLE-TOOTH REPLACEMENT | 14-YEAR FOLLOW-UP | DENTISTRY, ORAL SURGERY & MEDICINE | LEAST 5 YEARS | FIXED PARTIAL DENTURES | OF-THE-LITERATURE | RETROSPECTIVE ANALYSIS | Dental Implants - adverse effects | Dental Restoration Failure - statistics & numerical data | Crowns - adverse effects | Dental Prosthesis, Implant-Supported - adverse effects | Dental Prosthesis, Implant-Supported - methods | Dental Abutments - adverse effects | Humans | Dental Prosthesis Design
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8. Full Text The 212A Variant of the APJ Receptor Gene for the Endogenous Inotrope Apelin is Associated With Slower Heart Failure Progression in Idiopathic Dilated Cardiomyopathy
by Sarzani, Riccardo, MD, PhD and Forleo, Cinzia, MD, PhD and Pietrucci, Francesca, PhD and Capestro, Alessandro, MD and Soura, Elli, MD and Guida, Pietro, MS and Sorrentino, Sandro, PhD and Iacoviello, Massimo, MD, PhD and Romito, Roberta, MD and Dessì-Fulgheri, Paolo, MD and Pitzalis, Mariavittoria, MD, PhD and Rappelli, Alessandro, MD
Journal of Cardiac Failure, ISSN 1071-9164, 2007, Volume 13, Issue 7, pp. 521 - 529
Abstract Background Idiopathic dilated cardiomyopathy (IDC) has multiple genetic and acquired causes. Apelin is an endogenous peptide that increases cardiac... 
Cardiovascular | apelin | cardiomyopathy | APJ | CARDIAC & CARDIOVASCULAR SYSTEMS | ORPHAN RECEPTOR | CLASSIFICATION | LIGAND APELIN | BLOOD-PRESSURE | PEPTIDE APELIN | TISSUE DISTRIBUTION | IN-VIVO | CARDIAC CONTRACTILITY | RAT-BRAIN | UROTENSIN-II | Haplotypes | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Guanine | Genetic Variation | Intercellular Signaling Peptides and Proteins - metabolism | DNA Mutational Analysis | Adult | Female | Cytosine | Apelin | Cardiomyopathy, Dilated - genetics | Myocardial Contraction | Adenine | Genotype | Gene Dosage | Disease Progression | Linkage Disequilibrium | Polymorphism, Genetic | Homozygote | Cardiomyopathy, Dilated - physiopathology | Apelin Receptors | Alleles | Receptors, G-Protein-Coupled - genetics | Cardiomyopathy, Dilated
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9. Full Text A Geriatric Emergency Service for Acutely Ill Elderly Patients: Pattern of Use and Comparison with a Conventional Emergency Department in Italy
by Salvi, Fabio and Morichi, Valeria and Grilli, Annalisa and Giorgi, Raffaella and Spazzafumo, Liana and Polonara, Stefano and De Tommaso, Giuseppe and Rappelli, Alessandro and Dessì‐Fulgheri, Paolo
Journal of the American Geriatrics Society, ISSN 0002-8614, 11/2008, Volume 56, Issue 11, pp. 2131 - 2138
The current disease‐oriented, episodic model of emergency care does not adequately address the complex needs of older adults presenting to emergency... 
aged | geriatric health services | emergency medicine | outcomes | Aged | Geriatric health services | Emergency medicine | Outcomes | INTERVENTIONS | VISIT | OLDER-ADULTS | GERONTOLOGY | RISK | INDEX | MEDICINE | GERIATRICS & GERONTOLOGY | Hospital Mortality | Humans | Hospitalization - statistics & numerical data | Male | Treatment Outcome | Frail Elderly | Acute Disease - therapy | Acute Disease - mortality | Health Services for the Aged - utilization | Aged, 80 and over | Female | Italy | Retrospective Studies | Emergency Service, Hospital - utilization | Cohort Studies | Aged patients | Emergency service | Hospitals | Analysis | Convention bureaus | Older people | Emergency medical care
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10. Full Text Three-dimensional bone augmentation and immediate implant placement via transcrestal sinus lift: 8-year clinical outcomes
by Rizzo, Rosario and Quaranta, Alessandro and De Paoli, Massimo and Rappelli, Giorgio and Piemontese, Matteo
International Journal of Periodontics and Restorative Dentistry, ISSN 0198-7569, 2018, Volume 38, Issue 3, pp. 423 - 429
When the edentulous posterior maxilla shows severe atrophy (Cawood and Howell Class V to VI), the traditional approach requires at least two surgical... 
MAXILLARY | TECHNICAL NOTE | FLOOR ELEVATION | DENTISTRY, ORAL SURGERY & MEDICINE
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11. Full Text Three-dimensional bone augmentation and immediate implant placement via transcrestal sinus lift: Five-Year clinical outcomes
by Rizzo, Rosario and Quaranta, Alessandro and De Paoli, Massimo and Rappelli, Giorgio and Piemontese, Matteo
International Journal of Periodontics and Restorative Dentistry, ISSN 0198-7569, 2018, Volume 38, Issue 1, pp. 94 - 101
This study proposed a surgical technique that solves three-dimensional conditions of extreme bone atrophy. A total of 278 surgeries with transcrestal sinus... 
SURVIVAL | REGENERATION | ALLOGRAFT | DENTISTRY, ORAL SURGERY & MEDICINE | MAXILLARY SINUS | MEMBRANES | WINDOW
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12. Full Text Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives
by Leonetti, Gastone and Magnani, Bruno and Pessina, Achille Cesare and Rappelli, Alessandro and Trimarco, Bruno and Zanchetti, Alberto and COHORT Study Grp and COHORT Study Group
American Journal of Hypertension, ISSN 0895-7061, 2002, Volume 15, Issue 11, pp. 932 - 940
Background: Irrespective of their clinical relevance, side effects cannot be considered a negligible problem in antihypertensive therapy. The aim of this trial... 
essential hypertension | edema | lacidipine | elderly | amlodipine | Lercanidipine | Amlodipine | Edema | Essential hypertension | Elderly | Lacidipine | MANAGEMENT | EFFICACY | ANTIHYPERTENSIVE DRUGS | CALCIUM-ANTAGONISTS | BLOOD-PRESSURE | THERAPY | REAPPRAISAL | NIFEDIPINE | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | QUALITY-OF-LIFE | lercanidipine | Calcium Channel Blockers - adverse effects | Double-Blind Method | Humans | Calcium Channel Blockers - therapeutic use | Amlodipine - adverse effects | Hypertension - drug therapy | Male | Treatment Outcome | Amlodipine - therapeutic use | Dihydropyridines - adverse effects | Dihydropyridines - therapeutic use | Peripheral Vascular Diseases - chemically induced | Female | Aged | Edema - chemically induced | Drug Therapy, Combination
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13. Full Text A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males
by Sarzani, Riccardo and Bordicchia, Marica and Salvi, Fabio and Cola, Giovanna and Franchi, Eliana and Battistoni, Ilaria and Mancinelli, Lucia and Giovagnoli, Andrea and Dessì-Fulgheri, Paolo and Rappelli, Alessandro
American Journal of Hypertension, ISSN 0895-7061, 08/2008, Volume 21, Issue 8, pp. 960 - 963
Background Fatty acid amide hydrolase (FAAH) inhibitors, preventing endocannabinoid (EC) degradation, reduce blood pressure (BP) and heart rate in young male... 
ENERGY-BALANCE | OBESITY | FOOD-INTAKE | DYSREGULATION | ENDOCANNABINOID SYSTEM | PERIPHERAL VASCULAR DISEASE | ADIPOSE | Follow-Up Studies | Blood Pressure - genetics | Amidohydrolases - genetics | Humans | Middle Aged | Genotype | Male | Obesity - genetics | Receptor, Cannabinoid, CB1 - physiology | Genetic Variation | Aging - genetics | Adult | Hypertension - genetics | Young men | Enzymes | Hydrolases | Blood pressure | Genetic aspects | Health aspects
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14. Full Text Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans
by Bordicchia, Marica and Battistoni, Ilaria and Mancinelli, Lucia and Giannini, Elena and Refi, Giada and Minardi, Daniele and Muzzonigro, Giovanni and Mazzucchelli, Roberta and Montironi, Rodolfo and Piscitelli, Fabiana and Petrosino, Stefania and Dessì-Fulgheri, Paolo and Rappelli, Alessandro and Di Marzo, Vincenzo and Sarzani, Riccardo
Metabolism, ISSN 0026-0495, 2010, Volume 59, Issue 5, pp. 734 - 741
Abstract Dysregulation of the endocannabinoid system in the visceral adipose tissue (VAT) is associated with metabolic and cardiovascular complications of... 
Endocrinology & Metabolism | METABOLIC SYNDROME | OBESE MEN | ABDOMINAL ADIPOSITY | RENIN-ANGIOTENSIN SYSTEM | GENE CNR1 | TISSUE | ENDOCRINOLOGY & METABOLISM | OVERWEIGHT PATIENTS | RIMONABANT | WEIGHT | CARDIOMETABOLIC RISK-FACTORS | Cannabinoid Receptor Modulators - metabolism | Humans | Middle Aged | RNA, Messenger - genetics | Gene Expression Regulation | Genotype | Logistic Models | Male | Tomography, X-Ray Computed | Intra-Abdominal Fat - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Obesity - genetics | Obesity - metabolism | Obesity - pathology | Adiponectin - blood | RNA, Messenger - biosynthesis | Receptor, Cannabinoid, CB1 - genetics | Microvessels | Female | Aged | Polymorphism, Single Nucleotide | Intra-Abdominal Fat - pathology | Endocannabinoids | Receptor, Cannabinoid, CB1 - biosynthesis | DNA polymerases | Analysis | Messenger RNA
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15. Full Text Natriuretic Peptide Clearance Receptor Alleles and Susceptibility to Abdominal Adiposity
by Sarzani, Riccardo and Strazzullo, Pasquale and Salvi, Fabio and Iacone, Roberto and Pietrucci, Francesca and Siani, Alfonso and Barba, Gianvincenzo and Gerardi, Maria Clara and Dessì‐Fulgheri, Paolo and Rappelli, Alessandro
Obesity, ISSN 1930-7381, 02/2004, Volume 12, Issue 2, pp. 351 - 356
Objective: To test the association of the C(−55)A polymorphism of the natriuretic peptide clearance receptor (NPRC) with blood pressure (BP),... 
central obesity | clearance receptor | natriuretic | alleles | Natriuretic | Clearance receptor | Central obesity | Alleles | NUTRITION & DIETETICS | GENE | TISSUE | ENDOCRINOLOGY & METABOLISM | OBESE HYPERTENSIVES | EXPRESSION | LOW-CALORIE DIET | BLOOD | Cross-Sectional Studies | Follow-Up Studies | Gene Frequency | Humans | Middle Aged | Genotype | Male | Obesity - genetics | Abdomen | Polymorphism, Genetic | Adipose Tissue - metabolism | Obesity - epidemiology | Polymerase Chain Reaction | Receptors, Atrial Natriuretic Factor - genetics | Adult | Guanylate Cyclase - genetics | Aged | Hypertension - epidemiology | Hypertension - genetics | Adipose Tissue - anatomy & histology
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16. Full Text Patterns of hypertension management in Italy: Results of a pharmacoepidemiological survey on antihypertensive therapy
by Ambrosioni, Ettore and Leonetti, Gastone and Pessina, Achille C and Rappelli, Alessandro and Trimarco, Bruno and Zanchetti, Alberto and Sci Comm Italian Pharmacoepidemio
Journal of Hypertension, ISSN 0263-6352, 2000, Volume 18, Issue 11, pp. 1691 - 1699
Objective To collect statistically significant information on patterns of antihypertensive therapy in medical practice, with particular attention to the drugs... 
Antihypertensive therapy | Patient survey | Physician survey | Drug side effects | Hypertension management | POPULATION | antihypertensive therapy | PERIPHERAL VASCULAR DISEASE | hypertension management | patient survey | physician survey | drug side effects
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