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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, pp. E6404 - E6410
Journal Article
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 05/2020
A catalytic manifold that enables photoredox cross-electrophile coupling of alkyl bromides with DNA-tagged aryl iodides in aqueous solution is presented. This... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 02/2009, Volume 74, Issue 3, pp. 1156 - 1162
Eudistomides A (1) and B (2), two new cyclic peptides, were isolated from a Fijian ascidian Eudistoma sp. These five-residue cystine-linked cyclic peptides are... 
BETA-CARBOLINE ALKALOIDS | OLIVACEUM | CF RIGIDA | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | MARINE-DERIVED FUNGUS | CYANOBACTERIUM LYNGBYA-MAJUSCULA | CARIBBEAN TUNICATE | CYCLIC-PEPTIDES | GLAUCUS | LISSOCLINUM-PATELLA
Journal Article
Organic Letters, ISSN 1523-7060, 05/2006, Volume 8, Issue 10, pp. 2171 - 2174
Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A2 derivatives (6a−6c) has been accomplished. (15S)-Prostaglandin-A2 (1), from... 
Prostaglandins A - chemical synthesis | Hydrocarbons, Halogenated - chemical synthesis | Stereoisomerism | Prostaglandins A - chemistry | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Prostaglandins, Synthetic - chemical synthesis | Hydrocarbons, Halogenated - chemistry
Journal Article
Bioconjugate chemistry, ISSN 1043-1802, 01/2019, Volume 30, Issue 1, pp. 200 - 209
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 04/2020, Volume 22, Issue 8, pp. 2908 - 2913
The on-DNA synthesis of highly substituted cyclobutanes was achieved through a photocatalytic [2 + 2] cycloaddition reaction in aqueous solution. Readily... 
LIBRARIES | CHEMISTRY, ORGANIC | ALKYLATION
Journal Article
Methods in molecular biology (Clifton, N.J.), 2020, Volume 2078, p. 291
Incomplete removal of free (unconjugated) drug or drug-linker species used to prepare ADCs results in contaminated ADC samples which may pose a risk for... 
Journal Article
ACS combinatorial science, ISSN 2156-8952, 10/2019, Volume 21, Issue 10, pp. 650 - 655
DNA-encoded chemical library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the... 
CHEMISTRY, MEDICINAL | DNA-encoded chemical libraries (DECLs) | FIDELITY | DNA damage | on-DNA chemistry | CHEMISTRY, APPLIED | TECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | quantitative PCR (qPCR)
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, p. E6404
DNA-encoded libraries (DEL)-based discovery platforms have recently been widely adopted in the pharmaceutical industry, mainly due to their powerful diversity... 
Linkages | Cross coupling | Free radicals | Data processing | Chemical reactions | Parameter sensitivity | Data mining | Empirical analysis | Coupling (molecular) | Organic chemistry | Synthesis | Coding | Kinetics | Chemical synthesis | Pharmaceutical industry | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 08/2014, Volume 111, Issue 33, p. E3376
  Spliceostatins are potent spliceosome inhibitors biosynthesized by a hybrid nonribosomal peptide synthetase -polyketide synthase (NRPS-PKS) system of the... 
Metabolites | Natural products | Bacteria | Biosynthesis
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 08/2014, Volume 111, Issue 33, pp. E3376 - E3376
Spliceostatins are potent spliceosome inhibitors biosynthesized by a hybrid nonribosomal peptide synthetase -polyketide synthase (NRPS-PKS) system of the... 
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 06/2020, Volume 11, Issue 6, pp. 1101 - 1110
High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and... 
Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry | CHEMISTRY, MEDICINAL | EVOLUTION | COMBINATORIAL | high-throughput experimentation | parallel medicinal chemistry | EXPERIMENTATION | TECHNOLOGY
Journal Article
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 08/2014, Volume 77, Issue 8, pp. 1864 - 1870
Journal Article
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